Sophia Frangou

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Fronto-temporal function may distinguish bipolar disorder from schizophrenia
    S Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s Coillege London, London, UK
    Bipolar Disord 8:47-55. 2006
  2. ncbi request reprint The Maudsley Bipolar Disorder Project
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, London, England
    Epilepsia 46:19-25. 2005
  3. ncbi request reprint Examining ventral and dorsal prefrontal function in bipolar disorder: a functional magnetic resonance imaging study
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College London, De Crespigny Park, London, UK
    Eur Psychiatry 23:300-8. 2008
  4. ncbi request reprint The Maudsley bipolar disorder project. A survey of psychotropic prescribing patterns in bipolar I disorder
    Sophia Frangou
    Section of Neurobiology of Psychosis, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, UK
    Bipolar Disord 4:378-85. 2002
  5. ncbi request reprint Telemonitoring of medication adherence in patients with schizophrenia
    S Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Telemed J E Health 11:675-83. 2005
  6. ncbi request reprint Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study
    Sophia Frangou
    Section of Neurobiology of Psychosis, PO66, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 188:46-50. 2006
  7. pmc The Maudsley early onset schizophrenia study: cognitive function over a 4-year follow-up period
    Sophia Frangou
    Section of Neurobiology of Psychosis, London, SE5 8AF, UK
    Schizophr Bull 34:52-9. 2008
  8. ncbi request reprint Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College London, London, UK
    J Psychopharmacol 21:435-9. 2007
  9. doi request reprint Risk and resilience in bipolar disorder: rationale and design of the Vulnerability to Bipolar Disorders Study (VIBES)
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Biochem Soc Trans 37:1085-9. 2009
  10. ncbi request reprint Evidence for deficit in tasks of ventral, but not dorsal, prefrontal executive function as an endophenotypic marker for bipolar disorder
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 58:838-9. 2005

Detail Information

Publications92

  1. ncbi request reprint Fronto-temporal function may distinguish bipolar disorder from schizophrenia
    S Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s Coillege London, London, UK
    Bipolar Disord 8:47-55. 2006
    ..Our objective was to compare the cognitive profile of stable BDI and schizophrenic patients using neuropsychological tasks which utilize frontal systems but differ in terms of the exact neural circuits and cognitive processes involved...
  2. ncbi request reprint The Maudsley Bipolar Disorder Project
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, London, England
    Epilepsia 46:19-25. 2005
    ..The Maudsley Bipolar Disorder Project set out to investigate the cognitive and brain structural and functional characteristics of Bipolar Disorder I (BDI)...
  3. ncbi request reprint Examining ventral and dorsal prefrontal function in bipolar disorder: a functional magnetic resonance imaging study
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College London, De Crespigny Park, London, UK
    Eur Psychiatry 23:300-8. 2008
    ..Our findings suggest that there are trait abnormalities in dorsal and ventral PFC function in BD that may be more pronounced during tasks that rely on ventral-dorsal PFC interaction...
  4. ncbi request reprint The Maudsley bipolar disorder project. A survey of psychotropic prescribing patterns in bipolar I disorder
    Sophia Frangou
    Section of Neurobiology of Psychosis, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, UK
    Bipolar Disord 4:378-85. 2002
    ..As the treatment choices in BD1 disorder are increasing the aim of this study was to examine the current use of the pharmacological agents in BD1 patients and its association with clinical characteristics...
  5. ncbi request reprint Telemonitoring of medication adherence in patients with schizophrenia
    S Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Telemed J E Health 11:675-83. 2005
    ..The results of the study suggest that the use of telemonitoring in psychiatric settings was both feasible and acceptable and may be associated with significant clinical and service related benefits...
  6. ncbi request reprint Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study
    Sophia Frangou
    Section of Neurobiology of Psychosis, PO66, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 188:46-50. 2006
    ..Epidemiological and clinical studies suggest that increased intake of eicosapentaenoic acid (EPA) alleviates unipolar depression...
  7. pmc The Maudsley early onset schizophrenia study: cognitive function over a 4-year follow-up period
    Sophia Frangou
    Section of Neurobiology of Psychosis, London, SE5 8AF, UK
    Schizophr Bull 34:52-9. 2008
    ....
