Research Topics
Genomes and GenesSpecies | Britta J EickholtSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesisPietro Fazzari
Institute for Cancer Research and Treatment, University of Torino Medical School, Division of Molecular Oncology, Candiolo, Turin, Italy
BMC Dev Biol 7:55. 2007..In order to shed light on PlexinB1 function in vivo, we therefore undertook the genomic targeting of the mouse gene to obtain loss of function mutants...- Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinaseBritta J Eickholt
Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
PLoS ONE 2:e869. 2007..Our data identify p110delta as an important signaling component for efficient axonal elongation in the developing and regenerating nervous system... 
Functional diversity and mechanisms of action of the semaphorinsBritta J Eickholt
MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
Development 135:2689-94. 2008..Emerging new themes discussed at the meeting included the recognition of an increasingly complex way in which different cells regulate responsiveness, and the significance of considering semaphorins in the pathology of various diseases...- An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signalingBritta J Eickholt
Molecular Neurobiology Group, Medical Research Council Centre for Developmental Biology, King s College London, London SE1 1UL, United Kingdom
J Cell Biol 157:211-7. 2002..These studies reveal a novel compartmentalization of inactive GSK-3 in cells and demonstrate for the first time a requirement for GSK-3 activity in the Sema 3A signal transduction pathway... - A twin arginine signal peptide and the pH gradient trigger reversible assembly of the thylakoid [Delta]pH/Tat translocaseHiroki Mori
Horticultural Sciences and Plant Molecular and Cellular Biology, University of Florida, Gainesville, FL 32611, USA
J Cell Biol 157:205-10. 2002..It also explains in part how the system can exist in the membrane without compromising its ion and proton permeability barrier... - MyosinV controls PTEN function and neuronal cell sizeMichiel T van Diepen
MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, London SE1 1UL, UK
Nat Cell Biol 11:1191-6. 2009..Our data demonstrate a myosin-based transport mechanism that regulates PTEN function, providing new insights into the signalling networks regulating cell growth... 
PTEN couples Sema3A signalling to growth cone collapseNeil H Chadborn
MRC Centre for Developmental Neurobiology, King's College London, Guy's Campus, London, SE1 1UL, UK
J Cell Sci 119:951-7. 2006..These findings demonstrate a dependency on PTEN to regulate GSK-3 signalling in response to Sema3A and highlight the importance of subcellular distributions of PTEN to control growth cone behaviour...- A complementary peptide approach applied to the design of novel semaphorin/neuropilin antagonistsGareth Williams
Wolfson Centre for Age-Related Diseases, King's College London, London, UK
J Neurochem 92:1180-90. 2005..Semaphorin 3F stimulates growth cone collapse following binding to the closest relative to neuropilin-1 in the genome, neuropilin-2. Where tested, the peptides that antagonise semaphorin 3A failed to inhibit the semaphorin 3F response... - Semaphorin/neuropilin signaling influences the positioning of migratory neural crest cells within the hindbrain region of the chickNicola J Osborne
MRC Centre for Developmental Neurobiology, King's College London, London SE1 1UL, United Kingdom
Dev Dyn 232:939-49. 2005.... - Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPalpha during axonal extension in hippocampal neuronsKatharina E Cosker
MRC Centre for Developmental Neurobiology, King s College London, London, SE1 1UL, UK
J Cell Sci 121:796-803. 2008..We conclude that PITPalpha controls the polarized extension of axonal processes through the provision of PtdIns for localized PI3K-dependent signalling... - Neuronal activity drives matching of pre- and postsynaptic function during synapse maturationLouise Kay
MRC Centre for Developmental Neurobiology, King s College London, London, UK
Nat Neurosci 14:688-90. 2011.... - Function of PTEN during the formation and maintenance of neuronal circuits in the brainMichiel T van Diepen
MRC Centre for Developmental Neurobiology, King s College London, London, UK
Dev Neurosci 30:59-64. 2008..This review outlines recent work on the function of PTEN during vertebrate brain development and the current understanding of the signaling pathways downstream of PTEN that control neuronal connectivity in the brain... - Functional knockdown of neuropilin-1 in the developing chick nervous system by siRNA hairpins phenocopies genetic ablation in the mouseRomke Bron
MRC Centre for Developmental Neurobiology, 4th Floor New Hunt's House, London Bridge, London, United Kingdom
Dev Dyn 230:299-308. 2004.... - The neurodevelopmental implications of PI3K signalingKathryn Waite
MRC Centre for Developmental Neurobiology, King s College London, New Hunt s House, London, UK
Curr Top Microbiol Immunol 346:245-65. 2010..In this chapter, we will focus on the specific, yet divergent, cellular processes that are achieved through PI3K signaling in neurons and are key to brain development... - Intracellular kinases in semaphorin signalingAminul Ahmed
MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
Adv Exp Med Biol 600:24-37. 2007..What follows is a review of this work with respect to their functions in mediating specific semaphorin-induced responses... - Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodelingFrancis P G van Horck
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Curr Biol 12:241-5. 2002..Our results suggest an essential role for a Type I PIPkinase during neurite retraction in response to a number of diverse stimuli... - Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivoAdam R Cole
Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland
J Biol Chem 281:16591-8. 2006..This is the first GSK3 substrate found to be regulated in this manner and may explain the hyperphosphorylation of CRMP2 observed in Alzheimer's disease... - Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cellsQuenten Schwarz
Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
Development 135:1605-13. 2008..We conclude that neuropilins play multiple roles in the sensory nervous system by directing cranial neural crest cells, positioning sensory neurons and organising their axonal projections... - Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cellsRobin E Bachelder
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Cancer Res 63:5230-3. 2003..Our findings lead to the surprising conclusion that opposing autocrine loops involving NP1 regulate the chemotaxis of breast carcinoma cells. Moreover, our data indicate a novel autocrine function for VEGF in chemotaxis...