Research Topics
| Stephen J ChallacombeSummaryAffiliation: King's College London Country: UK Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Global oral health inequalities: oral infections-challenges and approachesS Challacombe
King s College London Dental Institute, Central Office, Guys Hospital, London, UK
Adv Dent Res 23:227-36. 2011..Current treatment is surgical, but plans for its eradication should be achievable. The global oral health community, especially the IADR, has a major role to play...- Overview of the Fourth International Workshop on the Oral Manifestations of HIV InfectionS J Challacombe
Division of Oral Medicine, Pathology, Microbiology and Immunology, Guy's, King's and St Thomas' Dental Institute, Guy's Hospital, London, UK
Oral Dis 8:9-14. 2002 - Global perspectives for the IADR and dental researchStephen Challacombe
Guys, Kings and St Thomas' Dental Institute, Kings College London, Oral Medicine and Pathology, Floor 28, Guys Tower, Guys Hospital, England SE1 9RT, UK
J Dent Res 82:671. 2003 - Oral mucosal immunity and HIV infection: current statusS J Challacombe
Division of Oral Medicine, Pathology, Microbiology and Immunology, Guy s King s and St Thomas Dental Institute, Guy s Hospital, London, UK
Oral Dis 8:55-62. 2002.... - The effects of HIV infection on oral mucosal immunityS J Challacombe
Department of Oral Medicine, Pathology and Immunology, Guys, Kings and St Thomas Dental Institute, King s College London, Floor 28, Guys Tower, Guys Hospital, London SE1 9RT, UK
Adv Dent Res 19:29-35. 2006..Thus, HIV infection appears to have both direct and indirect effects on oral mucosal immunity, affecting both cellular and humoral immunity as well as both specific and innate immunity... - HIV infection and specific mucosal immunity: workshop 4BS J Challacombe
Department of Oral Medicine, Kings College London Dental Institute, London, UK
Adv Dent Res 23:142-51. 2011..Similarly, experimental data emphasized the central role of neutralizing antibodies to prevent HIV infection via mucosal routes... - Bullous pemphigoid antigen II (BP180) and its soluble extracellular domains are major autoantigens in mucous membrane pemphigoid: the pathogenic relevance to HLA class II alleles and disease severityN Oyama
Department of Dermatologic Immunopathology, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London, UK
Br J Dermatol 154:90-8. 2006..The heterogeneity of clinical presentation and diversity of target autoantigens have contributed to difficulties in characterizing this condition immunologically... - Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasisJulian R Naglik
Department of Oral Medicine, Pathology and Immunology, King s College London Dental Institute, Kings College London, London, UK
Microbiology 154:3266-80. 2008..However, the overall contribution of the Sap1-3 and Sap4-6 subfamilies individually in inducing epithelial damage in the RHE models appears to be low... - A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cellsDavid L Moyes
Department of Oral Medicine, Pathology, and Immunology, King s College London Dental Institute, King s College London, London, UK
Cell Host Microbe 8:225-35. 2010..MAPK/MKP1/c-Fos activation may represent a "danger response" pathway that is critical for identifying and responding to the pathogenic switch of commensal microbes... - Candida albicans HWP1 gene expression and host antibody responses in colonization and diseaseJulian R Naglik
Department of Oral Medicine and Immunology, King's College London Dental Institute at Guy's, King's College and St Thomas' Hospitals, King's College London, London, UK
J Med Microbiol 55:1323-7. 2006..Overall, Hwp1 and hyphal growth forms appear to be important factors in benign and invasive interactions of C. albicans with human hosts... - Murine model of concurrent oral and vaginal Candida albicans colonization to study epithelial host-pathogen interactionsDurdana Rahman
Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College and St Thomas Hospitals, London SE1 9RT, UK
Microbes Infect 9:615-22. 2007.... - Serum and salivary IgA antibody responses to Saccharomyces cerevisiae, Candida albicans and Streptococcus mutans in orofacial granulomatosis and Crohn's diseaseN W Savage
Department of Oral Medicine and Pathology, Guy's, Kings and St Thomas's School of Medicine and Dentistry, Kings College London, Guy's Hospital, London, UK
