I Fogelman

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Bone mineral density in premenopausal women treated for node-positive early breast cancer with 2 years of goserelin or 6 months of cyclophosphamide, methotrexate and 5-fluorouracil (CMF)
    I Fogelman
    Department of Nuclear Medicine, Guy s, Kings and St Thomas Hospital Medical School, SE1 9RT, London, UK
    Osteoporos Int 14:1001-6. 2003
  2. pmc The impact of vitamin D status on changes in bone mineral density during treatment with bisphosphonates and after discontinuation following long-term use in post-menopausal osteoporosis
    Andrew Deane
    Department of Chemical Pathology and metabolic bone clinic, St Thomas Hospital Campus, Kings College London, London, UK
    BMC Musculoskelet Disord 8:3. 2007
  3. pmc A method for determining skeletal lengths from DXA images
    Usha Chinappen-Horsley
    King s College London, St Thomas Hospital Campus, Twin Research and Genetic Epidemiology Unit, Lambeth Palace Road, London, SE1 7EH, UK
    BMC Musculoskelet Disord 8:113. 2007
  4. ncbi request reprint Positron emission tomography and bone metastases
    Ignac Fogelman
    Division of Imaging, King s College, London, United Kingdom
    Semin Nucl Med 35:135-42. 2005
  5. ncbi request reprint Osteoblastic bone metastases in breast cancer: is not seeing believing?
    Ignac Fogelman
    Department of Nuclear Medicine, Guy s, King s and St Thomas School of Medicine, Guy s Campus, London, SE1 9RT, UK
    Eur J Nucl Med Mol Imaging 32:1250-2. 2005
  6. ncbi request reprint Bone densitometry: an update
    Ignac Fogelman
    Guy s, King s and St Thomas School of Medicine, London SE1 9RT, UK
    Lancet 366:2068-70. 2005
  7. doi request reprint Differences in regional bone metabolism at the spine and hip: a quantitative study using (18)F-fluoride positron emission tomography
    T Puri
    King s College London, PET Imaging Centre, Imaging Sciences and Biomedical Engineering, St Thomas Hospital, London, UK
    Osteoporos Int 24:633-9. 2013
  8. doi request reprint Regional bone metabolism at the lumbar spine and hip following discontinuation of alendronate and risedronate treatment in postmenopausal women
    M L Frost
    Osteoporosis Research Unit, King s College London, Guy s Hospital Campus, Great Maze Pond, London, UK
    Osteoporos Int 23:2107-16. 2012
  9. ncbi request reprint Multisite quantitative ultrasound: precision, age- and menopause-related changes, fracture discrimination, and T-score equivalence with dual-energy X-ray absorptiometry
    K M Knapp
    Radiological Sciences, Guy s, Kings and St Thomas Medical School, Guy s Hospital, London, UK
    Osteoporos Int 12:456-64. 2001
  10. ncbi request reprint Differential effects of hormone replacement therapy on bone mineral density and axial transmission ultrasound measurements in cortical bone
    K M Knapp
    Osteoporosis Screening and Research Unit, 16th Floor, Guy s Tower, Guy s Hospital, St Thomas Street, SE1 9RT, London, UK
    Osteoporos Int 14:289-94. 2003

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint Bone mineral density in premenopausal women treated for node-positive early breast cancer with 2 years of goserelin or 6 months of cyclophosphamide, methotrexate and 5-fluorouracil (CMF)
    I Fogelman
    Department of Nuclear Medicine, Guy s, Kings and St Thomas Hospital Medical School, SE1 9RT, London, UK
    Osteoporos Int 14:1001-6. 2003
    ....
  2. pmc The impact of vitamin D status on changes in bone mineral density during treatment with bisphosphonates and after discontinuation following long-term use in post-menopausal osteoporosis
    Andrew Deane
    Department of Chemical Pathology and metabolic bone clinic, St Thomas Hospital Campus, Kings College London, London, UK
    BMC Musculoskelet Disord 8:3. 2007
    ....
  3. pmc A method for determining skeletal lengths from DXA images
    Usha Chinappen-Horsley
    King s College London, St Thomas Hospital Campus, Twin Research and Genetic Epidemiology Unit, Lambeth Palace Road, London, SE1 7EH, UK
    BMC Musculoskelet Disord 8:113. 2007
    ..The aim of this study was to show that skeletal ratios, such as length of femur to height, could be accurately measured from a DXA (dual energy X-ray absorptiometry) image...
  4. ncbi request reprint Positron emission tomography and bone metastases
    Ignac Fogelman
    Division of Imaging, King s College, London, United Kingdom
    Semin Nucl Med 35:135-42. 2005
    ..The most important question, however, is irrespective of whether a lesion is seen on x-ray, CT, or bone scan and irrespective of lytic of blastic morphology: if the FDG-PET study is negative, what is the clinical relevance of that lesion?..
  5. ncbi request reprint Osteoblastic bone metastases in breast cancer: is not seeing believing?
    Ignac Fogelman
    Department of Nuclear Medicine, Guy s, King s and St Thomas School of Medicine, Guy s Campus, London, SE1 9RT, UK
    Eur J Nucl Med Mol Imaging 32:1250-2. 2005
  6. ncbi request reprint Bone densitometry: an update
    Ignac Fogelman
    Guy s, King s and St Thomas School of Medicine, London SE1 9RT, UK
    Lancet 366:2068-70. 2005
  7. doi request reprint Differences in regional bone metabolism at the spine and hip: a quantitative study using (18)F-fluoride positron emission tomography
    T Puri
    King s College London, PET Imaging Centre, Imaging Sciences and Biomedical Engineering, St Thomas Hospital, London, UK
    Osteoporos Int 24:633-9. 2013
    ..This study showed that regional bone blood flow and (18)F-fluoride bone plasma clearance measured by positron emission tomography are three times lower at the hip than the lumbar spine...
