Britta J Eickholt

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis
    Pietro Fazzari
    Institute for Cancer Research and Treatment, University of Torino Medical School, Division of Molecular Oncology, Candiolo, Turin, Italy
    BMC Dev Biol 7:55. 2007
  2. ncbi request reprint Functional diversity and mechanisms of action of the semaphorins
    Britta J Eickholt
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Development 135:2689-94. 2008
  3. pmc A twin arginine signal peptide and the pH gradient trigger reversible assembly of the thylakoid [Delta]pH/Tat translocase
    Hiroki Mori
    Horticultural Sciences and Plant Molecular and Cellular Biology, University of Florida, Gainesville, FL 32611, USA
    J Cell Biol 157:205-10. 2002
  4. pmc An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling
    Britta J Eickholt
    Molecular Neurobiology Group, Medical Research Council Centre for Developmental Biology, King s College London, London SE1 1UL, United Kingdom
    J Cell Biol 157:211-7. 2002
  5. pmc Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
    Britta J Eickholt
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS ONE 2:e869. 2007
  6. pmc MyosinV controls PTEN function and neuronal cell size
    Michiel T van Diepen
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, London SE1 1UL, UK
    Nat Cell Biol 11:1191-6. 2009
  7. ncbi request reprint PTEN couples Sema3A signalling to growth cone collapse
    Neil H Chadborn
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London, SE1 1UL, UK
    J Cell Sci 119:951-7. 2006
  8. ncbi request reprint A complementary peptide approach applied to the design of novel semaphorin/neuropilin antagonists
    Gareth Williams
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 92:1180-90. 2005
  9. pmc Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN
    Patricia Kreis
    MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS ONE 8:e71957. 2013
  10. ncbi request reprint Semaphorin/neuropilin signaling influences the positioning of migratory neural crest cells within the hindbrain region of the chick
    Nicola J Osborne
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, United Kingdom
    Dev Dyn 232:939-49. 2005

