Lee M Butcher

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms
    L M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Mol Psychiatry 10:384-92. 2005
  2. ncbi request reprint SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Hum Mol Genet 14:1315-25. 2005
  3. pmc Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies
    Sophia J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, DeCrispigny Park, London, UK
    BMC Genomics 8:214. 2007
  4. pmc A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples
    Angelica Ronald
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Behav Genet 40:31-45. 2010
  5. pmc Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genomics 6:52. 2005
  6. pmc Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    Nucleic Acids Res 34:e27. 2006
  7. ncbi request reprint A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds
    Nicole Harlaar
    Institute of Psychiatry, King s College London, London, UK
    J Child Psychol Psychiatry 46:1097-107. 2005
  8. pmc No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Med Genet 9:12. 2008
  9. pmc A three-stage genome-wide association study of general cognitive ability: hunting the small effects
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 40:759-67. 2010
  10. pmc The nature of nurture: a genomewide association scan for family chaos
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Box Number P082, De Crespigny Park, London, UK
    Behav Genet 38:361-71. 2008

Detail Information

Publications18

  1. ncbi request reprint Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms
    L M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Mol Psychiatry 10:384-92. 2005
    ..The present SNP strategy combined with DNA pooling and large samples represents a step towards identifying QTLs of small effect size associated with complex traits in the postgenomic era when all functional polymorphisms will be known...
  2. ncbi request reprint SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Hum Mol Genet 14:1315-25. 2005
    ..Although each SNP accounts for a small amount of variance, their effects are additive and they can be combined in a 'SNP set' that can be used as a genetic risk index for MMI in behavioral genomic analyses...
  3. pmc Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies
    Sophia J Docherty
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, DeCrispigny Park, London, UK
    BMC Genomics 8:214. 2007
    ..We demonstrate that this approach can be effectively applied to the truly genomewide Affymetrix GeneChip Mapping 500 K Array...
  4. pmc A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples
    Angelica Ronald
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Behav Genet 40:31-45. 2010
    ..When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families...
  5. pmc Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    BMC Genomics 6:52. 2005
    ..An efficient solution is to genotype case and control DNA pools using SNP microarrays. We demonstrate that this is practical using DNA pools of 100 individuals...
  6. pmc Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans
    Emma Meaburn
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    Nucleic Acids Res 34:e27. 2006
    ..We conclude that extending the SNP-MaP method to the Affymetrix GeneChip Mapping 100K Array set provides a useful screen of >100,000 SNP markers for QTL association scans...
  7. ncbi request reprint A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds
    Nicole Harlaar
    Institute of Psychiatry, King s College London, London, UK
    J Child Psychol Psychiatry 46:1097-107. 2005
    ..These children have also been studied at 2, 3, 4, and 7 years of age on measures of cognitive and language development and behaviour problems; family environment was also assessed...
  8. pmc No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins
    Claire M A Haworth
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Med Genet 9:12. 2008
    ..The purpose of the present study was to test the developmental origins of some of these associations in a large longitudinal sample of children...
  9. pmc A three-stage genome-wide association study of general cognitive ability: hunting the small effects
    Oliver S P Davis
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Behav Genet 40:759-67. 2010
    ..Larger samples, denser arrays and multiple replications will be necessary in the hunt for the genetic variants that influence human cognitive ability...
  10. pmc The nature of nurture: a genomewide association scan for family chaos
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Box Number P082, De Crespigny Park, London, UK
    Behav Genet 38:361-71. 2008
    ..Similar to GWA analyses of other complex traits, it is likely that most of the heritable variation in environmental measures such as family chaos is due to many genes of very small effect size...
  11. ncbi request reprint Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Box Number P082, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Behav Genet 34:549-55. 2004
    ..Thus, genotyping pooled DNA on microarrays can provide a systematic and powerful approach for identifying QTL associations for complex traits including behavioral dimensions and disorders...
  12. pmc Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays
    L M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Genes Brain Behav 7:435-46. 2008
    ..11 (P < 0.00000003) with g. This shows that future SNP sets that will incorporate many more SNPs could be useful for predicting genetic risk and for investigating functional systems of effects from genes to brain to behavior...
  13. ncbi request reprint Generalist genes and cognitive neuroscience
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Number P080, Institute of Psychiatry, DeCrespigny Park, London, SE5 8AF, United Kingdom
    Curr Opin Neurobiol 16:145-51. 2006
    ....
  14. pmc Human-specific CpG "beacons" identify loci associated with human-specific traits and disease
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    Epigenetics 7:1188-99. 2012
    ..Taken together, our data support a model for CpG beacons to contribute to CGI evolution from genesis to tissue-specific to constitutively active CGIs...
  15. doi request reprint Methylome analysis using MeDIP-seq with low DNA concentrations
    Oluwatosin Taiwo
    University College London UCL Cancer Institute, University College London, London, UK
    Nat Protoc 7:617-36. 2012
    ..The protocol described here, i.e., DNA extraction to generation of MeDIP-seq library, can be completed within 3-5 d...
  16. ncbi request reprint Genetic heterogeneity between the three components of the autism spectrum: a twin study
    Angelica Ronald
    SGDP Centre, Institute of Psychiatry, King s College London, UK
    J Am Acad Child Adolesc Psychiatry 45:691-9. 2006
    ....
  17. doi request reprint Future impact of integrated high-throughput methylome analyses on human health and disease
    Lee M Butcher
    UCL Cancer Institute, Paul O Gorman Building, University College London, 72 Huntley Street, London, WC1E 6BT, UK
    J Genet Genomics 35:391-401. 2008
    ....
  18. pmc A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays
    Claire L Simpson
    Department of Neurology, PO43, Institute of Psychiatry London SE5 8AF, UK
    Nucleic Acids Res 33:e25. 2005
    ....