  8. doi request reprint Regional bone metabolism at the lumbar spine and hip following discontinuation of alendronate and risedronate treatment in postmenopausal women
    M L Frost
    Osteoporosis Research Unit, King s College London, Guy s Hospital Campus, Great Maze Pond, London, UK
    Osteoporos Int 23:2107-16. 2012
    ..Bone metabolism at the spine remained stable following discontinuation of alendronate and risedronate at 1 year but increased in the hip in the alendronate group only...
  9. ncbi request reprint Multisite quantitative ultrasound: precision, age- and menopause-related changes, fracture discrimination, and T-score equivalence with dual-energy X-ray absorptiometry
    K M Knapp
    Radiological Sciences, Guy s, Kings and St Thomas Medical School, Guy s Hospital, London, UK
    Osteoporos Int 12:456-64. 2001
    ....
  10. ncbi request reprint Differential effects of hormone replacement therapy on bone mineral density and axial transmission ultrasound measurements in cortical bone
    K M Knapp
    Osteoporosis Screening and Research Unit, 16th Floor, Guy s Tower, Guy s Hospital, St Thomas Street, SE1 9RT, London, UK
    Osteoporos Int 14:289-94. 2003
    ..In conclusion, these results demonstrate a positive effect of HRT on SOS measurements at the radius and tibia and BMD measurements of the lumbar spine...
  11. ncbi request reprint Effects of 8 years of treatment with tibolone 2.5 mg daily on postmenopausal bone loss
    J Rymer
    Department of Obstetrics and Gynaecology, Guy s, King s and St Thomas Medical School, London, UK
    Osteoporos Int 12:478-83. 2001
    ..5 mg daily prevents bone loss in the lumbar spine and femoral neck over 8 years and adherence to treatment is high. The greater bone density compared with untreated women would be expected to reduce the risk of bone fractures...
  12. ncbi request reprint Morphometric X-ray absorptiometry and morphometric radiography of the spine: a comparison of analysis precision in normal and osteoporotic subjects
    J A Rea
    Osteoporosis Screening and Research Unit, Guy s Hospital, London, UK
    Osteoporos Int 9:536-44. 1999
    ..We conclude that MXA precision is generally poorer than that of MRX and that the presence of vertebral deformities has a more pronounced effect on MXA precision than on MRX precision...
  13. ncbi request reprint Can the WHO definition of osteoporosis be applied to multi-site axial transmission quantitative ultrasound?
    K M Knapp
    Osteoporosis Screening and Research Unit, Guy s Hospital, 16th Floor, Guy s Tower, St Thomas Street, SE1 9RT, London, UK
    Osteoporos Int 15:367-74. 2004
    ..6, -3.0, -3.0 and -2.2 and for osteopenia of -1.4, -1.6, -2.3, and -1.4, for the radius, tibia, phalanx and metatarsal, respectively, were recommended...
  14. ncbi request reprint An unexpected change in DXA calibration not detected by routine quality control checks
    G M Blake
    Department of Nuclear Medicine, Guy s Hospital, London, UK
    Osteoporos Int 9:115-20. 1999
    ....
  15. ncbi request reprint Does quantitative ultrasound imaging enhance precision and discrimination?
    M L Frost
    Osteoporosis Research Unit, Guy s Hospital, London, UK
    Osteoporos Int 11:425-33. 2000
    ..The inconsistencies of the imaging system used for this study demonstrate that further development is required before it will be possible to show improvements in long-term precision...
  16. doi request reprint The effect of weight and weight change on the long-term precision of spine and hip DXA measurements
    R Rajamanohara
    Osteoporosis Research Unit, Division of Imaging Sciences, King s College London Guy s Campus, London, UK
    Osteoporos Int 22:1503-12. 2011
    ..Weight changes up to 5 kg had little effect on precision...
  17. pmc Significant differences in UK and US female bone density reference ranges
    E Noon
    Osteoporosis Research Unit, Division of Imaging Sciences, King s College London, London, UK
    Osteoporos Int 21:1871-80. 2010
    ..6 standard deviation higher than their US counterparts...
  18. ncbi request reprint Visual assessment of vertebral deformity by X-ray absorptiometry: a highly predictive method to exclude vertebral deformity
    J A Rea
    Osteoporosis Screening and Research Unit, Guy s Hospital, London, UK
    Osteoporos Int 11:660-8. 2000
    ..VXA may prove useful in the clinical evaluation of patients at risk of osteoporosis as an adjunct to BMD scans or in the selection of subjects for osteoporosis-related clinical trials...
  19. doi request reprint Association of bone turnover markers and arterial stiffness in pre-dialysis chronic kidney disease (CKD)
    P Manghat
    Department of Chemical Pathology, St Thomas Hospital, London, UK
    Bone 48:1127-32. 2011
    ..029). Our data suggest a link between imbalances in bone turnover and arterial stiffness in pre-dialysis CKD. Longitudinal studies are needed to evaluate the clinical usefulness of these bone turnover markers as predictors of CVD in CKD...
  20. ncbi request reprint Can the WHO criteria for diagnosing osteoporosis be applied to calcaneal quantitative ultrasound?
