G French

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint The continuing crisis in antibiotic resistance
    G L French
    Department of Infection, King s College, Guy s and St Thomas Hospital, London, UK
    Int J Antimicrob Agents 36:S3-7. 2010
  2. doi request reprint Methods for screening for methicillin-resistant Staphylococcus aureus carriage
    G L French
    Department of Infection, King s College London and Guy s and St Thomas Hospital NHS Foundation Trust, St Thomas Hospital, London, UK
    Clin Microbiol Infect 15:10-6. 2009
  3. ncbi request reprint Tackling contamination of the hospital environment by methicillin-resistant Staphylococcus aureus (MRSA): a comparison between conventional terminal cleaning and hydrogen peroxide vapour decontamination
    G L French
    Department of Infection, King s College London, North Wing, St Thomas Hospital, UK
    J Hosp Infect 57:31-7. 2004
  4. doi request reprint What's new and not so new on the antimicrobial horizon?
    G L French
    Department of Infection, King s College and Guy s and St Thomas Hospital, London, UK
    Clin Microbiol Infect 14:19-29. 2008
  5. ncbi request reprint A review of tigecycline
    G L French
    King s College and Guy s and St Thomas Hospital, Department of Infection, St Thomas Hospital, London, UK
    J Chemother 20:3-11. 2008
  6. ncbi request reprint Safety and tolerability of linezolid
    Gary French
    Department of Infection, Guy s and St Thomas Hospital and King s College, London SE1 7EH, UK
    J Antimicrob Chemother 51:ii45-53. 2003
  7. ncbi request reprint Clinical impact and relevance of antibiotic resistance
    G L French
    Department of Infectious Diseases, King s College London, St Thomas Hospital, London SE1 7EH, UK
    Adv Drug Deliv Rev 57:1514-27. 2005
  8. ncbi request reprint Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin
    G L French
    Department of Infection, King s College London, St Thomas Hospital, London SE1 7EH, UK
    J Antimicrob Chemother 58:1107-17. 2006
  9. ncbi request reprint Identification and control of an outbreak of ciprofloxacin-susceptible EMRSA-15 on a neonatal unit
    J A Otter
    Infection and Immunology Delivery Unit, St Thomas Hospital and King s College London, London, UK
    J Hosp Infect 67:232-9. 2007
  10. doi request reprint The emergence of community-associated methicillin-resistant Staphylococcus aureus at a London teaching hospital, 2000-2006
    J A Otter
    Guy s and St Thomas Hospital, and King s College London, London, UK
    Clin Microbiol Infect 14:670-6. 2008

Detail Information

Publications32

  1. doi request reprint The continuing crisis in antibiotic resistance
    G L French
    Department of Infection, King s College, Guy s and St Thomas Hospital, London, UK
    Int J Antimicrob Agents 36:S3-7. 2010
    ..The potential for success of such coordinated efforts has been demonstrated by the recent dramatic reductions in MRSA and C. difficile infections in England...
  2. doi request reprint Methods for screening for methicillin-resistant Staphylococcus aureus carriage
    G L French
    Department of Infection, King s College London and Guy s and St Thomas Hospital NHS Foundation Trust, St Thomas Hospital, London, UK
    Clin Microbiol Infect 15:10-6. 2009
    ..New point-of-care PCR tests are being introduced that are potentially even more rapid but are even more expensive; studies on the clinical cost-effectiveness of these very rapid tests are awaited...
  3. ncbi request reprint Tackling contamination of the hospital environment by methicillin-resistant Staphylococcus aureus (MRSA): a comparison between conventional terminal cleaning and hydrogen peroxide vapour decontamination
    G L French
    Department of Infection, King s College London, North Wing, St Thomas Hospital, UK
    J Hosp Infect 57:31-7. 2004
    ..Further work is needed to determine the importance of environmental contamination with MRSA and the effect on hospital infection rates of effective decontamination...
  4. doi request reprint What's new and not so new on the antimicrobial horizon?
