Anthony J Cleare

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint The HPA axis and the genesis of chronic fatigue syndrome
    Anthony J Cleare
    Section of Neurobiology of Mood Disorders, Division of Psychological Medicine, The Institute of Psychiatry, London, SE5 8AF, UK
    Trends Endocrinol Metab 15:55-9. 2004
  2. ncbi request reprint Stress and fibromyalgia--what is the link?
    Anthony J Cleare
    Department of Psychological Medicine, Institute of Psychiatry, Box P065, Weston Education Centre, Cutcombe Road, London SE5 9RJ, United Kingdom
    J Psychosom Res 57:423-5. 2004
  3. ncbi request reprint Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635
    Anthony J Cleare
    Section of Neurobiology of Mood Disorders, Division of Psychological Medicine, Institute of Psychiatry and Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Biol Psychiatry 57:239-46. 2005
  4. ncbi request reprint The neuroendocrinology of chronic fatigue syndrome
    Anthony J Cleare
    Section of Neurobiology of Mood Disorders, Division of Psychological Medicine, The Institute of Psychiatry, London SE5 8AZ, United Kingdom
    Endocr Rev 24:236-52. 2003
  5. ncbi request reprint Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry and Guy s, King s and St Thomas School of Medicine, London SE5 8AZ, United Kingdom
    J Clin Endocrinol Metab 86:3545-54. 2001
  6. ncbi request reprint Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion
    A J Cleare
    Department of Psychological Medicine, Guy s, King s and St Thomas School of Medicine, 103 Denmark Hill, London SE3 8AF, UK
    Clin Endocrinol (Oxf) 55:113-9. 2001
  7. ncbi request reprint Urinary free cortisol in chronic fatigue syndrome
    A J Cleare
    Department of Psychological Medicine, Guy s King s and St Thomas School of Medicine and the Institute of Psychiatry, 103 Denmark Hill, London SE5 8AZ, UK
    Am J Psychiatry 158:641-3. 2001
  8. ncbi request reprint Ipsapirone challenge in aggressive men shows an inverse correlation between 5-HT1A receptor function and aggression
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry and Guy s King s and St Thomas School of Medicine, London, UK
    Psychopharmacology (Berl) 148:344-9. 2000
  9. ncbi request reprint Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome
    A J Cleare
    Department of Psychological Medicine, Guy s King s and St Thomas School of Medicine, and The Institute of Psychiatry, London, United Kingdom
    J Clin Endocrinol Metab 85:1433-9. 2000
  10. ncbi request reprint Levels of DHEA and DHEAS and responses to CRH stimulation and hydrocortisone treatment in chronic fatigue syndrome
    A J Cleare
    Division of Psychological Medicine, The Institute of Psychiatry and Guy s, King s and St Thomas School of Medicine, London SE5 8AF, UK
    Psychoneuroendocrinology 29:724-32. 2004

Detail Information

Publications73

  1. ncbi request reprint The HPA axis and the genesis of chronic fatigue syndrome
    Anthony J Cleare
    Section of Neurobiology of Mood Disorders, Division of Psychological Medicine, The Institute of Psychiatry, London, SE5 8AF, UK
    Trends Endocrinol Metab 15:55-9. 2004
    ..Nevertheless, the HPA axis might play a role in exacerbating or perpetuating symptoms late on in the course of the illness...
  2. ncbi request reprint Stress and fibromyalgia--what is the link?
    Anthony J Cleare
    Department of Psychological Medicine, Institute of Psychiatry, Box P065, Weston Education Centre, Cutcombe Road, London SE5 9RJ, United Kingdom
    J Psychosom Res 57:423-5. 2004
  3. ncbi request reprint Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635
    Anthony J Cleare
    Section of Neurobiology of Mood Disorders, Division of Psychological Medicine, Institute of Psychiatry and Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Biol Psychiatry 57:239-46. 2005
    ..We assessed brain 5-HT1A receptor binding potential directly using the specific radioligand [11C]WAY-100635 and positron emission tomography (PET)...
  4. ncbi request reprint The neuroendocrinology of chronic fatigue syndrome
    Anthony J Cleare
    Section of Neurobiology of Mood Disorders, Division of Psychological Medicine, The Institute of Psychiatry, London SE5 8AZ, United Kingdom
    Endocr Rev 24:236-52. 2003
    ....