  8. ncbi request reprint Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College London, London, UK
    J Psychopharmacol 21:435-9. 2007
    ..027). These results provide the first evidence for a probable neurotrophic role of ethyl-EPA treatment in BD underlining the need for more detailed investigation of its mechanism of action and therapeutic potential...
  9. doi request reprint Risk and resilience in bipolar disorder: rationale and design of the Vulnerability to Bipolar Disorders Study (VIBES)
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Biochem Soc Trans 37:1085-9. 2009
    ..It also outlines the rational and design of the Vulnerability to Bipolar Disorders Study (VIBES), which exemplifies a promising approach to delineating biological mechanisms mediating risk, resilience and disease expression in BD...
  10. ncbi request reprint Evidence for deficit in tasks of ventral, but not dorsal, prefrontal executive function as an endophenotypic marker for bipolar disorder
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 58:838-9. 2005
    ..We examined whether deficits in VPFC-related inhibitory processes, but not dorsal prefrontal (DPFC) based executive functions, represent an endophenotypic marker for bipolar disorder I (BDI)...
  11. ncbi request reprint The Maudsley Bipolar Disorder Project: executive dysfunction in bipolar disorder I and its clinical correlates
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, PO66, Division of Psychological Medicine, De Crespigny Park, London, United Kingdom
    Biol Psychiatry 58:859-64. 2005
    ....
  12. doi request reprint Abnormal functional activation and connectivity in the working memory network in early-onset schizophrenia
    Marinos Kyriakopoulos
    Institute of Psychiatry, King s College London and Child and Adolescent Mental Health Services, Maudsley Hospital, UK
    J Am Acad Child Adolesc Psychiatry 51:911-20.e2. 2012
    ..The aim of this study was to determine whether DLPFC activation and functional connectivity are impaired during WM in patients with early-onset schizophrenia (EOS; age of onset <18 years)...
  13. ncbi request reprint A diffusion tensor imaging study of fasciculi in schizophrenia
    Sukhwinder S Shergill
    Institute of Psychiatry, Kings College London, De Crespigny Park, UK
    Am J Psychiatry 164:467-73. 2007
    ..This study used diffusion tensor imaging to examine the integrity of the major white matter fasciculi, which connects the frontal and temporal-parietal cortices, and the corpus callosum in patients with schizophrenia...
  14. ncbi request reprint Familial liability to schizophrenia and premorbid adjustment
    Muriel Walshe
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 191:260-1. 2007
    ..Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence. This may represent a familial (presumed genetic) effect...
  15. doi request reprint Independent modulation of engagement and connectivity of the facial network during affect processing by CACNA1C and ANK3 risk genes for bipolar disorder
    Danai Dima
    Section of Neurobiology of Psychosis, Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, England
    JAMA Psychiatry 70:1303-11. 2013
    ..Both genes modulate ╬│-aminobutyric acid-transmitting interneuron function and can thus affect brain regional activation and interregional connectivity...
  16. pmc Emotional decision-making and its dissociable components in schizophrenia and schizoaffective disorder: a behavioural and MRI investigation
    Preethi Premkumar
    Department of Psychology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuropsychologia 46:2002-12. 2008
    ....
  17. doi request reprint Recent diffusion tensor imaging findings in early stages of schizophrenia
    Marinos Kyriakopoulos
    Section of Neurobiology of Psychosis, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King s College London, London, UK
    Curr Opin Psychiatry 22:168-76. 2009
    ..Diffusion tensor imaging (DTI) has increasingly been used to study white matter abnormalities in schizophrenia; in this review, we will discuss recent DTI findings focusing on the early stages of the disorder...
  18. doi request reprint Pilot investigation of the changes in cortical activation during facial affect recognition with lamotrigine monotherapy in bipolar disorder
    Jigar Jogia
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, PO66, De Crespigny Park, London, SE5 8AF, UK
    Br J Psychiatry 192:197-201. 2008
    ..Bipolar disorder is associated with dysfunction in prefrontal and limbic areas implicated in emotional processing...
  19. doi request reprint The effects of gender and COMT Val158Met polymorphism on fearful facial affect recognition: a fMRI study
    Matthew J Kempton
    Section of Neurobiology of Psychosis, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, King s College London, UK
    Int J Neuropsychopharmacol 12:371-81. 2009
    ..The COMT Val108/158Met polymorphism impacts on gender-related patterns of activation in limbic and paralimbic regions but the functional significance of any oestrogen-related COMT inhibition appears modest...
