Alice Egerton

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint The glutamate hypothesis of schizophrenia: neuroimaging and drug development
    Alice Egerton
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Curr Pharm Biotechnol 13:1500-12. 2012
  2. doi request reprint Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort
    Alice Egerton
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 74:106-12. 2013
  3. pmc Anterior cingulate glutamate levels related to clinical status following treatment in first-episode schizophrenia
    Alice Egerton
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Neuropsychopharmacology 37:2515-21. 2012
  4. ncbi request reprint Glutamate and psychosis risk
    Alice Egerton
    Department of Psychosis Studies, Institute of Psychiatry, King s Health Partners, King s College London, De Crespigny Park, Denmark Hill, London, UK
    Curr Pharm Des 18:466-78. 2012
  5. doi request reprint Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis
    James M Stone
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, United Kingdom
    Biol Psychiatry 68:599-602. 2010
  6. pmc Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis
    Paul Allen
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Schizophr Bull 38:1040-9. 2012
  7. pmc Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals
    Paul Allen
    Department of Psychosis Studies, Institute of Psychiatry, King s College, London, UK
    Schizophr Bull 38:1268-76. 2012
  8. doi request reprint Further evaluation of the carbon11-labeled D(2/3) agonist PET radiotracer PHNO: reproducibility in tracer characteristics and characterization of extrastriatal binding
    Alice Egerton
    Division of Neuroscience and Psychological Medicine, Department of Neuroscience and Mental Health, Imperial College London, London, United Kingdom
    Synapse 64:301-12. 2010
  9. doi request reprint Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformity
    Alice Egerton
    Institute of Psychiatry, King s College London, London, UK
    Neuroimage 53:777-81. 2010
  10. doi request reprint Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulators
    Suzanne J Reeves
    Department of Old Age Psychiatry, Institute of Psychiatry, Kings College London, UK
    Psychiatry Res 202:60-4. 2012

