Ursula M D'Souza

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint The role of monoamine oxidase A, MAOA, in the aetiology of antisocial behaviour: the importance of gene-environment interactions
    Ian W Craig
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, P082, De Crespigny Park, London, UK
    Novartis Found Symp 268:227-37; discussion 237-41, 242-53. 2005
  2. ncbi request reprint Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene
    Ursula M D'Souza
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Box Number P082, Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 56:691-7. 2004
  3. ncbi request reprint Functional polymorphisms in dopamine and serotonin pathway genes
    Ursula M D'Souza
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
    Hum Mutat 27:1-13. 2006
  4. ncbi request reprint From transcriptional regulation to aggressive behavior
    Ursula M D'Souza
    MRC Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, United Kingdom
    Behav Genet 33:549-62. 2003
  5. pmc Genes within the serotonergic system are differentially expressed in human brain
    Karen Sugden
    MRC Social, Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, UK
    BMC Neurosci 10:50. 2009
  6. doi request reprint Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS)
    Darya Gaysina
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 150:836-44. 2009
  7. doi request reprint Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders
    Ursula M D'Souza
    MRC Social, Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Prog Brain Res 172:73-98. 2008
  8. ncbi request reprint Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
  9. ncbi request reprint Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
  10. ncbi request reprint Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction
    Avshalom Caspi
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 57:1117-27. 2005

