Stephen J Challacombe

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint Professor Thomas Lehner: archetypal translational scientist
    S J Challacombe
    King s College London Dental Institute at Guys Hospital, London SE1 9RT, UK
    J Dent Res 92:393-6. 2013
  2. ncbi request reprint Global perspectives for the IADR and dental research
    Stephen Challacombe
    Guys, Kings and St Thomas Dental Institute, Kings College London, Oral Medicine and Pathology, Floor 28, Guys Tower, Guys Hospital, England SE1 9RT, UK
    J Dent Res 82:671. 2003
  3. doi request reprint Global oral health inequalities: oral infections-challenges and approaches
    S Challacombe
    King s College London Dental Institute, Central Office, Guys Hospital, London, UK
    Adv Dent Res 23:227-36. 2011
  4. doi request reprint HIV infection and specific mucosal immunity: workshop 4B
    S J Challacombe
    Department of Oral Medicine, Kings College London Dental Institute, London, UK
    Adv Dent Res 23:142-51. 2011
  5. ncbi request reprint The effects of HIV infection on oral mucosal immunity
    S J Challacombe
    Department of Oral Medicine, Pathology and Immunology, Guys, Kings and St Thomas Dental Institute, King s College London, Floor 28, Guys Tower, Guys Hospital, London SE1 9RT, UK
    Adv Dent Res 19:29-35. 2006
  6. ncbi request reprint Oral mucosal immunity and HIV infection: current status
    S J Challacombe
    Division of Oral Medicine, Pathology, Microbiology and Immunology, Guy s King s and St Thomas Dental Institute, Guy s Hospital, London, UK
    Oral Dis 8:55-62. 2002
  7. ncbi request reprint Overview of the Fourth International Workshop on the Oral Manifestations of HIV Infection
    S J Challacombe
    Division of Oral Medicine, Pathology, Microbiology and Immunology, Guy s, King s and St Thomas Dental Institute, Guy s Hospital, London, UK
    Oral Dis 8:9-14. 2002
  8. ncbi request reprint Bullous pemphigoid antigen II (BP180) and its soluble extracellular domains are major autoantigens in mucous membrane pemphigoid: the pathogenic relevance to HLA class II alleles and disease severity
    N Oyama
    Department of Dermatologic Immunopathology, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London, UK
    Br J Dermatol 154:90-8. 2006
  9. pmc Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis
    Julian R Naglik
    Department of Oral Medicine, Pathology and Immunology, King s College London Dental Institute, Kings College London, London, UK
    Microbiology 154:3266-80. 2008
  10. pmc A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells
    David L Moyes
    Department of Oral Medicine, Pathology, and Immunology, King s College London Dental Institute, King s College London, London, UK
    Cell Host Microbe 8:225-35. 2010

Collaborators

Detail Information

Publications47

  1. doi request reprint Professor Thomas Lehner: archetypal translational scientist
    S J Challacombe
    King s College London Dental Institute at Guys Hospital, London SE1 9RT, UK
    J Dent Res 92:393-6. 2013
    ..Arguably, his leadership, his students, and the establishment of immunology applied to oral mucosal diseases will be his greatest legacy. His contributions continue unabated...
  2. ncbi request reprint Global perspectives for the IADR and dental research
    Stephen Challacombe
    Guys, Kings and St Thomas Dental Institute, Kings College London, Oral Medicine and Pathology, Floor 28, Guys Tower, Guys Hospital, England SE1 9RT, UK
    J Dent Res 82:671. 2003
  3. doi request reprint Global oral health inequalities: oral infections-challenges and approaches
    S Challacombe
    King s College London Dental Institute, Central Office, Guys Hospital, London, UK
    Adv Dent Res 23:227-36. 2011
    ..Current treatment is surgical, but plans for its eradication should be achievable. The global oral health community, especially the IADR, has a major role to play...
  4. doi request reprint HIV infection and specific mucosal immunity: workshop 4B
    S J Challacombe
    Department of Oral Medicine, Kings College London Dental Institute, London, UK
    Adv Dent Res 23:142-51. 2011
    ..Similarly, experimental data emphasized the central role of neutralizing antibodies to prevent HIV infection via mucosal routes...
