M L Frost
Affiliation: King's College London
- Differences in regional bone perfusion and turnover between lumbar spine and distal humerus: (18)F-fluoride PET study of treatment-naïve and treated postmenopausal womenMichelle L Frost
King s College London, Osteoporosis Unit, Guy s Hospital, UK
Bone 45:942-8. 2009..18)F-PET may aid in our understanding of the importance of bone perfusion in osteoporosis and differences in regional bone turnover with disease and in response to therapy...
- Relationship of calcification of atherosclerotic plaque and arterial stiffness to bone mineral density and osteoprotegerin in postmenopausal women referred for osteoporosis screeningMichelle L Frost
Osteoporosis Screening and Research Unit, King s College London, Guy s Hospital, Great Maze Pond, London, SE1 9RT, UK
Calcif Tissue Int 83:112-20. 2008..01). These findings suggest that decreased BMD is associated with arterial calcification and stiffening and raise the possibility that OPG is a marker of arterial stiffening, independent of any association with BMD...
- ¹⁸F-fluoride PET as a noninvasive imaging biomarker for determining treatment efficacy of bone active agents at the hip: a prospective, randomized, controlled clinical studyMichelle L Frost
Osteoporosis Screening and Research Unit, King s College London, King s Health Partners, Guy s Campus, London, United Kingdom
J Bone Miner Res 28:1337-47. 2013..In conclusion, this is the first study to our knowledge to demonstrate that ¹⁸F-PET can be used as an imaging biomarker for determining treatment efficacy at the hip as early as 12 weeks after initiation of therapy...
- Regional bone metabolism at the lumbar spine and hip following discontinuation of alendronate and risedronate treatment in postmenopausal womenM L Frost
Osteoporosis Research Unit, King s College London, Guy s Hospital Campus, Great Maze Pond, London, UK
Osteoporos Int 23:2107-16. 2012..Bone metabolism at the spine remained stable following discontinuation of alendronate and risedronate at 1 year but increased in the hip in the alendronate group only...
- Long-term precision of 18F-fluoride PET skeletal kinetic studies in the assessment of bone metabolismMichelle L Frost
King s College London, Osteoporosis Screening and Research Unit, Guy s Hospital, London, United Kingdom
J Nucl Med 49:700-7. 2008..The main PET parameter of interest, termed K(i), reflects regional bone metabolism. The aim of this study was to compare the long-term precision of (18)F-fluoride PET with that of biochemical markers of bone turnover assessed over 6 mo...
- The relationship between regional bone turnover measured using 18F-fluoride positron emission tomography and changes in BMD is equivalent to that seen for biochemical markers of bone turnoverMichelle L Frost
Osteoporosis Screening and Research Unit, King s College London School of Medicine, Guy s Hospital, London
J Clin Densitom 10:46-54. 2007..This study has demonstrated that the relationship between regional bone turnover measured directly at the lumbar spine with changes in BMD is similar to that seen for global skeletal bone turnover using biochemical markers...
- Dissociation between global markers of bone formation and direct measurement of spinal bone formation in osteoporosisMichelle L Frost
Osteoporosis Screening and Research Unit, Guy s, King s, and St Thomas School of Medicine, King s College, London, United Kingdom
J Bone Miner Res 19:1797-804. 2004..Lower values of regional bone formation activity at the lumbar spine were seen in osteoporotic women, whereas global markers of bone formation were significantly increased...
- A prospective study of risedronate on regional bone metabolism and blood flow at the lumbar spine measured by 18F-fluoride positron emission tomographyMichelle L Frost
Osteoporosis Screening and Research Unit, Guy s, King s and St Thomas School of Medicine, King s College, Guy s Hospital, London, United Kingdom
J Bone Miner Res 18:2215-22. 2003..The net plasma clearance of fluoride to bone mineral reflecting osteoblastic activity decreased significantly after therapy...
- Contact quantitative ultrasound: an evaluation of precision, fracture discrimination, age-related bone loss and applicability of the WHO criteriaM L Frost
Osteoporosis Unit, Guy s Hospital, London, UK
Osteoporos Int 10:441-9. 1999..However, the widely accepted threshold of a T-score of less than -2.5 for the definition of osteoporosis may need modifying for the interpretation of QUS scans...