    M L Frost
    Osteoporosis Unit, Guy s Hospital, London, UK
    Osteoporos Int 11:321-30. 2000
    ..61, -1.94 and -1.90 for Sahara BUA, SOS and estimated heel BMD respectively and -1.45 and -2.10 for DTU BUA and SOS respectively Additional studies are needed to determine suitable T-score thresholds for other commercial QUS devices...
  21. ncbi request reprint Monitoring skeletal response to treatment which site to measure in the femur?
    G M Blake
    Department of Nuclear Medicine, Guy s Hospital, St Thomas St, London, SE1 9RT, UK
    J Clin Densitom 3:149-55. 2000
    ..In particular, total hip BMD appears to be as effective as femoral neck BMD for detecting response to treatment in the femur in the setting of a clinical trial or similar research study...
  22. ncbi request reprint Late low-dose steroid withdrawal in renal transplant recipients increases bone formation and bone mineral density
    C K T Farmer
    Department of Nephrology and Transplantation, King s College, London, UK
    Am J Transplant 6:2929-36. 2006
    ..2 ng/mL (p < 0.05) in the withdrawal group, but was unchanged in the controls. No change was seen in CTx. Corticosteroid withdrawal in renal transplant recipients results in an increase in BMD with a corresponding increase in serum OC...
  23. ncbi request reprint Contact quantitative ultrasound: an evaluation of precision, fracture discrimination, age-related bone loss and applicability of the WHO criteria
    M L Frost
    Osteoporosis Unit, Guy s Hospital, London, UK
    Osteoporos Int 10:441-9. 1999
    ..However, the widely accepted threshold of a T-score of less than -2.5 for the definition of osteoporosis may need modifying for the interpretation of QUS scans...
  24. ncbi request reprint Predicting the risk of fracture at any site in the skeleton: are all bone mineral density measurement sites equally effective?
    G M Blake
    Imaging Sciences, Guy s, King s and St Thomas School of Medicine, Guy s Campus, London, United Kingdom
    Calcif Tissue Int 78:9-17. 2006
    ....
  25. ncbi request reprint Does the combination of quantitative ultrasound and dual-energy X-ray absorptiometry improve fracture discrimination?
    M L Frost
    Osteoporosis Screening and Research Unit, Guy s Hospital, London, UK
    Osteoporos Int 12:471-7. 2001
    ..However, these increases were not clinically significant. In conclusion, the combination of axial BMD and calcaneal QUS measurements did not significantly improve fracture discrimination compared with either method alone...
  26. doi request reprint Parathyroid hormone(1-84) treatment of postmenopausal women with low bone mass receiving hormone replacement therapy
    I Fogelman
    Guy s, King s and St Thomas School of Medicine, St London, SE1 9RT, UK
    Calcif Tissue Int 83:85-92. 2008
    ..In conclusion, addition of PTH(1-84) to stable HT produced marked increases in lumbar spine BMD and may represent an additional approach to the treatment of PMO women receiving HT...
  27. ncbi request reprint Quantitative studies of bone with the use of 18F-fluoride and 99mTc-methylene diphosphonate
    G M Blake
    Department of Nuclear Medicine, Guy's Hospital, London, England
    Semin Nucl Med 31:28-49. 2001
    ..However, comparable data could probably be obtained by using 99mTc-MDP if methods for single photon emission computed tomography (SPECT) quantitation were improved...
  28. ncbi request reprint Long-term precision of DXA scanning assessed over seven years in forty postmenopausal women
    R Patel
    Department of Nuclear Medicine, Guy s Hospital, London, UK
    Osteoporos Int 11:68-75. 2000
    ..However, obesity may have an adverse effect on precision errors in individual patients and particular care is necessary to ensure reproducible patient positioning for femur scans...
  29. ncbi request reprint Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions
    G J Cook
    Clinical Positron Emission Tomography Centre and Department of Oncology, Guys Hospital, United Medical and Dental Schools, London, United Kingdom
    J Clin Oncol 16:3375-9. 1998
    ..We have compared 18FDG PET with 99mTc MDP bone scintigraphy in patients with skeletal metastases from breast cancer and have analyzed the data in subgroups based on radiographic characteristics of lesions...
  30. doi request reprint Circulating sclerostin and Dickkopf-1 (DKK1) in predialysis chronic kidney disease (CKD): relationship with bone density and arterial stiffness
    S Thambiah
    Department of Clinical Chemistry, St Thomas Hospital, London, UK
    Calcif Tissue Int 90:473-80. 2012
    ..027). Our data suggest that the Wnt pathway may play a role in CKD-MBD. Prospective studies are required to establish the clinical relevance of sclerostin and DKK1 as serological markers in CKD...
  31. ncbi request reprint Ten years of treatment with tibolone 2.5 mg daily: effects on bone loss in postmenopausal women
    J Rymer
    Guy s, King s and St Thomas School of Medicine, London, UK
    Climacteric 5:390-8. 2002
    ..To assess the effects of tibolone 2.5 mg daily over a 10-year period on bone loss and other efficacy parameters in postmenopausal women, and to confirm its long-term safety and tolerability...
  32. ncbi request reprint FDG-PET as a "metabolic biopsy" tool in thoracic lesions with indeterminate biopsy
    S F Hain
    The Clinical PET Centre, Guy s, Kings and St Thomas School of Medicine, St Thomas Hospital, London, UK
    Eur J Nucl Med 28:1336-40. 2001
    ..The high positive predictive value suggests that those with a positive scan must undergo further investigation, while the 100% negative predictive value means those with no FDG uptake can safely be spared further invasive investigations..
