Jean Marc Gallo

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining
    J Paul Chapple
    MRC Centre for Neurodegeneration Research, King s College London, Department of Clinical Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neurosci Lett 447:172-4. 2008
  2. pmc Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies
    Teresa Rodriguez-Martin
    Medical Research Council Centre for Neurodegeneration, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Proc Natl Acad Sci U S A 102:15659-64. 2005
  3. ncbi request reprint Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4
    J Paul Chapple
    MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Hum Mol Genet 16:2760-9. 2007
  4. ncbi request reprint Ligand-dependent aggregation of polyglutamine-expanded androgen receptor in neuronal cells
    R Siobhan Darrington
    Department of Neurology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neuroreport 13:2117-20. 2002
  5. ncbi request reprint Protective effects of estrogens on polyglutamine-expanded androgen receptor aggregation in mice
    R Siobhan Darrington
    Department of Neurology, Institute of Psychiatry, King s College London, Box PO38, De Crespigny Park, London, SE5 8AF, UK
    Neurosci Lett 350:37-40. 2003
  6. doi request reprint Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration
    Agnes L Nishimura
    Medical Research Council MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, SE5 8AF, UK
    Brain 133:1763-71. 2010
  7. ncbi request reprint Degradation properties of polyglutamine-expanded human androgen receptor in transfected cells
    Daniel A Cullen
    Department of Neurology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neurosci Lett 357:175-8. 2004
  8. ncbi request reprint A novel somatodendritic marker defined by a peptide derived from the ALS2 protein
    Virginie Bros
    Department of Neurology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF
    Neuroreport 15:2155-9. 2004
  9. ncbi request reprint Distinct patterns of tau-dependent process formation in mammalian cell lines
    Lucie I Bruijn
    Department of Neurology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neuroreport 15:2223-6. 2004
  10. doi request reprint Tau alternative splicing in familial and sporadic tauopathies
    Michael Niblock
    Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London, UK
    Biochem Soc Trans 40:677-80. 2012

