Affiliation: King's College London
- Testing for autoimmunity in humansDavid D'Cruz
The Lupus Research Unit, St Thomas Hospital, SE1 7EH, London, UK
Toxicol Lett 127:93-100. 2002..This review focuses on some of the major autoimmune rheumatic diseases and their associated autoantibody markers...
- The Euro-Lupus Nephritis Trial: the development of the sequential treatment protocolD P D'Cruz
The Rayne Institute, St Thomas Hospital, London
Lupus 18:875-7. 2009..In particular the prolonged high-dose regimen pioneered by the National Institutes of Health studies will no longer be used on account of its toxicity...
- Antiphospholipid (Hughes) syndrome: beyond pregnancy morbidity and thrombosisMaria Mialdea
The Lupus Research Unit, The Rayne Institute, 4thFloor, Lambeth Wing, St Thomas Hospital, London, SE1 7EH, UK
J Autoimmune Dis 6:3. 2009..We review a number of other manfestations including stenotic lesions, coronary artery disease and accelerated atherosclerosis, skeletal disorders and the concept of seronegative antiphospholipid syndrome...
- Renal manifestations of the antiphospholipid syndromeDavid D'Cruz
The Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, United Kingdom
Curr Rheumatol Rep 11:52-60. 2009..This article reviews the diagnosis and treatment of the major features of this syndrome, with particular reference to the kidney...
- Systemic lupus erythematosusDavid P D'Cruz
Lupus Research Unit, Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
Lancet 369:587-96. 2007..New therapeutic approaches, such as biological agents and mycophenolate mofetil, will also be discussed...
- Mycophenolate mofetil in systemic vasculitisD P D'Cruz
The Rayne Institute, St Thomas Hospital, London, UK
Lupus 14:s55-7. 2005..Mycophenolate mofetil (MMF) is increasingly being used in autoimmune disorders and this article reviews the use of this agent in the systemic vasculitides...
- Renal manifestations of the antiphospholipid syndromeD P D'Cruz
The Lupus Research Unit, The Rayne Institute St Thomas Hospital, London, UK
Lupus 14:45-8. 2005..The increasing risks of renal transplantation in antiphospholipid antibody positive patients is also discussed leading some authors to question whether these patients should undergo transplantation at all...
- Transverse myelitis as the first manifestation of systemic lupus erythematosus or lupus-like disease: good functional outcome and relevance of antiphospholipid antibodiesDavid P D'Cruz
Louise Coote Lupus Unit, St Thomas Hospital, London Rivermead Rehabilitation Centre, Oxford, United Kingdom
J Rheumatol 31:280-5. 2004..Although usually a late manifestation of SLE, it can occur at presentation. We investigated the clinical presentation, treatment and outcome of 15 patients with TM as the presenting manifestation of SLE or lupus-like disease...
- Drug-induced lupus and antiphospholipid syndrome associated with cysteamine therapyLeah Krischock
Department of Paediatric Nephrology, Evelina Children s Hospital, St Thomas Hospital, Westminster Bridge Road, London, UK
Nephrol Dial Transplant 24:1997-9. 2009..This is the first reported case of DIL and APS secondary to cysteamine therapy. Clinicians should exclude autoimmune abnormalities in patients with cystinosis, especially if patients report non-specific, unusual or unexplained symptoms...
- Native myocardial T1 mapping by cardiovascular magnetic resonance imaging in subclinical cardiomyopathy in patients with systemic lupus erythematosusValentina O Puntmann
Cardiovascular Imaging Department, Division of Imaging Sciences and Biomedical Engineering, King s College London, London, UK
Circ Cardiovasc Imaging 6:295-301. 2013..We investigated whether multiparametric imaging by cardiovascular magnetic resonance can detect differences between controls and asymptomatic SLE patients...
- Antibodies to apolipoprotein A-I, high-density lipoprotein, and C-reactive protein are associated with disease activity in patients with systemic lupus erythematosusSean G O'Neill
University College London, London, UK
Arthritis Rheum 62:845-54. 2010..We undertook this study to examine whether levels of these antibodies rise in association with increased SLE disease activity...
- Granulomatosis with polyangiitis involves sustained mucosal inflammation that is rich in B-cell survival factors and autoantigenYuan Zhao
Peter Gorer Department of Immunobiology, Guy s Hospital, London, UK
Rheumatology (Oxford) 51:1580-6. 2012..ANCAs specific for PR3 that is expressed by activated neutrophils and macrophages are associated with GPA. Our aim was to investigate regional immune mechanisms that might induce or support the autoimmune response in GPA...
- Primary Wegener's granulomatosis of the orbital apex with initial optic nerve infiltrationManoharan Shunmugam
Department of Ophthalmology, St Thomas Hospital, London, UK
Orbit 30:24-6. 2011..Wegener's granulomatosis should be considered in cases of isolated posterior optic neuropathy, and close attention should be placed on imaging the orbital apex...
- Dacryoadenitis and diffuse orbital inflammation: unusual first presentations of Churg-Strauss syndromeNatasha Jordan
St Thomas Hospital, Louise Coote Lupus Unit, London, United Kingdom
Orbit 30:160-1. 2011....