Rodrigo A Bressan
Affiliation: King's College London
- Typical antipsychotic drugs -- D(2) receptor occupancy and depressive symptoms in schizophreniaRodrigo A Bressan
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Schizophr Res 56:31-6. 2002..52, p=0.025). This study suggests that high striatal dopamine D(2) blockade by typical antipsychotic drugs may contribute to the emergence of depressive symptoms in typical antipsychotic treated schizophrenic patients...
- The posttraumatic stress disorder project in Brazil: neuropsychological, structural and molecular neuroimaging studies in victims of urban violenceRodrigo A Bressan
Laboratório Interdisciplinar de Neurosciencias Clínicas LiNC, Sao Paulo, Brazil
BMC Psychiatry 9:30. 2009..This paper shows the research rationale and design for these three case-control studies...
- Prolactinemia is uncoupled from central D2/D3 dopamine receptor occupancy in amisulpride treated patientsRodrigo A Bressan
Section of Neurochemical Imaging, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
Psychopharmacology (Berl) 175:367-73. 2004..Previous studies have found an association between striatal D2/D3 receptor occupancy and PRL in typical antipsychotic treated patients suggesting that PRL is a marker of central D2/D3 receptors blockade...
- Evaluation of NMDA receptors in vivo in schizophrenic patients with [123I]CNS 1261 and SPET: preliminary findingsRodrigo A Bressan
Institute of Psychiatry, King's College, London, WC2R 2LS, United Kingdom
Ann N Y Acad Sci 1003:364-7. 2003
- [Glutamatergic hypothesis of schizophrenia]Rodrigo A Bressan
Departamento de Psiquiatria, Universidade Federal de São Paulo UNIFESP São Paulo, SP, Brasil
Rev Bras Psiquiatr 25:177-83. 2003..Finaly the paper discusses the interaction between the dopaminergic and the glutamatergic systems; in special how hyperdopaminergic state found in schizophrenia can be associated to glutamatergic dysfunctions...
- Is regionally selective D2/D3 dopamine occupancy sufficient for atypical antipsychotic effect? an in vivo quantitative [123I]epidepride SPET study of amisulpride-treated patientsRodrigo A Bressan
British Association of Psychopharmacology, Harrogate, UK
Am J Psychiatry 160:1413-20. 2003..The authors' goal was to evaluate whether treatment with amisulpride results in "limbic selective" D(2)/D(3) receptor blockade in vivo...
- Depressive episodes in stable schizophrenia: critical evaluation of the DSM-IV and ICD-10 diagnostic criteriaRodrigo A Bressan
Schizophrenia Program, Department of Psychiatry, Federal University of Sao Paulo UNIFESP, Brazil
Psychiatry Res 117:47-56. 2003..Useful criteria for depressive episodes in schizophrenia should avoid a temporal relation with the psychotic episode...
- Optimizing limbic selective D2/D3 receptor occupancy by risperidone: a [123I]-epidepride SPET studyRodrigo A Bressan
Section of Neurochemical Imaging, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
J Clin Psychopharmacol 23:5-14. 2003..This finding is consistent with the relevance of 'limbic selective' D2/D3 receptor occupancy to the therapeutic efficacy of atypical antipsychotic drugs...
- Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET studyJames M Stone
Institute of Psychiatry, King s College London, London, UK
Psychopharmacology (Berl) 197:401-8. 2008..Ketamine induces effects resembling both positive and negative psychotic symptoms of schizophrenia. These are thought to arise through its action as an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor...
- Higher dopamine transporter density in Parkinson's disease patients with depressionAndre C Felicio
Instituto Israelita de Ensino e Pesquisa IIEP, Hospital Israelita Albert Einstein HIAE, Francisco Morato ave, 4293, Postal Code 05521 000, Sao Paulo, Brazil
Psychopharmacology (Berl) 211:27-31. 2010....
