C H Fu

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand
    Cynthia H Y Fu
    Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom
    Neuroimage 17:871-9. 2002
  2. ncbi Functional neuroimaging in psychiatry
    C H Fu
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Philos Trans R Soc Lond B Biol Sci 354:1359-70. 1999
  3. ncbi Neural responses to sad facial expressions in major depression following cognitive behavioral therapy
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, London
    Biol Psychiatry 64:505-12. 2008
  4. ncbi Pattern classification of sad facial processing: toward the development of neurobiological markers in depression
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    Biol Psychiatry 63:656-62. 2008
  5. ncbi Neural responses to happy facial expressions in major depression following antidepressant treatment
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, UK
    Am J Psychiatry 164:599-607. 2007
  6. ncbi Modulation of effective connectivity by cognitive demand in phonological verbal fluency
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
    Neuroimage 30:266-71. 2006
  7. ncbi Effects of ketamine on prefrontal and striatal regions in an overt verbal fluency task: a functional magnetic resonance imaging study
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Psychopharmacology (Berl) 183:92-102. 2005
  8. ncbi An fMRI study of verbal self-monitoring: neural correlates of auditory verbal feedback
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Cereb Cortex 16:969-77. 2006
  9. ncbi Effects of psychotic state and task demand on prefrontal function in schizophrenia: an fMRI study of overt verbal fluency
    Cynthia H Y Fu
    Division of Psychological Medicine, Institute of Psychiatry, 103 Denmark Hill, London SE5 8AF UK
    Am J Psychiatry 162:485-94. 2005
  10. ncbi A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy
    Nicholas D Walsh
    Institute of Psychiatry, King s College London, De Crespigny Park, 103 Denmark Hill, London, UK
    Biol Psychiatry 62:1236-43. 2007

Detail Information

Publications36

  1. ncbi A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand
    Cynthia H Y Fu
    Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom
    Neuroimage 17:871-9. 2002
    ..This may reflect the greater demands of the former, particularly in terms of arousal responses with increased task difficulty and the monitoring of potential response errors...
  2. ncbi Functional neuroimaging in psychiatry
    C H Fu
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Philos Trans R Soc Lond B Biol Sci 354:1359-70. 1999
    ..We will also discuss practical issues that are particular to studying psychiatric disorders and the potential contribution of functional neuroimaging to future psychiatric research...
  3. ncbi Neural responses to sad facial expressions in major depression following cognitive behavioral therapy
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, London
    Biol Psychiatry 64:505-12. 2008
    ..The present study investigated the neural correlates of implicit processing of sad facial expressions in depression pretreatment and posttreatment with cognitive behavioral therapy (CBT)...
  4. ncbi Pattern classification of sad facial processing: toward the development of neurobiological markers in depression
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    Biol Psychiatry 63:656-62. 2008
    ..We sought to examine the sensitivity and specificity of whole brain pattern classification of implicit processing of sad facial expressions in depression...
  5. ncbi Neural responses to happy facial expressions in major depression following antidepressant treatment
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, UK
    Am J Psychiatry 164:599-607. 2007
    ..However, depressed patients show impairments in this system. The present study investigated the neural correlates of implicit processing of happy facial expressions in depression and identified regions affected by antidepressant therapy...
  6. ncbi Modulation of effective connectivity by cognitive demand in phonological verbal fluency
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
    Neuroimage 30:266-71. 2006
    ....
  7. ncbi Effects of ketamine on prefrontal and striatal regions in an overt verbal fluency task: a functional magnetic resonance imaging study
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Psychopharmacology (Berl) 183:92-102. 2005
    ..Glutamatergic dysfunction at N-methyl-D: -aspartate (NMDA) receptors has been proposed as a neurochemical model for schizophrenia. A key feature of this disorder is impairments in cognitive function...
  8. ncbi An fMRI study of verbal self-monitoring: neural correlates of auditory verbal feedback
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Cereb Cortex 16:969-77. 2006
    ..These findings support the self-monitoring model as mismatches between expected and actual auditory feedback were associated with greater temporal activation...