  5. ncbi request reprint The effects of HIV infection on oral mucosal immunity
    S J Challacombe
    Department of Oral Medicine, Pathology and Immunology, Guys, Kings and St Thomas Dental Institute, King s College London, Floor 28, Guys Tower, Guys Hospital, London SE1 9RT, UK
    Adv Dent Res 19:29-35. 2006
    ..Thus, HIV infection appears to have both direct and indirect effects on oral mucosal immunity, affecting both cellular and humoral immunity as well as both specific and innate immunity...
  6. ncbi request reprint Oral mucosal immunity and HIV infection: current status
    S J Challacombe
    Division of Oral Medicine, Pathology, Microbiology and Immunology, Guy s King s and St Thomas Dental Institute, Guy s Hospital, London, UK
    Oral Dis 8:55-62. 2002
    ....
  7. ncbi request reprint Overview of the Fourth International Workshop on the Oral Manifestations of HIV Infection
    S J Challacombe
    Division of Oral Medicine, Pathology, Microbiology and Immunology, Guy s, King s and St Thomas Dental Institute, Guy s Hospital, London, UK
    Oral Dis 8:9-14. 2002
  8. ncbi request reprint Bullous pemphigoid antigen II (BP180) and its soluble extracellular domains are major autoantigens in mucous membrane pemphigoid: the pathogenic relevance to HLA class II alleles and disease severity
    N Oyama
    Department of Dermatologic Immunopathology, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London, UK
    Br J Dermatol 154:90-8. 2006
    ..The heterogeneity of clinical presentation and diversity of target autoantigens have contributed to difficulties in characterizing this condition immunologically...
  9. pmc Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis
    Julian R Naglik
    Department of Oral Medicine, Pathology and Immunology, King s College London Dental Institute, Kings College London, London, UK
    Microbiology 154:3266-80. 2008
    ..However, the overall contribution of the Sap1-3 and Sap4-6 subfamilies individually in inducing epithelial damage in the RHE models appears to be low...
  10. pmc A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells
    David L Moyes
    Department of Oral Medicine, Pathology, and Immunology, King s College London Dental Institute, King s College London, London, UK
    Cell Host Microbe 8:225-35. 2010
    ..MAPK/MKP1/c-Fos activation may represent a "danger response" pathway that is critical for identifying and responding to the pathogenic switch of commensal microbes...
  11. pmc Candida albicans HWP1 gene expression and host antibody responses in colonization and disease
    Julian R Naglik
    Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College and St Thomas Hospitals, King s College London, London, UK
    J Med Microbiol 55:1323-7. 2006
    ..Overall, Hwp1 and hyphal growth forms appear to be important factors in benign and invasive interactions of C. albicans with human hosts...
  12. pmc Murine model of concurrent oral and vaginal Candida albicans colonization to study epithelial host-pathogen interactions
    Durdana Rahman
    Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College and St Thomas Hospitals, London SE1 9RT, UK
    Microbes Infect 9:615-22. 2007
    ....
  13. pmc Serum and salivary IgA antibody responses to Saccharomyces cerevisiae, Candida albicans and Streptococcus mutans in orofacial granulomatosis and Crohn's disease
    N W Savage
    Department of Oral Medicine and Pathology, Guy s, Kings and St Thomas s School of Medicine and Dentistry, Kings College London, Guy s Hospital, London, UK
    Clin Exp Immunol 135:483-9. 2004
    ..Analysis of salivary IgA and IgA antibodies to S. cerevisiae as well as serum antibodies in patients presenting with OFG may allow prediction of gut involvement...
  14. pmc Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids
    Shamim H Kazmi
    Oral AIDS Research Unit, Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College, and St Thomas Hospitals, Floor 28, Guy s Tower, King s College London, London SE1 9RT, United Kingdom
    Clin Vaccine Immunol 13:1111-8. 2006
    ..The variation in HIV inhibitory activity between the fluids and between individuals suggests that there may be major differences in susceptibility to HIV infection depending both on the individual and on the mucosal fluid involved...
  15. doi request reprint Murine model of concurrent oral and vaginal Candida albicans colonisation
    Durdana Rahman
    Department of Oral Immunology, King s College London Dental Institute, London, UK
    Methods Mol Biol 845:527-35. 2012
    ..albicans epithelial colonisation...
