Alasdair J Edgar

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors
    Alasdair J Edgar
    Department of Craniofacial Development, King s College London Dental Institute at Guy s, King s College and St Thomas Hospitals, London, UK
    DNA Seq 18:235-41. 2007
  2. pmc Genomic structure and cloning of two transcript isoforms of human Sp8
    Maria athina Milona
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    BMC Genomics 5:86. 2004
  3. pmc Upregulated genes in sporadic, idiopathic pulmonary arterial hypertension
    Alasdair J Edgar
    Department of Craniofacial Development, King s College, London, SE1 9RT, UK
    Respir Res 7:1. 2006
  4. pmc Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene
    Alasdair J Edgar
    Department of Craniofacial Development, King s College, London, UK
    BMC Genomics 6:32. 2005
  5. ncbi request reprint Bone morphogenetic protein-2 induces expression of murine zinc finger transcription factor ZNF450
    Alasdair J Edgar
    Department of Craniofacial Development, GKT Dental Institute, King s College, Guy s Hospital, London SE1 9RT, United Kingdom
    J Cell Biochem 94:202-15. 2005
  6. pmc The human L-threonine 3-dehydrogenase gene is an expressed pseudogene
    Alasdair J Edgar
    Tissue Engineering and Regenerative Medicine Centre, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    BMC Genet 3:18. 2002
  7. pmc The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12
    Alasdair J Edgar
    Department of Clinical and Diagnostic Oral Science, Clinical Research Centre, Queen Mary, University of London, 2 Newark Street, London, E1 2AD, UK
    BMC Genomics 4:18. 2003
  8. pmc Molecular cloning and tissue distribution of mammalian L-threonine 3-dehydrogenases
    Alasdair J Edgar
    Tissue Engineering and Regenerative Medicine Centre, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    BMC Biochem 3:19. 2002
  9. ncbi request reprint Derivation of type II alveolar epithelial cells from murine embryonic stem cells
    Nadire N Ali
    Tissue Engineering Centre, Imperial College Faculty of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    Tissue Eng 8:541-50. 2002
  10. pmc Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells
    Maria athina Milona
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus Medical Center, Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    BMC Genomics 4:43. 2003

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Human GPR107 and murine Gpr108 are members of the LUSTR family of proteins found in both plants and animals, having similar topology to G-protein coupled receptors
    Alasdair J Edgar
    Department of Craniofacial Development, King s College London Dental Institute at Guy s, King s College and St Thomas Hospitals, London, UK
    DNA Seq 18:235-41. 2007
    ..LUSTR proteins are also found in Drosophila, Saccharomyces and Arabidopsis, but are absent from bacteria, archaea and viruses. This suggests that GPCRs are present in higher plants...
  2. pmc Genomic structure and cloning of two transcript isoforms of human Sp8
    Maria athina Milona
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    BMC Genomics 5:86. 2004
    ..They also have malformed brains with defective closure of the anterior and posterior neuropore during brain development...
  3. pmc Upregulated genes in sporadic, idiopathic pulmonary arterial hypertension
    Alasdair J Edgar
    Department of Craniofacial Development, King s College, London, SE1 9RT, UK
    Respir Res 7:1. 2006
    ....
  4. pmc Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene
    Alasdair J Edgar
    Department of Craniofacial Development, King s College, London, UK
    BMC Genomics 6:32. 2005
    ..Low levels of TA enzymatic activity have been found in vertebrates. It has been suggested that any detectable activity is due to serine hydroxymethyltransferase and that mammals lack a genuine threonine aldolase...
  5. ncbi request reprint Bone morphogenetic protein-2 induces expression of murine zinc finger transcription factor ZNF450
    Alasdair J Edgar
    Department of Craniofacial Development, GKT Dental Institute, King s College, Guy s Hospital, London SE1 9RT, United Kingdom
    J Cell Biochem 94:202-15. 2005
    ..However, ZNF450 mRNA was found also in a wide range of adult tissues. The consistent induction of ZNF450 by BMP-2 after 4 h in three murine pluripotent cell lines suggests that ZNF450 may play a role in the BMP-2 signalling pathway...
  6. pmc The human L-threonine 3-dehydrogenase gene is an expressed pseudogene
    Alasdair J Edgar
    Tissue Engineering and Regenerative Medicine Centre, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    BMC Genet 3:18. 2002
    ..The murine and porcine L-threonine dehydrogenase genes (TDH) have been identified previously, but the human gene has not been identified...
  7. pmc The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12
    Alasdair J Edgar
    Department of Clinical and Diagnostic Oral Science, Clinical Research Centre, Queen Mary, University of London, 2 Newark Street, London, E1 2AD, UK
    BMC Genomics 4:18. 2003
    ..Overlapping polyadenylation signal sequences have not been described previously...
  8. pmc Molecular cloning and tissue distribution of mammalian L-threonine 3-dehydrogenases
    Alasdair J Edgar
    Tissue Engineering and Regenerative Medicine Centre, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    BMC Biochem 3:19. 2002
    ..The L-threonine 3-dehydrogenase enzyme has been purified and characterised, but the L-threonine 3-dehydrogenase gene has not previously been identified in mammals...
  9. ncbi request reprint Derivation of type II alveolar epithelial cells from murine embryonic stem cells
    Nadire N Ali
    Tissue Engineering Centre, Imperial College Faculty of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    Tissue Eng 8:541-50. 2002
    ..These findings could form the basis for the enrichment of ES cell-derived cultures with type II pneumocytes, and provide an in vitro system for investigating mechanisms of lung repair and regeneration...
  10. pmc Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells
    Maria athina Milona
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus Medical Center, Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    BMC Genomics 4:43. 2003
    ..Regulation of its expression may prove useful for mediating skeletal repair...
  11. ncbi request reprint Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs
    Alasdair J Edgar
    Tissue Engineering Centre, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Biochem Biophys Res Commun 292:617-25. 2002
    ..mRNA expression levels of LABH1 and 3 were highest in liver and LABH2 highest in testis. These findings suggest that the LABH proteins consist of a novel family of membrane bound enzymes whose function has yet to be determined...
  12. ncbi request reprint Cyclin L is an RS domain protein involved in pre-mRNA splicing
    Liliane A Dickinson
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:25465-73. 2002
    ..Significantly, the IC(50) for splicing inhibition by p21 is similar to the IC(50) for inhibition of the cyclin L-associated kinase activity. Cyclin L and its associated kinase are thus new members of the pre-mRNA processing machinery...