- Increased dopamine transporter density in Parkinson's disease patients with Social Anxiety DisorderTais S Moriyama
Instituto do Cérebro, Instituto de Ensino e Pesquisa do Hospital Israelita Albert Einstein, Sao Paulo, Brazil
J Neurol Sci 310:53-7. 2011..39, p=0.03). No significant correlation was found for the right caudate (r=0.23, p=0.21). This finding may reinforce the hypothesis that dopaminergic dysfunction might be implicated in the pathogenesis of social anxiety in PD...
- A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [123I]CNS 1261Rodrigo A Bressan
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
Nucl Med Biol 31:155-64. 2004..Good agreement was obtained between kinetic and equilibrium analysis. SPET scanning with a bolus-infusion protocol is a valid method to estimate the total volume of distribution for [(123)I]CNS 1261 in clinical populations...
- Degenerative parkinsonism in patients with psychogenic parkinsonism: A dopamine transporter imaging studyAndre C Felicio
Movement Disorder Unit, Federal University of Sao Paulo, Sao Paulo, Brazil
Clin Neurol Neurosurg 112:282-5. 2010....
- Analysis of D2 dopamine receptor occupancy with quantitative SPET using the high-affinity ligand [123I]epidepride: resolving conflicting findingsKjell Erlandsson
Institute of Nuclear Medicine, Royal Free and University College Medical School, University College London, London, UK
Neuroimage 19:1205-14. 2003....
- Non-uniform blockade of intrastriatal D2/D3 receptors by risperidone and amisulprideJames M Stone
Section of Neurochemical Imaging, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
Psychopharmacology (Berl) 180:664-9. 2005..The striatum does not contain exclusively nigrostriatal dopamine tracts, however. The caudate nucleus and ventral parts of the striatum primarily contain limbic and associative dopamine pathways more relevant to psychosis...
- Impact of schizophrenia and chronic antipsychotic treatment on [123I]CNS-1261 binding to N-methyl-D-aspartate receptors in vivoRodrigo A Bressan
Institute of Psychiatry, King's College, London, United Kingdom
Biol Psychiatry 58:41-6. 2005..This supports an effect of the drug on glutamatergic systems that could be exploited for future antipsychotic drug discovery...
- Evaluation of patients with Clinically Unclear Parkinsonian Syndromes submitted to brain SPECT imaging using the technetium-99m labeled tracer TRODAT-1Andre C Felicio
Department of Neurology and Neurosurgery, Movement Disorder Unit, Federal University of Sao Paulo, Sao Paulo, Brazil
J Neurol Sci 291:64-8. 2010..In conclusion, our data provided further information about the role of the technetium-99m labeled tracer TRODAT-1 as a biomarker of DAT reduction that can also be used in the diagnosis of patients with CUPS...
- Ketamine displaces the novel NMDA receptor SPET probe [(123)I]CNS-1261 in humans in vivoJames M Stone
Institute of Psychiatry, King s College London, De Crespigny Park London, SE5 8AF UK
Nucl Med Biol 33:239-43. 2006..05). [(123)I]CNS-1261 appears to be a specific ligand in vivo for the intra-channel PCP/ketamine/MK-801 NMDA binding site...
- Role of processing speed and depressed mood on encoding, storage, and retrieval memory functions in patients diagnosed with schizophreniaGildas Brébion
Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
J Int Neuropsychol Soc 13:99-107. 2007..Neither processing speed nor depressed mood was associated with storage efficiency. It is concluded that both cognitive speed slowing and depressed mood impact on effortful encoding processes...
- Frontal Assessment Battery (FAB) is a simple tool for detecting executive deficits in chronic cannabis usersMaria Alice Fontes
LiNC Laboratório Interdisciplinar de Neurociências Clínicas, Departamento de Psiquiatria, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
J Clin Exp Neuropsychol 33:523-31. 2011..In the present study, the Frontal Assessment Battery (FAB), a brief, easy to use neuropsychological instrument aimed to evaluate EF, was used to evaluate cognitive functioning of CCU...
- Production of atypical category exemplars in patients with schizophreniaGildas Brébion
Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College London, London, UK
J Int Neuropsychol Soc 16:822-8. 2010..This semantic abnormality is not a feature of the patients with high ratings of certain negative symptoms...
