Jonathan Corcoran

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist
    Maria B Goncalves
    The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London, SE11UL, UK
    Eur J Neurosci 37:1182-92. 2013
  2. pmc Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β
    C I Jarvis
    The Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Eur J Neurosci 32:1246-55. 2010
  3. pmc A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord
    Marta Agudo
    The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, UK
    Neurobiol Dis 37:147-55. 2010
  4. ncbi request reprint The role of retinoic acid receptors in neurite outgrowth from different populations of embryonic mouse dorsal root ganglia
    J Corcoran
    Developmental Biology Research Centre, The Randall Institute, King s College London, London, WC2B 5RL, UK
    J Cell Sci 113:2567-74. 2000
  5. ncbi request reprint Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brain
    Jonathan P T Corcoran
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    Eur J Neurosci 20:896-902. 2004
  6. ncbi request reprint Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients
    Jonathan Corcoran
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    J Cell Sci 115:4735-41. 2002
  7. ncbi request reprint Retinoic acid receptor beta2 and neurite outgrowth in the adult mouse spinal cord in vitro
    Jonathan Corcoran
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    J Cell Sci 115:3779-86. 2002
  8. ncbi request reprint Alveolar proliferation, retinoid synthesizing enzymes, and endogenous retinoids in the postnatal mouse lung. Different roles for Aldh-1 and Raldh-2
    Matthew Hind
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    Am J Respir Cell Mol Biol 26:67-73. 2002
  9. ncbi request reprint Temporal/spatial expression of retinoid binding proteins and RAR isoforms in the postnatal lung
    Matthew Hind
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London SE1 9RT, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 282:L468-76. 2002
  10. doi request reprint Drug repositioning for Alzheimer's disease
    Anne Corbett
    Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, UK
    Nat Rev Drug Discov 11:833-46. 2012

Collaborators

  • Malcolm Maden
  • Liang Fong Wong
  • S B Kalindjian
  • Paul Edison
  • Clive Holmes
  • Matthew Hind
  • Po Lin So
  • Maria B Goncalves
  • Anne Corbett
  • C I Jarvis
  • Marta Agudo
  • Maria Beatriz C V Goncalves
  • Tony Malmqvist
  • Julian Jack
  • Robert Deacon
  • Earl Clarke
  • Carl Hobbs
  • Alistair Burns
  • Jim J Hagan
  • Amrit Mudher
  • Emma Jones
  • Stephen B Dunnett
  • Patrick Kehoe
  • JAMES PICKETT
  • Anthony Passmore
  • Frank Walsh
  • Cornelius Katona
  • Ian Kearns
  • Clive Ballard
  • Nicola Shepherd
  • E Clarke
  • Patrick Doherty
  • Elizabeth Bradbury
  • M Dogruel
  • M B Goncalves
  • S A Thomas
  • Meirion Davies
  • Stephen McMahon
  • Ping Yip
  • Julia Boyle
  • Stephen L Minger
  • Daniel J Webber
  • Sara Hall

Detail Information

Publications12

  1. pmc Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist
    Maria B Goncalves
    The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London, SE11UL, UK
    Eur J Neurosci 37:1182-92. 2013
    ..Therefore, stimulation of the RARα signalling pathway using a synthetic agonist, by both clearing Aβ and counteracting some of its toxic effects, offers therapeutic potential for the treatment of AD...
  2. pmc Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β
    C I Jarvis
    The Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Eur J Neurosci 32:1246-55. 2010
    ..In contrast, neither RARβ nor γ-agonists affect Aβ production or Aβ-mediated neuronal cell death. Therefore, RARα agonists have therapeutic potential for the treatment of AD...
  3. pmc A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord
    Marta Agudo
    The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, UK
    Neurobiol Dis 37:147-55. 2010
    ..Our data suggest that RARbeta agonists may be of therapeutic potential for human spinal cord injuries...
  4. ncbi request reprint The role of retinoic acid receptors in neurite outgrowth from different populations of embryonic mouse dorsal root ganglia
    J Corcoran
    Developmental Biology Research Centre, The Randall Institute, King s College London, London, WC2B 5RL, UK
    J Cell Sci 113:2567-74. 2000
    ..This specificity was confirmed by the use of receptor-selective agonists as only a RAR(beta)-selective compound stimulated neurite outgrowth. These results suggest a role for RA acting via RAR(beta)(2) in the outgrowth of neurites...
  5. ncbi request reprint Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brain
    Jonathan P T Corcoran
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    Eur J Neurosci 20:896-902. 2004
    ..This suggests that retinoids are important for the maintenance of the adult nervous system and their loss may in part play a role in Alzheimer's disease...
  6. ncbi request reprint Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients
    Jonathan Corcoran
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    J Cell Sci 115:4735-41. 2002
    ..Therefore, we propose that a defect in the retinoid signalling pathway is in part be responsible for some types of motoneuron disease...
  7. ncbi request reprint Retinoic acid receptor beta2 and neurite outgrowth in the adult mouse spinal cord in vitro
    Jonathan Corcoran
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    J Cell Sci 115:3779-86. 2002
    ..These data demonstrate that RARbeta2 is involved in neurite outgrowth, at least in vitro, and that this gene may in the future be of some therapeutic use...
  8. ncbi request reprint Alveolar proliferation, retinoid synthesizing enzymes, and endogenous retinoids in the postnatal mouse lung. Different roles for Aldh-1 and Raldh-2
    Matthew Hind
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    Am J Respir Cell Mol Biol 26:67-73. 2002
    ..These data suggest two patterns of alveolar proliferation with temporal and spatial association of the enzymes Aldh-1 and Raldh-2 and a dynamic role for different retinoids in both the septating and adult mouse lung...
  9. ncbi request reprint Temporal/spatial expression of retinoid binding proteins and RAR isoforms in the postnatal lung
    Matthew Hind
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London SE1 9RT, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 282:L468-76. 2002
    ..These data support a role of dynamic endogenous RA signaling during alveolar formation...
  10. doi request reprint Drug repositioning for Alzheimer's disease
    Anne Corbett
    Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, UK
    Nat Rev Drug Discov 11:833-46. 2012
    ..We highlight several compounds for which sufficient evidence is available to encourage further investigation to clarify an optimal dose and consider progression to clinical trials in patients with Alzheimer's disease...
  11. ncbi request reprint Timing of the retinoid-signalling pathway determines the expression of neuronal markers in neural progenitor cells
    Maria Beatriz C V Goncalves
    Stem Cell Laboratory, The Wolfson Centre for Age Related Diseases, London SE1 1UL, UK
    Dev Biol 278:60-70. 2005
    ..We finally show that activated RARalpha is one of the final steps required for a mature motoneuron phenotype...
  12. ncbi request reprint Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth
    Po Lin So
    The MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London SE1 1UL, UK
    Dev Biol 298:167-75. 2006
    ..This regulation is direct as when RARbeta2 is overexpressed in adult motoneurons Shh is induced in them. Finally we show that Shh alone cannot induce neurite outgrowth but potentiates RARbeta2 signalling in this process...