Detail Information

Publications39

  1. ncbi request reprint The role of monoamine oxidase A, MAOA, in the aetiology of antisocial behaviour: the importance of gene-environment interactions
    Ian W Craig
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, P082, De Crespigny Park, London, UK
    Novartis Found Symp 268:227-37; discussion 237-41, 242-53. 2005
    ....
  2. ncbi request reprint Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene
    Ursula M D'Souza
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Box Number P082, Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 56:691-7. 2004
    ..The location of the polymorphism in the 5'regulatory region of the DRD4 gene and the fact that it consists of potential transcription factor binding sites suggest that it might confer differential transcriptional activity of the alleles...
  3. ncbi request reprint Functional polymorphisms in dopamine and serotonin pathway genes
    Ursula M D'Souza
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
    Hum Mutat 27:1-13. 2006
    ....
  4. ncbi request reprint From transcriptional regulation to aggressive behavior
    Ursula M D'Souza
    MRC Social, Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, United Kingdom
    Behav Genet 33:549-62. 2003
    ..The results of this in silico study reveal common putative transcription factor binding sites among the set of genes investigated (especially for SRY), suggesting similar molecular transcriptional mechanisms...
  5. pmc Genes within the serotonergic system are differentially expressed in human brain
    Karen Sugden
    MRC Social, Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, UK
    BMC Neurosci 10:50. 2009
    ..In addition, the effect of genotype and gender on their expression levels was determined...
  6. doi request reprint Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS)
    Darya Gaysina
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 150:836-44. 2009
    ....
  7. doi request reprint Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders
    Ursula M D'Souza
    MRC Social, Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Prog Brain Res 172:73-98. 2008
    ....
  8. ncbi request reprint Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
    ..This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup...
  9. ncbi request reprint Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
    ..These findings may partly explain why not all victims of maltreatment grow up to victimize others, and they provide epidemiological evidence that genotypes can moderate children's sensitivity to environmental insults...
  10. ncbi request reprint Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction
    Avshalom Caspi
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 57:1117-27. 2005
    ..The vast majority of cannabis users do not develop psychosis, however, prompting us to hypothesize that some people are genetically vulnerable to the deleterious effects of cannabis...
  11. ncbi request reprint Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post-mortem midbrain tissue
    Keeley J Brookes
    MRC Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 144:1070-8. 2007
    ..Furthermore, a significant effect was found for the combined model (3'UTR and Int8 VNTR markers) on expression. These data provide further evidence on the plausible molecular mechanism underlying the aetiology of the disorder...
  12. doi request reprint ATP-binding cassette sub-family F member 1 (ABCF1) is identified as a putative therapeutic target of escitalopram in the inflammatory cytokine pathway
    Timothy R Powell
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, London, UK
    J Psychopharmacol 27:609-15. 2013
    ....
  13. pmc Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, England
    Proc Natl Acad Sci U S A 104:18860-5. 2007
    ..The finding shows that environmental exposures can be used to uncover novel candidate genes in complex phenotypes. It also shows that genes may work via the environment to shape the IQ, helping to close the nature versus nurture debate...
  14. doi request reprint Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder
    Sarah Cohen-Woods
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    Hum Mol Genet 18:1504-9. 2009
    ..It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences...
  15. doi request reprint Genetics of human aggressive behaviour
    Ian W Craig
    SGDP Centre, Institute of Psychiatry, Denmark Hill, PO 82, London SE5 8AF, UK
    Hum Genet 126:101-13. 2009
    ..Functional imaging studies of genetic variants affecting serotonin pathways have also provided valuable insights into potential links between genes, brain and aggressive behaviour...
  16. ncbi request reprint High-throughput single-nucleotide polymorphism genotyping by fluorescent competitive allele-specific polymerase chain reaction (SNiPTag)
    Joseph L McClay
    SGDP Research Centre, Institute of Psychiatry, Denmark Hill, London, SE5 8AF, United Kingdom
    Anal Biochem 301:200-6. 2002
    ..We outline a number of test assays for well-characterized SNPs in human candidate genes for behavioral disorders...
  17. doi request reprint Assessing individual differences in genome-wide gene expression in human whole blood: reliability over four hours and stability over 10 months
    Emma L Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Twin Res Hum Genet 12:372-80. 2009
    ..g., eQTLs) and correlates (e.g., psychopathology) of individual differences in gene expression...
  18. pmc A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples
    Angelica Ronald
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Behav Genet 40:31-45. 2010
    ..When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families...
  19. pmc A longitudinal study of epigenetic variation in twins
    Chloe Chung Yi Wong
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Epigenetics 5:516-26. 2010
    ..The observation of dynamic changes in DNA methylation over time highlights the importance of longitudinal research designs for epigenetic research...
  20. doi request reprint Genome-wide association study of major recurrent depression in the U.K. population
    Cathryn M Lewis
    Medical Research Council s Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    Am J Psychiatry 167:949-57. 2010
    ..K. and 1,594 comparison subjects screened negative for psychiatric disorders...
  21. pmc Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays
    Alexandra Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    BMC Res Notes 3:274. 2010
    ..The genotyping assay using the Affymetrix SNP 6.0 array is highly demanding on sample quality due to the small feature size, low redundancy, and lack of mismatch probes...
  22. ncbi request reprint The importance of stress and genetic variation in human aggression
    Ian W Craig
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London PO82, De Crespigny Park, London SE5 8AF, UK
    Bioessays 29:227-36. 2007
    ....
  23. ncbi request reprint Introductory guide to the language of molecular genetics
    Thalia C Eley
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 46:1039-41. 2005
    ..As much of the terminology is specific to the field, this introductory guide aims to aid readers who may be unfamiliar with the approaches of this discipline...
  24. pmc The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression
    Emma L Dempster
    Molecular Genetics, Psychological Medicine, Institute of Psychiatry, London, UK
    BMC Med Genet 7:10. 2006
    ..Previous research has suggested that activity and expression of COMT is altered in schizophrenia, and is mediated by one or more polymorphisms within the gene, including the functional Val158Met polymorphism...
  25. ncbi request reprint The genetic basis for sex differences in human behaviour: role of the sex chromosomes
    Ian W Craig
    SGDP Centre, Box PO 82, Institute of Psychiatry, Denmark Hill, London SE5, UK
    Ann Hum Genet 68:269-84. 2004
    ..The review concludes with a summary of the genetic basis for two sexually disparate types of behaviour...
  26. ncbi request reprint X inactivation as a source of behavioural differences in monozygotic female twins
    Caroline S Loat
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Kings College, London, UK
    Twin Res 7:54-61. 2004
    ....
  27. ncbi request reprint SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Hum Mol Genet 14:1315-25. 2005
    ..Although each SNP accounts for a small amount of variance, their effects are additive and they can be combined in a 'SNP set' that can be used as a genetic risk index for MMI in behavioral genomic analyses...
  28. ncbi request reprint Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes
    Ian W Craig
    SGDP Centre, Institute of Psychiatry, Box PO 82, Denmark Hill, London SE5, UK
    Eur J Hum Genet 12:639-46. 2004
    ..Six of the targets were represented by more than one probe set, which gave independent support for the conclusions reached...
  29. doi request reprint Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants
    Karim Malki
    Institute of Psychiatry, King s College London, United Kingdom
    Biol Psychiatry 69:360-5. 2011
    ..We report on an integrative analysis from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study using gene expression from mice to inform prioritization in a human pharmacogenetic study...
  30. ncbi request reprint The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity
    Michael J Parsons
    Department of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 56:406-10. 2004
    ..A prior investigation into affects of this SNP on promoter function, lacking the more downstream promoter, found no significant difference with a reporter gene assay...
  31. ncbi request reprint Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins
    Araceli Rosa
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:459-62. 2008
    ....
  32. pmc Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
    Jonathan Mill
    Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry SGDP Centre, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    BMC Genet 6:3. 2005
    ....
  33. ncbi request reprint A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds
    Nicole Harlaar
    Institute of Psychiatry, King s College London, London, UK
    J Child Psychol Psychiatry 46:1097-107. 2005
    ..These children have also been studied at 2, 3, 4, and 7 years of age on measures of cognitive and language development and behaviour problems; family environment was also assessed...
  34. ncbi request reprint Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Behav Genet 34:549-55. 2004
    ..Thus, genotyping pooled DNA on microarrays can provide a systematic and powerful approach for identifying QTL associations for complex traits including behavioral dimensions and disorders...
  35. doi request reprint Allele-specific expression of the serotonin transporter and its transcription factors following lamotrigine treatment in vitro
    Ursula M D'Souza
    MRC Social, Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 162:474-83. 2013
    ..These data provide an allele-specific in vitro model for examining the molecular targets of lamotrigine, and support the important role of the serotonin transporter gene in its clinical mechanism of action...
  36. ncbi request reprint Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships
    Matthew W Nash
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Section of Epidemiology, Institute of Psychiatry, King s College, London, UK
    Hum Mol Genet 13:2173-82. 2004
    ..2) around 64 cM (43-70 cM) near marker D1S2892 and another on chromosome 6p (LOD 2.7) around 47 cM (34-63 cM) near marker D6S1610. Further exploratory sex-specific analyses suggested that these QTLs might have sex-limited effects...
  37. pmc A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays
    Claire L Simpson
    Department of Neurology, PO43, Institute of Psychiatry London SE5 8AF, UK
    Nucleic Acids Res 33:e25. 2005
    ....
  38. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  39. pmc Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 62:355-8. 2007
    ..We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects...