Sandra Diebold

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint RNA-containing adenovirus/polyethylenimine transfer complexes effectively transduce dendritic cells and induce antigen-specific T cell responses
    Tatjana C Gust
    Max Delbruck Center for Molecular Medicine, MDC, Robert Rossle Str 10, D 13092 Berlin, Germany
    J Gene Med 6:464-70. 2004
  2. doi request reprint Innate recognition of viruses
    Sandra Diebold
    King s College London, Peter Gorer Department of Immunobiology, Division of Immunology, Infection and Inflammatory Disease, 2nd Floor Borough Wing, Guy s Hospital, London SE1 9RT, United Kingdom
    Immunol Lett 128:17-20. 2010
  3. pmc Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines
    S S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK
    Gene Ther 16:359-66. 2009
  4. doi request reprint Determination of T-cell fate by dendritic cells
    Sandra S Diebold
    Peter Gorer Department of Immunobiology, King s College London, Guy s Hospital, London, UK
    Immunol Cell Biol 86:389-97. 2008
  5. doi request reprint Recognition of viral single-stranded RNA by Toll-like receptors
    Sandra S Diebold
    King s College London, 2nd Floor Borough Wing, Peter Gorer Department of Immunobiology, Guy s Hospital, London SE1 9RT, United Kingdom
    Adv Drug Deliv Rev 60:813-23. 2008
  6. ncbi request reprint Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
  7. ncbi request reprint Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK
    Eur J Immunol 36:3256-67. 2006
  8. pmc Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9
    Andreas Pichlmair
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Virol 81:539-47. 2007
  9. ncbi request reprint Toll-like receptor 3 promotes cross-priming to virus-infected cells
    Oliver Schulz
    Immunobiology Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 433:887-92. 2005
  10. ncbi request reprint Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Nature 424:324-8. 2003

Collaborators

Detail Information

Publications14

  1. ncbi request reprint RNA-containing adenovirus/polyethylenimine transfer complexes effectively transduce dendritic cells and induce antigen-specific T cell responses
    Tatjana C Gust
    Max Delbruck Center for Molecular Medicine, MDC, Robert Rossle Str 10, D 13092 Berlin, Germany
    J Gene Med 6:464-70. 2004
    ..Given the unique properties of DCs, gene-modified DCs represent a particularly attractive approach for immunotherapy of diseases such as cancer...
  2. doi request reprint Innate recognition of viruses
    Sandra Diebold
    King s College London, Peter Gorer Department of Immunobiology, Division of Immunology, Infection and Inflammatory Disease, 2nd Floor Borough Wing, Guy s Hospital, London SE1 9RT, United Kingdom
    Immunol Lett 128:17-20. 2010
    ..This article gives an overview over the different viral nucleic acid sensors and their contribution to the orchestration of anti-viral immune responses...
  3. pmc Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines
    S S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK
    Gene Ther 16:359-66. 2009
    ..Our results underscore the potential role of TLR3 in mediating immune activation by dsRNA-bearing replicon plasmid-transfected cells and indicate that other innate sensing pathways can compensate for TLR3 absence in vivo...
  4. doi request reprint Determination of T-cell fate by dendritic cells
    Sandra S Diebold
    Peter Gorer Department of Immunobiology, King s College London, Guy s Hospital, London, UK
    Immunol Cell Biol 86:389-97. 2008
    ....
  5. doi request reprint Recognition of viral single-stranded RNA by Toll-like receptors
    Sandra S Diebold
    King s College London, 2nd Floor Borough Wing, Peter Gorer Department of Immunobiology, Guy s Hospital, London SE1 9RT, United Kingdom
    Adv Drug Deliv Rev 60:813-23. 2008
    ..Thus the development of suitable TLR7 and TLR8 antagonists could pave the way for therapeutic intervention of particular autoimmune diseases...
  6. ncbi request reprint Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
    ..These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses...
  7. ncbi request reprint Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK
    Eur J Immunol 36:3256-67. 2006
    ..Our results support the notion that TLR7 recognises uracil repeats in RNA and that it discriminates between viral and self ligands on the basis of endosomal accessibility rather than sequence...
  8. pmc Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9
    Andreas Pichlmair
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Virol 81:539-47. 2007
    ....
  9. ncbi request reprint Toll-like receptor 3 promotes cross-priming to virus-infected cells
    Oliver Schulz
    Immunobiology Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 433:887-92. 2005
    ..Thus, TLR3 may have evolved to permit cross-priming of CTLs against viruses that do not directly infect dendritic cells...
  10. ncbi request reprint Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Nature 424:324-8. 2003
    ....
  11. ncbi request reprint Mannose receptor-mediated gene delivery into antigen presenting dendritic cells
    Sandra S Diebold
    Max Delbruck Centre for Molecular Medicine, MDC, Robert Rossle Str 10, D 13125 Berlin, Germany
    Somat Cell Mol Genet 27:65-74. 2002
    ..Here, we review the current understanding of mannose receptor-mediated gene delivery into dendritic cells and discuss strategies to identify appropriate endosomolytic agents to improve DNA transfer efficacy...
  12. ncbi request reprint Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines
    Alexander D Edwards
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, GB
    Eur J Immunol 33:827-33. 2003
    ..However, lack of TLR7 expression could restrict the involvement of CD8 alpha(+) DC in recognition of certain mouse pathogens...
  13. ncbi request reprint Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering
    Alexander D Edwards
    Immunobiology Laboratory, Cancer Research U K, London Research Institute, London, United Kingdom
    J Immunol 169:3652-60. 2002
    ..These results show that T cell feedback amplifies innate signals for cytokine production by DC and suggest that pattern recognition rather than ontogeny determines the production of cytokines by individual DC subsets...
  14. ncbi request reprint The impact of c-met/scatter factor receptor on dendritic cell migration
    Steffen M Kurz
    Max Delbruck Center for Molecular Medicine, MDC, Berlin, Germany
    Eur J Immunol 32:1832-8. 2002
    ..Our results suggest an important role of the c-met/SF system in DC/LC migration...