A S David

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Testing a neurobiological model of depersonalization disorder using repetitive transcranial magnetic stimulation
    Emma Louise Jay
    Section of Cognitive Neuropsychiatry, Department of Psychosis Studies, Institute of Psychiatry, King s College London, Denmark Hill, London SE5 8AF, UK
    Brain Stimul 7:252-9. 2014
  2. pmc Working alliance and its relationship to outcomes in a randomized controlled trial (RCT) of antipsychotic medication
    Til Wykes
    NIHR MHRN and Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    BMC Psychiatry 13:28. 2013
  3. pmc Associations of homelessness and residential mobility with length of stay after acute psychiatric admission
    Alex D Tulloch
    King s College London, King s Health Partners, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    BMC Psychiatry 12:121. 2012
  4. pmc Self-evaluation in schizophrenia: an fMRI study with implications for the understanding of insight
    Nicholas J Bedford
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    BMC Psychiatry 12:106. 2012
  5. pmc Failures of metacognition and lack of insight in neuropsychiatric disorders
    Anthony S David
    Section of Cognitive Neuropsychology, Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    Philos Trans R Soc Lond B Biol Sci 367:1379-90. 2012
  6. doi Effect of video self-observations vs. observations of others on insight in psychotic disorders
    Anthony S David
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College London, London, United Kingdom
    J Nerv Ment Dis 200:358-61. 2012
  7. doi Why we need more debate on whether psychotic symptoms lie on a continuum with normality
    A S David
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College, London, UK
    Psychol Med 40:1935-42. 2010
  8. ncbi Investigation of facial recognition memory and happy and sad facial expression perception: an fMRI study
    M L Phillips
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatry Res 83:127-38. 1998
  9. ncbi A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics
    M L Phillips
    Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London, UK
    Psychiatry Res 92:11-31. 1999
  10. ncbi Depersonalization disorder: thinking without feeling
    M L Phillips
    Depersonalization Research Unit and Division of Psychological Medicine, Institute of Psychiatry, 103 Denmark Hill, SE5 8AF, London, UK
    Psychiatry Res 108:145-60. 2001

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. pmc Testing a neurobiological model of depersonalization disorder using repetitive transcranial magnetic stimulation
    Emma Louise Jay
    Section of Cognitive Neuropsychiatry, Department of Psychosis Studies, Institute of Psychiatry, King s College London, Denmark Hill, London SE5 8AF, UK
    Brain Stimul 7:252-9. 2014
    ..Functional magnetic resonance imaging (fMRI) has pointed to ventrolateral prefrontal cortex (VLPFC) inhibition of insula as a neurocognitive correlate of the disorder...
  2. pmc Working alliance and its relationship to outcomes in a randomized controlled trial (RCT) of antipsychotic medication
    Til Wykes
    NIHR MHRN and Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    BMC Psychiatry 13:28. 2013
    ..Long acting injections (LAI) have been associated with perceptions of coercion in cross sectional studies but there have been no longitudinal studies of the effects on clinical relationships with newer depot medications...
  3. pmc Associations of homelessness and residential mobility with length of stay after acute psychiatric admission
    Alex D Tulloch
    King s College London, King s Health Partners, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    BMC Psychiatry 12:121. 2012
    ....
  4. pmc Self-evaluation in schizophrenia: an fMRI study with implications for the understanding of insight
    Nicholas J Bedford
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    BMC Psychiatry 12:106. 2012
    ..This study set out to compare cerebral activation in schizophrenia patients versus controls during a self-evaluation task which included positive and negative traits as well as mental and physical illness terms...
  5. pmc Failures of metacognition and lack of insight in neuropsychiatric disorders
    Anthony S David
    Section of Cognitive Neuropsychology, Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    Philos Trans R Soc Lond B Biol Sci 367:1379-90. 2012
    ..The medial frontal cortex appears to play an important role in self-appraisal in health and disease...
  6. doi Effect of video self-observations vs. observations of others on insight in psychotic disorders
    Anthony S David
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College London, London, United Kingdom
    J Nerv Ment Dis 200:358-61. 2012
    ..In conclusion, video self-confrontation seems to be a safe and potentially effective means of enhancing insight, but evidence for a specific effect is lacking...
  7. doi Why we need more debate on whether psychotic symptoms lie on a continuum with normality
    A S David
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College, London, UK
    Psychol Med 40:1935-42. 2010
    ..Finding the distinctive characteristics of psychotic phenomena in people with clinical disorders, in addition to their origins in 'normal' cognitive processes, is a worthwhile goal...