  9. ncbi Effects of psychotic state and task demand on prefrontal function in schizophrenia: an fMRI study of overt verbal fluency
    Cynthia H Y Fu
    Division of Psychological Medicine, Institute of Psychiatry, 103 Denmark Hill, London SE5 8AF UK
    Am J Psychiatry 162:485-94. 2005
    ....
  10. ncbi A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy
    Nicholas D Walsh
    Institute of Psychiatry, King s College London, De Crespigny Park, 103 Denmark Hill, London, UK
    Biol Psychiatry 62:1236-43. 2007
    ..Impairments in the neural circuitry of verbal working memory are evident in depression. Factors of task demand and depressive state might have significant effects on its functional neuroanatomy...
  11. ncbi Neuroanatomy of verbal working memory as a diagnostic biomarker for depression
    Andre F Marquand
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Neuroreport 19:1507-11. 2008
    ....
  12. ncbi Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study
    Cynthia H Y Fu
    Institute of Psychiatry, King's College London, London, England
    Arch Gen Psychiatry 61:877-89. 2004
    ..Changes in anterior cingulate function associated with symptomatic improvement indicate that fMRI may be a useful surrogate marker of antidepressant treatment response...
  13. ncbi Neural correlates of sad faces predict clinical remission to cognitive behavioural therapy in depression
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Neuroreport 20:637-41. 2009
    ..The functional neuroanatomy of sad faces at the lowest and highest intensities identified patients, before the initiation of therapy, who had a full clinical response to CBT (sensitivity 71%, specificity 86%, P = 0.029)...
  14. ncbi Functional MRI of verbal self-monitoring in schizophrenia: performance and illness-specific effects
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Schizophr Bull 36:740-55. 2010
    ..Altered striatal and hypothalamic modulation to own and others' voice characterizes emotionally withdrawn and socially avoidant patients...
  15. ncbi Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
    Biol Psychiatry 65:473-80. 2009
    ..We addressed this by comparing the effects of COMT Val158Met genotype on cortical activation during a task of executive functions in healthy and schizophrenic subjects...
  16. ncbi Predictors of amygdala activation during the processing of emotional stimuli: a meta-analysis of 385 PET and fMRI studies
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, UK
    Brain Res Rev 58:57-70. 2008
    ..Methodological variables, such as type of analysis and magnet strength, were also independent predictors of amygdala activation...
  17. ncbi Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London WC2R 2LS, United Kingdom
    Proc Natl Acad Sci U S A 106:13600-5. 2009
    ....
  18. ncbi Acoustic noise and functional magnetic resonance imaging: current strategies and future prospects
    Edson Amaro
    Institute of Psychiatry, King s College, University College, London, UK
    J Magn Reson Imaging 16:497-510. 2002
    ..We also provide new data, using a silent event-related (SER) design, which demonstrate higher blood oxygen level-dependent (BOLD) response to a simple auditory cue when compared to a conventional image acquisition...
  19. ncbi The effects of neuregulin1 on brain function in controls and patients with schizophrenia and bipolar disorder
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, SE5 8AF, UK
    Neuroimage 42:817-26. 2008
    ..Our results suggest that genetic variation in neuregulin1 has a measurable impact on brain function and provide preliminary evidence for a disease-specific pattern of gene action in different regions of the prefrontal cortex...
  20. ncbi Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI
    Katya Rubia
    Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, London, UK
    Psychopharmacology (Berl) 179:791-803. 2005
    ....
  21. ncbi Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, PO67, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:1162-72. 2009
    ..The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia...
  22. ncbi Neural correlates of the misattribution of self-generated speech
    Paul P Allen
    Division of Psychological Medicine Section of Neuroimaging, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Hum Brain Mapp 26:44-53. 2005
    ..The degree to which different areas within this network are engaged varies with the source and acoustic quality of the speech. Accurate identification of one's own speech appears to depend on cingulate and prefrontal activity...
  23. ncbi Misattribution of external speech in patients with hallucinations and delusions
    Paul P Allen
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, P O BOX 67, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 69:277-87. 2004
    ..We examined whether patients with hallucinations and delusions would demonstrate an externalising bias on a task that did not involve cognitive self-monitoring...
