Research Topics
| D CotterSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Evidence for altered neuronal organisation within the planum temporale in major psychiatric disordersClare L Beasley
Department of Neuropathology, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
Schizophr Res 73:69-78. 2005..We propose that alterations in cortical cytoarchitecture within this region are subtle and involve reduced clustering of neurons, which may be due to altered neuronal organisation within cortical mini-columns or within cortical layers...- Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorderDavid Cotter
Department of Psychological Medicine and Neuropathology, Section of Experimental Neuropathology and Psychiatry, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
Cereb Cortex 12:386-94. 2002.... - Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorderD Cotter
Department of Psychological Medicine and Neuropathology, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 58:545-53. 2001..In this investigation, we have simultaneously assessed glial cell density and neuronal density and size in the anterior cingulate cortex in schizophrenia, major depressive disorder, and bipolar disorder... - Cortical selective vulnerability in motor neuron disease: a morphometric studyS Maekawa
Department of Neurology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Brain 127:1237-51. 2004..These findings support the notion that MND should be considered a multisystem disorder... - Increased dendritic MAP2 expression in the hippocampus in schizophreniaD Cotter
Department of Neuropathology, Institute of Psychiatry, London, UK
Schizophr Res 41:313-23. 2000..These findings add to the growing literature indicating the presence of synaptodendritic abnormalities in schizophrenia... - Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophreniaC Beasley
Department of Neuropathology, Institute of Psychiatry, DeCrespigny Park, SE5 8AF, London, UK
Neurosci Lett 302:117-20. 2001..This provides further evidence for an abnormality of the Wnt signalling pathway in schizophrenia... - The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophreniaDavid Cotter
Department of Psychological Medicine, Section of Experimental Neuropathology and PsychiatryInstitute of Psychiatry, London, United Kingdom
Biol Psychiatry 51:377-86. 2002..The findings indicate that there may be a pathophysiological condition, shared by subjects with schizophrenia and BPD, which operates to selectively reduce the number or protein expression of CB-immunoreactive neurons... - Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorderFiona Gaughran
Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
Brain Res Bull 70:221-7. 2006..We determined the distribution of hippocampal FGF-2 and its receptor (FGFR1) mRNA in post-mortem brains of people who suffered from major depression, bipolar disorder and schizophrenia and those of controls... - Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changesClare L Beasley
Department of Psychological Medicine, Institute of Psychiatry, London, UK
Proteomics 6:3414-25. 2006..These findings provide support for the view that cytoskeletal and mitochondrial dysfunction are important components of the neuropathology of the major psychiatric disorders... - Evidence for orbitofrontal pathology in bipolar disorder and major depression, but not in schizophreniaDavid Cotter
Department of Psychiatry, Education and Research Centre, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland
Bipolar Disord 7:358-69. 2005..Lesion studies and functional neuroimaging investigations implicate this region in affective disorders, and altered neuronal and glial cell composition have been observed in this region in subjects with major depressive disorder (MDD)... - Cell density and cortical thickness in Heschl's gyrus in schizophrenia, major depression and bipolar disorderDavid Cotter
Beaumont Hospital, Dublin 9, Ireland
Br J Psychiatry 185:258-9. 2004.... - Optimization of the first dimension for separation by two-dimensional gel electrophoresis of basic proteins from human brain tissueKyla Pennington
Department of Psychological Medicine, Institute of Psychiatry, UK
Proteomics 4:27-30. 2004..The combined use of anodic cup-loading and the hydroxyethyldisulphide containing solution (DeStreak) produced better resolution in both analytical and micropreparative protein loaded 2-DE gels than the other methods investigated... - Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal densityGursharan Chana
Department of Psychological Medicine, Section of Experimental Neuropathology and Psychiatry, Institute of Psychiatry, DeCrespigny Park, London, United Kingdom
Biol Psychiatry 53:1086-98. 2003..003). CONCLUSIONS: The results of this study indicate that reduced neuronal somal size and increased neuronal density in cortical layers 5 and 6 of the ACC may be key features of schizophrenia, MDD, and BPD... - Stress and the progression of the developmental hypothesis of schizophreniaDavid Cotter
Br J Psychiatry 181:363-5. 2002 - An investigation of the Wnt-signalling pathway in the prefrontal cortex in schizophrenia, bipolar disorder and major depressive disorderClare Beasley
Department of Neuropathology, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
Schizophr Res 58:63-7. 2002..We found no significant differences between the disease and control groups for any of the proteins studied, and therefore, cannot confirm our earlier findings of abnormalities of GSK-3beta in schizophrenia... - Glial cell number and nuclear size in the mediodorsal thalamic nucleus (MDNT) in schizophreniaGursharan Chana
Schizophr Res 102:344-5. 2008 - Neurological soft signs and dermatoglyphic anomalies in twins with schizophreniaBrendan D Kelly
Department of Adult Psychiatry, Hospitaller Order of St John of God, Cluain Mhuire Service, Co Dublin, Ireland
Eur Psychiatry 19:159-63. 2004..The effect of such an event on dermatoglyphic profiles appears lateralised to the right hand in affected twins... - Expression of Oct-6, a POU III domain transcription factor, in schizophreniaMaria Ilia
Department of Neuroscience, Institute of Psychiatry, King's College London, 1 Windsor Walk, Denmark Hill, London SE5 8AF, UK
Am J Psychiatry 159:1174-82. 2002..Further, it may provide a clue to the neurodevelopmental basis of the disease and could be a reliable means to examine the developmental brain abnormalities described in this disorder... - Examination of 2-DE in the Human Proteome Organisation Brain Proteome Project pilot studies with the new RAIN gel matching techniqueAndrew W Dowsey
Royal Society / Wolfson Foundation Medical Image Computing Laboratory, Department of Computing, Imperial College London, UK
Proteomics 6:5030-47. 2006.... - Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout miceDaniela Babovic
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
Behav Brain Res 183:236-9. 2007..Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1...