  8. ncbi Investigation of facial recognition memory and happy and sad facial expression perception: an fMRI study
    M L Phillips
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatry Res 83:127-38. 1998
    ....
  9. ncbi A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics
    M L Phillips
    Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London, UK
    Psychiatry Res 92:11-31. 1999
    ..We provide the first evidence for a distinction between two schizophrenic patient subgroups on the basis of recognition of and neural response to different negative facial expressions...
  10. ncbi Depersonalization disorder: thinking without feeling
    M L Phillips
    Depersonalization Research Unit and Division of Psychological Medicine, Institute of Psychiatry, 103 Denmark Hill, SE5 8AF, London, UK
    Psychiatry Res 108:145-60. 2001
    ....
  11. doi Regaining mental capacity for treatment decisions following psychiatric admission: a clinico-ethical study
    G S Owen
    Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, Western Education Centre, London, UK
    Psychol Med 41:119-28. 2011
    ..We sought to investigate the associations of regaining capacity to make treatment decisions following approximately 1 month of in-patient psychiatric treatment...
  12. doi Source memory errors in schizophrenia, hallucinations and negative symptoms: a synthesis of research findings
    G Brébion
    Institute of Psychiatry, King s College London, UK
    Psychol Med 42:2543-54. 2012
    ..We bring together here findings from a broad memory investigation to specify better the type of source memory failure that is associated with auditory and visual hallucinations...
  13. ncbi A specific neural substrate for perceiving facial expressions of disgust
    M L Phillips
    Department of Psychological Medicine, King s College School of Medicine and Dentistry, London, UK
    Nature 389:495-8. 1997
    ..The anterior insula is known to be involved in responses to offensive tastes. The neural response to facial expressions of disgust in others is thus closely related to appraisal of distasteful stimuli...
  14. ncbi Prevalence and predictors of mental incapacity in psychiatric in-patients
    Ruth Cairns
    Academic Department of Psychological Medicine, Institute of Psychiatry, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UK
    Br J Psychiatry 187:379-85. 2005
    ..Little is known about the proportion of psychiatric in-patients who lack capacity to make treatment decisions, or the associations of lack of capacity...
  15. ncbi The functional neuroanatomy of implicit-motion perception or representational momentum
    C Senior
    Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, London, UK
    Curr Biol 10:16-22. 2000
    ..We used functional magnetic resonance imaging (fMRI) to explore the neural substrate for representational momentum...
  16. doi The role of premorbid personality and cognitive factors in awareness of illness, memory, and behavioural functioning in Alzheimer's disease
    J Gilleen
    Psychological Medicine, Department of Old Age Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Cogn Neuropsychiatry 17:227-45. 2012
    ..Moreover, the study aims to contrast the strength of the relationship of premorbid personality and awareness with that of cognitive factors...
  17. ncbi A prospective study of the effects of anterior temporal lobectomy on emotion recognition and theory of mind
    P Shaw
    Section of Cognitive Neuropsychiatry, Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Neuropsychologia 45:2783-90. 2007
    ..The finding complements earlier demonstrations that damage to the right amygdala is associated with impaired processing of fear; amelioration of right amygdala function may conversely be associated with an improvement...
  18. ncbi Is semantic fluency differentially impaired in schizophrenic patients with delusions?
    S L Rossell
    Departments of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    J Clin Exp Neuropsychol 21:629-42. 1999
    ..The findings of reduced semantic fluency production and poor logical word associations may represent a disorganised storage of semantic information in deluded patients, which in turn affects efficient access...
  19. ncbi Differential effects of lesions of the amygdala and prefrontal cortex on recognizing facial expressions of complex emotions
    P Shaw
    Institute of Psychiatry, London
    J Cogn Neurosci 17:1410-9. 2005
    ..The results also suggest that the amygdala has a role in processing a wide range of emotional expressions...
  20. ncbi Towards a functional neuroanatomy of self processing: effects of faces and words
    T T Kircher
    Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, De Crespigny Park, SE5 8AF, London, UK
    Brain Res Cogn Brain Res 10:133-44. 2000
    ..The self-relevant stimuli engaged to a differential extent long term and working memory, semantic and emotional processes. We suggest that regions activated by these stimuli are engaged in self-processing...
  21. ncbi Reduced sensitivity to linguistic context in schizophrenic thought disorder: evidence from on-line monitoring for words in linguistically anomalous sentences
    G R Kuperberg
    Maudsley Hospital, London, United Kingdom
    J Abnorm Psychol 107:423-34. 1998
    ..These findings are consistent with the theory that schizophrenic thought disorder arises from a deficit in the use of linguistic context to process and produce speech...