  5. ncbi request reprint Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry and Guy s, King s and St Thomas School of Medicine, London SE5 8AZ, United Kingdom
    J Clin Endocrinol Metab 86:3545-54. 2001
    ..We conclude that the improvement in fatigue seen in some patients with chronic fatigue syndrome during hydrocortisone treatment is accompanied by a reversal of the blunted cortisol responses to human CRH...
  6. ncbi request reprint Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion
    A J Cleare
    Department of Psychological Medicine, Guy s, King s and St Thomas School of Medicine, 103 Denmark Hill, London SE3 8AF, UK
    Clin Endocrinol (Oxf) 55:113-9. 2001
    ..Because both of these features may be related to leptin metabolism, we undertook a study of leptin in CFS...
  7. ncbi request reprint Urinary free cortisol in chronic fatigue syndrome
    A J Cleare
    Department of Psychological Medicine, Guy s King s and St Thomas School of Medicine and the Institute of Psychiatry, 103 Denmark Hill, London SE5 8AZ, UK
    Am J Psychiatry 158:641-3. 2001
    ..The authors measured 24-hour urinary free cortisol in a group of well-characterized patients with chronic fatigue syndrome...
  8. ncbi request reprint Ipsapirone challenge in aggressive men shows an inverse correlation between 5-HT1A receptor function and aggression
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry and Guy s King s and St Thomas School of Medicine, London, UK
    Psychopharmacology (Berl) 148:344-9. 2000
    ..We conclude that impaired 5-HT(1A) receptor function is associated with increased aggressiveness...
  9. ncbi request reprint Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome
    A J Cleare
    Department of Psychological Medicine, Guy s King s and St Thomas School of Medicine, and The Institute of Psychiatry, London, United Kingdom
    J Clin Endocrinol Metab 85:1433-9. 2000
    ..Hydrocortisone treatment had no significant effect on any of these parameters. There is no evidence of GH deficiency in CFS. At the doses used, hydrocortisone treatment appears to have little impact on GH function...
  10. ncbi request reprint Levels of DHEA and DHEAS and responses to CRH stimulation and hydrocortisone treatment in chronic fatigue syndrome
    A J Cleare
    Division of Psychological Medicine, The Institute of Psychiatry and Guy s, King s and St Thomas School of Medicine, London SE5 8AF, UK
    Psychoneuroendocrinology 29:724-32. 2004
    ..Recent studies have also suggested that low dose hydrocortisone may be effective at reducing fatigue in CFS. We therefore also assessed these parameters prior to and following treatment with low dose oral hydrocortisone...
  11. doi request reprint Glucocorticoid receptor mediated negative feedback in chronic fatigue syndrome using the low dose (0.5 mg) dexamethasone suppression test
    Andrew Papadopoulos
    King s College London, Institute of Psychiatry, Section of Neurobiology of Mood Disorders, Division of Psychological Medicine, London SE5 8AF, United Kingdom
    J Affect Disord 112:289-94. 2009
    ..Chronic fatigue syndrome (CFS) is associated with hypocortisolism, but it is not yet clear the extent to which enhanced negative feedback may underlie this finding...
  12. doi request reprint Prednisolone suppression test in depression: prospective study of the role of HPA axis dysfunction in treatment resistance
    Mario F Juruena
    Section of Neurobiology of Mood Disorders, PO 74, Institute of Psychiatry, 103 Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 194:342-9. 2009
    ..People with severe depressive illness have raised levels of cortisol and reduced glucocorticoid receptor function...
  13. ncbi request reprint A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy
    Nicholas D Walsh
    Institute of Psychiatry, King s College London, De Crespigny Park, 103 Denmark Hill, London, UK
    Biol Psychiatry 62:1236-43. 2007
    ..Impairments in the neural circuitry of verbal working memory are evident in depression. Factors of task demand and depressive state might have significant effects on its functional neuroanatomy...
  14. ncbi request reprint Different responses to dexamethasone and prednisolone in the same depressed patients
    Mario F Juruena
    Stress, Psychiatry and Immunology Laboratory, Section of Clinical Neuropharmacology, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Psychopharmacology (Berl) 189:225-35. 2006
    ..Patients with major depression show hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, but the mechanisms underlying this abnormality are still unclear...
  15. ncbi request reprint Neural responses to happy facial expressions in major depression following antidepressant treatment
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, UK
    Am J Psychiatry 164:599-607. 2007
    ..However, depressed patients show impairments in this system. The present study investigated the neural correlates of implicit processing of happy facial expressions in depression and identified regions affected by antidepressant therapy...