- Higher striatal dopamine transporter density in PTSD: an in vivo SPECT study with [(99m)Tc]TRODAT-1Marcelo Q Hoexter
Instituto do Cérebro, Instituto de Ensino e Pesquisa do Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Psychopharmacology (Berl) 224:337-45. 2012..In vivo molecular imaging studies have shown that healthy 9R carriers have increased striatal DAT binding. However, no prior study evaluated in vivo striatal DAT density in PTSD...
- The effectiveness of a non-pharmacological intervention for weight gain management in severe mental disorders: results from a national multicentric studyCecília Attux
Schizophrenia Program, Department of Psychiatry, Universidade Federal de Sao Paulo, Brazil
Rev Bras Psiquiatr 33:117-21. 2011..To evaluate the effectiveness of a non-pharmacological intervention for weight gain management in severe mental disorders...
- Molecular imaging studies in Parkinson disease: reducing diagnostic uncertaintyAndre C Felicio
Department of Neurology and Neurosurgery, Movement Disorders Unit, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Neurologist 15:6-16. 2009....
- Role of processing speed and premorbid IQ on visual recognition in patients with schizophreniaGildas Brébion
Department of Psychological Medicine, Institute of Psychiatry, London, UK
J Clin Exp Neuropsychol 31:302-11. 2009..These data suggest that premorbid IQ is involved in visual-recognition efficiency. However, the deficit observed in patients is accounted for by decreased processing speed...
- Atypical antipsychotic drugs and tardive dyskinesia: relevance of D2 receptor affinityRodrigo A Bressan
Section of Neurochemical Imaging and Psychiatry, Department of Psychological Medicine, Institute of Psychiatry, London, UK
J Psychopharmacol 18:124-7. 2004..Potential psychopharmacological mechanisms explaining these differences are discussed, highlighting the importance of D2 receptor occupancy by atypical antipsychotic drugs for TD...
- Sleep disorders in Machado-Joseph disease: a dopamine transporter imaging studyJose Luiz Pedroso
Department of Neurology, Ataxia Unit, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
J Neurol Sci 324:90-3. 2013..This study assessed the relationship between sleep disorders in MJD and dopamine transporter (DAT) densities...
- Processing speed: a strong predictor of verbal memory performance in schizophreniaGildas Brébion
Institute of Psychiatry, London, UK
J Clin Exp Neuropsychol 28:370-82. 2006..These findings suggest that slowing in processing speed is an important contributor to verbal memory impairment in patients with schizophrenia. The possible role of various specific slowing functions is discussed...
- Violence and post-traumatic stress disorder in Sao Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic surveySergio Baxter Andreoli
Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
BMC Psychiatry 9:34. 2009....
- Olfactory heterogeneity in LRRK2 related ParkinsonismLaura Silveira-Moriyama
Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
Mov Disord 25:2879-83. 2010..Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD...
- A 6-month randomized controlled trial to test the efficacy of a lifestyle intervention for weight gain management in schizophreniaCecília Attux
Department of Psychiatry, Universidade Federal de Sao Paulo, Rua Machado Bitencourt, 222, Vila Clementino, CEP 04044 000, Sao Paulo, SP, Brazil
BMC Psychiatry 13:60. 2013..Patients with schizophrenia have lower longevity than the general population as a consequence of a combination of risk factors connected to the disease, lifestyle and the use of medications, which are related to weight gain...
- Cognitive and olfactory deficits in Machado-Joseph disease: a dopamine transporter studyPedro Braga-Neto
Ataxia Unit, Department of Neurology and Neurosurgery, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Parkinsonism Relat Disord 18:854-8. 2012..This finding raises the possibility of extra-striatal dopamine and other neurotransmitter system involvement or of cerebellum neurodegeneration exerting a direct influence on cognitive and sensorial information processing in MJD...
- Cannabis use before age 15 and subsequent executive functioningMaria Alice Fontes
Laboratório Interdisciplinar de Neurociências Clínicas and Unidade de Pesquisas em Álcool e Drogas, Departamento de Psiquiatria, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Br J Psychiatry 198:442-7. 2011..However, few large studies have measured differences in cognitive performance between chronic cannabis users who started in early adolescence (before age 15) with those who started later...
