S E File

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint A review of 25 years of the social interaction test
    Sandra E File
    Psychopharmacology Research Unit, Centre for Neuroscience, King s College London, Guy s Campus, UK
    Eur J Pharmacol 463:35-53. 2003
  2. ncbi request reprint Mood differences between male and female light smokers and nonsmokers
    Sandra E File
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, GKT School of Biomedical Sciences, King s College London, Guy s Campus, UK
    Pharmacol Biochem Behav 72:681-9. 2002
  3. ncbi request reprint Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Guy s Campus, SE1 1UL, London, UK
    Brain Res 888:311-313. 2001
  4. ncbi request reprint NKP608, an NK1 receptor antagonist, has an anxiolytic action in the social interaction test in rats
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, UK
    Psychopharmacology (Berl) 152:105-9. 2000
  5. ncbi request reprint Neurobiological mechanisms by which nicotine mediates different types of anxiety
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College, London, UK
    Eur J Pharmacol 393:231-6. 2000
  6. ncbi request reprint Nicotine has calming effects on stress-induced mood changes in females, but enhances aggressive mood in males
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, UK
    Int J Neuropsychopharmacol 4:371-6. 2001
  7. ncbi request reprint Beneficial effects of glycine (bioglycin) on memory and attention in young and middle-aged adults
    S E File
    Psychopharmacology Research Unit, United Medical and Dental Schools of Guy s and St Thomas Hospitals, Guy s Hospital, London, United Kingdom
    J Clin Psychopharmacol 19:506-12. 1999
  8. ncbi request reprint Factors controlling measures of anxiety and responses to novelty in the mouse
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Behav Brain Res 125:151-7. 2001
  9. ncbi request reprint Eating soya improves human memory
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London SE1 1UL, UK
    Psychopharmacology (Berl) 157:430-6. 2001
  10. ncbi request reprint Trough oestradiol levels associated with cognitive impairment in post-menopausal women after 10 years of oestradiol implants
    Sandra E File
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London SE1 1UL, UK
    Psychopharmacology (Berl) 161:107-12. 2002

Collaborators

Detail Information

Publications65

  1. ncbi request reprint A review of 25 years of the social interaction test
    Sandra E File
    Psychopharmacology Research Unit, Centre for Neuroscience, King s College London, Guy s Campus, UK
    Eur J Pharmacol 463:35-53. 2003
    ..The use of this test has, thus, played a crucial role in unravelling the neural basis of anxiety. It is hoped that in the next 25 years, the test will play a crucial role in determining the genetic basis of anxiety disorders...
  2. ncbi request reprint Mood differences between male and female light smokers and nonsmokers
    Sandra E File
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, GKT School of Biomedical Sciences, King s College London, Guy s Campus, UK
    Pharmacol Biochem Behav 72:681-9. 2002
    ..It is unlikely that either nicotine withdrawal or differences in cognitive performance could account for the greater anxiety, discontent and aggressive mood that was found in smokers...
  3. ncbi request reprint Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Guy s Campus, SE1 1UL, London, UK
    Brain Res 888:311-313. 2001
    ....
  4. ncbi request reprint NKP608, an NK1 receptor antagonist, has an anxiolytic action in the social interaction test in rats
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, UK
    Psychopharmacology (Berl) 152:105-9. 2000
    ..Evidence is starting to accumulate that NK1 receptor antagonists might have anxiolytic effects in animal tests and in patients...
  5. ncbi request reprint Neurobiological mechanisms by which nicotine mediates different types of anxiety
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College, London, UK
    Eur J Pharmacol 393:231-6. 2000
    ..On trial 2 in the elevated plus-maze (a model of specific phobia), nicotine (1 microg) has anxiolytic effects when administered to the dorsal hippocampus, but is ineffective (4 and 8 microg) in the lateral septum...