  22. ncbi Improving performance on the WCST: variations on the original procedure. Wisconsin Card Sorting Test
    S L Rossell
    Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Schizophr Res 28:63-76. 1997
    ..The results indicate that WCST deficits in elderly controls are due to limited capacity, whereas in patient with schizophrenia, the problem may be due to the impaired monitoring of responses...
  23. ncbi Corpus callosum area and functioning in schizophrenic patients with auditory--verbal hallucinations
    S L Rossell
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry and GKT School of Medicine, London SE5 8AF, UK
    Schizophr Res 50:9-17. 2001
    ....
  24. pmc Domains of awareness in schizophrenia
    J Gilleen
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Schizophr Bull 37:61-72. 2011
    ..In conclusion, awareness is multiply fractionated and multiply determined. Therapeutic interventions could, therefore, produce beneficial changes within specific domains of awareness...
  25. ncbi Cortical substrates for the perception of face actions: an fMRI study of the specificity of activation for seen speech and for meaningless lower-face acts (gurning)
    R Campbell
    Department of Human Communication Science, University College London, Chandler House, 2 Wakefield Street, WC1 N1PF, London, UK
    Brain Res Cogn Brain Res 12:233-43. 2001
    ..However, some temporal regions, such as the posterior part of the right superior temporal sulcus, appear to be common processing sites for processing both seen speech and gurns...
  26. doi Hallucinations and two types of free-recall intrusion in schizophrenia
    G Brébion
    Department of Psychiatry, Institute of Psychiatry, King s College, London, UK
    Psychol Med 39:917-26. 2009
    ....
  27. ncbi Primary and secondary depersonalisation disorder: a psychometric study
    M V Lambert
    Depersonalisation Research Unit, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Affect Disord 63:249-56. 2001
    ..DISCUSSION: Depersonalisation disorder comprises a measurable cluster of symptoms which may be quantified with the help of self-report scales. Primary and secondary forms overlap, with depressed mood a frequent feature...
  28. ncbi A critical period for the impact of amygdala damage on the emotional enhancement of memory?
    P Shaw
    Department of Psychological Medicine, Institute of Psychiatry, PO Box 68, De Crespigny Park, London SE5 8AF, UK
    Neurology 65:326-8. 2005
    ..This adds to evidence for an early critical period in the development of amygdala function...
  29. doi Psychiatric nurses' attitudes to antipsychotic depots in Hong Kong and comparison with London
    M X Patel
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    J Psychiatr Ment Health Nurs 15:758-66. 2008
    ..001). In conclusion, therefore, international variation exists and encompasses clinical practice aspects for both the patient and the depot formulation per se. Our participants wanted more involvement in treatment decision making...
  30. doi The determinants and outcomes of long-stay psychiatric admissions: a case-control study
    Alex D Tulloch
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    Soc Psychiatry Psychiatr Epidemiol 43:569-74. 2008
    ..Previous studies have suggested an association between long-stay and both schizophrenia and challenging behaviour, as well as rehousing or placement difficulties, but no UK study to date has compared such cases with control admissions...
  31. doi Correlates, change and 'state or trait' properties of insight in schizophrenia
    Benjamin D R Wiffen
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Schizophr Res 122:94-103. 2010
    ..The associations of insight into illness and clinical and socio-demographic variables in schizophrenia have been examined, yet little attention has been given to premorbid functioning, insight change and outcomes...
  32. ncbi The role of 'shared representations' in social perception and empathy: an fMRI study
    E J Lawrence
    Section of Cognitive Neuropsychiatry, PO Box 68, Institute of Psychiatry and GKT School of Medicine, Denmark Hill, London SE5 8AF, UK
    Neuroimage 29:1173-84. 2006
    ..Activity in the rostral anterior cingulate was associated with self-reports of personal distress and increased blood flow to the anterior cingulate (BA24) and inferior parietal cortex (BA40) was related to self-other overlap...
  33. pmc Schizophrenia-like psychosis arising de novo following a temporal lobectomy: timing and risk factors
    P Shaw
    Departments of Psychological Medicine, Institute of Psychiatry and Guy s, King s and St Thomas Medical School, London, UK
    J Neurol Neurosurg Psychiatry 75:1003-8. 2004
    ....
  34. ncbi Mental capacity, diagnosis and insight in psychiatric in-patients: a cross-sectional study
    G S Owen
    Departments of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, UK
    Psychol Med 39:1389-98. 2009
    ..Because it is a legal concept there is a need to clarify associations with variables that clinicians are more familiar with, especially insight...