    G L French
    Department of Infection, King s College and Guy s and St Thomas Hospital, London, UK
    Clin Microbiol Infect 14:19-29. 2008
    ..A clinical trial has demonstrated the non-inferiority of iclaprim, as compared with linezolid, in the treatment of cSSSIs, including those associated with MRSA...
  5. ncbi request reprint A review of tigecycline
    G L French
    King s College and Guy s and St Thomas Hospital, Department of Infection, St Thomas Hospital, London, UK
    J Chemother 20:3-11. 2008
    ..The remaining articles in the supplement report the European clinical experience from the pivotal clinical trials in complicated intra-abdominal infections, complicated skin and skin structure infections and community acquired pneumonia...
  6. ncbi request reprint Safety and tolerability of linezolid
    Gary French
    Department of Infection, Guy s and St Thomas Hospital and King s College, London SE1 7EH, UK
    J Antimicrob Chemother 51:ii45-53. 2003
    ....
  7. ncbi request reprint Clinical impact and relevance of antibiotic resistance
    G L French
    Department of Infectious Diseases, King s College London, St Thomas Hospital, London SE1 7EH, UK
    Adv Drug Deliv Rev 57:1514-27. 2005
    ..There is an urgent need to control antimicrobial resistance by improved antibiotic usage and reduction of hospital cross-infection...
  8. ncbi request reprint Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin
    G L French
    Department of Infection, King s College London, St Thomas Hospital, London SE1 7EH, UK
    J Antimicrob Chemother 58:1107-17. 2006
    ....
  9. ncbi request reprint Identification and control of an outbreak of ciprofloxacin-susceptible EMRSA-15 on a neonatal unit
    J A Otter
    Infection and Immunology Delivery Unit, St Thomas Hospital and King s College London, London, UK
    J Hosp Infect 67:232-9. 2007
    ..Ciprofloxacin-containing media should be used with caution for MRSA screening in settings where ciprofloxacin-susceptible strains (including community-associated MRSA) are increasing in prevalence...
  10. doi request reprint The emergence of community-associated methicillin-resistant Staphylococcus aureus at a London teaching hospital, 2000-2006
    J A Otter
    Guy s and St Thomas Hospital, and King s College London, London, UK
    Clin Microbiol Infect 14:670-6. 2008
    ..Ciprofloxacin susceptibility is a useful screening marker of CA-MRSA strains in London, which are more frequent than previously thought and whose incidence is increasing...
  11. doi request reprint Comparison of community-associated methicillin-resistant Staphylococcus aureus from teaching hospitals in London and the USA, 2004-2006: where is USA300 in the UK?
    J A Otter
    Guy s and St Thomas Hospital and King s College London, London, UK
    Eur J Clin Microbiol Infect Dis 28:835-9. 2009
    ..There are striking differences between the molecular epidemiology of CA-MRSA in UK and US hospitals, which may have implications for control...
  12. ncbi request reprint Significant reduction of endemic MRSA acquisition and infection in cardiothoracic patients by means of an enhanced targeted infection control programme
    S Schelenz
    Department of Infection, Guy s and St Thomas Hospital, London SE1 7EH, UK
    J Hosp Infect 60:104-10. 2005
    ....
  13. ncbi request reprint Enhanced surveillance of meticillin-resistant Staphylococcus aureus bacteraemia in a London teaching hospital
    D Jeyaratnam
    Department of Infection, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, UK
    J Hosp Infect 63:365-73. 2006
    ..We recommend that the mandatory national surveillance scheme should collect additional data on MRSA bacteraemia to provide information for a national strategy for MRSA control and to allow appropriate comparison between institutions...
  14. doi request reprint Hypermutability in clinical isolates of Klebsiella pneumoniae is uncommon and is unrelated to ciprofloxacin resistance
    S Aathithan
    Department of Infectious Diseases, Division of Immunology, Infection and Inflammatory Diseases, School of Medicine, King s College London, St Thomas Hospital, London SE1 7EH, UK
    Int J Antimicrob Agents 36:239-42. 2010
    ..Hypermutation in K. pneumoniae is uncommon and does not contribute to accumulation of QRDR mutations or directly to ciprofloxacin resistance...