  33. ncbi request reprint The value of bone scintigraphy in the evaluation of osteoporotic patients with back pain
    G J R Cook
    Department of Nuclear Medicine, Guys and St Thomas Hospitals Trust, London, UK
    Scand J Rheumatol 31:245-8. 2002
    ..In symptomatic osteoporotic patients the bone scan may be helpful in elucidating the etiology of back pain and can impact on patient management...
  34. ncbi request reprint The role of bone density measurements in the evaluation of new treatments for osteoporosis
    G M Blake
    Department of Nuclear Medicine, Guy s Hospital, St Thomas Street, London, SE1 9RT, UK
    Curr Pharm Des 8:1885-1905. 2002
    ....
  35. ncbi request reprint A comparison of fracture discrimination using calcaneal quantitative ultrasound and dual X-ray absorptiometry in women with a history of fracture at sites other than the spine and hip
    M L Frost
    Osteoporosis Screening and Research Unit, Guy s, King s and St Thomas School of Medicine, London, UK
    Calcif Tissue Int 71:207-11. 2002
    ..In conclusion, calcaneal QUS can discriminate between women with and those without fracture at the wrist or at sites other than the spine, hip, or forearm as well as axial DXA measurements of BMD can...
  36. ncbi request reprint Peripheral or central densitometry: does it matter which technique we use?
    G M Blake
    Department of Nuclear Medicine, Guy s Hospital, St Thomas Street, London SE1 9RT, United Kingdom
    J Clin Densitom 4:83-96. 2001
    ....
  37. ncbi request reprint Optimizing data acquisition and analysis of morphometric X-ray absorptiometry
    J A Rea
    Osteoporosis Screening and Research Unit, Guy s Hospital, London, UK
    Osteoporos Int 8:177-83. 1998
    ..2%). BMI and BMD had little or no effect on precision. We conclude that optimal results are obtained by the acquisition of both SE and HD scans. However, for rapid assessment by trained operators SE scans alone offer almost equal utility...
  38. pmc Biochemical prediction of response of bone metastases to treatment
    R E Coleman
    Imperial Cancer Research Fund Clinical Oncology Unit, Guy s Hospital, London, UK
    Br J Cancer 58:205-10. 1988
    ..Independent confirmation is needed, but our results suggest there are reliable alternatives to plain radiography in the early assessment of response of bone metastases to treatment...
  39. ncbi request reprint Detection of bone metastases in cancer patients by 18F-fluoride and 18F-fluorodeoxyglucose positron emission tomography
    G J Cook
    Department of Nuclear Medicine, Royal Marsden Hospital, Sutton, Surrey, UK
    Q J Nucl Med 45:47-52. 2001
    ....
  40. ncbi request reprint Quantitative studies of bone using (18)F-fluoride and (99m)Tc-methylene diphosphonate: evaluation of renal and whole-blood kinetics
    S J Park-Holohan
    Department of Nuclear Medicine, Guy's Hospital, St Thomas Street, London, SE1 9RT, UK
    Nucl Med Commun 22:1037-44. 2001
    ..In view of the data showing the rapid transport of (18)F-fluoride across the red cell membrane, bone kinetic data for (18)F are more accurately reported as whole-blood clearance rather than plasma clearance...
  41. ncbi request reprint Where now for the management of osteoporosis?
    Ignac Fogelman
    Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London SE1 9RT
    Hosp Med 66:284-7. 2005
    ..What impact can the expanding range of treatments make on the growing and costly burden of osteoporosis?..
  42. doi request reprint Precision of ¹⁸F-fluoride PET skeletal kinetic studies in the assessment of bone metabolism
    Y Al-Beyatti
    Osteoporosis Screening and Research Unit, Guy s Hospital, King s College London, 1st Floor, Tower Wing, London, SE1 9RT, UK
    Osteoporos Int 23:2535-41. 2012
    ..2% (7.5-11.8) for standardised uptake values, 11.7% (9.5-14.9) for plasma clearance measurements using the Patlak method and 14.5% (11.7-18.5) for plasma clearance measurements using the Hawkins three-compartment model...
  43. ncbi request reprint The role of positron emission tomography in skeletal disease
    G J Cook
    Department of Nuclear Medicine, Guys, Kings and St Thomas' School of Medicine, Kings College, London, England
    Semin Nucl Med 31:50-61. 2001
    ..A possible role for the use of the hypoxia selective tracer 18F-fluoromisonidazole in skeletal infection also exists. This article summarizes the current role of PET in the skeleton with regard to these tracers and diseases...
  44. ncbi request reprint The effect of weight change on total body dual-energy X-ray absorptiometry: results from a clinical trial
    G M Blake
    Department of Nuclear Medicine, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    Osteoporos Int 11:832-9. 2000
    ..We conclude that in a randomized study the effects of weight change can be corrected and total body DXA can give useful information about the response to treatment across the whole skeleton...
  45. ncbi request reprint Bone densitometry and the diagnosis of osteoporosis
    G M Blake
    Department of Nuclear Medicine, Guy s Hospital, London, England
    Semin Nucl Med 31:69-81. 2001
    ..degree of consistency among different methods? Finally, does it matter if the imperfect correlation among different types of measurement results in different patients being selected for treatment on the basis of different techniques?..
