Affiliation: King's College London
- Lactoferrin--a multifunctional protein with antimicrobial propertiesSebastien Farnaud
Metalloprotein Research Group, Randall Centre for Molecular Mechanisms of Cell Function, King s College London, 3 6 A New Hunt s House, Guy s Campus, London SE1 1UL, UK
Mol Immunol 40:395-405. 2003..This article reviews the antimicrobial activities of lactoferrin and discusses the potential mode of action of lactoferrin-derived cationic peptides against Gram-negative bacteria in the light of recent studies...
- Modelling of a metal-containing hepcidinSebastien Farnaud
Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Hospital Campus, 3 6b New Hunt s House, London, SE1 1UL, UK
Biometals 19:527-33. 2006..The co-purification of iron with both peptides, together with our 3D model, suggest a conformational polymorphism for hepcidin, reminiscent of the iron regulatory proteins IRPs...
- Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modellingSebastien Farnaud
Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, St Thomas Street, London SE1 1UL, UK
FEMS Microbiol Lett 238:221-6. 2004..The location of the beta-strand in relation to the positive charges, seems to define the efficiency of the activity of the peptide and may explain the difference in activity obtained between HLP-2 and BLP-2...
- Transferrin receptor 2 is crucial for iron sensing in human hepatocytesChiara Rapisarda
King s College London, UK
Am J Physiol Gastrointest Liver Physiol 299:G778-83. 2010..Taken together our data suggest that transferrin receptor 2 is a likely candidate to explain the differences in iron sensing between hepatoma cell lines and primary human hepatocytes...
- An overview of molecular aspects of iron metabolismBasharut A Syed
Metalloprotein Research Group, Randall Division of Cell and Molecular Biophysics, King s College London, London, UK
Hemoglobin 30:69-80. 2006..Our current knowledge of the molecular aspects of mammalian iron metabolism and NTBI are presented in this review...
- Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiaePeter J Sargent
Metalloprotein Research Group, Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, St Thomas Street, 3 6b New Hunts House, London, SE1 1UL, UK
Biometals 19:513-9. 2006..In addition, the recombinant transferrin was found to be as effective as native transferrin as a growth factor in cell culture medium...
- Structure/function overview of proteins involved in iron storage and transportPeter J Sargent
Metalloprotein Research Group, Randall Research Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
Curr Med Chem 12:2683-93. 2005....
- Interactions of lactoferricin-derived peptides with LPS and antimicrobial activitySebastien Farnaud
Randall Centre for Molecular Mechanisms of Cell Function, King s College London, New Hunt s House, Guy s Campus, St Thomas Street, London SE1 1UL, UK
FEMS Microbiol Lett 233:193-9. 2004....
- The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranesChristof Junkes
Leibniz Institute of Molecular Pharmacology, Robert Rossle Str 10, 13125 Berlin, Germany
J Pept Sci 14:535-43. 2008..coli. In addition to membrane permeabilization, the data provided evidence for the involvement of other mechanisms in growth inhibition and killing of bacteria...
- Isolation of lactoferrin from milk of different species: calorimetric and antimicrobial studiesCelia Conesa
Tecnologia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
Comp Biochem Physiol B Biochem Mol Biol 150:131-9. 2008..The minimum bactericidal concentrations (MBCs) were also measured and it was found that camel lactoferrin was the most active lactoferrin against E. coli 0157:H7, whereas alpaca and human lactoferrins were the least active...
- Support for a three-dimensional structure predicting a Cys-Glu-Lys catalytic triad for Pseudomonas aeruginosa amidase comes from site-directed mutagenesis and mutations altering substrate specificityCarlos Novo
Unidade de Tecnologica de Proteínas e Anticorpos Monoclonais, Departmento de Biotecnologia, Instituto Nacional de Engenharia e Tecnologia Industrial, Edificio F, Estrada do Paço do Lumiar 1649 038, Lisbon, Portugal
Biochem J 365:731-8. 2002..Support for the structure for the P. aeruginosa amidase came from site-direct mutagenesis and from the locations of amino acid residues that altered substrate specificity or binding when mutated...