Affiliation: King's College London
Apergis Schoute J, Iordanidou P, Faure C, Jego S, SchÃ¶ne C, Aitta Aho T, et al
. Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits. J Neurosci. 2015;35:5435-41 pubmed publisher
..Collectively, our data provide functional microcircuit evidence that intra-LH feedforward loops may facilitate appropriate switching between sleep and wake signals, potentially preventing sleep disorders. ..
Burdakov D, Karnani M, Gonzalez A. Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control. Physiol Behav. 2013;121:117-24 pubmed publisher
..Further studies of how LH circuits counteract evolutionarily-relevant environmental fluctuations will provide key information about the logic and fragilities of brain controllers of healthy homeostasis. ..
GonzÃ¡lez J, Jensen L, Iordanidou P, Strom M, Fugger L, Burdakov D. Inhibitory Interplay between Orexin Neurons and Eating. Curr Biol. 2016;26:2486-2491 pubmed publisher
..These results support an inhibitory interplay between OH signals and eating, and demonstrate that OH cell activity is rapidly controllable, across nutritional states, by voluntary action. ..