Clin Exp Immunol 135:483-9. 2004..Analysis of salivary IgA and IgA antibodies to S. cerevisiae as well as serum antibodies in patients presenting with OFG may allow prediction of gut involvement... - Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluidsShamim H Kazmi
Oral AIDS Research Unit, Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College, and St Thomas Hospitals, Floor 28, Guy s Tower, King s College London, London SE1 9RT, United Kingdom
Clin Vaccine Immunol 13:1111-8. 2006..The variation in HIV inhibitory activity between the fluids and between individuals suggests that there may be major differences in susceptibility to HIV infection depending both on the individual and on the mucosal fluid involved... - Murine model of concurrent oral and vaginal Candida albicans colonisationDurdana Rahman
Department of Oral Immunology, King s College London Dental Institute, London, UK
Methods Mol Biol 845:527-35. 2012..albicans epithelial colonisation... - Serum and saliva antibodies do not inhibit Candida albicans Sap2 proteinase activity using a BSA hydrolysis assayJulian R Naglik
Department of Oral Medicine, Pathology and Immunology, GKT Dental Institute, Kings College London Guy s Campus, London, UK
Med Mycol 43:73-7. 2005..Therefore, no evidence was found to demonstrate that specific or non-specific antibodies in serum or saliva could inhibit C. albicans Sap2 activity... - Immunodiagnosis of pemphigus and mucous membrane pemphigoidS J Challacombe
Department of Oral Medicine and Pathology, and Institute of Dermatology, Guy's, King's and St Thomas' Medical and Dental College, London, UK
Acta Odontol Scand 59:226-34. 2001.... - Candida albicans secreted aspartyl proteinases in virulence and pathogenesisJulian R Naglik
Department of Oral Medicine, Pathology and Immunology, GKT Dental Institute, Kings College London, London, United Kingdom
Microbiol Mol Biol Rev 67:400-28, table of contents. 2003..We have critically discussed the data relevant to each of these seven criteria, with specific emphasis on how this proteinase family could contribute to Candida virulence and pathogenesis... - A case of vulvovaginal gingival lichen planus in association with Good's syndromeKarwan A Moutasim
King s College London Dental Institute at Guy s, King s and St Thomas Hospitals, London, UK
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e57-60. 2008..The clinical features, investigation findings, and challenges in the management of a patient presenting with VVG LP and Good's Syndrome are discussed... - Pyoderma gangrenosum associated with severe oropharyngeal involvement and IgA paraproteinaemiaJ F Setterfield
St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
Br J Dermatol 144:393-6. 2001..We report a patient with combined cutaneous and oropharyngeal pyoderma gangrenosum in association with an IgA lambda paraproteinaemia. The differential diagnosis of oral pyoderma gangrenosum is discussed... - The use of two substrates to improve the sensitivity of indirect immunofluorescence in the diagnosis of pemphigusK E Harman
St John s Institute of Dermatology, St Thomas Hospital, and Department of Oral Medicine and Pathology, Guy s Hospital, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College, London, U K
Br J Dermatol 142:1135-9. 2000..This combination of substrates should not only increase the sensitivity of detecting pemphigus antibodies, but will aid in the differentiation of PV from PF. It is also possible that the data might be more useful for disease monitoring... - The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levelsK E Harman
St John s Institute of Dermatology, St Thomas Hospital, London, UK
Br J Dermatol 144:775-80. 2001..However, IIF is not able to measure separately Dsg1 and 3 antibodies, unlike enzyme-linked immunosorbent assays (ELISA), which utilize recombinant proteins... - Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3K E Harman
St John s Institute of Dermatology, King s Collrggr Hospita, London, UK
Clin Exp Dermatol 25:236-40. 2000..The Dsg 1 and Dsg 3 ELISAs also provided objective, quantitative, reproducible data which allowed differentiation of PV from PF and in view of these advantages, they are likely to become a routine technique in diagnostic laboratories... - Mucous membrane pemphigoid: HLA-DQB1*0301 is associated with all clinical sites of involvement and may be linked to antibasement membrane IgG productionJ Setterfield