  6. ncbi request reprint Nicotine has calming effects on stress-induced mood changes in females, but enhances aggressive mood in males
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, UK
    Int J Neuropsychopharmacol 4:371-6. 2001
    ....
  7. ncbi request reprint Beneficial effects of glycine (bioglycin) on memory and attention in young and middle-aged adults
    S E File
    Psychopharmacology Research Unit, United Medical and Dental Schools of Guy s and St Thomas Hospitals, Guy s Hospital, London, United Kingdom
    J Clin Psychopharmacol 19:506-12. 1999
    ..It may also benefit the impaired retrieval shown in patients with schizophrenia, Parkinson's disease, and Huntington's disease...
  8. ncbi request reprint Factors controlling measures of anxiety and responses to novelty in the mouse
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Behav Brain Res 125:151-7. 2001
    ..It is important to control for possible changes in social investigation, neophobia, olfactory sensitivity, anxiety and exploration, before it is concluded that a changed performance in this task is due to changes in learning...
  9. ncbi request reprint Eating soya improves human memory
    S E File
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London SE1 1UL, UK
    Psychopharmacology (Berl) 157:430-6. 2001
    ..Soya foods are rich in isoflavone phytoestrogens with weak agonist activity at oestrogen receptors. Oestrogen treatment has been found to improve memory in men awaiting gender reassignment and in post-menopausal women...
  10. ncbi request reprint Trough oestradiol levels associated with cognitive impairment in post-menopausal women after 10 years of oestradiol implants
    Sandra E File
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London SE1 1UL, UK
    Psychopharmacology (Berl) 161:107-12. 2002
    ..There is some evidence that with long-term treatment the benefits decline, or reverse...
  11. ncbi request reprint Endogenous acetylcholine in the dorsal hippocampus reduces anxiety through actions on nicotinic and muscarinic1 receptors
    S E File
    United Medical and Dental Schools of Guy s and St Thomas Hospitals, Division of Pharmacology, London, United Kingdom
    Behav Neurosci 112:352-9. 1998
    ....
  12. ncbi request reprint Tolerance to midazolam's anxiolytic effects after short-term nicotine treatment
    E E Irvine
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, London SE1 1UL, UK
    Neuropharmacology 40:710-6. 2001
    ....
  13. ncbi request reprint The dorsal raphé nucleus is a crucial structure mediating nicotine's anxiolytic effects and the development of tolerance and withdrawal responses
    S Cheeta
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, London SE1 UL, UK
    Psychopharmacology (Berl) 155:78-85. 2001
    ....
  14. ncbi request reprint Do different mechanisms underlie two anxiogenic effects of systemic nicotine?
    S Tucci
    Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, UK
    Behav Pharmacol 14:323-9. 2003
    ..Thus, both alpha7 and alpha4beta2 nAChRs might have a role in mediating the anxiogenic effects of nicotine...
  15. ncbi request reprint Development of tolerance to nicotine's anxiogenic effect in the social interaction test
    E E Irvine
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, SE1 1UL, London, UK
    Brain Res 894:95-100. 2001
    ..This suggests that tolerance to the anxiogenic effect of nicotine administered into the dorsal hippocampus could be mediated by a reduction in the nicotine enhancement of 5-HT release in this area...
  16. ncbi request reprint Tolerance to nicotine's effects in the elevated plus-maze and increased anxiety during withdrawal
    E E Irvine
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, SE1 1UL, London, UK
    Pharmacol Biochem Behav 68:319-25. 2001
    ..A low dose of nicotine (5 ng) injected into the dorsal hippocampus was without effect in vehicle pretreated rats, but it was able to reverse the anxiogenic effect found after 24 h of withdrawal from 6 days of nicotine treatment...
  17. ncbi request reprint In adolescence, female rats are more sensitive to the anxiolytic effect of nicotine than are male rats
    S Cheeta
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, SE1 1UL, London, UK
    Neuropsychopharmacology 25:601-7. 2001
    ..This sex difference in sensitivity to nicotine's anxiolytic effects suggests there may be sex differences in the factors initiating and maintaining teenage smoking...
