Sebastien Farnaud

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Lactoferrin--a multifunctional protein with antimicrobial properties
    Sebastien Farnaud
    Metalloprotein Research Group, Randall Centre for Molecular Mechanisms of Cell Function, King s College London, 3 6 A New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Mol Immunol 40:395-405. 2003
  2. ncbi request reprint Modelling of a metal-containing hepcidin
    Sebastien Farnaud
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Hospital Campus, 3 6b New Hunt s House, London, SE1 1UL, UK
    Biometals 19:527-33. 2006
  3. ncbi request reprint Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling
    Sebastien Farnaud
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    FEMS Microbiol Lett 238:221-6. 2004
  4. pmc Transferrin receptor 2 is crucial for iron sensing in human hepatocytes
    Chiara Rapisarda
    King s College London, UK
    Am J Physiol Gastrointest Liver Physiol 299:G778-83. 2010
  5. ncbi request reprint An overview of molecular aspects of iron metabolism
    Basharut A Syed
    Metalloprotein Research Group, Randall Division of Cell and Molecular Biophysics, King s College London, London, UK
    Hemoglobin 30:69-80. 2006
  6. ncbi request reprint Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae
    Peter J Sargent
    Metalloprotein Research Group, Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, St Thomas Street, 3 6b New Hunts House, London, SE1 1UL, UK
    Biometals 19:513-9. 2006
  7. ncbi request reprint Structure/function overview of proteins involved in iron storage and transport
    Peter J Sargent
    Metalloprotein Research Group, Randall Research Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Curr Med Chem 12:2683-93. 2005
  8. ncbi request reprint Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity
    Sebastien Farnaud
    Randall Centre for Molecular Mechanisms of Cell Function, King s College London, New Hunt s House, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    FEMS Microbiol Lett 233:193-9. 2004
  9. ncbi request reprint The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes
    Christof Junkes
    Leibniz Institute of Molecular Pharmacology, Robert Rossle Str 10, 13125 Berlin, Germany
    J Pept Sci 14:535-43. 2008
  10. doi request reprint Isolation of lactoferrin from milk of different species: calorimetric and antimicrobial studies
    Celia Conesa
    Tecnologia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
    Comp Biochem Physiol B Biochem Mol Biol 150:131-9. 2008

Collaborators

  • Peter J Sargent
  • Richard Cammack
  • Margitta Dathe
  • C Novo
  • Robert W Evans
  • Chiara Rapisarda
  • Celia Conesa
  • Christof Junkes
  • Basharut A Syed
  • Paul A Sharp
  • Anil Dhawan
  • Robin D Hughes
  • Juliana Puppi
  • María Dolores Pérez
  • Miguel Calvo
  • Axel Wessolowski
  • Michael Bienert
  • Carmen Rota
  • Liam Good
  • Lourdes Sanchez

Detail Information

Publications11

  1. ncbi request reprint Lactoferrin--a multifunctional protein with antimicrobial properties
    Sebastien Farnaud
    Metalloprotein Research Group, Randall Centre for Molecular Mechanisms of Cell Function, King s College London, 3 6 A New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Mol Immunol 40:395-405. 2003
    ..This article reviews the antimicrobial activities of lactoferrin and discusses the potential mode of action of lactoferrin-derived cationic peptides against Gram-negative bacteria in the light of recent studies...
  2. ncbi request reprint Modelling of a metal-containing hepcidin
    Sebastien Farnaud
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Hospital Campus, 3 6b New Hunt s House, London, SE1 1UL, UK
    Biometals 19:527-33. 2006
    ..The co-purification of iron with both peptides, together with our 3D model, suggest a conformational polymorphism for hepcidin, reminiscent of the iron regulatory proteins IRPs...
  3. ncbi request reprint Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling
    Sebastien Farnaud
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    FEMS Microbiol Lett 238:221-6. 2004
    ..The location of the beta-strand in relation to the positive charges, seems to define the efficiency of the activity of the peptide and may explain the difference in activity obtained between HLP-2 and BLP-2...
  4. pmc Transferrin receptor 2 is crucial for iron sensing in human hepatocytes
    Chiara Rapisarda
    King s College London, UK
    Am J Physiol Gastrointest Liver Physiol 299:G778-83. 2010
    ..Taken together our data suggest that transferrin receptor 2 is a likely candidate to explain the differences in iron sensing between hepatoma cell lines and primary human hepatocytes...
  5. ncbi request reprint An overview of molecular aspects of iron metabolism
    Basharut A Syed
    Metalloprotein Research Group, Randall Division of Cell and Molecular Biophysics, King s College London, London, UK
    Hemoglobin 30:69-80. 2006
    ..Our current knowledge of the molecular aspects of mammalian iron metabolism and NTBI are presented in this review...
  6. ncbi request reprint Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae
    Peter J Sargent
    Metalloprotein Research Group, Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, St Thomas Street, 3 6b New Hunts House, London, SE1 1UL, UK
    Biometals 19:513-9. 2006
    ..In addition, the recombinant transferrin was found to be as effective as native transferrin as a growth factor in cell culture medium...
  7. ncbi request reprint Structure/function overview of proteins involved in iron storage and transport
    Peter J Sargent
    Metalloprotein Research Group, Randall Research Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Curr Med Chem 12:2683-93. 2005
    ....
  8. ncbi request reprint Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity
    Sebastien Farnaud
    Randall Centre for Molecular Mechanisms of Cell Function, King s College London, New Hunt s House, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    FEMS Microbiol Lett 233:193-9. 2004
    ....
  9. ncbi request reprint The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes
    Christof Junkes
    Leibniz Institute of Molecular Pharmacology, Robert Rossle Str 10, 13125 Berlin, Germany
    J Pept Sci 14:535-43. 2008
    ..coli. In addition to membrane permeabilization, the data provided evidence for the involvement of other mechanisms in growth inhibition and killing of bacteria...
  10. doi request reprint Isolation of lactoferrin from milk of different species: calorimetric and antimicrobial studies
    Celia Conesa
    Tecnologia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
    Comp Biochem Physiol B Biochem Mol Biol 150:131-9. 2008
    ..The minimum bactericidal concentrations (MBCs) were also measured and it was found that camel lactoferrin was the most active lactoferrin against E. coli 0157:H7, whereas alpaca and human lactoferrins were the least active...
  11. pmc Support for a three-dimensional structure predicting a Cys-Glu-Lys catalytic triad for Pseudomonas aeruginosa amidase comes from site-directed mutagenesis and mutations altering substrate specificity
    Carlos Novo
    Unidade de Tecnologica de Proteínas e Anticorpos Monoclonais, Departmento de Biotecnologia, Instituto Nacional de Engenharia e Tecnologia Industrial, Edificio F, Estrada do Paço do Lumiar 1649 038, Lisbon, Portugal
    Biochem J 365:731-8. 2002
    ..Support for the structure for the P. aeruginosa amidase came from site-direct mutagenesis and from the locations of amino acid residues that altered substrate specificity or binding when mutated...