  35. pmc Hand and mouth: cortical correlates of lexical processing in British Sign Language and speechreading English
    Cheryl M Capek
    Deafness Cognition and Language Research Centre DCAL, University College London, London, UK
    J Cogn Neurosci 20:1220-34. 2008
    ..Distinct regions within the temporal cortex are not only differentially sensitive to perception of the distinctive articulators for speech and for sign but also show sensitivity to the different articulators within the (signed) language...
  36. ncbi Dissociating linguistic and nonlinguistic gestural communication in the brain
    Mairead MacSweeney
    Department of Human Communication Science, University College London, London, WC1N 1PG, UK
    Neuroimage 22:1605-18. 2004
    ..This suggests that the left posterior perisylvian cortex is of fundamental importance to language processing, regardless of the modality in which it is conveyed...
  37. ncbi Cortical activity during rotational and linear transformations
    J Barnes
    Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, University of London, Malet Street, WC1E 7HX, London, UK
    Neuropsychologia 38:1148-56. 2000
    ..The findings demonstrate the extent to which neural substrates for image transformation and perception overlap and are distinct as well as revealing functional specialisation within perception and transformation processing systems...
  38. doi Psychiatrists' use, knowledge and attitudes to first- and second-generation antipsychotic long-acting injections: comparisons over 5 years
    M X Patel
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    J Psychopharmacol 24:1473-82. 2010
    ..Concerns about patient acceptance continue as do negative views about some aspects of LAI use; these may compromise medication choices offered to patients...
  39. ncbi Perception of facial and vocal affect by people with schizophrenia in early and late stages of illness
    Katarzyna Kucharska-Pietura
    Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 187:523-8. 2005
    ..Emotion recognition impairments have been demonstrated in schizophrenia, but few studies have examined whether these reflect generalised or specific perceptual deficits or are associated with illness course...
  40. ncbi The perception of emotional chimeric faces in patients with depression, mania and unilateral brain damage
    Katarzyna Kucharska-Pietura
    Section of Cognitive Neuropsychiatry, Department of Psychological Medicine, Institute of Psychiatry, London
    Psychol Med 33:739-45. 2003
    ..The aim of this work was to examine lateral perceptual bias in bipolar I and II patients in a hypomanic state and unipolar depressed patients and those with unilateral hemisphere damage following stroke...
  41. ncbi Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study
    J H MacCabe
    Department of Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 38:1133-40. 2008
    ..We investigated whether school performance at age 16 is associated with risk of adult schizophrenia and other psychoses in a large national cohort, while controlling for multiple confounders...
  42. ncbi Are auditory hallucinations the consequence of abnormal cerebral lateralization? A morphometric MRI study of the sylvian fissure and planum temporale
    J Shapleske
    Institute of Psychiatry and GKT School of Medicine, Section of Cognitive Neuropsychiatry, London SE5 8AF, UK
    Biol Psychiatry 49:685-93. 2001
    ....
  43. doi Are depot antipsychotics more coercive than tablets? The patient's perspective
    M X Patel
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    J Psychopharmacol 24:1483-9. 2010
    ..Although forced medication is sometimes required, the experience of coercion should be minimised by giving patients a fair say in treatment decisions, regardless of formulation...
  44. ncbi An investigation into the perception of dominance from schematic faces: a study using the World-Wide Web
    C Senior
    Institute of Psychiatry, School of Medicine and Dentistry, London, England
    Behav Res Methods Instrum Comput 31:341-6. 1999
    ..Young North American males were overrepresented in our sample, but comparison with other surveys indicates that the population sampled by the Internet is becoming more representative...
  45. ncbi Systematic review of patient and nurse attitudes to depot antipsychotic medication
    J Walburn
    Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 179:300-7. 2001
    ..What data there are show a positive attitude to depots from patients. Future randomised controlled trials should include satisfaction as an outcome...
  46. ncbi Common and distinct neural substrates for pragmatic, semantic, and syntactic processing of spoken sentences: an fMRI study
    G R Kuperberg
    Institute of Psychiatry, London
    J Cogn Neurosci 12:321-41. 2000
    ..We suggest that this region may play a key role in using pragmatic, semantic (selection restriction), and subcategorical information to construct a higher representation of meaning of sentences...
  47. ncbi Autonomic response in the perception of disgust and happiness in depersonalization disorder
    Mauricio Sierra
    Institute of Psychiatry, Denmark Hill, London, UK
    Psychiatry Res 145:225-31. 2006
    ..The findings of this study provide further support to the idea that patients with depersonalization have a selective impairment in the processing of threatening or unpleasant emotional stimuli...
  48. ncbi A computational morphometric MRI study of schizophrenia: effects of hallucinations
    Jane Shapleske
    Department of Psychological Medicine, Institute of Psychiatry, London SE5 8AF, UK
    Cereb Cortex 12:1331-41. 2002
    ....