  18. ncbi request reprint Antagonism of the anxiolytic effect of nicotine in the dorsal raphe nucleus by dihydro-beta-erythroidine
    S Cheeta
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, London SE1 1UL, UK
    Pharmacol Biochem Behav 70:491-6. 2001
    ..Because of the pharmacological profile of DH beta E, our results suggest that the anxiolytic effect of nicotine in the DRN is mediated by the alpha 4 beta 2 nicotinic receptor subtype...
  19. ncbi request reprint Time-course of changes in the social interaction test of anxiety following acute and chronic administration of nicotine
    E E Irvine
    Neuroscience Research Centre, GKT School of Biomedical Sciences, King s College London, UK
    Behav Pharmacol 10:691-7. 1999
    ..Thus, an oppositional mechanism may underlie tolerance to the anxiolytic effects, whereas there is as yet no evidence for this type of mechanism mediating tolerance to the anxiogenic effects...
  20. ncbi request reprint Bimodal modulation by nicotine of anxiety in the social interaction test: role of the dorsal hippocampus
    S E File
    Neuroscience Research Centre, GKT School of Biomedical Sciences, King s College London, Guy s Campus, United Kingdom
    Behav Neurosci 112:1423-9. 1998
    ..Our results show that the dorsal hippocampus is one area that can mediate anxiogenic effects in the social interaction test, but the brain region mediating anxiolytic effects remains to be identified...
  21. ncbi request reprint Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test
    S E File
    Psychopharmacology Research Unit, UMDS, Guy s Hospital, London, United Kingdom
    Pharmacol Biochem Behav 58:747-52. 1997
    ..These results suggest that the compound may prove to be a useful anxiolytic and that substance P may play a role in mediating states of anxiety...
  22. ncbi request reprint Stimulation of nicotinic receptors in the lateral septal nucleus increases anxiety
    A M Ouagazzal
    Psychopharmacology Research Unit, Neuroscience Research Centre, GKT School of Biomedical Science, King s College London, Hodgkin Building, Guy s Campus, London SE1 9RT, UK
    Eur J Neurosci 11:3957-62. 1999
    ..These findings provide further evidence for the role of the lateral septum in the modulation of anxiety and suggest that cholinergic projections to this brain area facilitate anxiety through nicotinic receptors...
  23. ncbi request reprint Anxiolytic actions of the substance P (NK1) receptor antagonist L-760735 and the 5-HT1A agonist 8-OH-DPAT in the social interaction test in gerbils
    S Cheeta
    Psychopharmacology Research Unit, Centre for Neuroscience, King's College London, SE1 1UL, London, UK
    Brain Res 915:170-5. 2001
    ....
  24. ncbi request reprint Different treatment regimens and the development of tolerance to nicotine's anxiogenic effects
    E E Irvine
    Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, UK
    Pharmacol Biochem Behav 68:769-76. 2001
    ..There was no evidence that the treatment regimen affected the rate of development of tolerance, despite very different peak plasma nicotine concentrations...
  25. ncbi request reprint Methyllycaconitine (MLA) blocks the nicotine evoked anxiogenic effect and 5-HT release in the dorsal hippocampus: possible role of alpha7 receptors
    S A Tucci
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Neuropharmacology 44:367-73. 2003
    ..Thus the anxiolytic and anxiogenic effects of nicotine can be distinguished both by brain region and by nicotinic receptor subtype...
  26. pmc Social isolation modifies nicotine's effects in animal tests of anxiety
    S Cheeta
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, London, SE1 1UL
    Br J Pharmacol 132:1389-95. 2001
    ..7. These results provide further evidence that the two animal tests model distinct states of anxiety, and show how social isolation powerfully modifies both anxiolytic and anxiogenic effects of nicotine...