  20. doi request reprint Familial and disease specific abnormalities in the neural correlates of the Stroop Task in Bipolar Disorder
    Francesco Pompei
    Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College, London, UK
    Neuroimage 56:1677-84. 2011
    ..Our findings suggest that while reduced parietal engagement relates to genetic risk, fronto-striatal dysfunction reflects processes underpinning disease expression for mood disorders...
  21. doi request reprint Cognitive functioning in patients with affective disorders and schizophrenia: a meta-analysis
    Evgenia Stefanopoulou
    Section of Neurobiology of Psychosis, Institute of Psychiatry and Biomedical Research Centre for Mental Health, King s College London, London, UK
    Int Rev Psychiatry 21:336-56. 2009
    ..Differences between diagnostic groups were quantitative rather than qualitative...
  22. doi request reprint The impact of familial risk for schizophrenia or bipolar disorder on cognitive control during episodic memory retrieval
    Tessa Christodoulou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, UK
    Psychiatry Res 197:212-6. 2012
    ....
  23. ncbi request reprint The Maudsley Bipolar Disorder Project: the effect of medication, family history, and duration of illness on IQ and memory in bipolar I disorder
    Stuart Donaldson
    Section of Neurobiology of Psychosis, Institute of Psychiatry, De Crespigny Park, London, England
    J Clin Psychiatry 64:86-93. 2003
    ..This study examines the contribution of known and potential predictors to both general intellectual function and memory in a representative population of bipolar I disorder patients...
  24. doi request reprint Multimodal analyses identify linked functional and white matter abnormalities within the working memory network in schizophrenia
    Gisela Sugranyes
    Section of Neurobiology of Psychosis, Dept of Psychosis Studies, Institute of Psychiatry, King s College London, UK
    Schizophr Res 138:136-42. 2012
    ..Yet little is known about how alterations at the functional level related to abnormalities in anatomical connectivity...
  25. ncbi request reprint Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study
    Elvira Bramon
    Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 27:960-8. 2005
    ..We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study...
  26. ncbi request reprint The Maudsley Early-Onset Schizophrenia Study: cognitive function in adolescent-onset schizophrenia
    Eugenia Kravariti
    Department of Psychiatry, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 65:95-103. 2003
    ..Our data are not consistent with worse cognition or progression of neuropsychological impairment in adolescent-onset schizophrenia...
  27. doi request reprint Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotype
    Elvira Bramon
    Institute of Psychiatry King s College London, Division of Psychological Medicine and Psychiatry box 63, De Crespigny Park, London SE5 8AF, United Kingdom
    Schizophr Res 103:178-85. 2008
    ..Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype...
  28. doi request reprint The impact of general intellectual ability and white matter volume on the functional outcome of patients with Bipolar Disorder and their relatives
    Irene Forcada
    Institute of Psychiatry, King s College London, King s Health Partners, London, UK
    J Affect Disord 130:413-20. 2011
    ..Therefore we focused on delineating the relationship between psychosocial functioning, cognition and brain structure, in relation to disease expression and genetic risk for BD...
  29. doi request reprint Effect of age at onset of schizophrenia on white matter abnormalities
    Marinos Kyriakopoulos
    Section of Neurobiology of Psychosis, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 195:346-53. 2009
    ....
  30. doi request reprint Frontopolar cortical inefficiency may underpin reward and working memory dysfunction in bipolar disorder
    Jigar Jogia
    Section of Neurobiology of Psychosis, Department of Psychosis Studies, Kings College London, London, UK
    World J Biol Psychiatry 13:605-15. 2012
    ..The aim of this study was to determine the common and distinct patterns of functional brain abnormalities during reward and working memory processing in patients with bipolar disorder...
  31. doi request reprint Structural brain correlates of response inhibition in Bipolar Disorder I
    Morgan Haldane
    Section of Neurobiology of Psychosis Box P066, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Psychopharmacol 22:138-43. 2008
    ....
  32. doi request reprint No gender differences in brain activation during the N-back task: an fMRI study in healthy individuals
    Heike Schmidt
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, United Kingdom
    Hum Brain Mapp 30:3609-15. 2009
    ....