  16. ncbi request reprint Urinary cortisol and cortisol metabolite excretion in chronic fatigue syndrome
    Walid K Jerjes
    Department of Clinical Biochemistry, Guy s, King s and St Thomas School of Medicine, King s College London, UK
    Psychosom Med 68:578-82. 2006
    ....
  17. pmc Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression
    Livia A Carvalho
    King s College London, Section for Laboratory of Stress, Psychiatry and Immunology, Institute of Psychiatry, London, UK
    Neuropsychopharmacology 33:3182-9. 2008
    ..Upcoming studies shall test whether assessing the effects of antidepressants in vitro on GR function could predict future treatment response in a clinical setting...
  18. doi request reprint Neural responses to sad facial expressions in major depression following cognitive behavioral therapy
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, London
    Biol Psychiatry 64:505-12. 2008
    ..The present study investigated the neural correlates of implicit processing of sad facial expressions in depression pretreatment and posttreatment with cognitive behavioral therapy (CBT)...
  19. ncbi request reprint Effect of acute tryptophan depletion on pre-frontal engagement
    Paul P Allen
    Division of Psychological Medicine P067, Institute of Psychiatry, De Crespigny Park, London, UK
    Psychopharmacology (Berl) 187:486-97. 2006
    ..We tested the hypothesis that acute tryptophan depletion (ATD) would attenuate pre-frontal activation during both tasks...
  20. doi request reprint Longitudinal course of symptom severity and fluctuation in patients with treatment-resistant unipolar and bipolar depression
    Francis K Vergunst
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, Affective Disorders Research Group, Box P074, 103 Denmark Hill, SE5 8AF, London, UK
    Psychiatry Res 207:143-9. 2013
    ..We suggest that the longitudinal illness course is an important outcome to be considered in future TRD research...
  21. ncbi request reprint Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome
    Walid K Jerjes
    Department of Clinical Biochemistry, Guy s, King s and St Thomas School of Medicine, Bessemer Road, SE5 9RS London, UK
    J Psychosom Res 60:145-53. 2006
    ....
  22. doi request reprint The ratio of cortisol/DHEA in treatment resistant depression
    Kalypso Markopoulou
    King s College London, Institute of Psychiatry, Section of Neurobiology of Mood Disorders, United Kingdom
    Psychoneuroendocrinology 34:19-26. 2009
    ..This study measured cortisol, DHEA and their ratio in treatment resistant depression (TRD) and healthy controls and also related these measures to treatment outcome...
  23. pmc The prednisolone suppression test in depression: dose-response and changes with antidepressant treatment
    Mario F Juruena
    Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology, Institute of Psychiatry, King s College London, Department of Psychological Medicine, London, UK
    Psychoneuroendocrinology 35:1486-91. 2010
    ..Thus, we propose that the prednisolone suppression test may offer specific biological and clinical information, related to its action at both the GR and the MR...
  24. doi request reprint Prospective evaluation of specialist inpatient treatment for refractory affective disorders
    Sarah C Wooderson
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, Section of Neurobiology of Mood Disorders, London SE5 8AZ, UK
    J Affect Disord 131:92-103. 2011
    ..Little data exist to inform the treatment of severe and resistant affective disorders. We report here the effectiveness of specialist multimodal inpatient treatment for refractory affective disorders...
  25. ncbi request reprint Enhanced feedback sensitivity to prednisolone in chronic fatigue syndrome
    Walid K Jerjes
    Department of Clinical Biochemistry, Guy s, King s and St Thomas School of Medicine, Bessemer Road, London SE5 9RS, UK
    Psychoneuroendocrinology 32:192-8. 2007
    ..The objective of the study was to use this test to look for alterations in negative feedback control of the HPA axis in CFS patients...
  26. doi request reprint Neuroanatomy of verbal working memory as a diagnostic biomarker for depression
    Andre F Marquand
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Neuroreport 19:1507-11. 2008
    ....
  27. ncbi request reprint Circadian rhythm of urinary steroid metabolites
    Walid K Jerjes
    Department of Clinical Biochemistry, Guy s, King s College London School of Medicine, Bessemer Road, London SE5 9RS, UK
    Ann Clin Biochem 43:287-94. 2006
    ....
  28. pmc Evidence for a role of progesterone in menstrual cycle-related variability in prepulse inhibition in healthy young women
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 35:929-37. 2010
    ....
  29. doi request reprint Salivary cortisol output before and after cognitive behavioural therapy for chronic fatigue syndrome
    Amanda D L Roberts
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, De Crespigny Park, London SE5 8AF, UK
    J Affect Disord 115:280-6. 2009
    ..We aimed to determine whether therapy aimed at reversing these factors--cognitive behavioural therapy for CFS--could increase cortisol output in CFS...
  30. ncbi request reprint A multidimensional tool to quantify treatment resistance in depression: the Maudsley staging method
    Abebaw Fekadu
    King s College London, Institute of Psychiatry, Section of Neurobiology of Mood Disorders, Department of Psychological Medicine and Psychiatry, London, UK
    J Clin Psychiatry 70:177-84. 2009
    ..However, current unitary models of staging fail to represent its complexity. We aimed to devise a model to stage treatment-resistant depression, taking into account the core factors contributing to treatment failure...
  31. ncbi request reprint Long-term impact of residual symptoms in treatment-resistant depression
    Abebaw Fekadu
    King s College London, Institute of Psychiatry, Section of Neurobiology of Mood Disorders, England, UK
    Can J Psychiatry 56:549-57. 2011
    ..The aim of our study was to assess the impact of posttreatment clinical states on longer-term outcome...
  32. ncbi request reprint 5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletion
    Melissa Lamar
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Neurobiol Aging 30:1135-46. 2009
    ..Maintaining successful Simon performance during ATD is achieved by increasing cerebellar and parietal contributions to compensate for decreased fronto-cingulo-striatal involvement...
  33. doi request reprint The Maudsley Staging Method for treatment-resistant depression: prediction of longer-term outcome and persistence of symptoms
    Abebaw Fekadu
    Institute of Psychiatry, Section of Neurobiology of Mood Disorders, Department of Psychological Medicine and Psychiatry, King s College London, United Kingdom
    J Clin Psychiatry 70:952-7. 2009
    ..We hypothesized that patients with higher scores on the MSM would experience a worse longer-term outcome in terms of time spent in a depressive episode and level of functional impairment...
  34. ncbi request reprint Assessment of subtle changes in glucocorticoid negative feedback using prednisolone: comparison of salivary free cortisol and urinary cortisol metabolites as endpoints
    Walid K Jerjes
    Department of Clinical Biochemistry, Guy s, King s and St Thomas School of Medicine, Bessemer Road, London SE5 9RS, UK
    Clin Chim Acta 364:279-86. 2006
    ..We compared capillary gas chromatography, which distinguishes urinary cortisol and prednisolone metabolites, and salivary cortisol immunoassay...
  35. doi request reprint Can evidence change belief? Reported mobile phone sensitivity following individual feedback of an inability to discriminate active from sham signals
    Rosa Nieto-Hernandez
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, Section of General Hospital Psychiatry, London, UK
    J Psychosom Res 65:453-60. 2008
    ....
  36. ncbi request reprint Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI
    Katya Rubia
    Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, London, UK
    Psychopharmacology (Berl) 179:791-803. 2005
    ....
  37. pmc Subregional hippocampal deformations in major depressive disorder
    James Cole
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    J Affect Disord 126:272-7. 2010
    ..The present study sought to examine hippocampal volume and subregional morphology in patients with major depressive disorder, who were all medication-free and in an acute depressive episode of moderate severity...
  38. ncbi request reprint Neuroendocrine and hypothermic effects of 5-HT1A receptor stimulation with ipsapirone in healthy men: a placebo-controlled study
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Int Clin Psychopharmacol 13:23-32. 1998
    ..The presence of an oxytocin response to ipsapirone suggests that oxytocin is a potential marker for serotonergic function in neuroendocrine challenge studies, but this awaits further study...
  39. doi request reprint The impact of childhood adversity on suicidality and clinical course in treatment-resistant depression
    Catherine Tunnard
    Division of Psychological Medicine and Psychiatry, Section of Neurobiology of Mood Disorders, Institute of Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AZ, UK The National Affective Disorder Unit, South London and Maudsley NHS Foundation Trust, UK
    J Affect Disord 152:122-30. 2014
    ..Childhood adversity is a risk factor for the development of depression and can also affect clinical course. We investigated this specifically in treatment-resistant depression (TRD)...