  49. doi Relationship between post-operative depression/anxiety and hippocampal/amygdala volumes in temporal lobectomy for epilepsy
    Thomas Paparrigopoulos
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College London, DeCrespigny Park, London, United Kingdom
    Epilepsy Res 81:30-5. 2008
    ..The objective of the study was to investigate the relationship between post-operative depressive/anxiety symptoms and hippocampal/amygdala volumes following anterior temporal lobectomy...
  50. pmc Outcome of first-episode schizophrenia in India: longitudinal study of effect of insight and psychopathology
    Balasubramanian Saravanan
    Section of Cognitive Neuropsychiatry, PO Box 68, Institute of Psychiatry, King s College London, Denmark Hill, London SE58AF, UK
    Br J Psychiatry 196:454-9. 2010
    ..Transcultural studies have found lack of insight to be an almost invariable feature of acute and chronic schizophrenia, but its influence on prognosis is unclear...
  51. ncbi Reliability of mental capacity assessments in psychiatric in-patients
    Ruth Cairns
    Academic Department of Psychological Medicine, Institute of Psychiatry, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UK
    Br J Psychiatry 187:372-8. 2005
    ..Previous work on the reliability of mental capacity assessments in patients with psychiatric illness has been limited...
  52. ncbi Cross-modal semantic priming in schizophrenia
    Simon Surguladze
    Division of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
    J Int Neuropsychol Soc 8:884-92. 2002
    ....
  53. ncbi The cognitive neuropsychiatry of delusions: from psychopathology to neuropsychology and back again
    James Gilleen
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, London, UK
    Psychol Med 35:5-12. 2005
    ..Here we present a review of the contributions from various disciplines, principally cognitive neuroscience, towards a new understanding...
  54. ncbi Prevalence of mental incapacity in medical inpatients and associated risk factors: cross-sectional study
    Vanessa Raymont
    Institute of Psychiatry, King s College London, UK
    Lancet 364:1421-7. 2004
    ....
  55. doi Influence of COMT val158met and ADRA2B deletion polymorphisms on recollection and familiarity components of human emotional memory
    K H Naudts
    Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, London, UK
    J Psychopharmacol 26:819-29. 2012
    ..There were no main effects or interactions in relation to ADRA2B genotype...
  56. ncbi The impact of early and late damage to the human amygdala on 'theory of mind' reasoning
    P Shaw
    Section of Cognitive Neuropsychiatry, Department of Psychological Medicine, Centre for Neuroscience Research, King s College, London, UK
    Brain 127:1535-48. 2004
    ..We conclude that the amygdala may play an important role in the neural systems supporting the normal development of ToM reasoning...
  57. doi Insight in eating disorders: clinical and cognitive correlates
    G Konstantakopoulos
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College, London, UK
    Psychol Med 41:1951-61. 2011
    ..The aim of this study was to explore the extent of lack of insight and its components in eating disorders (EDs) and to investigate the relationship between insight and clinical and cognitive characteristics in this group...
  58. doi Empathy and enduring depersonalization: the role of self-related processes
    Emma J Lawrence
    Section of Cognitive Neuropsychiatry, Department of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Soc Neurosci 2:292-306. 2007
    ..These findings suggest affective empathy to be reliant on intact emotional experience in the observer. In addition, excessive self-focus may be detrimental to an empathic response...
  59. doi Role of processing speed and premorbid IQ on visual recognition in patients with schizophrenia
    Gildas Brébion
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    J Clin Exp Neuropsychol 31:302-11. 2009
    ..These data suggest that premorbid IQ is involved in visual-recognition efficiency. However, the deficit observed in patients is accounted for by decreased processing speed...
  60. doi Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study
    James H MacCabe
    Department of Psychiatry, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Br J Psychiatry 196:109-15. 2010
    ..Anecdotal and biographical reports suggest that bipolar disorder may be associated with high IQ or creativity, but evidence for any such connection is weak...
  61. doi Visual hallucinations in schizophrenia: confusion between imagination and perception
    Gildas Brébion
    Institute of Psychiatry, King s College, London
    Neuropsychology 22:383-9. 2008
    ..The aim of this study was to investigate the association between visual hallucinations and a specific type of reality-monitoring deficit, namely confusion between imagined and perceived pictures...
  62. pmc Impairments in cognition across the spectrum of psychiatric disorders: evidence from a Swedish conscript cohort
    Anthony S David
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College, London, UK
    Schizophr Bull 34:1035-41. 2008
    ..Cognitive deficits are widespread in psychiatric disorders and should be taken into account in clinical interactions...