  46. doi request reprint Fibroblast growth factor-23 is associated with C-reactive protein, serum phosphate and bone mineral density in chronic kidney disease
    P Manghat
    Department of Chemical Pathology, 5th Floor, North Wing, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
    Osteoporos Int 21:1853-61. 2010
    ..C-reactive protein (CRP) and serum phosphate correlated with FGF-23. A significant association was seen between FGF-23 and BMD at the hip...
  47. doi request reprint Circulating fibroblast growth factor-23 increases following intermittent parathyroid hormone (1-34) in postmenopausal osteoporosis: association with biomarker of bone formation
    M Sridharan
    Osteoporosis Clinic, Guy s Hospital, London, UK
    Calcif Tissue Int 87:398-405. 2010
    ..78, P < 0.001). FGF-23 is increased by intermittent PTH(1-34). This is related to early changes in P1NP, suggesting that the skeletal effects of PTH may involve FGF-23. Further studies are required to elucidate this...
  48. ncbi request reprint Dual X-ray absorptiometry: clinical evaluation of a new cone-beam system
    G M Blake
    Guy s, King s and St Thomas School of Medicine, St Thomas Street, London SE1 9RT, UK
    Calcif Tissue Int 76:113-20. 2005
    ....
  49. ncbi request reprint The role of fluorodeoxyglucose, 18F-dihydroxyphenylalanine, 18F-choline, and 18F-fluoride in bone imaging with emphasis on prostate and breast
    Werner Langsteger
    PET CT Center LINZ, Department of Nuclear Medicine and Endocrinology, St Vincent s Hospital, Linz, Austria, and Division of Imaging, King s College, London, UK
    Semin Nucl Med 36:73-92. 2006
    ..Nevertheless, prospective studies with large patient groups will be essential to define the exact diagnostic role of FCH and DOPA PET in different clinical settings...
  50. ncbi request reprint The relationship between gonadotrophins, gonadal hormones and bone mass in men
    N Karim
    Department of Chemical Pathology, St Thomas Hospital, London, UK
    Clin Endocrinol (Oxf) 68:94-101. 2008
    ..Data in men are lacking. The aim was to investigate the relationship between circulating concentrations of Inh B and Act A and FSH/LH/testosterone (T) and their contribution to bone mineral density (BMD) in a male population...
  51. ncbi request reprint Radiation dose to the patient and operator from a peripheral dual X-ray absorptiometry system
    R Patel
    Department of Nuclear Medicine, Guy s Hospital, London, UK r
    J Clin Densitom 2:397-401. 1999
    ..4 microSv/h. These figures compare with a natural background radiation in the United Kingdom of 7 microSv/d. In conclusion the radiation doses from forearm pDXA to both patients and operator were found to be truly trivial...
  52. doi request reprint Effect of increasing vertebral marrow fat content on BMD measurement, T-Score status and fracture risk prediction by DXA
    G M Blake
    Osteoporosis Scanning and Research Unit, King s College London School of Medicine, London, UK
    Bone 44:495-501. 2009
    ....
  53. ncbi request reprint A direct in vivo measurement of 99mTc-methylene diphosphonate protein binding
    G M Blake
    Department of Nuclear Medicine, Guy s Hospital, London, UK
    Nucl Med Commun 24:829-35. 2003
    ..The results confirm that the fraction of free 99mTc-MDP varies with time and shows significant differences between individuals, which are dependent on GFR and K(bone) amongst other factors...
  54. ncbi request reprint Multisite quantitative ultrasound: Colles' fracture discrimination in postmenopausal women
    K M Knapp
    Radiological Sciences, Guy s, Kings and St Thomas Medical School, Guy s Hospital, London, UK
    Osteoporos Int 13:474-9. 2002
    ....
  55. ncbi request reprint Quantitative ultrasound and bone mineral density are equally strongly associated with risk factors for osteoporosis
    M L Frost
    Osteoporosis Screening and Research Unit, Guy's Hospital, London, United Kingdom
    J Bone Miner Res 16:406-16. 2001
    ..Provided revised diagnostic criteria are adopted for QUS, similar proportions of postmenopausal women are identified as osteopenic or osteoporotic as with BMD...
  56. ncbi request reprint Vertebral morphometry: a comparison of long-term precision of morphometric X-ray absorptiometry and morphometric radiography in normal and osteoporotic subjects
    J A Rea
    Osteoporosis Screening and Research Unit, Guy s Hospital, London, UK
    Osteoporos Int 12:158-66. 2001
    ....
  57. ncbi request reprint Atypical Paget's disease with quantitative assessment of tracer kinetics
    Gopinath Gnanasegaran
    Department of Nuclear Medicine, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK
    Clin Nucl Med 32:765-9. 2007
    ..A patient with an unusual pattern of disease is presented together with quantitative assessment of the tracer kinetics pre- and posttreatment...
  58. ncbi request reprint The effect of season and vitamin D supplementation on bone mineral density in healthy women: a double-masked crossover study
    R Patel
    Department of Nuclear Medicine, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    Osteoporos Int 12:319-25. 2001
    ..Vitamin D supplementation was found to have no effect on BMD...
  59. ncbi request reprint Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-beta oestradiol and raloxifene
    J Cheung
    Department of Chemical Pathology, St Thomas Hospital, London, UK
    J Endocrinol 177:423-33. 2003
    ..The data also suggest that, in contrast to E(2), RAL may exert its anti-resorptive actions, at least in part, via the RANKL/OPG pathway. Further in vivo studies are required to confirm this...