  27. ncbi request reprint Anxiolytic effects in the plus-maze of 5-HT1A-receptor ligands in dorsal raphé and ventral hippocampus
    S E File
    Psychopharmacology Research Unit, UMDS Division of Pharmacology, Guy s Hospital, London, UK
    Pharmacol Biochem Behav 54:123-8. 1996
    ..These results demonstrate that both the intracerebral location of the injection and test experience profoundly influence the effects of 5-HT1A ligands on behaviour of rats in the elevated plus-maze test of anxiety...
  28. ncbi request reprint Gincosan (a combination of Ginkgo biloba and Panax ginseng): the effects on mood and cognition of 6 and 12 weeks' treatment in post-menopausal women
    D E Hartley
    Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London, SE1 1UL, UK
    Nutr Neurosci 7:325-33. 2004
    ..Thus, after chronic administration, Gincosan appeared to have no beneficial effects in post-menopausal women...
  29. ncbi request reprint Are lorazepam-induced deficits in attention similar to those resulting from aging?
    E Fluck
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, England
    J Clin Psychopharmacol 21:126-30. 2001
    ..In the PASAT, both the lorazepam (2.5 mg) group and the middle-aged women were more impaired than the middle-aged men. These results raise the important possibility of gender differences in age-related decline of attentional processes...
  30. pmc A comparison of rat brain amino acid and monoamine content in diazepam withdrawal and after exposure to a phobic stimulus
    N Andrews
    Psychopharmacology Research Unit, Guy s Hospital, London
    Br J Pharmacol 109:171-4. 1993
    ..It is hoped comparative studies such as this will enable better understanding of anxiety states in the rat which could parallel the different classes of anxiety recognised in the clinic..
  31. ncbi request reprint Evidence against oppositional and pharmacokinetic mechanisms of tolerance to diazepam's sedative effects
    C Fernandes
    UMDS Division of Pharmacology, Guy s Hospital, London, UK
    Brain Res 734:236-42. 1996
    ..Thus, the mechanism underlying this behavioural tolerance was not oppositional in nature. It is suggested that a situation-independent learned behavioural strategy is the most likely mechanism for the observed tolerance...
  32. ncbi request reprint Striking changes in anxiety in Huntington's disease transgenic mice
    S E File
    Department of Psychopharmacology, UMDS, Guy s Hospital, London SE1 9RT, UK
    Brain Res 805:234-40. 1998
    ..The results indicated that some of the reduced anxiety could be attributed to the presence of an endogenous anxiolytic ligand...
  33. ncbi request reprint Anxiety conditioned to nicotine in the elevated plus-maze is time dependent
    S Tucci
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Behav Pharmacol 13:615-20. 2002
    ..The importance of the timing of the nicotine-associated cues was demonstrated by the failure to obtain conditioned anxiogenic effects when rats were exposed to the plus-maze on day 1, 30 min after nicotine (0.45 or 0.1 mg/kg)...
  34. ncbi request reprint Effects of nicotine and a cannabinoid receptor agonist on negative contrast: distinction between anxiety and disappointment?
    Rachel F Genn
    Psychopharmacology Research Unit, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London, SE1 1UL, UK
    Psychopharmacology (Berl) 177:93-9. 2004
    ..Both nicotine and a cannabinoid receptor agonist have been reported to change anxiety and both have actions on the reward process, but their effects on SNC have not been investigated...
  35. ncbi request reprint Nicotine regulates 5-HT(1A) receptor gene expression in the cerebral cortex and dorsal hippocampus
    P J Kenny
    Psychopharmacology Research Unit, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, London SE1 1UL, UK
    Eur J Neurosci 13:1267-71. 2001
    ..The rapid regulation of expression of 5-HT(1A) receptor mRNA leads to the hypothesis that nicotine-induced 5-HT release may alter the postsynaptic sensitivity to 5-HT...