  63. doi Insight: demographic differences and associations with one-year outcome in schizophrenia and schizoaffective disorder
    Benjamin D R Wiffen
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, UK
    Clin Schizophr Relat Psychoses 4:169-75. 2010
    ..This study aims to quantify the association of insight with outcome, sociodemographic variables and diagnosis in a large stable patient sample...
  64. ncbi Self-awareness after acquired and traumatic brain injury
    Laura J Bach
    Lishman Brain Injury Unit, Maudsley Hospital, Denmark Hill, London, UK
    Neuropsychol Rehabil 16:397-414. 2006
    ..Theory of mind ability was related to self-awareness and a possible role for metacognition and affective processes in self-awareness is discussed to account for social self-awareness deficits...
  65. pmc The mental health of UK Gulf war veterans: phase 2 of a two phase cohort study
    Khalida Ismail
    Gulf War Illnesses Research Unit, Guy s, King s, and St Thomas s School of Medicine, London SE5 8AZ
    BMJ 325:576. 2002
    ....
  66. doi Processing speed deficits in schizophrenia: reexamining the evidence
    Emma E M Knowles
    Department of Psychosis Studies, Institute of Psychiatry, King s Health Partners, King s College London, De Crespigny Park, London, SE5 8AF UK
    Am J Psychiatry 167:828-35. 2010
    ..The authors present an extended meta-analysis of processing speed and other specific cognitive functions in schizophrenia and examine the role of potential moderator variables...
  67. doi Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance
    Ayana A Gibbs
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College London, United Kingdom
    Eur Neuropsychopharmacol 20:272-5. 2010
    ..Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to met(158) carriers...
  68. pmc Mental capacity and psychiatric in-patients: implications for the new mental health law in England and Wales
    Gareth S Owen
    Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London SE5 9RJ, UK
    Br J Psychiatry 195:257-63. 2009
    ..In England and Wales mental health services need to take account of the Mental Capacity Act 2005 and the Mental Health Act 1983. The overlap between these two causes dilemmas for clinicians...
  69. doi Neural response to specific components of fearful faces in healthy and schizophrenic adults
    Joaquim Radua
    King s College London Institute of Psychiatry, London, UK
    Neuroimage 49:939-46. 2010
    ..PCA-based analysis could be useful in isolating brain response to salient facial features in psychiatric populations...
  70. doi Depression, avolition, and attention disorders in patients with schizophrenia: associations with verbal memory efficiency
    Gildas Brébion
    Unit of Research and Development, Sant Joan de Déu Serveis de Salut Mental, C Doctor Antoni Pujadas 42, 08830 Sant Boi de Llobregat, Barcelona, Spain
    J Neuropsychiatry Clin Neurosci 21:206-15. 2009
    ..It is suggested that more consideration should be given to depression and motivation in the investigation of cognitive impairment in schizophrenia, as well as in cognitive remediation strategies...
  71. doi Working memory span and motor and cognitive speed in schizophrenia
    Gildas Brébion
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Cogn Behav Neurol 22:101-8. 2009
    ..The aim of this study was to investigate the verbal working memory deficit and decrease of motor and cognitive speed in patients with schizophrenia, and to clarify their associations with negative and depressive symptomatology...
  72. ncbi Autonomic response in depersonalization disorder
    Mauricio Sierra
    Institute of Psychiatry, 103 Denmark Hill, London SE5 8AZ, England
    Arch Gen Psychiatry 59:833-8. 2002
    ..In this study, we tested the prediction that autonomic response to emotional stimuli would be reduced in patients with depersonalization disorder...
  73. doi Production of atypical category exemplars in patients with schizophrenia
    Gildas Brébion
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College London, London, UK
    J Int Neuropsychol Soc 16:822-8. 2010
    ..This semantic abnormality is not a feature of the patients with high ratings of certain negative symptoms...
  74. doi Psychiatric disorders in temporal lobe epilepsy: an overview from a tertiary service in Brazil
    Guilherme Nogueira M de Oliveira
    Neuropsychiatric Unit, Neurology Division, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Seizure 19:479-84. 2010
    ..To evaluate the frequency and intensity of psychiatric disorders in a group of temporal lobe epilepsy (TLE) patients from a tertiary-care center...
  75. ncbi Depersonalization and individualism: the effect of culture on symptom profiles in panic disorder
    Mauricio Sierra-Siegert
    Depersonalization Research Unit, Institute of Psychiatry, King s College, London, UK
    J Nerv Ment Dis 195:989-95. 2007
    ..Two features may be relevant in the genesis of depersonalization...