  33. ncbi request reprint The Maudsley early onset schizophrenia study. Predictors of psychosocial outcome at 4-year follow-up
    Nora S Vyas
    Section of Neurobiology of Psychosis, Institute of Psychiatry, London, UK
    Eur Child Adolesc Psychiatry 16:465-70. 2007
    ....
  34. ncbi request reprint Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trial
    Til Wykes
    Institute of Psychiatry, Kings College London, De Crespigny Park, London, SE5 8AF, UK
    Schizophr Res 94:221-30. 2007
    ..The objective of this study is to evaluate the efficacy of CRT in alleviating cognitive deficits compared to treatment as usual and explore the mediating and moderating effects of cognitive improvement...
  35. ncbi request reprint A diffusion tensor imaging study of white matter in early-onset schizophrenia
    Marinos Kyriakopoulos
    Section of Neurobiology of Psychosis, Centre for Neuroimaging Sciences, King s College London, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 63:519-23. 2008
    ..Voxel-based analysis of diffusion tensor magnetic resonance imaging (DTI) data was used to examine white matter integrity in adolescents with early-onset schizophrenia (EOS), defined as schizophrenia beginning before the 18th birthday...
  36. doi request reprint Memory in intellectually matched groups of young participants with 22q11.2 deletion syndrome and those with schizophrenia
    Eugenia Kravariti
    NIHR Biomedical Research Centre, South London and Maudsley NHS Foundation Trust Institute of Psychiatry King s College London, De Crespigny Park, London SE5 8AF, UK
    Res Dev Disabil 31:864-8. 2010
    ..Verbal memory was markedly superior in the 22qDS group by 21 points. There were no group differences in visual memory. The inherently low COMT activity in 22qDS merits investigation as a potential protective factor for verbal memory...
  37. ncbi request reprint Normal cerebral volume asymmetries in early onset schizophrenia
    Michael Hadjulis
    Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom
    Biol Psychiatry 55:148-53. 2004
    ..The aim of this study was to examine whether there is abnormal brain lateralization in early onset schizophrenia (EOS) and whether it is related to the unusually early onset of the disorder...
  38. ncbi request reprint Hyperactivity in adolescents born very preterm is associated with decreased caudate volume
    Chiara Nosarti
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 57:661-6. 2005
    ....
  39. doi request reprint Diffusion tensor imaging in schizophrenia
    Marinos Kyriakopoulos
    Section of Neurobiology of Psychosis Institute of Psychiatry, King s College London, London, UK
    Eur Psychiatry 23:255-73. 2008
    ..Although the findings are not completely consistent, frontal and temporal white matter seems to be more commonly affected. Limitations and future directions of this method are discussed...
  40. doi request reprint Dissociable and common deficits in inhibitory control in schizophrenia and bipolar disorder
    Tessa Christodoulou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, P066, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Eur Arch Psychiatry Clin Neurosci 262:125-30. 2012
    ..Our results suggest that failure in contextual maintenance is primarily associated with familial risk for SZ, while response inhibition may be a shared marker of familial risk for both disorders...
  41. pmc The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention
    Gaia Ruberto
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 6:e16671. 2011
    ..Preclinical data suggest that this may principally apply to sequential signal detection, a core process of sustained attention...
  42. doi request reprint No differential effect of age on brain matter volume and cognition in bipolar patients and healthy individuals
    Antonio Sarnicola
    Section of Neurobiology of Psychosis, King s College London, Institute of Psychiatry, London SE5 8AF, UK
    Bipolar Disord 11:316-22. 2009
    ..There is a paucity of evidence regarding the evolution of these deficits over time. This study examined the relationship between age and brain morphology and cognition in patients with BD type I...
  43. ncbi request reprint Comparative profile analysis of cognitive function in recent-onset and chronic patients with adolescent-onset schizophrenia
    Eugenia Kravariti
    Institute of Psychiatry, Division of Psychological Medicine, London SE5 8AF, UK
    Schizophr Res 94:240-4. 2007
    ..Attention/mental flexibility emerged as a selective strength, and planning as a selective deficit, while verbal memory showed a trend towards selective impairment in the patients...
  44. doi request reprint Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder
    Matthew J Kempton
    Department of Neuroimaging, PO89, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 68:675-90. 2011
    ..Although differences in clinical characteristics exist between major depressive disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that distinguish the disorders have not been identified...