  40. doi request reprint The role of mineralocorticoid receptor function in treatment-resistant depression
    Mario F Juruena
    1King s College London, Institute of Psychiatry, Section of Neurobiology of Mood Disorders, London, UK
    J Psychopharmacol 27:1169-79. 2013
    ..This study aimed to evaluate the functional activity of the mineralocorticoid receptor system in regulating the hypothalamic-pituitary-adrenal axis in well-defined treatment-resistant depression patients...
  41. pmc Do acute psychological and psychobiological responses to trauma predict subsequent symptom severities of PTSD and depression?
    Thomas Ehring
    Department of Psychology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Psychiatry Res 161:67-75. 2008
    ....
  42. doi request reprint What happens to patients with treatment-resistant depression? A systematic review of medium to long term outcome studies
    Abebaw Fekadu
    King s College London, Institute of Psychiatry, Division of Psychological Medicine, Section of Neurobiology of Mood Disorders, PO 074, 103 Denmark Hill, London, SE5 8AZ, UK
    J Affect Disord 116:4-11. 2009
    ..We conducted a systematic review of outcome studies of TRD in order to summarise findings on the longer term outcome of TRD and make recommendations...
  43. doi request reprint Amygdala activation to masked happy facial expressions
    Mario F Juruena
    Institute of Psychiatry, King s College London, London, UK
    J Int Neuropsychol Soc 16:383-7. 2010
    ..Masked happy faces elicited greater amygdala activation bilaterally as compared to masked sad faces. Our findings indicate that the amygdala is highly responsive to non-consciously perceived happy facial expressions...
  44. ncbi request reprint Psychological factors associated with self-reported sensitivity to mobile phones
    G James Rubin
    King s College London, Institute of Psychiatry, London, United Kingdom
    J Psychosom Res 64:1-9; discussion 11-2. 2008
    ..Research suggests that electromagnetic fields do not trigger these symptoms. In this study, we examined the differences between these two "sensitive" groups and healthy controls...
  45. ncbi request reprint [The hypothalamic pituitary adrenal axis, glucocorticoid receptor function and relevance to depression]
    Mario F Juruena
    Division of Psychological Medicine, Section of Neurobiology of Mood Disorders, Institute of Psychiatry, University of London, London, UK
    Rev Bras Psiquiatr 26:189-201. 2004
    ..Because the effects of glucocorticoids are mediated by intracellular receptors including, most notably, the glucocorticoid receptor (GR), several studies have examined the number and/or function of GRs in depressed patients...
  46. ncbi request reprint What advice do patients with infectious mononucleosis report being given by their general practitioner?
    Bridget Candy
    Department of Psychological Medicine, Institute of Psychiatry, Weston Education Centre, London, UK
    J Psychosom Res 58:435-7. 2005
    ..The aim of this study was to describe the advice that patients with acute infectious mononucleosis recall having been given by their general practitioner (GP; family or primary care doctor)...
  47. doi request reprint A comparison of prepulse inhibition in pre- and postmenopausal women and age-matched men
    Veena Kumari
    King s College London, Department of Psychology, Institute of Psychiatry, London, UK
    Neuropsychopharmacology 33:2610-8. 2008
    ..There appear to be no substantial relationships between individual differences in endogenous levels of sex hormones and PPI; fluctuations within an individual may have a stronger role...
  48. doi request reprint Cortisol responses to serial MRI scans in healthy adults and in depression
    Sabine Peters
    Institute of Psychiatry, King s College London, De Crespigny Park, London, United Kingdom
    Psychoneuroendocrinology 36:737-41. 2011
    ..In summary, the MRI experience is stressful, particularly for the initial scan, but the stress response is reduced with subsequent scans...
  49. ncbi request reprint Toxoplasmosis as a cause for behaviour disorders--overview of evidence and mechanisms
    Abebaw Fekadu
    Department of Psychiatry, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    Folia Parasitol (Praha) 57:105-13. 2010
    ..The neurotropic protozoan parasite Toxoplasma gondii is one of the main candidates and has been associated with various psychiatric conditions, including schizophrenia...
  50. ncbi request reprint The neuroendocrinology of chronic fatigue syndrome and fibromyalgia
    A J Parker
    Department of Psychological Medicine, Guy's, King's and St Thomas' School of Medicine and the Institute of Psychiatry, London
    Psychol Med 31:1331-45. 2001
    ..Longitudinal studies of populations at risk for CFS will help to resolve these issues...