  16. ncbi request reprint Serum and saliva antibodies do not inhibit Candida albicans Sap2 proteinase activity using a BSA hydrolysis assay
    Julian R Naglik
    Department of Oral Medicine, Pathology and Immunology, GKT Dental Institute, Kings College London Guy s Campus, London, UK
    Med Mycol 43:73-7. 2005
    ..Therefore, no evidence was found to demonstrate that specific or non-specific antibodies in serum or saliva could inhibit C. albicans Sap2 activity...
  17. ncbi request reprint Immunodiagnosis of pemphigus and mucous membrane pemphigoid
    S J Challacombe
    Department of Oral Medicine and Pathology, and Institute of Dermatology, Guy's, King's and St Thomas' Medical and Dental College, London, UK
    Acta Odontol Scand 59:226-34. 2001
    ....
  18. pmc Candida albicans secreted aspartyl proteinases in virulence and pathogenesis
    Julian R Naglik
    Department of Oral Medicine, Pathology and Immunology, GKT Dental Institute, Kings College London, London, United Kingdom
    Microbiol Mol Biol Rev 67:400-28, table of contents. 2003
    ..We have critically discussed the data relevant to each of these seven criteria, with specific emphasis on how this proteinase family could contribute to Candida virulence and pathogenesis...
  19. doi request reprint A case of vulvovaginal gingival lichen planus in association with Good's syndrome
    Karwan A Moutasim
    King s College London Dental Institute at Guy s, King s and St Thomas Hospitals, London, UK
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e57-60. 2008
    ..The clinical features, investigation findings, and challenges in the management of a patient presenting with VVG LP and Good's Syndrome are discussed...
  20. doi request reprint Investigating the relationship between hyposalivation and mucosal wetness
    S Osailan
    King s College London Dental Institute, London, UK
    Oral Dis 17:109-14. 2011
    ..Mucosal wetness (MW) reflects the layer of residual saliva that covers the oral mucosal surfaces...
  21. ncbi request reprint Mucous membrane pemphigoid: HLA-DQB1*0301 is associated with all clinical sites of involvement and may be linked to antibasement membrane IgG production
    J Setterfield
    St John s Institute of Dermatology GKT, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Br J Dermatol 145:406-14. 2001
    ..Class I human leucocyte antigens (HLA) -A, -B, -Cw and class II HLA-DRB1, -DQB1 alleles were determined in 131 British Caucasian patients with mucous membrane pemphigoid (MMP) using serological and DNA-based methods...
  22. ncbi request reprint Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3
    K E Harman
    St John s Institute of Dermatology, King s Collrggr Hospita, London, UK
    Clin Exp Dermatol 25:236-40. 2000
    ..The Dsg 1 and Dsg 3 ELISAs also provided objective, quantitative, reproducible data which allowed differentiation of PV from PF and in view of these advantages, they are likely to become a routine technique in diagnostic laboratories...
  23. ncbi request reprint The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgaris
    Karen E Harman
    St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, U K
    Br J Dermatol 146:684-7. 2002
    ..It is not known whether the transition to PF is permanent or whether disease relapses in the future may be associated with the re-emergence of Dsg3 antibodies, oral ulceration and a PV phenotype...
  24. ncbi request reprint The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 144:775-80. 2001
    ..However, IIF is not able to measure separately Dsg1 and 3 antibodies, unlike enzyme-linked immunosorbent assays (ELISA), which utilize recombinant proteins...
  25. ncbi request reprint Pyoderma gangrenosum associated with severe oropharyngeal involvement and IgA paraproteinaemia
    J F Setterfield
    St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 144:393-6. 2001
    ..We report a patient with combined cutaneous and oropharyngeal pyoderma gangrenosum in association with an IgA lambda paraproteinaemia. The differential diagnosis of oral pyoderma gangrenosum is discussed...
  26. ncbi request reprint The use of two substrates to improve the sensitivity of indirect immunofluorescence in the diagnosis of pemphigus
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, and Department of Oral Medicine and Pathology, Guy s Hospital, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College, London, U K
    Br J Dermatol 142:1135-9. 2000
    ..This combination of substrates should not only increase the sensitivity of detecting pemphigus antibodies, but will aid in the differentiation of PV from PF. It is also possible that the data might be more useful for disease monitoring...