  45. ncbi request reprint Effective connectivity during processing of facial affect: evidence for multiple parallel pathways
    Danai Dima
    Section of Neurobiology of Psychosis, Department of Psychosis Studies, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    J Neurosci 31:14378-85. 2011
    ....
  46. pmc Child Behavior Checklist-Mania Scale (CBCL-MS): development and evaluation of a population-based screening scale for bipolar disorder
    Efstathios Papachristou
    Child Psychiatry Department, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 8:e69459. 2013
    ..Early identification of Bipolar Disorder (BD) remains poor despite the high levels of disability associated with the disorder...
  47. doi request reprint Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder
    Francesco Pompei
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, UK
    Neuroimage 57:576-82. 2011
    ....
  48. ncbi request reprint Mapping IQ and gray matter density in healthy young people
    Sophia Frangou
    Section of Neurobiology of Psychosis, P066, Division of Psychological Medicine, Institute of Psychiatry, London SE5 8AF, UK
    Neuroimage 23:800-5. 2004
    ..These findings suggest that general intellectual ability in healthy young people is related to specific brain regions known to be involved in the executive control of attention, working memory, and response selection...
  49. ncbi request reprint Pathophysiology of early onset schizophrenia
    Marinos Kyriakopoulos
    Section of Neurobiology of Psychosis, Institute of Psychiatry, De Crespigny Park, King s College, London, UK
    Int Rev Psychiatry 19:315-24. 2007
    ..Future research in early onset cases is likely to increase further our insight into the neurodevelopmental origins of schizophrenia and the complex gene-environment interactions affecting its emergence...
  50. ncbi request reprint Changes in brain activation during working memory and facial recognition tasks in patients with bipolar disorder with Lamotrigine monotherapy
    Morgan Haldane
    Section of Neurobiology of Psychosis, Institute of Psychiatry, PO66 De Crespigny Park London SE5 8AF, UK
    Eur Neuropsychopharmacol 18:48-54. 2008
    ..Therefore, LTG monotherapy in BD patients may enhance cortical function within neural circuits involved in memory and emotional self-regulation...
  51. ncbi request reprint Meta-analysis of the P300 and P50 waveforms in schizophrenia
    Elvira Bramon
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 70:315-29. 2004
    ..To determine whether patients with schizophrenia have abnormalities in the P300 and P50 waves and to quantify the magnitude of any differences from controls...
  52. ncbi request reprint Increased developmental deviance and premorbid dysfunction in early onset schizophrenia
    Apostolos Vourdas
    Section of Neurobiology of Psychosis, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 62:13-22. 2003
    ..Age of onset was related to developmental deviance, premorbid schizophrenia spectrum traits and childhood adjustment in EOS patients only...
  53. ncbi request reprint The Maudsley early onset schizophrenia study: cognitive function in adolescents with recent onset schizophrenia
    Eugenia Kravariti
    Section of General Psychiatry, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
    Schizophr Res 61:137-48. 2003
    ..However, deficits in general and verbal memory remained highly significant after co-varying for IQ...
  54. ncbi request reprint Mismatch negativity in schizophrenia: a family study
    Elvira Bramon
    Institute of Psychiatry, PO Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 67:1-10. 2004
    ..We investigated whether MMN is a potential marker of genetic vulnerability to schizophrenia by comparing MMN in a group of patients with schizophrenia, their unaffected relatives, and controls...
  55. ncbi request reprint Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression
    Natalia S Lawrence
    Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 55:578-87. 2004
    ..We compared responses within subcortical and prefrontal cortical regions to emotionally salient material in patients with BP and MDD using functional magnetic resonance imaging...
  56. ncbi request reprint The Maudsley bipolar disorder project. Clinical characteristics of bipolar disorder I in a Catchment area treatment sample
    Vanessa Raymont
    Section of Neurobiology of Psychosis, P066, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
    Eur Psychiatry 18:13-7. 2003
    ..Male gender and substance abuse were associated with younger age at first presentation, while women with co-morbid substance abuse had more manic episodes. Male patients were more likely than females to be unemployed or single...
  57. ncbi request reprint The neurodevelopmental theory of schizophrenia: evidence from studies of early onset cases
    Jess Kinros
    Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College, London, UK
    Isr J Psychiatry Relat Sci 47:110-7. 2010
    ..developmental, cognitive, genetic and brain imaging findings are outlined and discussed in relation to the neurodevelopmental theory. The main limitations of the theory are presented, and future conceptualizations are formulated...