  76. ncbi Predictors of amygdala activation during the processing of emotional stimuli: a meta-analysis of 385 PET and fMRI studies
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, UK
    Brain Res Rev 58:57-70. 2008
    ..Methodological variables, such as type of analysis and magnet strength, were also independent predictors of amygdala activation...
  77. ncbi Chronic depersonalization following illicit drug use: a controlled analysis of 40 cases
    Nicholas Medford
    Depersonalization Research Unit and Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Addiction 98:1731-6. 2003
    ....
  78. ncbi Processing speed: a strong predictor of verbal memory performance in schizophrenia
    Gildas Brébion
    Institute of Psychiatry, London, UK
    J Clin Exp Neuropsychol 28:370-82. 2006
    ..These findings suggest that slowing in processing speed is an important contributor to verbal memory impairment in patients with schizophrenia. The possible role of various specific slowing functions is discussed...
  79. ncbi Social outcomes in schizophrenia: from description to action
    Alex D Tulloch
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Curr Opin Psychiatry 19:140-4. 2006
    ..The studies we reviewed looked at the effects on summary measures, for example, quality of life, as well as simpler, more self-explanatory outcomes such as employment, marital status, financial independence and housing...
  80. ncbi A systematic review and quantitative appraisal of fMRI studies of verbal fluency: role of the left inferior frontal gyrus
    Sergi G Costafreda
    Brain Image Analysis Unit, Department of Biostatistics and Computing, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 27:799-810. 2006
    ..The results support distinct dorsal-ventral locations for phonologic and semantic processes within the LIFG. Current limitations to meta-analytic integration of published functional neuroimaging studies are discussed...
  81. ncbi A reversal of the normal pattern of parahippocampal response to neutral and fearful faces is associated with reality distortion in schizophrenia
    Simon Surguladze
    Division of Psychological Medicine, Kings College London Institute and Brain Image Analysis Unit of Psychiatry, London, UK
    Biol Psychiatry 60:423-31. 2006
    ..The neural mechanisms underlying this deficit and the relationship with different symptoms remain poorly understood...
  82. ncbi Cognitive-behaviour therapy for depersonalisation disorder: an open study
    Elaine C M Hunter
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Behav Res Ther 43:1121-30. 2005
    ..These initial results suggest that a CBT approach to DPD may be effective, but further trials with larger sample sizes and more rigorous research methodology are needed to determine the specificity of this approach...
  83. ncbi Hallucinations, negative symptoms, and response bias in a verbal recognition task in schizophrenia
    Gildas Brébion
    Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Neuropsychology 19:612-7. 2005
    ..Hallucinations and anhedonia therefore presented an opposite association with the response bias. The influence of word frequency and delay on this association is discussed...
  84. ncbi Deriving meaning: Distinct neural mechanisms for metaphoric, literal, and non-meaningful sentences
    Argyris K Stringaris
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College London, Denmark Hill, London SE5 8AF, UK
    Brain Lang 100:150-62. 2007
    ..In contrast to previous studies, our results do not support the view the right hemispheric is specifically involved in metaphor comprehension...
  85. ncbi Perception of emotions from faces and voices following unilateral brain damage
    Katarzyna Kucharska-Pietura
    Section of Cognitive Neuropsychiatry, Division of Psychological Medicine, Institute of Psychiatry P068, De Crespigny Park, London SE5 8AF, UK
    Neuropsychologia 41:1082-90. 2003
    ..It is possible that the left hemisphere has a particular role in the perception of emotion conveyed through meaningful speech...
  86. ncbi Emotional memory: separating content and context
    Nicholas Medford
    Section of Cognitive Neuropsychiatry, Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, King s College, London SE5 8AF, UK
    Psychiatry Res 138:247-58. 2005
    ..These findings, if applicable to the wider population, may have application in a range of psychiatric disorders where interactions between emotion and cognition are relevant...
  87. doi Increased inferior frontal activation during word generation: a marker of genetic risk for schizophrenia but not bipolar disorder?
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:3287-98. 2009
    ..Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia...
  88. ncbi Prognostic indicators for early discontinuation of risperidone long-acting injection
    Maxine X Patel
    Division of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, De Crespigny Park, London, UK
    Int Clin Psychopharmacol 19:233-9. 2004
    ..RLAI discontinuation is high early on but subsequently tapers off. Preceding antipsychotic type (depot versus oral) is a stronger prognostic indicator than treatment refractoriness for RLAI discontinuation...
  89. ncbi Semantic organization and verbal memory efficiency in patients with schizophrenia
    Gildas Brébion
    Division of Psychological Medicine, Institute of Psychology, King s College London, London, United Kingdom
    Neuropsychology 18:378-83. 2004
    ..These results suggest that depth of semantic organization is a crucial factor of verbal memory performance in schizophrenia. However, semantic organizational deficit does not account for the whole recall impairment...