  24. ncbi A systematic review and quantitative appraisal of fMRI studies of verbal fluency: role of the left inferior frontal gyrus
    Sergi G Costafreda
    Brain Image Analysis Unit, Department of Biostatistics and Computing, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 27:799-810. 2006
    ..The results support distinct dorsal-ventral locations for phonologic and semantic processes within the LIFG. Current limitations to meta-analytic integration of published functional neuroimaging studies are discussed...
  25. ncbi Effect of acute tryptophan depletion on pre-frontal engagement
    Paul P Allen
    Division of Psychological Medicine P067, Institute of Psychiatry, De Crespigny Park, London, UK
    Psychopharmacology (Berl) 187:486-97. 2006
    ..We tested the hypothesis that acute tryptophan depletion (ATD) would attenuate pre-frontal activation during both tasks...
  26. ncbi Increased inferior frontal activation during word generation: a marker of genetic risk for schizophrenia but not bipolar disorder?
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:3287-98. 2009
    ..Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia...
  27. ncbi Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations
    Andrea Mechelli
    Division of Psychological Medicine, Section of Neuroimaging, King s College London, London, SE5 8AF, United Kingdom
    Hum Brain Mapp 28:1213-22. 2007
    ..Although this finding is based on external rather than internal speech, the same mechanism may contribute to the faulty appraisal of inner speech that putatively underlies AVH...
  28. ncbi Neural correlates of the misattribution of speech in schizophrenia
    Paul Allen
    Division of Psychological Medicine Section of Neuroimaging, Department of Neuroimaging, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    Br J Psychiatry 190:162-9. 2007
    ..The neurocognitive basis of auditory verbal hallucinations is unclear...
  29. ncbi A functional MRI study of happy and sad affective states induced by classical music
    Martina T Mitterschiffthaler
    King s College London, Institute of Psychiatry, Centre for Neuroimaging Sciences, London, United Kingdom
    Hum Brain Mapp 28:1150-62. 2007
    ....
  30. ncbi Prognostic and diagnostic potential of the structural neuroanatomy of depression
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, London, UK
    PLoS ONE 4:e6353. 2009
    ..In the present study, we examined the prognostic and diagnostic potential of the structural neural correlates of depression...
  31. ncbi Amygdala activation to masked happy facial expressions
    Mario F Juruena
    Institute of Psychiatry, King s College London, London, UK
    J Int Neuropsychol Soc 16:383-7. 2010
    ..Masked happy faces elicited greater amygdala activation bilaterally as compared to masked sad faces. Our findings indicate that the amygdala is highly responsive to non-consciously perceived happy facial expressions...
  32. ncbi Subregional hippocampal deformations in major depressive disorder
    James Cole
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    J Affect Disord 126:272-7. 2010
    ..The present study sought to examine hippocampal volume and subregional morphology in patients with major depressive disorder, who were all medication-free and in an acute depressive episode of moderate severity...
  33. ncbi Increased superior temporal activation associated with external misattributions of self-generated speech in schizophrenia
    Cynthia H Y Fu
    Schizophr Res 100:361-3. 2008
  34. ncbi Modulation of neural response to happy and sad faces by acute tryptophan depletion
    Paolo Fusar-Poli
    Department of Applied and Psychobehavioural Health Sciences, University of Pavia, via Bassi 21, 27100, Pavia, Italy
    Psychopharmacology (Berl) 193:31-44. 2007
    ..We used functional neuroimaging (fMRI) to investigate the effects of experimental manipulation of central 5HT levels on the regional neural response to happy and sad facial expressions...
  35. ncbi Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment
    Chi Hua Chen
    Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK
    Biol Psychiatry 62:407-14. 2007
    ..It would be therapeutically useful to predict clinical response to antidepressant drugs. We evaluated structural magnetic resonance imaging (MRI) and functional MRI (fMRI) data as predictors of symptom change in people with depression...
  36. ncbi Functional coupling of the amygdala in depressed patients treated with antidepressant medication
    Chi Hua Chen
    Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychopharmacology 33:1909-18. 2008
    ....