Collaborators

Detail Information

Publications20

  1. pmc Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining
    J Paul Chapple
    MRC Centre for Neurodegeneration Research, King s College London, Department of Clinical Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neurosci Lett 447:172-4. 2008
    ..Lamin immunocytochemistry would be of value to monitor the state of the nuclear envelope in experimental paradigms aimed at establishing the significance of perinuclear aggregates of pathogenic proteins...
  2. pmc Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies
    Teresa Rodriguez-Martin
    Medical Research Council Centre for Neurodegeneration, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Proc Natl Acad Sci U S A 102:15659-64. 2005
    ..Our results demonstrate that an alternatively spliced exon can be replaced by trans-splicing and open the way to novel therapeutic applications of SMaRT for tauopathies and other disorders linked to aberrant alternative splicing...
  3. ncbi request reprint Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4
    J Paul Chapple
    MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Hum Mol Genet 16:2760-9. 2007
    ..This study represents the first characterization of TNRC4 and provides further insight into the mechanisms of brain-specific alternative splicing and their possible pathological implications...
  4. ncbi request reprint Ligand-dependent aggregation of polyglutamine-expanded androgen receptor in neuronal cells
    R Siobhan Darrington
    Department of Neurology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neuroreport 13:2117-20. 2002
    ....
  5. ncbi request reprint Protective effects of estrogens on polyglutamine-expanded androgen receptor aggregation in mice
    R Siobhan Darrington
    Department of Neurology, Institute of Psychiatry, King s College London, Box PO38, De Crespigny Park, London, SE5 8AF, UK
    Neurosci Lett 350:37-40. 2003
    ..We conclude that estrogens protect polyglutamine-expanded AR from aggregation through a non-genomic mechanism possibly involving estrogen binding to the AR...
  6. doi request reprint Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration
    Agnes L Nishimura
    Medical Research Council MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, SE5 8AF, UK
    Brain 133:1763-71. 2010
    ..We propose that cellular apoptosis susceptibility protein associated defective nuclear transport may play a mechanistic role in the pathogenesis of the TDP-43 positive frontotemporal lobar degeneration...
  7. ncbi request reprint Degradation properties of polyglutamine-expanded human androgen receptor in transfected cells
    Daniel A Cullen
    Department of Neurology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neurosci Lett 357:175-8. 2004
    ....
  8. ncbi request reprint A novel somatodendritic marker defined by a peptide derived from the ALS2 protein
    Virginie Bros
    Department of Neurology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF
    Neuroreport 15:2155-9. 2004
    ..ARDA was also selectively localized to the somatodendritic compartment of motor neurons in human spinal cord. The ARDA antigen therefore represents a novel somatodendritic marker for embryonic and adult neurons...
  9. ncbi request reprint Distinct patterns of tau-dependent process formation in mammalian cell lines
    Lucie I Bruijn
    Department of Neurology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neuroreport 15:2223-6. 2004
    ..These results suggest that cell-specific factors are involved in tau-dependent microtubule organization, a notion that could facilitate functional assessment of tau abnormalities associated with neurodegenerative disease...
  10. doi request reprint Tau alternative splicing in familial and sporadic tauopathies
    Michael Niblock
    Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London, UK
    Biochem Soc Trans 40:677-80. 2012
    ..Tau alternative splicing could represent a target for therapeutic intervention to delay the progression of pathology in familial as well as sporadic tauopathies...
  11. pmc Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing
    Maria Elena Avale
    Department of Clinical Neuroscience, Centre for Neurodegeneration Research, King s College London, Institute ofPsychiatry, De Crespigny Park, London, UK
    Hum Mol Genet 22:2603-11. 2013
    ..These results validate the potential of SMaRT to correct tau mis-splicing and provide a framework for its therapeutic application to neurodegenerative conditions linked to aberrant RNA processing...
  12. doi request reprint Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells
    Agnes L Nishimura
    Department of Clinical Neuroscience, King s College London, London, United Kingdom
    PLoS ONE 9:e91269. 2014
    ..We conclude that RNA interference can be used to selectively target the TDP-43(M337V) allele in mammalian and patient cells, thus demonstrating the potential for using RNA interference as a therapeutic tool for ALS...
  13. ncbi request reprint The role of RNA and RNA processing in neurodegeneration
    Jean Marc Gallo
    Medical Research Council Centre for Neurodegeneration Research, Department of Neurology, Institute of Psychiatry, King s College London, SE5 8AF, United Kingdom
    J Neurosci 25:10372-5. 2005
  14. pmc Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing
    Teresa Rodriguez-Martin
    Department of Clinical Neuroscience, MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London SE5 8AF, UK
    Hum Mol Genet 18:3266-73. 2009
    ..In conclusion, RNA trans-splicing could provide the basis of therapeutic strategies for impaired alternative splicing caused by pathogenic mutations in cis-acting splicing elements...
  15. doi request reprint Aberrant RNA processing events in neurological disorders
    Karen Anthony
    MRC Centre for Neurodegeneration Research, King s College London, Department of Clinical Neuroscience, Institute of Psychiatry, De Crespigny Park, London, UK
    Brain Res 1338:67-77. 2010
    ..Here we review RNA processing events and their extensive coupling to one another and detail the associations of RNA processing including, but not exclusively, alternative splicing with neurodegeneration...
  16. ncbi request reprint Dynamic properties of APC-decorated microtubules in living cells
    Rejith Dayanandan
    Department of Neuroscience, Institute of Psychiatry, King s College London, United Kingdom
    Cell Motil Cytoskeleton 54:237-47. 2003
    ....
  17. doi request reprint Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic
    Youn Bok Lee
    Department of Clinical Neuroscience, King s College London, Institute of Psychiatry, London SE5 8AF, UK
    Cell Rep 5:1178-86. 2013
    ..We show that expanded G4C2 repeats are potently neurotoxic and bind hnRNP-H and other RNA binding proteins. We propose that RNA toxicity and protein sequestration may disrupt RNA processing and contribute to neurodegeneration. ..
  18. pmc The role of CELF proteins in neurological disorders
    Jean Marc Gallo
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, Department of Clinical Neuroscience, De Crespigny Park, London UK
    RNA Biol 7:474-9. 2010
    ..The involvement of CELF proteins suggest that individual pathogenic pathways in a number of neurological conditions overlap at the level of RNA processing...
  19. doi request reprint Modelling C9ORF72 hexanucleotide repeat expansion in amyotrophic lateral sclerosis and frontotemporal dementia
    Alan Stepto
    Department of Neuroscience, Institute of Psychiatry, King s College London, PO Box 37, 16 De Crespigny Park, London, SE5 8AF, UK
    Acta Neuropathol 127:377-89. 2014
    ..These studies in cell and animal models therefore identify RNA toxicity, RBP sequestration and accumulation of DPRs as emerging pathogenic pathways underlying C9 ALS/FTLD. ..
  20. doi request reprint Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
    Caroline Vance
    Department of Clinical Neuroscience, King s College London, Medical Research Council MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London SE5 8AF, UK
    Science 323:1208-11. 2009
    ..FUS is involved in the regulation of transcription and RNA splicing and transport, and it has functional homology to another ALS gene, TARDBP, which suggests that a common mechanism may underlie motor neuron degeneration...