  27. ncbi request reprint A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 143:343-8. 2000
    ..Pemphigus vulgaris (PV) is characterized by pathogenic autoantibodies to desmoglein (Dsg) 3, but additional antibodies to Dsg1, the pemphigus foliaceus antigen, are detectable in some cases...
  28. ncbi request reprint Cicatricial pemphigoid: serial titres of circulating IgG and IgA antibasement membrane antibodies correlate with disease activity
    J Setterfield
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 140:645-50. 1999
    ..Greatest improvement was seen in patients with the greatest change in either IgG or IgA antibody titre. We suggest that serial antibody titres may therefore be useful in the assessment and management of CP...
  29. doi request reprint Protein and mucin retention on oral mucosal surfaces in dry mouth patients
    Rashida Pramanik
    NIHR Biomedical Research Centre and KCL Salivary Research Unit, Kings College London and Guy s and St Thomas NHS, Guy sCampus, London, UK
    Eur J Oral Sci 118:245-53. 2010
    ..It is concluded that oral mucosal surfaces in dry mouth patients can retain MUC5B and other salivary proteins, although the functional integrity of these proteins is uncertain...
  30. doi request reprint Clinical assessment of disease severity in recurrent aphthous stomatitis
    Anwar R Tappuni
    Barts and the London School of Medicine and Dentistry, Institute of Dentistry, Queen Mary University of London, London, UK
    J Oral Pathol Med 42:635-41. 2013
    ..This could be partly due to the difficulty in evaluating the efficacy of oral ulcer treatment objectively. In this paper, we present a method for assessing and monitoring the severity of oral ulcers before and after treatment...
  31. ncbi request reprint Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections
    Julian R Naglik
    Department of Oral Medicine, Pathology, and Immunology, Guy s, King s, and St Thomas Dental Institute, Kings College London, London, United Kingdom
    J Infect Dis 188:469-79. 2003
    ..This study demonstrates the differential expression of the hydrolytic enzyme genes in humans and correlates the expression of specific Candida species virulence genes with active disease and anatomical location...
  32. ncbi request reprint Salivary calprotectin levels are raised in patients with oral candidiasis or Sjögren's syndrome but decreased by HIV infection
    S P Sweet
    Oral AIDS Research Unit, Division of Oral Medicine and Pathology, Guy's Hospital, St Thomas Street, London SE1 9RT, United Kingdom
    Oral Microbiol Immunol 16:119-23. 2001
    ....
  33. ncbi request reprint The clinical and microbiological effects of a novel acidified sodium chlorite mouthrinse on oral bacterial mucosal infections
    L Fernandes-Naglik
    Division of Oral Medicine and Pathology, Microbiology and Immunology, Guy's King's and St Thomas' Dental Institute, King's College, London, UK
    Oral Dis 7:276-80. 2001
    ..There were no other significant differences between the treatments. ASC appears to be an effective alternative to chlorhexidine mouthrinse...
  34. ncbi request reprint A scoring system for mucosal disease severity with special reference to oral lichen planus
    M Escudier
    Department of Oral Medicine, King s College London Dental Institute, Guy s Hospital, London, U K
    Br J Dermatol 157:765-70. 2007
    ..Further research involving large placebo-controlled, randomized clinical trials is needed. These will require carefully selected and standardized outcome measures...
  35. ncbi request reprint Improvement in orofacial granulomatosis on a cinnamon- and benzoate-free diet
    Allison White
    Department of Dietetics, Kings College London, Medical and Dental Schools, Guy s, Kings and St Thomas s Hospital, London, UK
    Inflamm Bowel Dis 12:508-14. 2006
    ..Thus, this study was undertaken to investigate the benefits of a CB-free diet as first-line treatment of patients with OFG...
  36. ncbi request reprint Clinicopathological case 1: mucous membrane pemphigoid, epidermolysis bullosa acquisita and linear immunoglobulin A disease
    K E Harman
    St John s Institute of Dermatology GKT, St Thomas Hospital, London, UK
    Clin Exp Dermatol 28:461-2. 2003
  37. ncbi request reprint Impact of wearing an intra-oral lubricating device on oral health in dry mouth patients
    P M Frost
    GKT Dental Institute, King s College, London, UK
    Oral Dis 12:57-62. 2006
    ..To establish whether an intra-oral lubricating device for dry mouth alters the oral environment...
