Genomes and Genes
Affiliation: King's College London
- TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthoodFrancesca Ducci
Medical Research Council Social Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, United Kingdom
Biol Psychiatry 69:650-60. 2011..CHRNA5-CHRNA3-CHRNB4 and TTC12-ANKK1-DRD2 gene-clusters influence smoking behavior. Our aim was to test developmental changes in their effects as well as the interplays between them and with nongenetic factors...
- Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohortFrancesca Ducci
Division of Psychological Medicine, PO63, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Am J Psychiatry 166:1031-40. 2009....
- Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescentsSylvane Desrivieres
MRC SGDP Centre, Institute of Psychiatry, Kings College, UK
Addict Biol 16:510-3. 2011..0067; odds ratio=1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction...
- The genetic basis of addictive disordersFrancesca Ducci
Institute of Psychiatry, Psychological Medicine, Kings College, London, UK
Psychiatr Clin North Am 35:495-519. 2012..However, the genetic predictors available are few in number and account for only a small portion of the genetic variance in liability, and have not been integrated into clinical nosology or care...
- Genetic approaches to addiction: genes and alcoholFrancesca Ducci
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism NIH, Rockville, MD 20892, USA
Addiction 103:1414-28. 2008..Alcoholism is a chronic relapsing disorder with an enormous societal impact. Understanding the genetic basis of alcoholism is crucial to characterize individuals' risk and to develop efficacious prevention and treatment strategies...
- Sex-specific role for adenylyl cyclase type 7 in alcohol dependenceSylvane Desrivieres
Medical Research Council Social, Genetic and Developmental Psychiatry, King s College London, United Kingdom
Biol Psychiatry 69:1100-8. 2011..To further understand the role of cAMP synthesis in alcohol drinking and dependence, we investigated a specific adenylyl cyclase isoform, adenylyl cyclase (AC) Type 7, whose activity is selectively enhanced by ethanol...
- Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumptionGunter Schumann
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London SE5 8AF, United Kingdom
Proc Natl Acad Sci U S A 108:7119-24. 2011..001). Our finding of a regulator of alcohol consumption adds knowledge to our understanding of genetic mechanisms influencing alcohol drinking behavior...