  51. doi request reprint Discrepancy between subjective and objective severity in treatment-resistant depression: prediction of treatment outcome
    L J Rane
    King s College London, Institute of Psychiatry, Division of Psychological Medicine and Psychiatry, Section of Neurobiology of Mood Disorders, 103 Denmark Hill, London SE5 8AZ, UK
    J Psychiatr Res 44:1082-7. 2010
    ..Identifying predictors of outcome among patients with treatment-resistant depression (TRD) is challenging. We hypothesised that discrepancy between self-rated and observer-rated scales may be a simple way of making such a prediction...
  52. ncbi request reprint Neural basis of the emotional Stroop interference effect in major depression
    M T Mitterschiffthaler
    Neuroimaging Research Group, Clinical Neuroscience, Institute of Psychiatry, King s College London, UK
    Psychol Med 38:247-56. 2008
    ..Functional neuroimaging studies of the emotional Stroop effect advocate a critical involvement of the anterior cingulate cortex (ACC) during these processes...
  53. ncbi request reprint Plasma tryptophan and trait aggression
    J Wingrove
    Section of Clinical Psychopharmacology, Institute of Psychiatry, King s College, London, UK
    J Psychopharmacol 13:235-7. 1999
    ....
  54. doi request reprint Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome
    Andrew S Papadopoulos
    Department of Psychological Medicine, Institute of Psychiatry, Box P074, 103 Denmark Hill, London SE5 8AZ, UK
    Nat Rev Endocrinol 8:22-32. 2012
    ..Given what is now a fairly consistent pattern of findings for the type of HPA axis changes found in CFS, we recommend that future work focuses on improving our understanding of the cause and relevance of these observed changes...
  55. doi request reprint Can exposure to a terrestrial trunked radio (TETRA)-like signal cause symptoms? A randomised double-blind provocation study
    Rosa Nieto-Hernandez
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Occup Environ Med 68:339-44. 2011
    ..6 Hz. We tested whether exposure to a continuous wave signal at 385.25 MHz or a TETRA-like signal resulted in symptoms among users reporting sensitivity to TETRA compared to users not reporting sensitivity to TETRA...
  56. ncbi request reprint Autonomic function and serum erythropoietin levels in chronic fatigue syndrome
    Andrea S Winkler
    Department of Medicine, Division of Psychological Medicine, GKT School of Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 9RJ, UK
    J Psychosom Res 56:179-83. 2004
    ....
  57. ncbi request reprint Salivary cortisol response to awakening in chronic fatigue syndrome
    Amanda D L Roberts
    Section of General Hospital Psychiatry, Division of Psychological Medicine, Guy s, King s and St Thomas School of Medicine and Dentistry, London, UK
    Br J Psychiatry 184:136-41. 2004
    ..The results of this test correlate closely with those of more invasive dynamic tests reported in the literature; furthermore, it can be undertaken in a naturalistic setting...
  58. ncbi request reprint A randomised controlled trial of a psycho-educational intervention to aid recovery in infectious mononucleosis
    Bridget Candy
    Department of Psychological Medicine, Guy s, King s and St Thomas School of Medicine, 103 Denmark Hill, London SE5 8AZ, UK
    J Psychosom Res 57:89-94. 2004
    ..We therefore developed a brief psycho-educational intervention aimed at improving recovery from infectious mononucleosis, and piloted a randomised controlled trial to evaluate the intervention...
  59. ncbi request reprint Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial
    A J Cleare
    Department of Psychological Medicine, Guy s King s and St Thomas School of Medicine and the Institute of Psychiatry, London, UK
    Lancet 353:455-8. 1999
    ..Reports of mild hypocortisolism in chronic fatigue syndrome led us to postulate that low-dose hydrocortisone therapy may be an effective treatment...
  60. ncbi request reprint Serotonergic function and negative and depressive symptomatology in schizophrenia and major depression
    K M Abel
    Institute of Psychiatry, London, UK
    Psychoneuroendocrinology 22:539-48. 1997
    ..We wished to explore whether these symptoms could be distinguished biologically by directly comparing serotonergic function in these two illnesses...
  61. pmc Are some people sensitive to mobile phone signals? Within participants double blind randomised provocation study
    G James Rubin
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, Section of General Hospital Psychiatry, Weston Education Centre PO62, London SE5 9RJ
    BMJ 332:886-91. 2006
    ..To test whether people who report being sensitive to mobile phone signals have more symptoms when exposed to a pulsing mobile signal than when exposed to a sham signal or a non-pulsing signal...