  38. ncbi request reprint Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome
    F Barone
    Guy s, King s, and St Thomas School of Medicine, Guy s Campus, London, UK
    Arthritis Rheum 52:1773-84. 2005
    ..This study aimed to evaluate the microanatomic association between CXCL13 and CCL21 expression and the acquisition of lymphoid features in periductal foci...
  39. ncbi request reprint The management of oral lichen planus
    J F Setterfield
    St John s Institute of Dermatology, St Thomas Hospital, London, Department of Oral Medicine and Pathology, Guy s Hospital, London, UK
    Clin Exp Dermatol 25:176-82. 2000
    ..Thus the management of this disorder will vary widely both between patients, and for individual patients, with fluctuations in disease activity. Here we discuss the therapeutic options available and review the evidence for their use...
  40. ncbi request reprint Erythema migrans: an unusual presentation
    V S Lucas
    Department of Oral Medicine and Pathology, United Medical School, Guy s Hospital, London
    Br Dent J 175:258-9. 1993
    ..A case of erythema migrans affecting the attached gingivae and the upper and lower labial mucosa is described. No lesions were found on the tongue although this is the site most commonly affected...
  41. pmc Oral lesions in infection with human immunodeficiency virus
    Maeve M Coogan
    Division of Oral Microbiology, School of Dentistry, University of the Witwatersrand, Wits, South Africa
    Bull World Health Organ 83:700-6. 2005
    ..It is important that all health care workers receive education and training on the relevance of oral health needs and the use of oral lesions as surrogate markers in HIV infection...
  42. ncbi request reprint The vulvovaginal gingival syndrome: a severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1*0201 allele
    Jane F Setterfield
    St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    J Am Acad Dermatol 55:98-113. 2006
    ..The vulvovaginal gingival syndrome is an uncommon and severe variant of lichen planus characterized by erosions or desquamation of vulval, vaginal, and gingival mucosae with a predilection for scarring and stricture formation...
  43. ncbi request reprint CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization
    Francesca Barone
    Divisione di Reumatologia Dipartimento di Clinica e Terapia Applicata, Universita La Sapienza Roma, Rome, Italy
    J Immunol 180:5130-40. 2008
    ....
  44. ncbi request reprint Use of prophylactic antifungals in the immunocompromised host
    Jonathan A Ship
    New York University College of Dentistry and the Bluestone Center for Clinical Research, New York, NY 10010 4086, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:S6.e1-14. 2007
    ..Additional exploration is needed to determine which antifungal drug formulation, dose, and method of delivery is preferable for the type of fungal infection and the underlying etiology...
  45. ncbi request reprint Management of recurrent oral herpes simplex infections
    Sook Bin Woo
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:S12.e1-18. 2007
    ..Valacyclovir 500 mg twice a day is also effective in suppressing erythema multiforme triggered by HSV. Further studies are needed to compare treatment efficacy between topical penciclovir, docosanol, and ACV cream for RHL...
  46. ncbi request reprint Human serum IgA1 is substituted with up to six O-glycans as shown by matrix assisted laser desorption ionisation time-of-flight mass spectrometry
    Edward Tarelli
    Medical Biomics Centre, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    Carbohydr Res 339:2329-35. 2004
    ..Hexa-substitution accounts for around 5-10% the glycoforms. This is, we believe, the first report of hexa-O-substitution with GalNAc of human serum IgA1...
  47. ncbi request reprint Glycoform composition profiling of O-glycopeptides derived from human serum IgA1 by matrix-assisted laser desorption ionization-time of flight-mass spectrometry
    Shideh Pouria
    GKT School of Medicine and Dentistry, London SE5 9RS, UK
    Anal Biochem 330:257-63. 2004
    ..The MS methodology together with the Java data analysis are expected to be generally applicable for profiling O-linked glycopeptides derived from other glycoproteins and probably for N-linked glycopeptide pools...

Research Grants1

  1. The oral mucosal proteome: perturbation in HIV infection and Candida co infection
    Stephen Challacombe; Fiscal Year: 2007
    ..This could also lead to therapies for the treatment of the co-infections associated with HIV such as oral Thrush. ..