Genomes and Genes
Affiliation: King's College London
- Methotrexate therapy in asthma increases T cell susceptibility to corticosteroid inhibitionC J Corrigan
Guy s, King s and St Thomas Imperial College Schools of Medicine, London, UK
Clin Exp Allergy 33:1090-6. 2003..We hypothesized that MTX therapy of these patients increases the susceptibility of their T cells to corticosteroid inhibition...
- Methotrexate therapy of oral corticosteroid-dependent asthmatics reduces serum immunoglobulins: correlation with clinical response to therapyC J Corrigan
Guy s, King s and St Thomas, London, UK
Clin Exp Allergy 35:579-84. 2005..In a previous report, we showed that MTX increases T cell inhibition by CS. In this report we focus on effects of MTX on immunoglobulin concentrations and their possible clinical relevance...
- Clinical and molecular aspects of glucocorticoid resistant asthmaChris J Corrigan
Division of Asthma, Allergy and Lung Biology, King s College London, London, England, UK MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London London, England, UK
Ther Clin Risk Manag 3:771-87. 2007..Finally, there are suggestions for clinical management of these patients based on accumulated evidence...
- The eotaxins in asthma and allergic inflammation: implications for therapyC Corrigan
Department of Respiratory, Medicine and Allergy, Guy s, King s and St Thomas School of Medicine, 5th Floor Thomas Guy House, Guy s Hospital, London, SE1 9RT, UK
Curr Opin Investig Drugs 1:321-8. 2000..This article reviews the evidence for this involvement and describes new approaches to therapeutics that are evolving as a result...
- The ADMIT series--issues in inhalation therapy. 3) Mild persistent asthma: the case for inhaled corticosteroid therapyChris J Corrigan
Department of Asthma, Allergy and Respiratory Science, King s College London School of Medicine, London, UK
Prim Care Respir J 18:148-58. 2009..ICS has variable effects on features of airways remodelling but the long term physiological consequences of these effects, if any, are as yet unknown...
- Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitisChris Corrigan
Department of Asthma, Allergy and Respiratory Science, Guy s Hospital, London, UK
J Allergy Clin Immunol 115:316-22. 2005..We previously compared expression of cysLT 1 on mucosal leukocytes in patients with aspirin-sensitive and aspirin-tolerant rhinosinusitis...
- Mechanisms of intrinsic asthmaChris Corrigan
Guy s, King s and St Thomas School of Medicine, King s College, London, UK
Curr Opin Allergy Clin Immunol 4:53-6. 2004..With the current availability of anti-IgE therapy for asthma, clarification of this issue has never been more timely and relevant...
- Asthma refractory to glucocorticoids: the role of newer immunosuppressantsChris J Corrigan
Department of Respiratory Medicine and Allergy, Guy s, King s and St Thomas School of Medicine, Thomas Guy House, Guy s Hospital, London SE1 9RT, UK
Am J Respir Med 1:47-54. 2002....
- Counter regulation of the high affinity IgE receptor, FcepsilonRI, on human airway dendritic cells by IL-4 and IL-10A Faith
MRC Asthma UK Centre in Allergic Mechanisms of Asthma, King s College, London, UK
Allergy 64:1602-7. 2009..Little is known, however, of the expression and function of FcepsilonRI on DC in the human respiratory tract...
- Role of cysteinyl leukotrienes in human allergen-specific Th2 responses induced by granulocyte macrophage-colony stimulating factorA Faith
Asthma UK and MRC, Centre in Allergic Mechanisms of Asthma, King s College London, and Department of Asthma, Allergy and Respiratory Science, Guy s Hospital, London, UK
Allergy 63:168-75. 2008..We hypothesized that exposure of AM and monocytes from atopic asthmatic patients to GM-CSF would enhance their antigen presenting function, and investigated putative mechanisms for this effect...
- Efficacy and safety of preseasonal-specific immunotherapy with an aluminium-adsorbed six-grass pollen allergoidC J Corrigan
Guy s, King s and St Thomas s School of Medicine, London, UK
Allergy 60:801-7. 2005..The clinical efficacy and safety of a six-grass pollen allergoid has been studied. The advent of more exacting clinical guidelines and a better appreciation of the possible mechanisms of treatment prompted this reappraisal...
- Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary diseaseSun Ying
King s College London, Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
J Immunol 181:2790-8. 2008..Increased expression of these chemokines is not, however, associated with selective accumulation of T cells bearing their receptors...
- Expression of activation markers and cytokine mRNA by peripheral blood CD4 and CD8 T cells in atopic and nonatopic childhood asthma: effect of inhaled glucocorticoid therapyVasso Gemou-Engesaeth
Department of Pediatrics, Ulleval University Hospital, Oslo, Norway
Pediatrics 109:E24. 2002..Activated CD8 as well as CD4 T cells contribute to the production of asthma-relevant cytokines in both atopic and nonatopic childhood asthma...
- IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cellsYui Hsi Wang
Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Exp Med 204:1837-47. 2007..Our results provide a plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells...
- Lack of filaggrin expression in the human bronchial mucosaSun Ying
J Allergy Clin Immunol 118:1386-8. 2006
- Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patientsTuck Kay Loke
King s College London, MRC, London SE1 9RT
J Allergy Clin Immunol 118:368-75. 2006..Overexpression of the transcriptional regulatory factor activator protein 1 might contribute to T-cell glucocorticoid (GC) refractoriness in GC-resistant asthma...
- Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cellsSun Ying
King s College London, MRC and Asthma UK Centre, Department of Asthma, Allergy and Respiratory Science, UK
J Allergy Clin Immunol 117:312-8. 2006..PGE(2) acts via G-protein-coupled receptors, E-prostanoid (EP)(1-4,) but there is little information on the expression of PGE(2) receptors in this condition...