  60. ncbi request reprint Monitoring treatment for osteoporosis by using bone densitometry
    G M Blake
    Department of Nuclear Medicine, Guy's Hospital, London, England
    Semin Nucl Med 31:212-22. 2001
    ..However, when new therapies are first introduced, follow-up scans have a useful role in building up the physician's experience and confidence...
  61. ncbi request reprint Diabetes and bone: advantages and limitations of radiological, radionuclide and hybrid techniques in the assessment of diabetic foot
    G Gnanasegaran
    Department of Nuclear Medicine, Guys and St Thomas Hospital NHS Foundation Trust Hospital, London, UK
    Minerva Endocrinol 34:237-54. 2009
    ..In this review we discuss the efficacy of radiological and radionuclide techniques in the assessment of diabetic foot infection...
  62. ncbi request reprint Comparison of myocardial gated single photon emission computerised tomography, planar radionuclide ventriculography and echocardiography in evaluating left ventricular ejection fraction, wall thickening and wall motion
    H K Mohan
    Department of Nuclear Medicine, Guy s and St Thomas Hospital, London, UK
    Int J Clin Pract 58:1120-6. 2004
    ..However, estimates of wall thickening from echocardiography cannot be used interchangeably with those derived from gated myocardial perfusion SPECT...
  63. ncbi request reprint The relationship between regional bone turnover measured using 18F-fluoride positron emission tomography and changes in BMD is equivalent to that seen for biochemical markers of bone turnover
    Michelle L Frost
    Osteoporosis Screening and Research Unit, King s College London School of Medicine, Guy s Hospital, London
    J Clin Densitom 10:46-54. 2007
    ..This study has demonstrated that the relationship between regional bone turnover measured directly at the lumbar spine with changes in BMD is similar to that seen for global skeletal bone turnover using biochemical markers...
  64. ncbi request reprint Effect of bone strontium on BMD measurements
    Glen M Blake
    King s College London School of Medicine, London, UK
    J Clin Densitom 10:34-8. 2007
    ..This latter correction will be required for the interpretation of future DXA scans in patients who have discontinued strontium ranelate treatment...
  65. ncbi request reprint A review of strontium ranelate and its effect on DXA scans
    Glen M Blake
    King s College London School of Medicine, London, UK
    J Clin Densitom 10:113-9. 2007
    ....
  66. ncbi request reprint Role of dual-energy X-ray absorptiometry in the diagnosis and treatment of osteoporosis
    Glen M Blake
    King s College London School of Medicine, London, UK
    J Clin Densitom 10:102-10. 2007
    ..This review article discusses the evidence for these and other advantages of central DXA, including its role in the new WHO algorithm for treating patients on the basis of individual fracture risk...
  67. ncbi request reprint A study to determine the dependence of 99mTc-MDP protein binding on plasma clearance and serum albumin concentration
    Amelia E B Moore
    King s College London School of Medicine, UK
    Nucl Med Commun 28:187-92. 2007
    ..In this study, the dependence of Tc-MDP protein binding on total plasma clearance (Ktotal) and serum albumin concentration was investigated using data from two groups of patients...
  68. ncbi request reprint The correction of BMD measurements for bone strontium content
    Glen M Blake
    King s College London School of Medicine, London, UK
    J Clin Densitom 10:259-65. 2007
    ....
  69. doi request reprint Assessment of regional changes in skeletal metabolism following 3 and 18 months of teriparatide treatment
    Amelia E B Moore
    King s College London, Guy s Campus, London, United Kingdom
    J Bone Miner Res 25:960-7. 2010
    ..This is the first study showing a direct metabolic effect of TPTD at different skeletal sites in vivo, as measured by tracer kinetics...
  70. doi request reprint Differences in regional bone perfusion and turnover between lumbar spine and distal humerus: (18)F-fluoride PET study of treatment-naïve and treated postmenopausal women
    Michelle L Frost
    King s College London, Osteoporosis Unit, Guy s Hospital, UK
    Bone 45:942-8. 2009
    ..18)F-PET may aid in our understanding of the importance of bone perfusion in osteoporosis and differences in regional bone turnover with disease and in response to therapy...
  71. doi request reprint The clinical role of dual energy X-ray absorptiometry
    Glen M Blake
    King s College London School of Medicine, London, UK
    Eur J Radiol 71:406-14. 2009
    ..This review discusses the evidence for these and other clinical aspects of DXA scanning, including its role in the new WHO algorithm for treating patients on the basis of their individual fracture risk...
  72. doi request reprint An update on dual-energy x-ray absorptiometry
    Glen M Blake
    King s College London, Guy s Campus, London, United Kingdom
    Semin Nucl Med 40:62-73. 2010
    ..We also discuss the recently published clinical guidelines that incorporate the FRAX fracture risk assessment in decisions about patient treatment...
  73. doi request reprint Relationship of calcification of atherosclerotic plaque and arterial stiffness to bone mineral density and osteoprotegerin in postmenopausal women referred for osteoporosis screening
    Michelle L Frost
    Osteoporosis Screening and Research Unit, King s College London, Guy s Hospital, Great Maze Pond, London, SE1 9RT, UK
    Calcif Tissue Int 83:112-20. 2008
    ..01). These findings suggest that decreased BMD is associated with arterial calcification and stiffening and raise the possibility that OPG is a marker of arterial stiffening, independent of any association with BMD...
  74. pmc Quantitative trait loci for bone lengths on chromosome 5 using dual energy X-Ray absorptiometry imaging in the Twins UK cohort
    Usha Chinappen-Horsley
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital, London, United Kingdom
    PLoS ONE 3:e1752. 2008
    ..Replication and further fine mapping of this region is ongoing to determine potential genes influencing bone size and diseases affecting bone...
  75. doi request reprint Quantitative measurements of bone remodeling using 99mTc-methylene diphosphonate bone scans and blood sampling
    Amelia E B Moore
    School of Medicine, King s College London, London, United Kingdom
    J Nucl Med 49:375-82. 2008
    ..3 y) before participation in a clinical trial of an osteoporosis therapy. The aim was to compare the consistency and accuracy of the 3 methods before their use in evaluating the subjects' response to treatment...
  76. ncbi request reprint How important are BMD accuracy errors for the clinical interpretation of DXA scans?
    Glen M Blake
    King s College London School of Medicine, London, United Kingdom
    J Bone Miner Res 23:457-62. 2008
  77. pmc Strontium ranelate: a novel treatment for postmenopausal osteoporosis: a review of safety and efficacy
    Glen M Blake
    King s College London School of Medicine, London, UK
    Clin Interv Aging 1:367-75. 2006
    ....
  78. doi request reprint Long-term precision of 18F-fluoride PET skeletal kinetic studies in the assessment of bone metabolism
    Michelle L Frost
    King s College London, Osteoporosis Screening and Research Unit, Guy s Hospital, London, United Kingdom
    J Nucl Med 49:700-7. 2008
    ..The main PET parameter of interest, termed K(i), reflects regional bone metabolism. The aim of this study was to compare the long-term precision of (18)F-fluoride PET with that of biochemical markers of bone turnover assessed over 6 mo...
  79. pmc The role of DXA bone density scans in the diagnosis and treatment of osteoporosis
    Glen M Blake
    King s College London School of Medicine, London, UK
    Postgrad Med J 83:509-17. 2007
    ..This review discusses the evidence for these and other clinical aspects of DXA scanning, including its role in the new WHO algorithm for treating patients on the basis of their individual fracture risk...
  80. doi request reprint Clinical evaluation of a phalangeal bone mineral density assessment system
    Rajesh Patel
    Department of Biosurgery and Surgical Technology, Division of Surgery, Academic Bone Densitometry Unit, Imperial College London, London, UK
    J Clin Densitom 13:292-300. 2010
    ..AccuDEXA measurements could, therefore, provide an alternative method for identifying individuals with low bone mass, provided care is taken in interpreting T-scores, perhaps, through the use of device-specific thresholds...
  81. ncbi request reprint Theoretical model for the interpretation of BMD scans in patients stopping strontium ranelate treatment
    Glen M Blake
    King s College London School of Medicine, London, United Kingdom
    J Bone Miner Res 21:1417-24. 2006
    ..We used clinical trial data and a model of long-term strontium kinetics to estimate the effect of past strontium treatment on future BMD measurements...
  82. ncbi request reprint An evaluation of the United Kingdom National Osteoporosis Society position statement on the use of peripheral dual-energy X-ray absorptiometry
    Rajesh Patel
    Department of Nuclear Medicine, Guy s Hospital, London, UK
    Osteoporos Int 15:497-504. 2004
    ..We conclude that use of forearm BMD alone with a modified T-score threshold of -2.1 would save the need for spine and hip DXA scans and identify only slightly fewer fracture cases for treatment...
  83. ncbi request reprint A prospective study of risedronate on regional bone metabolism and blood flow at the lumbar spine measured by 18F-fluoride positron emission tomography
    Michelle L Frost
    Osteoporosis Screening and Research Unit, Guy s, King s and St Thomas School of Medicine, King s College, Guy s Hospital, London, United Kingdom
    J Bone Miner Res 18:2215-22. 2003
    ..The net plasma clearance of fluoride to bone mineral reflecting osteoblastic activity decreased significantly after therapy...
  84. ncbi request reprint An investigation of unique and shared gene effects on speed of sound and bone density using axial transmission quantitative ultrasound and DXA in twins
    Karen M Knapp
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, United Kingdom
    J Bone Miner Res 18:1525-30. 2003
    ..Genetic influences were found for all SOS and BMD measurements. A combination of shared and unique genetic influences was found to control BMD and SOS at the radius...
  85. ncbi request reprint Effects of dietary improvement on bone metabolism in elderly underweight women with osteoporosis: a randomised controlled trial
    Geeta Hampson
    Department of Chemical Pathology, 5th Floor, North Wing, St Thomas Hospital, SE1 7EH, London, UK
    Osteoporos Int 14:750-6. 2003
    ..05]. Serum osteocalcin increased at 12 months in group 2 ( P=0.01). Dietary improvement in elderly women with low BMI is associated with a reduction in bone resorption with a small but "net" positive effect on bone formation...
  86. ncbi request reprint Validation of ultrafiltration as a method of measuring free 99mTc-MDP
    Amelia E B Moore
    Department of Nuclear Medicine, Guy s Hospital, London, United Kingdom
    J Nucl Med 44:891-7. 2003
    ....
  87. ncbi request reprint Dual energy x-ray absorptiometry and its clinical applications
    Glen M Blake
    Department of Nuclear Medicine, Guy s, King s and St Thomas School of Medicine, St Thomas Street, London SE1 9RT, United Kingdom
    Semin Musculoskelet Radiol 6:207-18. 2002
    ..However, in general, the results from these devices cannot be interpreted using the WHO definition of osteoporosis, and until there is a consensus over establishing an equivalent threshold, their use is premature...
  88. ncbi request reprint Nuclear medicine studies in metabolic bone disease
    Sharon F Hain
    Department of Nuclear Medicine, Guy s and St Thomas NHS Trust, King s College, London, England, UK
    Semin Musculoskelet Radiol 6:323-29. 2002
    ..More recently, positron emission tomography (PET) scanning has been found to be helpful in the more difficult cases...
  89. ncbi request reprint Conventional measurements of GFR using 51Cr-EDTA overestimate true renal clearance by 10 percent
    Amelia E B Moore
    Department of Nuclear Medicine, Guy s Hospital, St Thomas Street, London, SE1 9RT, UK
    Eur J Nucl Med Mol Imaging 30:4-8. 2003
    ..As a result, conventional measurements of GFR using (51)Cr-EDTA overestimate the true renal clearance of tracer by approximately 10%...
  90. ncbi request reprint Bone densitometry, steroids and osteoporosis
    Glen M Blake
    Department of Nuclear Medicine, Guy s Hospital, London, UK
    Curr Opin Nephrol Hypertens 11:641-7. 2002
    ....
  91. ncbi request reprint Dissociation between global markers of bone formation and direct measurement of spinal bone formation in osteoporosis
    Michelle L Frost
    Osteoporosis Screening and Research Unit, Guy s, King s, and St Thomas School of Medicine, King s College, London, United Kingdom
    J Bone Miner Res 19:1797-804. 2004
    ..Lower values of regional bone formation activity at the lumbar spine were seen in osteoporotic women, whereas global markers of bone formation were significantly increased...
  92. ncbi request reprint Absolute fracture risk varies with bone densitometry technique used. A theoretical and in vivo study of fracture cases
    Glen M Blake
    Department of Nuclear Medicine, Guy s Hospital, St Thomas Street, London, UK
    J Clin Densitom 5:109-16. 2002
    ..It was concluded that equating estimates of absolute fracture risk for different types of scan should not be used as the basis of deriving equivalent T-scores for interpreting peripheral measurements...
  93. ncbi request reprint Validation of a blood-sampling method for the measurement of 99mTc-methylene diphosphonate skeletal plasma clearance
    Amelia E B Moore
    School of Medicine, King s College London, London, United Kingdom
    J Nucl Med 47:581-6. 2006
    ..The aim of this study was to validate the accuracy of the AUC method by comparing K(bone) values obtained by that method with those obtained by gamma-camera imaging...
  94. doi request reprint Quantitative studies of bone using (99m)Tc-methylene diphosphonate skeletal plasma clearance
    Glen M Blake
    King s College London School of Medicine, London, United Kingdom
    Semin Nucl Med 39:369-79. 2009
    ....
  95. ncbi request reprint Fracture prediction by bone density measurements at sites other than the fracture site: the contribution of BMD correlation
    Glen M Blake
    Guy s, King s and St Thomas School of Medicine, Guy s Campus, St Thomas Street, SE1 9RT, London, UK
    Calcif Tissue Int 76:249-55. 2005
    ..Overall, this study points to BMD correlation as an important factor in explaining the ability of measurements made at distant sites to predict fracture risk...
  96. pmc Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment
    Oliver D Howes
    The Institute of Psychiatry, London SE5 8AF, UK
    J Clin Psychopharmacol 25:259-61. 2005
    ..BMD was correlated with body mass index but there was no correlation with prolactin. BMD was not correlated with prolactin levels and showed no clinically significant reduction. The low BMD in black males warrants further investigation...
  97. ncbi request reprint Quantitative studies of bone in postmenopausal women using (18)F-fluoride and (99m)Tc-methylene diphosphonate
    Glen M Blake
    Department of Nuclear Medicine, Guy s Hospital, London, United Kingdom
    J Nucl Med 43:338-45. 2002
    ..In this study we evaluated their use to quantify bone turnover in women receiving antiresorptive therapy compared with that of untreated control subjects...
  98. ncbi request reprint Does the combination of two BMD measurements improve fracture discrimination?
    Glen M Blake
    Department of Nuclear Medicine, Guy s Hospital, London, United Kingdom
    J Bone Miner Res 18:1955-63. 2003
    ..This study used a bivariate gaussian model to examine the effect of combining two different BMD measurements. The results show that, in practice, there is little benefit unless the measurements are completely unrelated...
  99. ncbi request reprint Recent advances in imaging hepatocellular carcinoma: diagnosis, staging and response assessment: functional imaging
    S F Hain
    Department of Nuclear Medicine, Guy s and St Thomas Hospital and King s College, London, UK
    Cancer J 10:121-7. 2004
    ..131I is an important therapeutic tool. FDG-PET is useful in certain cases, especially for finding metastases and monitoring response to therapy...
  100. ncbi request reprint Development of a phantom for morphometric X-ray absorptiometry
    J A Rea
    Osteoporosis Screening and Research Unit, 16th Floor Guy's Tower, Guy's Hospital, St Thomas' Street, London SE1 9RT, UK
    Br J Radiol 74:341-50. 2001
    ..The MXA phantom appears to be a useful tool for documenting the stability of the mechanical instruments and for checking the long-term consistency of operator precision...
  101. ncbi request reprint Detection of an elusive osteoid osteoma using a registration bone scan
    Y Wilson
    Peripheral Nerve Injury and Hand Unit, Royal National Orthopaedic Hospital, London, UK
    J Hand Surg Br 22:801-4. 1997
    ..The lesion was removed with complete relief of pain...