David J Cousins

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi Therapeutic approaches for control of transcription factors in allergic disease
    David J Cousins
    MRC Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, United Kingdom
    J Allergy Clin Immunol 121:803-9; quiz 810-1. 2008
  2. ncbi Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines
    David J Cousins
    Department of Respiratory Medicine and Allergy, GKT School of Medicine, King s College, London, United Kingdom
    J Immunol 169:2498-506. 2002
  3. ncbi Fibronectin is a TH1-specific molecule in human subjects
    Hilary Sandig
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, Guy s Hospital, London, United Kingdom
    J Allergy Clin Immunol 124:528-35, 535.e1-5. 2009
  4. ncbi Human Th2 cells selectively express the orexigenic peptide, pro-melanin-concentrating hormone
    Hilary Sandig
    Medical Research Council Asthma U K Centre in Allergic Mechanisms of Asthma and Genomics Centre, King s College London, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 104:12440-4. 2007
  5. ncbi Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1
    Celine N Parmentier
    King s College London, London, UK
    J Allergy Clin Immunol 129:1136-42. 2012
  6. ncbi IL-2 regulates expression of C-MAF in human CD4 T cells
    Aradhana Rani
    Department of Immunobiology, King s College London, London SE1 9RT, United Kingdom
    J Immunol 187:3721-9. 2011
  7. ncbi DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation
    Samantha Santangelo
    Department of Respiratory Medicine and Allergy, King s College, London, United Kingdom
    J Immunol 169:1893-903. 2002
  8. ncbi Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function
    Zoe Urry
    MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, United Kingdom
    J Clin Invest 119:387-98. 2009
  9. ncbi Regulation of GM-CSF expression by the transcription factor c-Maf
    Jane Gilmour
    Medical Research Council and Asthma UK Center in Allergic Mechanisms of Asthma, King s College London, Guy s Hospital, London, UK
    J Allergy Clin Immunol 120:56-63. 2007
  10. ncbi Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma
    Katharina Mahn
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 106:10775-80. 2009

Collaborators

  • Tak H Lee
  • James E Pease
  • Catherine M Hawrylowicz
  • Richard G Jenner
  • Brian J O'Connor
  • Sun Ying
  • F Chung
  • S J Hirst
  • K Fan Chung
  • J P Ward
  • Joanne McDonald
  • Hilary Sandig
  • Jane Gilmour
  • Paul Lavender
  • Celine N Parmentier
  • Holly Bowen
  • Aradhana Rani
  • Samantha Santangelo
  • Katharina Mahn
  • Christopher J Corrigan
  • Zoe Urry
  • Zahid Sattar
  • David F Richards
  • Matthew Arno
  • Kai Yin Chau
  • David F Rogan
  • Dontcho Z Staynov
  • Grzegorz Woszczek
  • Elisabeth Fuerst
  • Stipo Jurcevic
  • Aditi S Kanhere
  • Mark Hackett
  • Susan John
  • Behdad Afzali
  • Lemlem Tewolde-Berhan
  • Audrey Kelly
  • Jack A Ragheb
  • Isabela Pedroza-Pacheco
  • Mark R Holt
  • Charlotta Karner
  • K Fan Chung
  • Clare G McVicker
  • Zarin Brown
  • Vladimir A Snetkov
  • David E Simcock
  • Patricia Macedo
  • Leonard Siew
  • Oluwaseun O Ojo
  • Emma Hickman
  • Emmanuel Xystrakis
  • Varsha Kanabar
  • Andrea M Keane-Myers
  • Santa Jeremy Ono
  • Alfredo Fusco
  • Remi J Creusot
  • Guidalberto Manfioletti
  • Lisa Menozzi
  • Kai-Yin Chau
  • Monica Fedele
  • Yasuhiro Ikeda
  • Lionel Feigenbaum
  • Panayiotis A Ioannou
  • Michael Antoniou
  • Nicole E E Winkelmann