  58. ncbi request reprint Brain structural changes in schizophrenia patients with persistent hallucinations
    Owen G O'Daly
    P O Box 63, Section of General Psychiatry, Institute of Psychiatry, London, UK
    Psychiatry Res 156:15-21. 2007
    ..Such deficits may obscure important cues for recognition of internal speech, contributing to failures of self-monitoring...
  59. doi request reprint Sex differences in bipolar disorder: a review of neuroimaging findings and new evidence
    Jigar Jogia
    Department of Psychosis Studies, Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, London, UK
    Bipolar Disord 14:461-71. 2012
    ..The sex of an individual is known to modulate the clinical presentation of bipolar disorder (BD), but little is known as to whether there are significant sex-by-diagnosis interactions on the brain structural and functional correlates of BD...
  60. pmc Autism spectrum disorders and schizophrenia: meta-analysis of the neural correlates of social cognition
    Gisela Sugranyes
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 6:e25322. 2011
    ..Additionally, it is not known whether deficits in ASD and SZ arise from similar or disease-specific disruption of the social cognition network...
  61. doi request reprint Dissociable brain structural changes associated with predisposition, resilience, and disease expression in bipolar disorder
    Matthew J Kempton
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    J Neurosci 29:10863-8. 2009
    ....
  62. ncbi request reprint Which executive skills should we target to affect social functioning and symptom change? A study of a cognitive remediation therapy program
    Clare Reeder
    Department of Psychology, Institute of Psychiatry, London, UK
    Schizophr Bull 30:87-100. 2004
    ..Regardless of treatment type, increased response inhibition speed was associated with reduced negative symptoms. Stimulus-driven responding and response inhibition speed may therefore make useful targets for intervention...
  63. ncbi request reprint Predictors of outcome in a representative population of bipolar disorder
    Sophia Frangou
    Section of Neurobiology of Psychosis, Institute of Psychiatry, De Crespigny Park, London, UK
    Bipolar Disord 4:41-2. 2002
  64. ncbi request reprint Neuropsychology of bipolar disorder: a review
    Seema Quraishi
    Section of Neurobiology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
    J Affect Disord 72:209-26. 2002
    ..The aim of this study was to describe the profile of cognitive deficits in BD at different phases of the illness and determine whether it is different from that of schizophrenia and unipolar (UP) depression...
  65. ncbi request reprint Adolescents who were born very preterm have decreased brain volumes
    Chiara Nosarti
    Division of Psychological Medicine, Department of Psychiatry, Institute of Psychiatry, London, UK
    Brain 125:1616-23. 2002
    ..The functional significance of these abnormalities merits further investigation...
  66. ncbi request reprint Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder--a postmortem study
    Tanja Maria Michel
    Clinical Neurochemistry, Department Psychiatry and Psychotherapy, University Hospital Wurzburg, F├╝rchsleinstr 15, 97080 Wurzburg, Germany
    Psychiatry Res 151:145-50. 2007
    ..There was no significant change in Mn-SOD enzyme concentration in either region. Our findings contribute to the growing body of evidence implicating oxidative stress in the pathophysiology of depressive disorder...
  67. ncbi request reprint Is there an association between the COMT gene and P300 endophenotypes?
    E Bramon
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Eur Psychiatry 21:70-3. 2006
    ..However, the available neurophysiologic evidence suggests that any such association, if present, must be very subtle...
  68. ncbi request reprint Superior temporal gyrus abnormalities in early-onset schizophrenia: similarities and differences with adult-onset schizophrenia
    H Matsumoto
    Institute of Psychiatry, Division of Psychological Medicine, Section of Neurobiology of Psychosis, De Crespigny Park, London, SE5 8AF, UK
    Am J Psychiatry 158:1299-304. 2001
    ..The relationship between language-related symptoms and superior temporal gyrus volume is similar to that seen in adult-onset cases but not as lateralized...
  69. doi request reprint Common and distinct neural correlates of emotional processing in Bipolar Disorder and Major Depressive Disorder: a voxel-based meta-analysis of functional magnetic resonance imaging studies
    Giuseppe Delvecchio
    European College of Neuropsychopharmacology, Networks Initiative, Neuroimaging Network, London, UK
    Eur Neuropsychopharmacol 22:100-13. 2012
    ..These data suggest that whereas limbic overactivation is reported consistently in patients with mood disorders, future research should consider the relevance of a wider network of regions in formulating conceptual models of BD and MDD...