  15. doi request reprint Panton-Valentine leukocidin-encoding bacteriophage and gene sequence variation in community-associated methicillin-resistant Staphylococcus aureus
    J A Otter
    Department of Infection, St Thomas Hospital and King s College London, Lambeth Palace Road, London, UK
    Clin Microbiol Infect 16:68-73. 2010
    ..The PVL gene sequence and the PVL-encoding phage varied with lineage. Further work is required to determine whether PVL sequence and/or phage variations result in biological differences...
  16. doi request reprint Bacterial contamination on touch surfaces in the public transport system and in public areas of a hospital in London
    J A Otter
    Department of Infection, St Thomas Hospital and King s College London, UK
    Lett Appl Microbiol 49:803-5. 2009
    ..To investigate bacterial contamination on hand-touch surfaces in the public transport system and in public areas of a hospital in central London...
  17. ncbi request reprint Simultaneous identification and typing of multi-drug-resistant Mycobacterium tuberculosis isolates by analysis of pncA and rpoB
    T J Brown
    Department of Microbiology, St Thomas Hospital, London
    J Med Microbiol 49:651-6. 2000
    ..This result was available within 36 h. The analysis of rpoB and pncA is a rapid and practical means of simultaneously identifying and typing MDR isolates of M. tuberculosis...
  18. ncbi request reprint A simultaneous outbreak on a neonatal unit of two strains of multiply antibiotic resistant Klebsiella pneumoniae controllable only by ward closure
    M B Macrae
    Department of Infection, St Thomas' Hospital, 5th Floor North Wing, Lambeth Palace Road, London, UK
    J Hosp Infect 49:183-92. 2001
    ..All patients, regardless of their admission history, should be screened on admission for carriage of multiply resistant enterobacteria by a sensitive method, and units should have plans for temporary ward closure should outbreaks occur...
  19. doi request reprint Utility of antimicrobial susceptibility-based algorithms for the presumptive identification of genotypically-defined community-associated methicillin-resistant Staphylococcus aureus at a London teaching hospital
    J A Otter
    Department of Infection, St Thomas Hospital and King s College London, 5th Floor, North Wing, Lambeth Palace Road, London, SE1 7EH, Canada
    Eur J Clin Microbiol Infect Dis 30:459-63. 2011
    ..We sought to determine whether antimicrobial susceptibility (AMS)-based algorithms could be used to presumptively identify CA-MRSA in a hospital MRSA collection...
  20. ncbi request reprint Antibiotic resistance: effect of different criteria for classifying isolates as duplicates on apparent resistance frequencies
    K P Shannon
    Department of Infection, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London SE1 7EH, UK
    J Antimicrob Chemother 49:201-4. 2002
    ..To investigate the effect of screening specimens and different criteria for exclusion of duplicate isolates when surveillance of antimicrobial resistances is performed...
  21. ncbi request reprint Guidelines for the control of glycopeptide-resistant enterococci in hospitals
    B D Cookson
    Laboratory of HealthCare Associated Infection, Specialist and Reference Microbiology Division, Health Protection Agency, London, UK
    J Hosp Infect 62:6-21. 2006
    ..Evidence identified to support recommendations has been categorized. A risk assessment approach is recommended and areas for research and development identified...
  22. ncbi request reprint Validation of the NCCLS proposal to use results only from the first isolate of a species per patient in the calculation of susceptibility frequencies
    K P Shannon
    Department of Infection, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London SE1 7EH, UK
    J Antimicrob Chemother 50:965-9. 2002
    ....