St John s Institute of Dermatology GKT, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Br J Dermatol 145:406-14. 2001..Class I human leucocyte antigens (HLA) -A, -B, -Cw and class II HLA-DRB1, -DQB1 alleles were determined in 131 British Caucasian patients with mucous membrane pemphigoid (MMP) using serological and DNA-based methods... - A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotypeK E Harman
St John s Institute of Dermatology, St Thomas Hospital, London, UK
Br J Dermatol 143:343-8. 2000..Pemphigus vulgaris (PV) is characterized by pathogenic autoantibodies to desmoglein (Dsg) 3, but additional antibodies to Dsg1, the pemphigus foliaceus antigen, are detectable in some cases... - Investigating the relationship between hyposalivation and mucosal wetnessS Osailan
King s College London Dental Institute, London, UK
Oral Dis 17:109-14. 2011..Mucosal wetness (MW) reflects the layer of residual saliva that covers the oral mucosal surfaces... - Cicatricial pemphigoid: serial titres of circulating IgG and IgA antibasement membrane antibodies correlate with disease activityJ Setterfield
St John s Institute of Dermatology, St Thomas Hospital, London, UK
Br J Dermatol 140:645-50. 1999..Greatest improvement was seen in patients with the greatest change in either IgG or IgA antibody titre. We suggest that serial antibody titres may therefore be useful in the assessment and management of CP... - The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgarisKaren E Harman
St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, U K
Br J Dermatol 146:684-7. 2002..It is not known whether the transition to PF is permanent or whether disease relapses in the future may be associated with the re-emergence of Dsg3 antibodies, oral ulceration and a PV phenotype... - Protein and mucin retention on oral mucosal surfaces in dry mouth patientsRashida Pramanik
NIHR Biomedical Research Centre and KCL Salivary Research Unit, Kings College London and Guy s and St Thomas NHS, Guy sCampus, London, UK
Eur J Oral Sci 118:245-53. 2010..It is concluded that oral mucosal surfaces in dry mouth patients can retain MUC5B and other salivary proteins, although the functional integrity of these proteins is uncertain... - Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infectionsJulian R Naglik
Department of Oral Medicine, Pathology, and Immunology, Guy s, King s, and St Thomas Dental Institute, Kings College London, London, United Kingdom
J Infect Dis 188:469-79. 2003..This study demonstrates the differential expression of the hydrolytic enzyme genes in humans and correlates the expression of specific Candida species virulence genes with active disease and anatomical location... - Salivary calprotectin levels are raised in patients with oral candidiasis or Sjögren's syndrome but decreased by HIV infectionS P Sweet
Oral AIDS Research Unit, Division of Oral Medicine and Pathology, Guy's Hospital, St Thomas Street, London SE1 9RT, United Kingdom
Oral Microbiol Immunol 16:119-23. 2001.... - A scoring system for mucosal disease severity with special reference to oral lichen planusM Escudier
Department of Oral Medicine, King s College London Dental Institute, Guy s Hospital, London, U K
Br J Dermatol 157:765-70. 2007..Further research involving large placebo-controlled, randomized clinical trials is needed. These will require carefully selected and standardized outcome measures... - The clinical and microbiological effects of a novel acidified sodium chlorite mouthrinse on oral bacterial mucosal infectionsL Fernandes-Naglik
Division of Oral Medicine and Pathology, Microbiology and Immunology, Guy's King's and St Thomas' Dental Institute, King's College, London, UK
Oral Dis 7:276-80. 2001..There were no other significant differences between the treatments. ASC appears to be an effective alternative to chlorhexidine mouthrinse... - Improvement in orofacial granulomatosis on a cinnamon- and benzoate-free dietAllison White
Department of Dietetics, Kings College London, Medical and Dental Schools, Guy's, Kings and St Thomas's Hospital, London, UK
Inflamm Bowel Dis 12:508-14. 2006..With the disease most prevalent in the younger population, a CB-free diet can be recommended as primary treatment. Subsequent topical or systemic immunomodulatory therapy may then be avoided or used as second line... - Clinicopathological case 1: mucous membrane pemphigoid, epidermolysis bullosa acquisita and linear immunoglobulin A diseaseK E Harman
St. John's Institute of Dermatology (GKT, St. Thomas' Hospital, London, UK