  90. ncbi Cellular immune activation in Gulf War veterans
    Anna Skowera
    Department of Immunobiology, King s and St Thomas School of Medicine, King s College London, London, UK
    J Clin Immunol 24:66-73. 2004
    ..05) but no changes in other cytokines. These data show that multisymptom illness in Gulf War veterans is characterized by ongoing Th1-type immune activation and a biased generation of memory cells secreting the suppressor cytokine, IL-10...
  91. ncbi Time-resolved fMRI of mental rotation revisited--dissociating visual perception from mental rotation in female subjects
    Christine Ecker
    Brain Image Analysis Unit, PO Box 89, Centre for Neuroimaging Sciences CNS, Institute of Psychiatry, King s College London, DeCrespigny Park, London, SE5 8AF, UK
    Neuroimage 32:432-44. 2006
    ....
  92. ncbi Depersonalization in psychiatric patients: a transcultural study
    Mauricio Sierra
    Depersonalization Research Unit, Institute of Psychiatry, King s College, London, UK
    J Nerv Ment Dis 194:356-61. 2006
    ....
  93. ncbi The effect of long-acting risperidone on working memory in schizophrenia: a functional magnetic resonance imaging study
    Simon A Surguladze
    Department of Psychiatry, King s College London Institute of Psychiatry, De Crespigny Park, London, UK
    J Clin Psychopharmacol 27:560-70. 2007
    ..We conclude that RLAI may contribute to normalization of brain activation in regions involved in working memory functioning in people with chronic schizophrenia...
  94. ncbi Unpacking the depersonalization syndrome: an exploratory factor analysis on the Cambridge Depersonalization Scale
    Mauricio Sierra
    Depersonalization Research Unit, Psychological Medicine, Institute of Psychiatry, Denmark Hill, London
    Psychol Med 35:1523-32. 2005
    ..Depersonalization has long been considered a syndrome but there is poor agreement on its constituent symptoms...
  95. ncbi Are people with schizophrenia more logical than healthy volunteers?
    Gareth S Owen
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Br J Psychiatry 191:453-4. 2007
    ..The study is an example of how experimental psychopathology can illuminate areas of philosophical dispute that are difficult to settle by thought alone...
  96. ncbi Visual memory errors in schizophrenic patients with auditory and visual hallucinations
    Gildas Brébion
    Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    J Int Neuropsychol Soc 13:832-8. 2007
    ..In conclusion, the association between hallucinations and response bias extends across modalities to picture recognition. The association between hallucinations and temporal context impairment extends to spatial context...
  97. ncbi Limbic and prefrontal responses to facial emotion expressions in depersonalization
    Erwin Lemche
    Section of Neuroscience and Emotion, Brain Image Analysis Unit, Neuroimaging Research Group, Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK
    Neuroreport 18:473-7. 2007
    ....
  98. ncbi Imaging repressed memories in motor conversion disorder
    Richard A A Kanaan
    Department of Psychological Medicine, King s College London, Institute of Psychiatry, London, UK
    Psychosom Med 69:202-5. 2007
    ..This makes assessments based on subjective reports unreliable. We circumvent this by using a standardized method to quantify stressful life events and by assessing objectively the neural correlates of emotion processing...
  99. ncbi Role of processing speed and depressed mood on encoding, storage, and retrieval memory functions in patients diagnosed with schizophrenia
    Gildas Brébion
    Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    J Int Neuropsychol Soc 13:99-107. 2007
    ..Neither processing speed nor depressed mood was associated with storage efficiency. It is concluded that both cognitive speed slowing and depressed mood impact on effortful encoding processes...
  100. ncbi Temporal context discrimination in patients with schizophrenia: associations with auditory hallucinations and negative symptoms
    Gildas Brébion
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, London, UK
    Neuropsychologia 45:817-23. 2007
    ..A deficit in remembering the temporal context of events (a type of source memory) has been observed in schizophrenia, and suggested to be associated with positive symptoms...
  101. ncbi Lamotrigine as an add-on treatment for depersonalization disorder: a retrospective study of 32 cases
    Mauricio Sierra
    Depersonalisation Research Unit, Psychological Medicine, Institute of Psychiatry, London, UK
    Clin Neuropharmacol 29:253-8. 2006
    ..Lamotrigine as sole agent was not found to be effective in a previous small double-blind, randomized crossover trial. However, evidence from open trials suggests that it may be beneficial as an add-on medication with antidepressants...