Research Topics
| Alice EgertonSummaryAffiliation: King's College London Country: UK Publications
| Collaborators
|
Detail Information
Publications
The dopaminergic basis of human behaviors: A review of molecular imaging studiesAlice Egerton
Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, United Kingdom
Neurosci Biobehav Rev 33:1109-32. 2009....- Dopamine release in the human striatum: motor and cognitive tasks revisitedJulia M Lappin
Institute of Psychiatry, King s College London, London, UK
J Cereb Blood Flow Metab 29:554-64. 2009..No additional DA release was observed specific to the cognitive component of either task... 
The glutamate hypothesis of schizophrenia: neuroimaging and drug developmentAlice Egerton
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
Curr Pharm Biotechnol 13:1500-12. 2012..Here, we review the contribution of imaging studies to date in understanding glutamatergic abnormalities in psychosis, and discuss the potential of new glutamatergic compounds for treatment of the disorder...- Truth, lies or self-deception? Striatal D(2/3) receptor availability predicts individual differences in social conformityAlice Egerton
Institute of Psychiatry, King s College London, London, UK
Neuroimage 53:777-81. 2010..54 p=0.06) but not SDE (r=0.23, ns). Whilst these associations are modest, results suggest that striatal D(2/3) receptor availability may be particularly associated with social conformity, rather than self-deception... - The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic functionAlice Egerton
Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK
Neuroimage 50:524-31. 2010..This information can be used to optimize the experimental design of future studies investigating changes in brain dopaminergic function with 18F-DOPA... - Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET studyAlice Egerton
Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Neuroimage 50:260-6. 2010..These findings have important implications for understanding the mechanism of action underlying bupropions' therapeutic efficacy and for the development of novel treatments for addiction and depression... - Further evaluation of the carbon11-labeled D(2/3) agonist PET radiotracer PHNO: reproducibility in tracer characteristics and characterization of extrastriatal bindingAlice Egerton
Division of Neuroscience and Psychological Medicine, Department of Neuroscience and Mental Health, Imperial College London, London, United Kingdom
Synapse 64:301-12. 2010.... - Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists: [11C]raclopride PET studies in the ratAlice Egerton
Division of Neuroscience and Psychological Medicine, Department of Neuroscience and Mental Health, Imperial College London, London, W12 0NN, UK
Psychopharmacology (Berl) 200:487-96. 2008..However, it is not known whether 5-HT2A/2C receptor-mediated modulation of DA release can be quantified with non-invasive neurochemical imaging, as would be required for investigation of these processes in man... 
Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosisPaul Allen
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
Schizophr Bull 38:1040-9. 2012....- Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosisJames M Stone
Department of Psychosis Studies, Institute of Psychiatry, King s College London, United Kingdom
Biol Psychiatry 68:599-602. 2010..Animal models of psychosis propose that striatal hyperdopaminergia is driven by abnormalities in hippocampal glutamatergic neurotransmission, but this has never been tested in humans... - History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availabilityPaul R A Stokes
Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
J Psychopharmacol 26:144-9. 2012..These findings suggest that, unlike other drugs of abuse, a history of cannabis use is not associated with alterations in striatal dopamine D(2)/D(3) receptor availability... - Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulatorsSuzanne J Reeves
Department of Old Age Psychiatry, Institute of Psychiatry, Kings College London, UK
Psychiatry Res 202:60-4. 2012..Future studies that combine D2/3 receptor imaging with behavioral measures of impulsivity are required to further elucidate the precise relationship between individual components of trait impulsivity and brain dopaminergic function... - Anterior cingulate glutamate levels related to clinical status following treatment in first-episode schizophreniaAlice Egerton
Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Neuropsychopharmacology 37:2515-21. 2012..Treatment with compounds acting on the glutamatergic system might therefore be beneficial in patients who respond poorly to dopaminergic antipsychotics... - Significant decreases in frontal and temporal [11C]-raclopride binding after THC challengePaul R A Stokes
MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
Neuroimage 52:1521-7. 2010..The interpretation of these findings in relation to prefrontal dopamine release is discussed... - The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET studyAndrew J Montgomery
MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London W12 0NN, United Kingdom
Synapse 61:637-45. 2007..These results support a role for the DA system in nicotine addiction, but reveal a more complex relationship than suggested by studies in animals... - Striatal dopamine (D2) receptor availability predicts socially desirable respondingSuzanne J Reeves
Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Neuroimage 34:1782-9. 2007..How this relates to dopaminergic tone will need to be further explored... - Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individualsPaul Allen
Department of Psychosis Studies, Institute of Psychiatry, King s College, London, UK
Schizophr Bull 38:1268-76. 2012..We investigated whether functional magnetic resonance imaging (fMRI) in conjunction with a phonological fluency task at presentation could distinguish subjects who subsequently developed psychosis from those who did not... - Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging studyOliver D Howes
Hammersmith Hospital, London, UK
Am J Psychiatry 168:1311-7. 2011..The authors addressed this issue by measuring dopamine synthesis capacity in individuals at ultra-high risk of psychosis and then following them to determine their clinical outcome... - Agonist-dependent internalization of D2 receptors: Imaging quantification by confocal microscopyJulian L Goggi
MRC Clinical Science Centre, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London, United Kingdom
Synapse 61:231-41. 2007.... - Glutamate and psychosis riskAlice Egerton
Department of Psychosis Studies, Institute of Psychiatry, King s Health Partners, King s College London, De Crespigny Park, Denmark Hill, London, UK
Curr Pharm Des 18:466-78. 2012..If glutamatergic abnormalities are present early in the disorder, this suggests that glutamatergic therapies may be useful in psychosis prevention...