Detail Information

Publications19

  1. ncbi request reprint The glutamate hypothesis of schizophrenia: neuroimaging and drug development
    Alice Egerton
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Curr Pharm Biotechnol 13:1500-12. 2012
    ..Here, we review the contribution of imaging studies to date in understanding glutamatergic abnormalities in psychosis, and discuss the potential of new glutamatergic compounds for treatment of the disorder...
  2. doi request reprint Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort
    Alice Egerton
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 74:106-12. 2013
    ..The purpose of this study was to test if this finding would be replicated in a second UHR cohort...
  3. pmc Anterior cingulate glutamate levels related to clinical status following treatment in first-episode schizophrenia
    Alice Egerton
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Neuropsychopharmacology 37:2515-21. 2012
    ..Treatment with compounds acting on the glutamatergic system might therefore be beneficial in patients who respond poorly to dopaminergic antipsychotics...
  4. ncbi request reprint Glutamate and psychosis risk
    Alice Egerton
    Department of Psychosis Studies, Institute of Psychiatry, King s Health Partners, King s College London, De Crespigny Park, Denmark Hill, London, UK
    Curr Pharm Des 18:466-78. 2012
    ..If glutamatergic abnormalities are present early in the disorder, this suggests that glutamatergic therapies may be useful in psychosis prevention...
  5. doi request reprint Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis
    James M Stone
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, United Kingdom
    Biol Psychiatry 68:599-602. 2010
    ..Animal models of psychosis propose that striatal hyperdopaminergia is driven by abnormalities in hippocampal glutamatergic neurotransmission, but this has never been tested in humans...
  6. pmc Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis
    Paul Allen
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Schizophr Bull 38:1040-9. 2012
    ....
  7. pmc Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals
    Paul Allen
    Department of Psychosis Studies, Institute of Psychiatry, King s College, London, UK
    Schizophr Bull 38:1268-76. 2012
    ..We investigated whether functional magnetic resonance imaging (fMRI) in conjunction with a phonological fluency task at presentation could distinguish subjects who subsequently developed psychosis from those who did not...
  8. doi request reprint Further evaluation of the carbon11-labeled D(2/3) agonist PET radiotracer PHNO: reproducibility in tracer characteristics and characterization of extrastriatal binding
    Alice Egerton
    Division of Neuroscience and Psychological Medicine, Department of Neuroscience and Mental Health, Imperial College London, London, United Kingdom
    Synapse 64:301-12. 2010
    ....
  9. doi request reprint Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformity
    Alice Egerton
    Institute of Psychiatry, King s College London, London, UK
    Neuroimage 53:777-81. 2010
    ..54 p=0.06) but not SDE (r=0.23, ns). Whilst these associations are modest, results suggest that striatal D(2/3) receptor availability may be particularly associated with social conformity, rather than self-deception...
  10. doi request reprint Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulators
    Suzanne J Reeves
    Department of Old Age Psychiatry, Institute of Psychiatry, Kings College London, UK
    Psychiatry Res 202:60-4. 2012
    ..Future studies that combine D2/3 receptor imaging with behavioral measures of impulsivity are required to further elucidate the precise relationship between individual components of trait impulsivity and brain dopaminergic function...
  11. doi request reprint History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability
    Paul R A Stokes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    J Psychopharmacol 26:144-9. 2012
    ..These findings suggest that, unlike other drugs of abuse, a history of cannabis use is not associated with alterations in striatal dopamine D(2)/D(3) receptor availability...
  12. pmc Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study
    Oliver D Howes
    1 King s College London, Department of Psychosis Studies, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Brain 136:3242-51. 2013
    ..30, P = 0.11). These findings indicate that elevated dopamine synthesis capacity is seen in the nigral origin of dopamine neurons as well as their striatal terminals in schizophrenia, and is linked to symptom severity in patients...
  13. doi request reprint Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists: [11C]raclopride PET studies in the rat
    Alice Egerton
    Division of Neuroscience and Psychological Medicine, Department of Neuroscience and Mental Health, Imperial College London, London, W12 0NN, UK
    Psychopharmacology (Berl) 200:487-96. 2008
    ..However, it is not known whether 5-HT2A/2C receptor-mediated modulation of DA release can be quantified with non-invasive neurochemical imaging, as would be required for investigation of these processes in man...
  14. doi request reprint The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function
    Alice Egerton
    Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
    Neuroimage 50:524-31. 2010
    ..This information can be used to optimize the experimental design of future studies investigating changes in brain dopaminergic function with 18F-DOPA...
  15. pmc Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging study
    Oliver D Howes
    Hammersmith Hospital, London, UK
    Am J Psychiatry 168:1311-7. 2011
    ..The authors addressed this issue by measuring dopamine synthesis capacity in individuals at ultra-high risk of psychosis and then following them to determine their clinical outcome...
  16. ncbi request reprint Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge
    Paul R A Stokes
    MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
    Neuroimage 52:1521-7. 2010
    ..The interpretation of these findings in relation to prefrontal dopamine release is discussed...
  17. doi request reprint Does human presynaptic striatal dopamine function predict social conformity?
    Paul R A Stokes
    1Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    J Psychopharmacol 28:237-43. 2014
    ....
  18. ncbi request reprint Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms
    Michael A P Bloomfield
    Psychiatric Imaging Group, Medical Research Council Clinical Sciences Centre, Institute of Clinical Sciences, Hammersmith Hospital, Imperial College London Department of Psychosis Studies, Institute of Psychiatry, King s College London King s Health Partners, London, United Kingdom
    Biol Psychiatry 75:470-8. 2014
    ..It has been proposed, although never directly tested, that the link between cannabis use and schizophrenia is mediated by altered dopaminergic function...
  19. ncbi request reprint Dopamine release in the human striatum: motor and cognitive tasks revisited
    Julia M Lappin
    Institute of Psychiatry, King s College London, London, UK
    J Cereb Blood Flow Metab 29:554-64. 2009
    ..No additional DA release was observed specific to the cognitive component of either task...