  23. ncbi request reprint An outbreak of multidrug-resistant Pseudomonas aeruginosa infection associated with contamination of bronchoscopes and an endoscope washer-disinfector
    S Schelenz
    Department of Infection, Guy s King s and St Thomas School of Medicine, St Thomas Hospital Campus, London, SE17EH, UK
    J Hosp Infect 46:23-30. 2000
    ..Several other washer-disinfectors were also found to be faulty. The potential hazards of automated endoscope washer-disinfectors and the importance of controlled professional maintenance, servicing and training is discussed...
  24. pmc Rifampin resistance in Mycobacterium kansasii is associated with rpoB mutations
    J L Klein
    Department of Infection, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London SE1 7EH, United Kingdom
    Antimicrob Agents Chemother 45:3056-8. 2001
    ..Although our results are derived from a small number of isolates and confirmation with larger numbers would be useful, they strongly suggest that mutations within rpoB form the molecular basis of rifampin resistance in this species...
  25. ncbi request reprint Comparative in vitro activity of gemifloxacin
    A King
    Microbiology Department, GKT School of Medicine, St Thomas Hospital, London, UK
    J Antimicrob Chemother 45:1-12. 2000
    ..Gemifloxacin was also the most potent quinolone against Gram-positive anaerobes and fusobacteria but trovafloxacin was the most potent agent tested against other Gram-negative anaerobes...
  26. pmc Diagnosis of bacteriuria by detection of volatile organic compounds in urine using an automated headspace analyzer with multiple conducting polymer sensors
    S Aathithan
    Department of Infection, Guy's, King's College and St. Thomas' School of Medicine, St. Thomas' Hospital, London SE1 7EH, United Kingdom
    J Clin Microbiol 39:2590-3. 2001
    ..5 and 87.6%, respectively. The OMA is a promising automated system for the rapid routine screening of urine specimens, and further clinical trials are in progress...
  27. ncbi request reprint Highly epidemic strains of methicillin-resistant Staphylococcus aureus not distinguished by capsule formation, protein A content or adherence to HEp-2 cells
    S Aathithan
    Department of Infection, Guy's King's and St Thomas' School of Medicine, St Thomas' Hospital, London, UK
    Eur J Clin Microbiol Infect Dis 20:27-32. 2001
    ....
  28. doi request reprint Two-step glutamate dehydrogenase antigen real-time polymerase chain reaction assay for detection of toxigenic Clostridium difficile
    S D Goldenberg
    Guy s and St Thomas NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, UK
    J Hosp Infect 74:48-54. 2010
    ..Current EIA(A/B) tests for CDI are of inadequate sensitivity and should be replaced; however, this may result in apparent changes in CDI rates that would need to be explained in national surveillance statistics...
  29. pmc Octreotide induced prolongation of colonic transit increases faecal anaerobic bacteria, bile acid metabolising enzymes, and serum deoxycholic acid in patients with acromegaly
    L A Thomas
    Gastroenterology Unit, Division of Medicine, GKT School of Medicine, Kings College, London, UK
    Gut 54:630-5. 2005
    ....
  30. pmc Carbapenem resistance in Escherichia coli associated with plasmid-determined CMY-4 beta-lactamase production and loss of an outer membrane protein
    P D Stapleton
    Department of Microbiology, UMDS, St Thomas Hospital, London, United Kingdom
    Antimicrob Agents Chemother 43:1206-10. 1999
    ..Furthermore, in the presence of an OMP deficiency, the level of expression of a plasmid-mediated class C beta-lactamase is an important factor in determining whether E. coli isolates are fully resistant to carbapenems...
  31. doi request reprint Guidelines for UK practice for the diagnosis and management of methicillin-resistant Staphylococcus aureus (MRSA) infections presenting in the community
    Dilip Nathwani
    Infection Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Antimicrob Chemother 61:976-94. 2008
    ....
  32. ncbi request reprint Review of new guidelines for prophylaxis and treatment of MRSA infections
    Gary French
    Department of Infection, St Thomas Hospital, London
    Br J Hosp Med (Lond) 67:482-6. 2006
    ..K. These guidelines will help clinicians choose appropriate therapy and point to areas where further research is needed. This review summarizes the main recommendations and discusses their implementation into clinical practice...