David J Chambers

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Invited commentary
    David J Chambers
    Cardiac Surgical Research, The Rayne Institute King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, SE1 7EH United Kingdom
    Ann Thorac Surg 84:133. 2007
  2. doi request reprint Cardioprotection with esmolol cardioplegia: efficacy as a blood-based solution
    Masahiro Fujii
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute King s College London, St Thomas Hospital, London, UK
    Eur J Cardiothorac Surg 43:619-27. 2013
  3. doi request reprint Cardioplegia and cardiac surgery: pharmacological arrest and cardioprotection during global ischemia and reperfusion
    David J Chambers
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London SE1 7EH, UK
    Pharmacol Ther 127:41-52. 2010
  4. doi request reprint Esmolol cardioplegia: the cellular mechanism of diastolic arrest
    Hazem B Fallouh
    Cardiac Surgical Research, The Rayne Institute King s College London, St Thomas Hospital, London, UK
    Cardiovasc Res 87:552-60. 2010
  5. doi request reprint Does intermittent cross-clamp fibrillation provide equivalent myocardial protection compared to cardioplegia in patients undergoing bypass graft revascularisation?
    Marco Scarci
    Guy s and St Thomas NHS Foundation Trust, 6th Floor, St Thomas Hospital, London, UK
    Interact Cardiovasc Thorac Surg 9:872-8. 2009
  6. doi request reprint Invited commentary
    David J Chambers
    Cardiac Surgical Research, The Rayne Institute, King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, United Kingdom
    Ann Thorac Surg 86:1292. 2008
  7. doi request reprint Ischaemic postconditioning: does cardioplegia influence protection?
    Yuji Maruyama
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, UK
    Eur J Cardiothorac Surg 42:530-9. 2012
  8. doi request reprint Is blood versus crystalloid cardioplegia relevant? Significantly improved protection may require new cardioplegic concepts!
    Hazem B Fallouh
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, UK
    Interact Cardiovasc Thorac Surg 7:1162-3. 2008
  9. ncbi request reprint Mechanisms and alternative methods of achieving cardiac arrest
    David J Chambers
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute, Guy s and St Thomas NHS Hospital Trust, St Thomas Campus, London SE1 7EH, United Kingdom
    Ann Thorac Surg 75:S661-6. 2003
  10. ncbi request reprint Invited commentary
    David J Chambers
    Cardiac Surgical Research, The Rayne Institute, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, SE1 7EH United Kingdom
    Ann Thorac Surg 83:1109. 2007

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Invited commentary
    David J Chambers
    Cardiac Surgical Research, The Rayne Institute King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, SE1 7EH United Kingdom
    Ann Thorac Surg 84:133. 2007
  2. doi request reprint Cardioprotection with esmolol cardioplegia: efficacy as a blood-based solution
    Masahiro Fujii
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute King s College London, St Thomas Hospital, London, UK
    Eur J Cardiothorac Surg 43:619-27. 2013
    ..This study compared the efficacy of blood-based esmolol cardioplegia with hyperkalaemic cardioplegia in a novel blood-perfused rat heart preparation...
  3. doi request reprint Cardioplegia and cardiac surgery: pharmacological arrest and cardioprotection during global ischemia and reperfusion
    David J Chambers
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London SE1 7EH, UK
    Pharmacol Ther 127:41-52. 2010
    ..In this context, the agents are discussed in terms of their clinical potential for use during cardiac surgery, with particular reference to the safety aspects of the agents...
  4. doi request reprint Esmolol cardioplegia: the cellular mechanism of diastolic arrest
    Hazem B Fallouh
    Cardiac Surgical Research, The Rayne Institute King s College London, St Thomas Hospital, London, UK
    Cardiovasc Res 87:552-60. 2010
    ..Esmolol, an ultra-short-acting beta-blocker, acts as a cardioplegic agent at millimolar concentrations. We investigated the mechanism by which esmolol induces diastolic ventricular arrest...
  5. doi request reprint Does intermittent cross-clamp fibrillation provide equivalent myocardial protection compared to cardioplegia in patients undergoing bypass graft revascularisation?
    Marco Scarci
    Guy s and St Thomas NHS Foundation Trust, 6th Floor, St Thomas Hospital, London, UK
    Interact Cardiovasc Thorac Surg 9:872-8. 2009
    ....