  70. ncbi request reprint Brain volumes in adult survivors of very low birth weight: a sibling-controlled study
    Paul Fearon
    Section of General Psychiatry, Division of Psychological Medicine, Box 63, Institute of Psychiatry, London SE5 8AF, United Kingdom
    Pediatrics 114:367-71. 2004
    ..To establish whether adults who were born very low birth weight (VLBW) show altered volumes of certain brain structures...
  71. ncbi request reprint New insights help define the pathophysiology of bipolar affective disorder: neuroimaging and neuropathology findings
    Morgan Haldane
    Section of Neurobiology of Psychosis Box P066, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Prog Neuropsychopharmacol Biol Psychiatry 28:943-60. 2004
    ..In contrast, amygdala activity shows a persistent increase. We suggest that abnormal interaction between the amygdala and the ventral/orbitofrontal cortex may be a central feature of the pathophysiology of BD...
  72. doi request reprint Gender differences in immediate memory in bipolar disorder
    D Carrus
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 40:1349-55. 2010
    ..Although cognitive abnormalities are an established feature of BD, there is limited information regarding whether gender also influences the pattern and severity of cognitive impairment...
  73. doi request reprint The Maudsley Early Onset Schizophrenia Study: the effect of age of onset and illness duration on fronto-parietal gray matter
    L Burke
    Child and Adolescent Services, South London and Maudsley NHS Trust, Denmark Hill, London, UK
    Eur Psychiatry 23:233-6. 2008
    ..To further explore this effect we examined the relationship between age of onset and duration of illness on brain morphology in adolescents with EOS...
  74. pmc A comprehensive testing protocol for MRI neuroanatomical segmentation techniques: Evaluation of a novel lateral ventricle segmentation method
    Matthew J Kempton
    King s College London, Institute of Psychiatry, Department of Neuroimaging, UK
    Neuroimage 58:1051-9. 2011
    ..We also demonstrate that the novel segmentation algorithm and FreeSurfer are both effective in determining lateral ventricular volume and are well suited for multicentre and longitudinal MRI studies...
  75. ncbi request reprint Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives
    Katja Schulze
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 53:562-70. 2003
    ..The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in schizophrenia...
  76. ncbi request reprint Structural magnetic imaging of the hippocampus in early onset schizophrenia
    H Matsumoto
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 49:824-31. 2001
    ....
  77. ncbi request reprint The Maudsley Family Study, II: Endogenous event-related potentials in familial schizophrenia
    S Frangou
    Department of Psychological Medicine, King s College School of Medicine and Dentistry, London, UK
    Schizophr Res 23:45-53. 1997
    ..These included six of the eight obligate carriers. Our results suggest that ERP abnormalities may serve as markers of genetic vulnerability in schizophrenia and may be useful in genetic linkage studies...
  78. ncbi request reprint Aripiprazole in schizophrenia: consensus guidelines
    M J Travis
    Institute of Psychiatry, London, UK
    Int J Clin Pract 59:485-95. 2005
    ..The purpose of these guidelines is to outline the consensus reached by the Schizophrenia Innovation Working Group on best practice in prescribing and appropriate use of aripiprazole in the UK...
  79. ncbi request reprint The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia
    E T Bullmore
    Institute of Psychiatry, Department of Psychological Medicine, Denmark Hill, London, UK
    Schizophr Res 28:143-56. 1997
    ....
  80. doi request reprint Impulsivity, personality and bipolar disorder
    M Lewis
    Section of Neurobiology of Psychosis, PO66 Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Eur Psychiatry 24:464-9. 2009
    ..The aim of this study was to examine the relationship of impulsivity to clinical status and personality characteristics in patients with BD...
  81. ncbi request reprint Service use and costs of treating schizophrenia with atypical antipsychotics
    M Lewis
    Section of Neurobiology of Psychosis, Institute of Psychiatry, De Crespigny Park, London, England
    J Clin Psychiatry 62:749-56. 2001
    ..CONCLUSION: Clozapine was reserved for more severe forms of schizophrenia, but its cost impact was relatively low. Risperidone, as prescribed in ordinary practice, may be more cost-effective than olanzapine...
