Research Topics
| Christine EckerSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Translational approaches to the biology of Autism: false dawn or a new era?C Ecker
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College, London, UK
Mol Psychiatry 18:435-42. 2013..The aim of this review is, therefore, to summarize some of these important new findings and highlight their potential significant translational value to the future of ASD research...
Brain surface anatomy in adults with autism: the relationship between surface area, cortical thickness, and autistic symptomsChristine Ecker
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, London, UK
JAMA Psychiatry 70:59-70. 2013..However, CV is a product of 2 distinct parameters, cortical thickness (CT) and surface area (SA), that in turn have distinct genetic and developmental origins...- Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: a multicenter magnetic resonance imaging studyChristine Ecker
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, De Crespigny Park, London, England
Arch Gen Psychiatry 69:195-209. 2012..There is consensus that autism spectrum disorder (ASD) is accompanied by differences in neuroanatomy. However, the neural substrates of ASD during adulthood, as well as how these relate to behavioral variation, remain poorly understood... - Describing the brain in autism in five dimensions--magnetic resonance imaging-assisted diagnosis of autism spectrum disorder using a multiparameter classification approachChristine Ecker
Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, Brain Image Analysis Unit, Centre for Neuroimaging Sciences, King s College, London SE5 8AF, United Kingdom
J Neurosci 30:10612-23. 2010..The spatial patterns detected using SVM may help further exploration of the specific genetic and neuropathological underpinnings of ASD, and provide new insights into the most likely multifactorial etiology of the condition... 
Serotonin and the neural processing of facial emotions in adults with autism: an fMRI study using acute tryptophan depletionEileen M Daly
Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, King s College London, London, England
Arch Gen Psychiatry 69:1003-13. 2012....- Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medicationSimon A Surguladze
Division of Psychological Medicine and Psychiatry, King s College London Institute of Psychiatry, London, UK
J Psychopharmacol 25:722-33. 2011..Our results suggest that networks implicated in the allocation of attentional resources (VMPFC) and emotion processing (amygdala, cerebellum) are differentially affected in patients on CONV versus RLAI... - Fronto-striatal circuitry and inhibitory control in autism: findings from diffusion tensor imaging tractographyMarieke Langen
Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, UK
Cortex 48:183-93. 2012..There are few studies, however, that have measured the micro-structural organisation of white matter tracts connecting striatum and frontal cortex... - Investigating the predictive value of whole-brain structural MR scans in autism: a pattern classification approachChristine Ecker
Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
Neuroimage 49:44-56. 2010..Also, these differences provide significant predictive power for group membership, which is related to symptom severity... - Combining path analysis with time-resolved functional magnetic resonance imaging: the neurocognitive network underlying mental rotationChristine Ecker
Brain Image Analysis Unit, Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK
J Cogn Neurosci 20:1003-20. 2008..The results of path analysis in fMRI should therefore only be interpreted in the light of a specific experimental design and should not be considered as general indicators of effective connections... - Detecting functional nodes in large-scale cortical networks with functional magnetic resonance imaging: a principal component analysis of the human visual systemChristine Ecker
Brain Image Analysis Unit, Department of Biostatistics and Computing, Institute of Psychiatry, London, United Kingdom
Hum Brain Mapp 28:817-34. 2007.... - Reduced activation and inter-regional functional connectivity of fronto-striatal networks in adults with childhood Attention-Deficit Hyperactivity Disorder (ADHD) and persisting symptoms during tasks of motor inhibition and cognitive switchingAna Cubillo
Department of Child Psychiatry, Institute of Psychiatry, King s College, London SE5 8AF, UK
J Psychiatr Res 44:629-39. 2010..This suggests that neuro-functional abnormalities in ADHD patients are likely to continue between childhood and early adulthood... - Effects of acute tryptophan depletion on neural processing of facial expressions of emotion in humansEileen Daly
Section of Brain Maturation, Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
Psychopharmacology (Berl) 210:499-510. 2010..Acute tryptophan depletion (ATD) temporarily lowers brain serotonin (5-HT) synthesis, and behavioral studies have shown that this alters the processing of facial expressions of emotion... - Is there a common underlying mechanism for age-related decline in cortical thickness?Christine Ecker
Section of Brain Maturation, PO50, Institute of Psychiatry, De Crespigny Park, London SE58AF, UK
Neuroreport 20:1155-60. 2009..This model reconciles two seemingly mutually exclusive hypotheses, namely, the existence of different decay functions being caused by the same underlying mechanism... - Autism in adults. New biologicial findings and their translational implications to the cost of clinical servicesDeclan G M Murphy
Department of Forensic and Developmental Sciences, Institute of Psychiatry, Kings College London, London, UK
Brain Res 1380:22-33. 2011.... - The development of emotion-processing in children: effects of age, emotion, and intensityCatherine M Herba
Department of Psychological Medicine, Institute of Psychiatry, KCL, UK
J Child Psychol Psychiatry 47:1098-106. 2006..This study examined the effects of age and two novel factors (intensity and emotion category) on healthy children's developing emotion-processing from 4 to 15 years using two matching paradigms... - Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depressionNatalia S Lawrence
Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 55:578-87. 2004..CONCLUSIONS: Compared with healthy controls and MDD patients, BD patients demonstrated increased subcortical and ventral prefrontal cortical responses to both positive and negative emotional expressions... - Time-resolved fMRI of mental rotation revisited--dissociating visual perception from mental rotation in female subjectsChristine Ecker
Brain Image Analysis Unit, PO Box 89, Centre for Neuroimaging Sciences CNS, Institute of Psychiatry, King s College London, DeCrespigny Park, London, SE5 8AF, UK
Neuroimage 32:432-44. 2006.... - Human attachment security is mediated by the amygdala: evidence from combined fMRI and psychophysiological measuresErwin Lemche
Division of Psychological Medicine, Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
Hum Brain Mapp 27:623-35. 2006..We thereby demonstrate a key role of the amygdala in mediating autonomic activity associated with human attachment insecurity...