  36. ncbi request reprint Oestrogen receptor-beta and neurohypophysial hormones: functional interaction and neuroanatomical localisation
    M L Forsling
    Neuroendocrine and Psychopharmacology Research Laboratories, Centre for Neuroscience, King s College London, Guy s Campus, London SE1 1UL, UK
    Pharmacol Biochem Behav 76:535-42. 2003
    ....
  37. pmc A rat model of spontaneous myopathy and malignant hyperthermia
    L E Gonzalez
    Psychopharmacology Research Unit, United Medical and Dental Schools, Guy s Hospital, London, United Kingdom
    Am J Pathol 152:1099-103. 1998
    ..The association of histological abnormalities with an acute, fatal syndrome clinically resembling malignant hyperthermia provides a strong basis for a new and extremely useful animal model to study this fatal disorder...
  38. ncbi request reprint Mice lacking the cell adhesion molecule Thy-1 fail to use socially transmitted cues to direct their choice of food
    V Mayeux-Portas
    Molecular Neurobiology Group, Laboratoire Physiopathologie Neuromusculaire, GKT Medical School, EPI 99 30, Institut de Biologie, London, Montpellier, SE1 1UL, 34060, UK, France
    Curr Biol 10:68-75. 2000
    ..Analysis of Thy-1 null mice has shown the presence of excessive GABAergic inhibition of neurotransmission in the dentate gyrus of the hippocampal formation selectively, without any neurological or behavioural effects being apparent...
  39. ncbi request reprint Differential cognitive effects of Ginkgo biloba after acute and chronic treatment in healthy young volunteers
    Sarah Elsabagh
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London, SE1 1UL, UK
    Psychopharmacology (Berl) 179:437-46. 2005
    ..In addition, only one study has investigated the effects of chronic treatment in young volunteers...
  40. ncbi request reprint The cognitive-enhancing properties of modafinil are limited in non-sleep-deprived middle-aged volunteers
    Delia C Randall
    Psychopharmacology Research Unit, Centre for Neuroscience Research, King s College London, London, UK
    Pharmacol Biochem Behav 77:547-55. 2004
    ..Thus, this study found limited evidence of cognitive-enhancing properties of modafinil in healthy middle-aged volunteers...
  41. ncbi request reprint Cognitive function in late versus early postmenopausal stage
    Sarah Elsabagh
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London SE1 1UL, UK
    Maturitas 56:84-93. 2007
    ..The aim of the present analysis was to determine the nature of cognitive decline across a range of functions within a period of 5 years from early to late postmenopausal stage...
  42. ncbi request reprint Binge drinking and sex: effects on mood and cognitive function in healthy young volunteers
    David E Hartley
    Psychopharmacology Research Unit, Centre for Neuroscience, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Pharmacol Biochem Behav 78:611-9. 2004
    ..Thus, compared with a group of teetotallers, the binge drinkers had lower trait anxiety and depression and poorer performance in tests of sustained attention, episodic memory and planning ability...
  43. ncbi request reprint Mood changes after cognitive testing in late middle-age: impacts of sex and habitual alcohol consumption
    Sarah Elsabagh
    Psychopharmacology Research Unit, Centre for Neuroscience, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Pharmacol Biochem Behav 78:621-8. 2004
    ..Thus, the middle-aged women responded much more than did the men with negative mood changes to the psychological stress of cognitive testing, although their cognitive performance was not worse...
  44. ncbi request reprint Does drinking have effects on mood and cognition in male and female students?
    Delia C Randall
    Psychopharmacology Research Unit, Centre for Neuroscience, King s College London, UK
    Pharmacol Biochem Behav 78:629-38. 2004
    ..In conclusion, there was no evidence that the group drinking moderate levels of alcohol had any cognitive impairment and the teetotal group responded to the cognitive tests with the greatest increases in negative mood...