  82. doi request reprint Acute citalopram administration may disrupt contextual information processing in healthy males
    S Almeida
    Institute of Psychiatry, King s College London, UK
    Eur Psychiatry 25:87-91. 2010
    ..These findings provide a useful guide for designing future studies in clinical populations...
  83. ncbi request reprint The relationship of impulsivity to response inhibition and decision-making in remitted patients with bipolar disorder
    T Christodoulou
    Section of Neurobiology of Psychosis PO66, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Eur Psychiatry 21:270-3. 2006
    ..Abnormalities in these two cognitive domains have been reported in BD patients but their relationship with impulsivity has not been explored...
  84. ncbi request reprint Cell density and cortical thickness in Heschl's gyrus in schizophrenia, major depression and bipolar disorder
    David Cotter
    Beaumont Hospital, Dublin 9, Ireland
    Br J Psychiatry 185:258-9. 2004
    ....
  85. ncbi request reprint Increased prepulse inhibition of the acoustic startle response is associated with better strategy formation and execution times in healthy males
    Panos Bitsios
    Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, Heraklion, Greece
    Neuropsychologia 44:2494-9. 2006
    ..Our findings suggest that greater PPI is associated with superior abilities in strategy formation and execution times. We suggest that this is due to more efficient early information processing...
  86. ncbi request reprint Stroop performance in bipolar disorder: further evidence for abnormalities in the ventral prefrontal cortex
    Dina M Kronhaus
    Institute for Adaptive and Neural Computation, School of Informatics, The University of Edinburgh, Edinburgh, UK
    Bipolar Disord 8:28-39. 2006
    ..We aimed to examine the relationship between functional abnormalities, impaired task performance and the severity of depressive symptoms in bipolar patients...
  87. ncbi request reprint The level of prepulse inhibition in healthy individuals may index cortical modulation of early information processing
    Stella G Giakoumaki
    Department of Psychiatry and Behavioural Sciences, Medical School, University of Crete, Heraklion 71003, Crete, Greece
    Brain Res 1078:168-70. 2006
    ..These data suggest that high-PPI status reflects greater efficiency in tasks that engage SAS...
  88. ncbi request reprint Validation of the Investigator's Assessment Questionnaire, a new clinical tool for relative assessment of response to antipsychotics in patients with schizophrenia and schizoaffective disorder
    Rajiv Tandon
    Department of Psychiatry Adjunct, University of Florida, Gainesville, FL, USA
    Psychiatry Res 136:211-21. 2005
    ..35 days in the study and a decrease in CGI-I of 0.21 units. These results provide initial validation of the IAQ as a tool for evaluating antipsychotic response in patients with schizophrenia or schizoaffective disorder...
  89. ncbi request reprint The effects of dopamine agonists on prepulse inhibition in healthy men depend on baseline PPI values
    Panos Bitsios
    Department of Psychiatry and Behavioural Sciences, Faculty of Medicine, University of Crete, P O Box 2208, Heraklion, 71003, Crete, Greece
    Psychopharmacology (Berl) 182:144-52. 2005
    ..This study examines whether individual variation in baseline PPI may account for the inconsistencies in DA agonist-induced PPI disruption in humans...
  90. ncbi request reprint Evidence of disrupted prepulse inhibition in unaffected siblings of bipolar disorder patients
    Stella G Giakoumaki
    Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, Crete, Greece
    Biol Psychiatry 62:1418-22. 2007
    ..To address this issue, the present study examined whether disrupted PPI is present in individuals at high risk for BD...
  91. ncbi request reprint Is the prophylactic antidepressant efficacy of lithium in bipolar I disorder dependent on study design and lithium level?
    Wolfram Emanuel Severus
    Department of Psychiatry, University of Munich, Germany
    J Clin Psychopharmacol 25:457-62. 2005
    ..In these trials, factors previously associated with predicting response to lithium should also be assessed...
  92. ncbi request reprint Disruption of prepulse inhibition of the startle reflex by the preferential D(3) agonist ropinirole in healthy males
    Stella G Giakoumaki
    Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, P O Box 2208, Heraklion, 71003, Crete, Greece
    Psychopharmacology (Berl) 194:289-95. 2007
    ..Emerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects...