Sheila A Fisher

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Meta-analysis of genome scans of age-related macular degeneration
    Sheila A Fisher
    Department of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, London SE1 9RT, UK
    Hum Mol Genet 14:2257-64. 2005
  2. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
  3. pmc Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease
    Natalie J Prescott
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Hum Mol Genet 19:1828-39. 2010
  4. pmc Power of genetic association studies in the presence of linkage disequilibrium and allelic heterogeneity
    Sheila A Fisher
    Division of Genetics and Molecular Medicine, Institute of Psychiatry, King s College London, London, UK
    Hum Hered 66:210-22. 2008
  5. pmc Meta-analysis of genome-wide linkage studies across autoimmune diseases
    Paola Forabosco
    King s College London School of Medicine, Department of Medical and Molecular Genetics, London, UK
    Eur J Hum Genet 17:236-43. 2009
  6. ncbi request reprint Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD)
    Sheila A Fisher
    Department of Medical and Molecular Genetics, Guy s King s and St Thomas School of Medicine, King s College London, London, United Kingdom
    Hum Mutat 28:406-13. 2007
  7. ncbi request reprint Data acquisition for meta-analysis of genome-wide linkage studies using the genome search meta-analysis method
    Paola Forabosco
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    Hum Hered 64:74-81. 2007
  8. pmc Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease
    Muddassar M Mirza
    Division of Medical and Molecular Genetics, Guy s, King s, and Thomas s School of Medicine, King s College London, Guy s Hospital, London, United Kingdom
    Am J Hum Genet 72:1018-22. 2003
  9. ncbi request reprint Identification, evolution, and association study of a novel promoter and first exon of the human NOD2 (CARD15) gene
    Kathy King
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Genomics 90:493-501. 2007
  10. ncbi request reprint Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population
    Alexandra V Pearce
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Int J Colorectal Dis 22:419-24. 2007

Detail Information

Publications36

  1. ncbi request reprint Meta-analysis of genome scans of age-related macular degeneration
    Sheila A Fisher
    Department of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, London SE1 9RT, UK
    Hum Mol Genet 14:2257-64. 2005
    ..Several of the regions identified here showed only weak evidence for linkage in the individual studies. These results will help prioritize regions for future positional and functional candidate gene studies in AMD...
  2. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  3. pmc Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease
    Natalie J Prescott
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Hum Mol Genet 19:1828-39. 2010
    ....
  4. pmc Power of genetic association studies in the presence of linkage disequilibrium and allelic heterogeneity
    Sheila A Fisher
    Division of Genetics and Molecular Medicine, Institute of Psychiatry, King s College London, London, UK
    Hum Hered 66:210-22. 2008
    ....
  5. pmc Meta-analysis of genome-wide linkage studies across autoimmune diseases
    Paola Forabosco
    King s College London School of Medicine, Department of Medical and Molecular Genetics, London, UK
    Eur J Hum Genet 17:236-43. 2009
    ..This study illustrates the concept that linkage and association studies have power to identify very different types of disease-predisposing variants...
  6. ncbi request reprint Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD)
    Sheila A Fisher
    Department of Medical and Molecular Genetics, Guy s King s and St Thomas School of Medicine, King s College London, London, United Kingdom
    Hum Mutat 28:406-13. 2007
    ..0026...
  7. ncbi request reprint Data acquisition for meta-analysis of genome-wide linkage studies using the genome search meta-analysis method
    Paola Forabosco
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    Hum Hered 64:74-81. 2007
    ..Ranks are then summed across studies, with high summed ranks potentially showing evidence for linkage in the meta-analysis...
  8. pmc Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease
    Muddassar M Mirza
    Division of Medical and Molecular Genetics, Guy s, King s, and Thomas s School of Medicine, King s College London, Guy s Hospital, London, United Kingdom
    Am J Hum Genet 72:1018-22. 2003
    ..0019). These findings suggest that genetic variants at the 5q31 (IBD5) locus may hasten the onset of Crohn disease and cooperate with CARD15 in disease causation...
  9. ncbi request reprint Identification, evolution, and association study of a novel promoter and first exon of the human NOD2 (CARD15) gene
    Kathy King
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Genomics 90:493-501. 2007
    ..We show that there is no significant association between variants in the novel NOD2 promoter region and CD...
  10. ncbi request reprint Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population
    Alexandra V Pearce
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Int J Colorectal Dis 22:419-24. 2007
    ....
  11. ncbi request reprint Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6
    Sheila A Fisher
    Division of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, UK
    Eur J Hum Genet 10:259-65. 2002
    ..The existence of sex-specific linkage is further evidence of the complex mechanisms involved in IBD and will facilitate future studies to identify susceptibility genes...
  12. ncbi request reprint A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
    Natalie J Prescott
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Gastroenterology 132:1665-71. 2007
    ..We investigated this association in independent U.K. cohorts of Crohn's disease and ulcerative colitis...
  13. ncbi request reprint Mutation, selection, and evolution of the Crohn disease susceptibility gene CARD15
    Kathy King
    Department of Medical and Molecular Genetics, Guy s, King s and St Thomas School of Medicine, King s College London, London, United Kingdom
    Hum Mutat 27:44-54. 2006
    ..The strategy developed here may have general application to the assessment of mutation pathogenicity and genetic models in other complex disorders...
  14. pmc Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome
    Akio Tanaka
    St John s Institute of Dermatology, King s College London, Guy s Campus, London, UK
    Am J Hum Genet 90:511-7. 2012
    ..Collectively, the clinicopathological and molecular findings point to a cancer syndrome and provide evidence implicating a germline mutation in ATR and susceptibility to malignancy in humans...
  15. ncbi request reprint Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method
    Jane Hermanowski
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    Eur J Hum Genet 15:703-10. 2007
    ..These regions may provide targets to focus candidate gene studies or to prioritise results from genome-wide association studies...
  16. pmc Assessment of the contribution of CFH and chromosome 10q26 AMD susceptibility loci in a Russian population isolate
    Sheila A Fisher
    Department of Medical and Molecular Genetics, Guy s King s and St Thomas School of Medicine, King s College, London, UK
    Br J Ophthalmol 91:576-8. 2007
    ..The contribution of both loci to AMD was investigated in an isolated north-west Russian population...
  17. ncbi request reprint Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study
    Clive M Onnie
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, UK
    Inflamm Bowel Dis 12:263-71. 2006
    ....
  18. ncbi request reprint Association of DLG5 R30Q variant with inflammatory bowel disease
    Mark J Daly
    The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
    Eur J Hum Genet 13:835-9. 2005
    ..This study provides support for the hypothesis that DLG5 constitutes a true IBD risk factor of modest effect...
  19. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  20. pmc IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease
    Mark Tremelling
    IBD Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge, England, UK
    Gastroenterology 132:1657-64. 2007
    ..We tested for association between IL23R and IBD in a large independent UK panel to determine the size of the effect and explore subphenotype correlation and interaction with CARD15...
  21. pmc Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Jeffrey C Barrett
    Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 40:955-62. 2008
    ..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...
  22. ncbi request reprint Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
    David A van Heel
    Department of Gastoenterology, Imperial College London, UK
    Hum Mol Genet 13:763-70. 2004
    ..Clustering of adjacent bins was observed for chromosomes 6p, 16, 19p. The meta-analysis has identified novel loci and prioritized genomic regions for further gene identification studies...
  23. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  24. doi request reprint Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA
    Lars G Fritsche
    Institute of Human Genetics, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Nat Genet 40:892-6. 2008
    ..Our data suggest that ARMS2 has a key role in AMD, possibly through mitochondria-related pathways...
  25. ncbi request reprint Genetic variation in myosin IXB is associated with ulcerative colitis
    Adriaan A van Bodegraven
    Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
    Gastroenterology 131:1768-74. 2006
    ..These findings suggested the current study investigating a possible further role for MYO9B variation in inflammatory bowel disease...
  26. ncbi request reprint The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families
    Emma M Ogilvie
    University College London, London, UK
    Arthritis Rheum 48:3202-6. 2003
    ..The present study was undertaken to confirm the previous findings and to assess possible association with variations of the A(n)T(n) tract in the promoter...
  27. ncbi request reprint Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer
    Jane M McGregor
    Department of Photobiology, St Johns Institute of Dermatology, Guy s, Kings and St Thomas School of Medicine, St Thomas Hospital, London, U K
    J Invest Dermatol 119:84-90. 2002
    ..016), irrespective of the mutant status of the concomitant allele. Together these data infer functional differences between polymorphic forms of p53 that are likely to be relevant to skin carcinogenesis...
  28. ncbi request reprint Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
    Liisa Koivukoski
    Department of Endocrinology, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Hum Mol Genet 13:2325-32. 2004
    ..We conclude that modest or non-significant linkage on chromosomes 3p14.1-q12.3 and 2p12-q22.1 in each individual study translates into genome-wide significant or highly suggestive linkages to HT and DBP in our GSMA analysis...
  29. ncbi request reprint Diverse effects of the CARD15 and IBD5 loci on clinical phenotype in 630 patients with Crohn's disease
    Clive M Onnie
    Division of Genetics and Molecular Medicine, King s College London School of Medicine, Guy s Hospital, London, UK
    Eur J Gastroenterol Hepatol 20:37-45. 2008
    ..We studied 630 well-characterized patients to clarify the genotype/phenotype relationship in CD...
  30. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  31. ncbi request reprint Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: evidence for an early onset/disease severity effect
    Sophia Steer
    Guy s, King s and St Thomas School of Medicine, London, UK
    Arthritis Rheum 52:358-60. 2005
  32. pmc Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    Miles Parkes
    Inflammatory Bowel Disease Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Genet 39:830-2. 2007
    ..We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13...
  33. ncbi request reprint Combined evidence from three large British Association studies rejects TUCAN/CARD8 as an IBD susceptibility gene
    Sheila A Fisher
    Gastroenterology 132:2078-80. 2007
  34. ncbi request reprint Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk
    Andrea Rivera
    Institute of Human Genetics, University of Regensburg, Germany
    Hum Mol Genet 14:3227-36. 2005
    ..Our data show a disease odds ratio of 57.6 (95% CI: 37.2, 89.0) conferred by homozygosity for risk alleles at both CFH and LOC387715 when compared with the baseline non-risk genotype...
  35. ncbi request reprint Direct or indirect association in a complex disease: the role of SLC22A4 and SLC22A5 functional variants in Crohn disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    Hum Mutat 27:778-85. 2006
    ....
  36. ncbi request reprint The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    Andrew P Cuthbert
    Division of Medical and Molecular Genetics, Guy s, King s, and St Thomas School of Medicine, London, England, United Kingdom
    Gastroenterology 122:867-74. 2002
    ....