  45. ncbi request reprint Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndrome
    Delia C Randall
    Psychopharmacology Research Unit, Centre for Neuroscience Research, King s College London, London, UK
    J Psychopharmacol 19:647-60. 2005
    ..It is discussed whether the limited and mixed cognitive effects that we observed could have occurred by chance, or whether a subgroup of CFS patients with daytime sleepiness would have shown greater benefits...
  46. ncbi request reprint Limited cognitive benefits in Stage +2 postmenopausal women after 6 weeks of treatment with Ginkgo biloba
    Sarah Elsabagh
    Psychopharmacology Research Unit, Centre for Neuroscience, King s College London, London and Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK
    J Psychopharmacol 19:173-81. 2005
    ..The beneficial effects of ginkgo were limited to the test of mental flexibility and to those with poorer performance...
  47. ncbi request reprint Cognitive improvement after 6 weeks of soy supplements in postmenopausal women is limited to frontal lobe function
    Sandra E File
    Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London, UK
    Menopause 12:193-201. 2005
    ..To assess the effects of 6 weeks of treatment with soy supplements on mood, menopausal symptoms, and cognition in postmenopausal women not taking other forms of hormone therapy...
  48. ncbi request reprint Does modafinil enhance cognitive performance in young volunteers who are not sleep-deprived?
    Delia C Randall
    Psychopharmacology Research Unit, Centre for Neuroscience Research, King s College London, London, UK
    J Clin Psychopharmacol 25:175-9. 2005
    ....
  49. ncbi request reprint Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones
    Rosanna Duffy
    Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, Franklin Wilkins Building, King s College London, London SE1 9NN, UK
    Pharmacol Biochem Behav 75:721-9. 2003
    ..Thus, significant cognitive improvements in postmenopausal women can be gained from 12 weeks of consumption of a supplement containing soya isoflavones that are independent of any changes in menopausal symptoms, mood or sleepiness...
  50. ncbi request reprint Cognitive effects of 10 years of hormone-replacement therapy with tibolone
    Emma Fluck
    Psychopharmacology Research Unit, Centre for Neuroscience, King s College, London, United Kingdom
    J Clin Psychopharmacol 22:62-7. 2002
    ..Our results suggest that the effects of HRT on cognition may be influenced by the type of HRT, the duration of treatment, the nature of the tests, and the brain region controlling the cognitive function...
  51. ncbi request reprint Conditioned anxiety to nicotine
    Sandra E File
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Psychopharmacology (Berl) 164:309-17. 2002
    ..Despite its reinforcing properties nicotine has also been reported to produce anxiety in humans and anxiogenic effects in animal tests of anxiety...
  52. ncbi request reprint Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats
    Sandra E File
    Psychopharmacology Research Unit and Biochemical Neuropharmacology Group, Centre for Neuroscience Research, King s College London, Hodgkin Building, Guy s Campus, SE1 1UL, London, UK
    Neurosci Lett 338:135-8. 2003
    ..No changes in glutamic acid decarboxylase-67 or glial fibrillary acidic protein mRNA were found. This suggests a role for oestrogen-beta receptors in regulating BDNF mRNA expression...
  53. ncbi request reprint The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat
    David E Hartley
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, Kings College London, Guy s Campus, SE1 1UL, London, UK
    Psychopharmacology (Berl) 167:46-53. 2003
    ..It is therefore possible that the soya content of diet could have significant effects on brain and behaviour and be an important source of between-laboratory variability...
  54. ncbi request reprint Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety
    Sonia Tucci
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, UK
    Psychopharmacology (Berl) 167:251-6. 2003
    ..Conditioned anxiety has also been observed 24 h after testing in the SI with a high dose of nicotine...