  6. doi request reprint Invited commentary
    David J Chambers
    Cardiac Surgical Research, The Rayne Institute, King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, United Kingdom
    Ann Thorac Surg 86:1292. 2008
  7. doi request reprint Ischaemic postconditioning: does cardioplegia influence protection?
    Yuji Maruyama
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, UK
    Eur J Cardiothorac Surg 42:530-9. 2012
    ..We examined the efficacy of postconditioning following ischaemic protection with cardioplegic arrest and the importance of index ischaemia and cardioplegia formulation...
  8. doi request reprint Is blood versus crystalloid cardioplegia relevant? Significantly improved protection may require new cardioplegic concepts!
    Hazem B Fallouh
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute King s College London, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, UK
    Interact Cardiovasc Thorac Surg 7:1162-3. 2008
    ..To achieve significant improvements in cardioplegic protection, more radical and conceptual changes in the solution, such as those potentially achieved by 'polarised' arrest, should be explored...
  9. ncbi request reprint Mechanisms and alternative methods of achieving cardiac arrest
    David J Chambers
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute, Guy s and St Thomas NHS Hospital Trust, St Thomas Campus, London SE1 7EH, United Kingdom
    Ann Thorac Surg 75:S661-6. 2003
    ..Similarly, agents that induce calcium desensitization may also prove to enhance protection. These alternative techniques, however, require extensive characterization before introduction into routine clinical use can be recommended...
  10. ncbi request reprint Invited commentary
    David J Chambers
    Cardiac Surgical Research, The Rayne Institute, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London, SE1 7EH United Kingdom
    Ann Thorac Surg 83:1109. 2007
  11. ncbi request reprint Invited commentary
    David J Chambers
    The Rayne Institute, Guy s and St Thomas NHS Foundation Trust, St Thomas Campus, London, SE1 7EH, United Kingdom
    Ann Thorac Surg 81:1416. 2006
  12. ncbi request reprint Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat
    Ryuzo Bessho
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute, Guy s and St Thomas NHS Trust, St Thomas Hospital, London SE1 7EH, UK
    J Thorac Cardiovasc Surg 124:340-51. 2002
    ....
  13. ncbi request reprint ICVTS on-line discussion A. The safety of using millimolar doses of lidocaine as cardioplegia
    Hazem B Fallouh
    Cardiac Surgery Department, St Thomas Hospital, London SE1 7EH, United Kingdom
    Interact Cardiovasc Thorac Surg 6:176. 2007
  14. ncbi request reprint Oxidative stress injury during cardiac surgery: how important is it?
    David J Chambers
    Cardiovasc Res 73:626-8. 2007
  15. ncbi request reprint Myocardial protection with intermittent cross-clamp fibrillation: does preconditioning play a role?
    Masahiro Fujii
    Cardiac Surgical Research Cardiothoracic Surgery, The Rayne Institute, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, London SE1 7EH, UK
    Eur J Cardiothorac Surg 28:821-31. 2005
    ..This study examined whether protection induced by intermittent cross-clamp fibrillation involves an ischemic preconditioning mechanism...
  16. ncbi request reprint Changes in P-selectin expression on cardiac microvessels in blood-perfused rat hearts subjected to ischemia-reperfusion
    Andrew O Chukwuemeka
    Cardiac Surgical Research Cardiothoracic Surgery, Rayne Institute, Guy s and St Thomas NHS Trust, St Thomas Campus, London, United Kingdom
    Ann Thorac Surg 79:204-11. 2005
    ..The purpose of this study was to define the kinetic changes in expression of P-selectin on myocardial vessels in a model of global ischemia-reperfusion injury...
  17. ncbi request reprint Experimental studies on myocardial protection with intermittent cross-clamp fibrillation: additive effect of the sodium-hydrogen exchanger inhibitor, cariporide
    Masahiro Fujii
    Cardiac Surgical Research and Cardiothoracic Surgery, The Rayne Institute, Guy s and St Thomas NHS Trust, St Thomas Hospital, London, United Kingdom
    Ann Thorac Surg 77:1398-407. 2004
    ..In this study, we examined whether cariporide (Aventis Pharma, Frankfurt, Germany), a specific sodium-hydrogen exchanger inhibitor, enhanced the protective effect of intermittent cross-clamp fibrillation (ICCF)...