Detail Information

Publications12

  1. ncbi Therapeutic approaches for control of transcription factors in allergic disease
    David J Cousins
    MRC Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, United Kingdom
    J Allergy Clin Immunol 121:803-9; quiz 810-1. 2008
    ..In this review we examine the role of each transcription factor in allergic disease and discuss approaches that have been taken to therapeutically interfere with transcription factor function in allergic disease...
  2. ncbi Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines
    David J Cousins
    Department of Respiratory Medicine and Allergy, GKT School of Medicine, King s College, London, United Kingdom
    J Immunol 169:2498-506. 2002
    ....
  3. ncbi Fibronectin is a TH1-specific molecule in human subjects
    Hilary Sandig
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, Guy s Hospital, London, United Kingdom
    J Allergy Clin Immunol 124:528-35, 535.e1-5. 2009
    ..A major T(H)1-mediated effector mechanism involves the IFN-gamma-induced killing of the pathogen by infected macrophages...
  4. ncbi Human Th2 cells selectively express the orexigenic peptide, pro-melanin-concentrating hormone
    Hilary Sandig
    Medical Research Council Asthma U K Centre in Allergic Mechanisms of Asthma and Genomics Centre, King s College London, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 104:12440-4. 2007
    ....
  5. ncbi Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1
    Celine N Parmentier
    King s College London, London, UK
    J Allergy Clin Immunol 129:1136-42. 2012
    ..Recent data have implicated CysLTs in the establishment and amplification of T(H)2 responses in murine models, although the precise mechanisms are unresolved...
  6. ncbi IL-2 regulates expression of C-MAF in human CD4 T cells
    Aradhana Rani
    Department of Immunobiology, King s College London, London SE1 9RT, United Kingdom
    J Immunol 187:3721-9. 2011
    ..Thus, our findings demonstrate the importance of IL-2 in Th2 differentiation in human T cells and support the notion that IL-2R-directed therapies may have utility in the treatment of allergic disorders...
  7. ncbi DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation
    Samantha Santangelo
    Department of Respiratory Medicine and Allergy, King s College, London, United Kingdom
    J Immunol 169:1893-903. 2002
    ....
  8. ncbi Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function
    Zoe Urry
    MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, United Kingdom
    J Clin Invest 119:387-98. 2009
    ..We therefore suggest that TLR9 could be used to monitor and potentially modulate the function of 1alpha25VitD3-induced IL-10-secreting Treg in vivo, and that this has implications in cancer therapy and vaccine design...
  9. ncbi Regulation of GM-CSF expression by the transcription factor c-Maf
    Jane Gilmour
    Medical Research Council and Asthma UK Center in Allergic Mechanisms of Asthma, King s College London, Guy s Hospital, London, UK
    J Allergy Clin Immunol 120:56-63. 2007
    ....
  10. ncbi Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma
    Katharina Mahn
    Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 106:10775-80. 2009
    ..Our findings implicate a deficiency in SERCA2 in ASM in asthma that contributes to its secretory and hyperproliferative phenotype in asthma, and which may play a key role in mechanisms of airway remodeling...
  11. ncbi Analysis of intergenic transcription in the human IL-4/IL-13 gene cluster
    David F Rogan
    Department of Asthma, Allergy, and Respiratory Science, Guy s, King s, and St Thomas School of Medicine, King s College London, London SE1 9RT, UK
    Proc Natl Acad Sci U S A 101:2446-51. 2004
    ..These results support a progressive differentiation model of T cell lineage commitment...
  12. ncbi IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1
    Kai Yin Chau
    Department of Immunology, Institute of Ophthalmology, University College London and Moorfields Eye Hospital, NHS Foundation Trust, 11 43 Bath Street, London EC1V 9EL, UK
    Int Immunol 17:297-306. 2005
    ..In vitro binding assays further demonstrated a specific interaction of HMGA1 to defined regions of the IFNG gene proximal promoter...