  55. ncbi request reprint Modafinil affects mood, but not cognitive function, in healthy young volunteers
    Delia C Randall
    Psychopharmacology Research Unit, Centre for Neuroscience Research, King s College London, London, UK
    Hum Psychopharmacol 18:163-73. 2003
    ..Further changes in mood were revealed after the stress of cognitive testing, with the 100 mg group showing greater increases in the 'psychological anxiety' and the 'aggressive mood' factors (as measured from the Bond and Lader scales)...
  56. ncbi request reprint Effects on cognition and mood in postmenopausal women of 1-week treatment with Ginkgo biloba
    David E Hartley
    Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, King s College London, Guy s Campus, London SE1 1UL, UK
    Pharmacol Biochem Behav 75:711-20. 2003
    ..The benefits of Ginkgo on memory and frontal lobe function found in this study are modest but are unlikely to be secondary to major mood changes...
  57. doi request reprint Animal tests of anxiety
    Sandra E File
    King s College London, London, United Kingdom
    Curr Protoc Neurosci . 2004
    ..The protocols are described in terms of drug screening tests, but can be modified easily for other purposes...
  58. ncbi request reprint Age-associated sex differences in response to food deprivation in two animal tests of anxiety
    Rachel F Genn
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London SE1 1 UL, UK
    Neurosci Biobehav Rev 27:155-61. 2003
    ..In both tests there were age-associated differences in the female rats, with the adolescent females being less anxious (higher percentage of open arm entries and increased social interaction) than the adults...
  59. ncbi request reprint Dietary restriction and nicotine can reduce anxiety in female rats
    Rachel F Genn
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, London, UK
    Neuropsychopharmacology 28:1257-63. 2003
    ..Circulating female hormones reduce this effect, but in adult females the combination of dietary restriction and nicotine may have important anxiolytic effects that impact on the initiation of regular smoking...
  60. ncbi request reprint Involvement of 5-HT1A receptors in animal tests of anxiety and depression: evidence from genetic models
    David H Overstreet
    Bowles Center for Alcoholic Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Stress 6:101-10. 2003
    ..Further study with additional tests of anxiety are needed to confirm this intriguing relationship...
  61. ncbi request reprint Unconditioned and conditioned anxiogenic effects of the cannabinoid receptor agonist CP 55,940 in the social interaction test
    Rachel F Genn
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Pharmacol Biochem Behav 77:567-73. 2004
    ..We provide the first evidence for unconditioned and conditioned anxiogenic-like responses to a cannabinoid agonist in the social interaction test...
  62. ncbi request reprint Cognitive effects of modafinil in student volunteers may depend on IQ
    Delia C Randall
    Psychopharmacology Research Unit, Centre for Neuroscience Research, King s College London, London, UK
    Pharmacol Biochem Behav 82:133-9. 2005
    ..Furthermore, the results indicate that high IQ may limit detection of modafinil's positive effects...
  63. ncbi request reprint Nicotinic--serotonergic interactions in brain and behaviour
    Pallab Seth
    Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, SE1 1UL, London, UK
    Pharmacol Biochem Behav 71:795-805. 2002
    ..There is also evidence for nicotinic--serotonergic interactions in the acquisition of the water maze, passive avoidance, and impulsivity in the five-choice serial reaction task...
  64. ncbi request reprint Nicotine and cannabinoids: parallels, contrasts and interactions
    Maria Paz Viveros
    Departamento de Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense, Ciudad Universitaria, c Jose Antonio Novais 2, 28040, Madrid, Spain
    Neurosci Biobehav Rev 30:1161-81. 2006
    ..The two drugs also have opposite effects on cognition and the possibility of long-lasting cognitive impairments resulting from adolescent consumption of cannabis is of particular concern...
  65. ncbi request reprint Endocannabinoid system and stress and anxiety responses
    M P Viveros
    Departmento de Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense, 28040 Madrid, Spain
    Pharmacol Biochem Behav 81:331-42. 2005
    ..Thus, the endocannabinoid system appears to play a pivotal role in the regulation of emotional states and may constitute a novel pharmacological target for anti-anxiety therapy...