Collaborators

Detail Information

Publications20

  1. pmc Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis
    Pietro Fazzari
    Institute for Cancer Research and Treatment, University of Torino Medical School, Division of Molecular Oncology, Candiolo, Turin, Italy
    BMC Dev Biol 7:55. 2007
    ..In order to shed light on PlexinB1 function in vivo, we therefore undertook the genomic targeting of the mouse gene to obtain loss of function mutants...
  2. ncbi request reprint Functional diversity and mechanisms of action of the semaphorins
    Britta J Eickholt
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Development 135:2689-94. 2008
    ..Emerging new themes discussed at the meeting included the recognition of an increasingly complex way in which different cells regulate responsiveness, and the significance of considering semaphorins in the pathology of various diseases...
  3. pmc A twin arginine signal peptide and the pH gradient trigger reversible assembly of the thylakoid [Delta]pH/Tat translocase
    Hiroki Mori
    Horticultural Sciences and Plant Molecular and Cellular Biology, University of Florida, Gainesville, FL 32611, USA
    J Cell Biol 157:205-10. 2002
    ..It also explains in part how the system can exist in the membrane without compromising its ion and proton permeability barrier...
  4. pmc An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling
    Britta J Eickholt
    Molecular Neurobiology Group, Medical Research Council Centre for Developmental Biology, King s College London, London SE1 1UL, United Kingdom
    J Cell Biol 157:211-7. 2002
    ..These studies reveal a novel compartmentalization of inactive GSK-3 in cells and demonstrate for the first time a requirement for GSK-3 activity in the Sema 3A signal transduction pathway...
  5. pmc Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
    Britta J Eickholt
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS ONE 2:e869. 2007
    ..Our data identify p110delta as an important signaling component for efficient axonal elongation in the developing and regenerating nervous system...
  6. pmc MyosinV controls PTEN function and neuronal cell size
    Michiel T van Diepen
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, London SE1 1UL, UK
    Nat Cell Biol 11:1191-6. 2009
    ..Our data demonstrate a myosin-based transport mechanism that regulates PTEN function, providing new insights into the signalling networks regulating cell growth...
  7. ncbi request reprint PTEN couples Sema3A signalling to growth cone collapse
    Neil H Chadborn
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London, SE1 1UL, UK
    J Cell Sci 119:951-7. 2006
    ..These findings demonstrate a dependency on PTEN to regulate GSK-3 signalling in response to Sema3A and highlight the importance of subcellular distributions of PTEN to control growth cone behaviour...
  8. ncbi request reprint A complementary peptide approach applied to the design of novel semaphorin/neuropilin antagonists
    Gareth Williams
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    J Neurochem 92:1180-90. 2005
    ..Semaphorin 3F stimulates growth cone collapse following binding to the closest relative to neuropilin-1 in the genome, neuropilin-2. Where tested, the peptides that antagonise semaphorin 3A failed to inhibit the semaphorin 3F response...
  9. pmc Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN
    Patricia Kreis
    MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS ONE 8:e71957. 2013
    ....
  10. ncbi request reprint Semaphorin/neuropilin signaling influences the positioning of migratory neural crest cells within the hindbrain region of the chick
    Nicola J Osborne
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, United Kingdom
    Dev Dyn 232:939-49. 2005
    ....
  11. ncbi request reprint Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPalpha during axonal extension in hippocampal neurons
    Katharina E Cosker
    MRC Centre for Developmental Neurobiology, King s College London, London, SE1 1UL, UK
    J Cell Sci 121:796-803. 2008
    ..We conclude that PITPalpha controls the polarized extension of axonal processes through the provision of PtdIns for localized PI3K-dependent signalling...
  12. doi request reprint Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation
    Louise Kay
    MRC Centre for Developmental Neurobiology, King s College London, London, UK
    Nat Neurosci 14:688-90. 2011
    ....
  13. ncbi request reprint Function of PTEN during the formation and maintenance of neuronal circuits in the brain
    Michiel T van Diepen
    MRC Centre for Developmental Neurobiology, King s College London, London, UK
    Dev Neurosci 30:59-64. 2008
    ..This review outlines recent work on the function of PTEN during vertebrate brain development and the current understanding of the signaling pathways downstream of PTEN that control neuronal connectivity in the brain...
  14. doi request reprint The neurodevelopmental implications of PI3K signaling
    Kathryn Waite
    MRC Centre for Developmental Neurobiology, King s College London, New Hunt s House, London, UK
    Curr Top Microbiol Immunol 346:245-65. 2010
    ..In this chapter, we will focus on the specific, yet divergent, cellular processes that are achieved through PI3K signaling in neurons and are key to brain development...
  15. ncbi request reprint Functional knockdown of neuropilin-1 in the developing chick nervous system by siRNA hairpins phenocopies genetic ablation in the mouse
    Romke Bron
    MRC Centre for Developmental Neurobiology, 4th floor New Hunt s House, London Bridge, London, United Kingdom
    Dev Dyn 230:299-308. 2004
    ....
  16. ncbi request reprint Intracellular kinases in semaphorin signaling
    Aminul Ahmed
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Adv Exp Med Biol 600:24-37. 2007
    ..What follows is a review of this work with respect to their functions in mediating specific semaphorin-induced responses...
  17. ncbi request reprint Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling
    Francis P G van Horck
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Curr Biol 12:241-5. 2002
    ..Our results suggest an essential role for a Type I PIPkinase during neurite retraction in response to a number of diverse stimuli...
  18. pmc Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells
    Quenten Schwarz
    Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    Development 135:1605-13. 2008
    ..We conclude that neuropilins play multiple roles in the sensory nervous system by directing cranial neural crest cells, positioning sensory neurons and organising their axonal projections...
  19. pmc Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo
    Adam R Cole
    Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland
    J Biol Chem 281:16591-8. 2006
    ..This is the first GSK3 substrate found to be regulated in this manner and may explain the hyperphosphorylation of CRMP2 observed in Alzheimer's disease...
  20. ncbi request reprint Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer Res 63:5230-3. 2003
    ..Our findings lead to the surprising conclusion that opposing autocrine loops involving NP1 regulate the chemotaxis of breast carcinoma cells. Moreover, our data indicate a novel autocrine function for VEGF in chemotaxis...