  62. ncbi request reprint Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 61:877-89. 2004
    ..Depression is associated with interpersonal difficulties related to abnormalities in affective facial processing...
  63. ncbi request reprint Four days of citalopram increase suppression of cortisol secretion by prednisolone in healthy volunteers
    Carmine M Pariante
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, 1 Windsor Walk, Denmark Hill, PO 51, London, SE5 8AF, UK
    Psychopharmacology (Berl) 177:200-6. 2004
    ..In contrast, acute antidepressant treatment induces an activation of basal HPA axis activity...
  64. ncbi request reprint Peripheral hormonal responses to D-fenfluramine as a probe of central serotonergic function in humans
    K M Abel
    Department of Psychological Medicine, King s College School of Medicine and Dentistry and the Institute of Psychiatry, London, UK
    Psychopharmacology (Berl) 142:68-72. 1999
    ..4 +/- 26.3 nmol/l; DEX+ = 0.0 nmol/l (all blunted) (df 7,1; P = 0.03). The completely blunted peripheral cortisol response indicates that DFEN cortisol responses are of central origin only...
  65. doi request reprint Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?
    A D L Roberts
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Psychol Med 40:515-22. 2010
    ..The clinical significance of this is unclear. We aimed to determine whether hypocortisolism exerted any effect on the response of CFS to cognitive behavioural therapy (CBT)...
  66. ncbi request reprint Does central serotonergic function correlate inversely with aggression? A study using D-fenfluramine in healthy subjects
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatry Res 69:89-95. 1997
    ....
  67. pmc Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment
    S J Bull
    King s College London, Section and Laboratory of Stress, Psychiatry and Immunology, Institute of Psychiatry, London, UK
    Mol Psychiatry 14:1095-104. 2009
    ....
  68. pmc Recovery from infectious mononucleosis: a case for more than symptomatic therapy? A systematic review
    Bridget Candy
    Department of Psychological Medicine, Guy s, King s and St Thomas School of Medicine, London
    Br J Gen Pract 52:844-51. 2002
    ..More information is needed on the course of ill health subsequent to the onset of infectious mononucleosis. Certain risk factors associated with delay may be amenable to a simple intervention in primary care...
  69. ncbi request reprint Predictors of fatigue following the onset of infectious mononucleosis
    B Candy
    Department of Psychological Medicine, Public Health Laboratory and Medical Microbiology, Guy s, King s and St Thomas School of Medicine and Institute of Psychiatry, London
    Psychol Med 33:847-55. 2003
    ..This study explored immunological, endocrine, behavioural and cognitive responses to the acute illness and assessed which components of these groups of risk factors predicted a chronic course...
  70. pmc Antinuclear autoantibodies (ANA) in Gulf War-related illness and chronic fatigue syndrome (CFS) patients
    A Skowera
    Department of Immunology, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    Clin Exp Immunol 129:354-8. 2002
    ..None of the patients/or veterans we studied had ANA of the NE type. Our results show that multisymptom illness due to CFS or related to Gulf War service is not associated with antinuclear autoimmunity...
  71. ncbi request reprint Personality as a determinant of social functioning in depression
    Gopinath Ranjith
    Affective Disorders Unit, Bethlem Royal Hospital, Beckenham BR3 3BX, UK
    J Affect Disord 84:73-6. 2005
    ..We investigated the personality dimensions of neuroticism and extraversion as determinants of social functioning measured by SASS in patients with depression...
  72. ncbi request reprint 24-hour pituitary and adrenal hormone profiles in chronic fatigue syndrome
    Annabella Di Giorgio
    Department of Neurological and Psychiatric Services, University of Bari, Bari, Italy
    Psychosom Med 67:433-40. 2005
    ..Our aim was to assess 24-hour pituitary and adrenal function using frequent blood sampling...
  73. ncbi request reprint Modulation of neural response to happy and sad faces by acute tryptophan depletion
    Paolo Fusar-Poli
    Department of Applied and Psychobehavioural Health Sciences, University of Pavia, via Bassi 21, 27100, Pavia, Italy
    Psychopharmacology (Berl) 193:31-44. 2007
    ..We used functional neuroimaging (fMRI) to investigate the effects of experimental manipulation of central 5HT levels on the regional neural response to happy and sad facial expressions...