- A comparison of fracture discrimination using calcaneal quantitative ultrasound and dual X-ray absorptiometry in women with a history of fracture at sites other than the spine and hipM L Frost
Osteoporosis Screening and Research Unit, Guy s, King s and St Thomas School of Medicine, London, UK
Calcif Tissue Int 71:207-11. 2002..In conclusion, calcaneal QUS can discriminate between women with and those without fracture at the wrist or at sites other than the spine, hip, or forearm as well as axial DXA measurements of BMD can...
- Does the combination of quantitative ultrasound and dual-energy X-ray absorptiometry improve fracture discrimination?M L Frost
Osteoporosis Screening and Research Unit, Guy s Hospital, London, UK
Osteoporos Int 12:471-7. 2001..However, these increases were not clinically significant. In conclusion, the combination of axial BMD and calcaneal QUS measurements did not significantly improve fracture discrimination compared with either method alone...
- Does quantitative ultrasound imaging enhance precision and discrimination?M L Frost
Osteoporosis Research Unit, Guy s Hospital, London, UK
Osteoporos Int 11:425-33. 2000..The inconsistencies of the imaging system used for this study demonstrate that further development is required before it will be possible to show improvements in long-term precision...
- Can the WHO criteria for diagnosing osteoporosis be applied to calcaneal quantitative ultrasound?M L Frost
Osteoporosis Unit, Guy s Hospital, London, UK
Osteoporos Int 11:321-30. 2000..61, -1.94 and -1.90 for Sahara BUA, SOS and estimated heel BMD respectively and -1.45 and -2.10 for DTU BUA and SOS respectively Additional studies are needed to determine suitable T-score thresholds for other commercial QUS devices...
- Differences in regional bone metabolism at the spine and hip: a quantitative study using (18)F-fluoride positron emission tomographyT Puri
King s College London, PET Imaging Centre, Imaging Sciences and Biomedical Engineering, St Thomas Hospital, London, UK
Osteoporos Int 24:633-9. 2013..This study showed that regional bone blood flow and (18)F-fluoride bone plasma clearance measured by positron emission tomography are three times lower at the hip than the lumbar spine...
- Significant differences in UK and US female bone density reference rangesE Noon
Osteoporosis Research Unit, Division of Imaging Sciences, King s College London, London, UK
Osteoporos Int 21:1871-80. 2010..6 standard deviation higher than their US counterparts...
- Changes in QUS and BMD measurements with antiresorptive therapy: a two-year longitudinal studyM L Frost
Osteoporosis Screening and Research Unit, Guy's Hospital, London, UK
Calcif Tissue Int 69:138-46. 2001..Future improvements in the precision of calcaneal QUS measurements are required to increase the utility of QUS for monitoring purposes...
- Precision of ¹⁸F-fluoride PET skeletal kinetic studies in the assessment of bone metabolismY Al-Beyatti
Osteoporosis Screening and Research Unit, Guy s Hospital, King s College London, 1st Floor, Tower Wing, London, SE1 9RT, UK
Osteoporos Int 23:2535-41. 2012..2% (7.5-11.8) for standardised uptake values, 11.7% (9.5-14.9) for plasma clearance measurements using the Patlak method and 14.5% (11.7-18.5) for plasma clearance measurements using the Hawkins three-compartment model...
- Quantitative ultrasound and bone mineral density are equally strongly associated with risk factors for osteoporosisM L Frost
Osteoporosis Screening and Research Unit, Guy's Hospital, London, United Kingdom
J Bone Miner Res 16:406-16. 2001..Provided revised diagnostic criteria are adopted for QUS, similar proportions of postmenopausal women are identified as osteopenic or osteoporotic as with BMD...
- Circulating fibroblast growth factor-23 increases following intermittent parathyroid hormone (1-34) in postmenopausal osteoporosis: association with biomarker of bone formationM Sridharan
Osteoporosis Clinic, Guy s Hospital, London, UK
Calcif Tissue Int 87:398-405. 2010..78, P < 0.001). FGF-23 is increased by intermittent PTH(1-34). This is related to early changes in P1NP, suggesting that the skeletal effects of PTH may involve FGF-23. Further studies are required to elucidate this...
- Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal womenJohn Somner
Department of Chemical Pathology, St Thomas Hospital, London, SE1 7EH United Kingdom
J Clin Endocrinol Metab 89:344-51. 2004..012). Subjects with the CC genotype had significantly lower BMD (mean +/- SD: TT, 0.7 +/- 0.16; CC, 0.6 +/- 0.08 g/cm(2); P = 0.006). In conclusion, both CYP 17 and CYP 19 are candidate genes for osteoporosis in postmenopausal women...