Clin Exp Dermatol 28:461-2. 2003 - Erythema migrans: an unusual presentationV S Lucas
Department of Oral Medicine and Pathology, United Medical School, Guy s Hospital, London
Br Dent J 175:258-9. 1993..A case of erythema migrans affecting the attached gingivae and the upper and lower labial mucosa is described. No lesions were found on the tongue although this is the site most commonly affected... - The management of oral lichen planusJ F Setterfield
St John s Institute of Dermatology, St Thomas Hospital, London, Department of Oral Medicine and Pathology, Guy s Hospital, London, UK
Clin Exp Dermatol 25:176-82. 2000..Thus the management of this disorder will vary widely both between patients, and for individual patients, with fluctuations in disease activity. Here we discuss the therapeutic options available and review the evidence for their use... - Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndromeF Barone
Guy s, King s, and St Thomas School of Medicine, Guy s Campus, London, UK
Arthritis Rheum 52:1773-84. 2005..This study aimed to evaluate the microanatomic association between CXCL13 and CCL21 expression and the acquisition of lymphoid features in periductal foci... - Impact of wearing an intra-oral lubricating device on oral health in dry mouth patientsP M Frost
GKT Dental Institute, King s College, London, UK
Oral Dis 12:57-62. 2006..To establish whether an intra-oral lubricating device for dry mouth alters the oral environment... - Oral lesions in infection with human immunodeficiency virusMaeve M Coogan
Division of Oral Microbiology, School of Dentistry, University of the Witwatersrand, Wits, South Africa
Bull World Health Organ 83:700-6. 2005..It is important that all health care workers receive education and training on the relevance of oral health needs and the use of oral lesions as surrogate markers in HIV infection... - The vulvovaginal gingival syndrome: a severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1*0201 alleleJane F Setterfield
St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
J Am Acad Dermatol 55:98-113. 2006..The vulvovaginal gingival syndrome is an uncommon and severe variant of lichen planus characterized by erosions or desquamation of vulval, vaginal, and gingival mucosae with a predilection for scarring and stricture formation... - CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organizationFrancesca Barone
Divisione di Reumatologia Dipartimento di Clinica e Terapia Applicata, Universita La Sapienza Roma, Rome, Italy
J Immunol 180:5130-40. 2008.... - Human serum IgA1 is substituted with up to six O-glycans as shown by matrix assisted laser desorption ionisation time-of-flight mass spectrometryEdward Tarelli
Medical Biomics Centre, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
Carbohydr Res 339:2329-35. 2004..Hexa-substitution accounts for around 5-10% the glycoforms. This is, we believe, the first report of hexa-O-substitution with GalNAc of human serum IgA1... - Glycoform composition profiling of O-glycopeptides derived from human serum IgA1 by matrix-assisted laser desorption ionization-time of flight-mass spectrometryShideh Pouria
GKT School of Medicine and Dentistry, London SE5 9RS, UK
Anal Biochem 330:257-63. 2004..The MS methodology together with the Java data analysis are expected to be generally applicable for profiling O-linked glycopeptides derived from other glycoproteins and probably for N-linked glycopeptide pools... - Use of prophylactic antifungals in the immunocompromised hostJonathan A Ship
New York University College of Dentistry and the Bluestone Center for Clinical Research, New York, NY 10010 4086, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:S6.e1-14. 2007..Additional exploration is needed to determine which antifungal drug formulation, dose, and method of delivery is preferable for the type of fungal infection and the underlying etiology... - Management of recurrent oral herpes simplex infectionsSook Bin Woo
Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:S12.e1-18. 2007..Valacyclovir 500 mg twice a day is also effective in suppressing erythema multiforme triggered by HSV. Further studies are needed to compare treatment efficacy between topical penciclovir, docosanol, and ACV cream for RHL...
Research Grants
- The oral mucosal proteome: perturbation in HIV infection and Candida co infectionStephen Challacombe; Fiscal Year: 2007..This could also lead to therapies for the treatment of the co-infections associated with HIV such as oral Thrush. ..