- [Early Trauma Inventory (ETI): cross-cultural adaptation and internal consistency]Marcelo Feijó de Mello
Departamento de Psiquiatria, Universidade Federal de Sao Paulo, Rua Botucatu 431, Sao Paulo, Brazil
Cad Saude Publica 26:713-24. 2010..The ETI is a valid instrument with good consistency for evaluating history of childhood and adolescent trauma in adults...
- Ten-year growth in the scientific production of Brazilian Psychiatry: the impact of the new evaluation policiesJeronimo Gerolin
Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
Rev Bras Psiquiatr 32:6-10. 2010..A new set of more stringent criteria has been proposed for Qualis. Our aim was to evaluate the impact of the new Qualis criteria on the scientific production of Post-Graduation Programs in psychiatry over the last 10 years...
- Depression, avolition, and attention disorders in patients with schizophrenia: associations with verbal memory efficiencyGildas Brébion
Unit of Research and Development, Sant Joan de Déu Serveis de Salut Mental, C Doctor Antoni Pujadas 42, 08830 Sant Boi de Llobregat, Barcelona, Spain
J Neuropsychiatry Clin Neurosci 21:206-15. 2009..It is suggested that more consideration should be given to depression and motivation in the investigation of cognitive impairment in schizophrenia, as well as in cognitive remediation strategies...
- Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naïve patientsPedro G Alvarenga
Department and Institute of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
J Psychiatr Res 46:1635-42. 2012..Despite their relevant contribution, some methodological limitations, such as patient's previous medication intake, may have contributed to inconsistent findings...
- [Non-pharmacological interventions for weight gain in patients with schizophrenia taking antipsychotics]Cecília Attux
Departamento de Psiquiatria, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
Arq Bras Endocrinol Metabol 53:391-8. 2009..Obesity is also associated with metabolic disturbances such as diabetes mellitus. Weight gain interventions are necessary in this population, especially non-pharmacological interventions...
- Word frequency effects on free recall and recognition in patients with schizophreniaGildas Brébion
Department of Psychological Medicine, Institute of Psychiatry, 103 Denmark Hill, London SE5 8AZ, UK
J Psychiatr Res 39:215-22. 2005..We investigated the word frequency effects in a sample of patients with schizophrenia, assuming these data may shed light on certain encoding processes...
- Auras and clinical features in temporal lobe epilepsy: a new approach on the basis of voxel-based morphometryMaria Teresa Castilho Garcia Santana
Unidade de Pesquisa e Tratamento das Epilepsias UNIPETE, Department of Neurology and Neurosurgery, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
Epilepsy Res 89:327-38. 2010..For the first time, we have demonstrated GMV reductions anatomically correspondent to psychic (mesial areas) and autonomic auras (mesial and insular areas) reproducing previous cortical stimulation studies...
- Towards a multifactorial approach for prediction of bipolar disorder in at risk populationsElisa Brietzke
Program for Recognition and Intervention in Individuals in at Risk Mental States PRISMA, Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
J Affect Disord 140:82-91. 2012..Moreover, insufficient response with conventional pharmacological and manual-based psychosocial interventions, as well as evidence of illness progression and acceleration, invite the need for early detection and primary prevention...
- Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia--a potential biomarker?Ary Gadelha
Departamento de Psiquiatria, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
J Psychiatr Res 47:657-63. 2013....
- ZDHHC8 gene may play a role in cortical volumes of patients with schizophreniaVanessa K Ota
Disciplina de Genetica, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo UNIFESP, Rua Botucatu, 740, Edifício Leitão da Cunha, 1 andar, CEP 04023 900, Sao Paulo, Brazil
Schizophr Res 145:33-5. 2013..Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes...
- Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a brazilian pilot study on early onset schizophrenia familiesAry Gadelha
Interdisciplinary Lab of Clinical Neurosciences LiNC, and Schizophrenia Program PROESQ, Department of Psychiatry, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
PLoS ONE 7:e52262. 2012..Of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia...
- Clinical and molecular neuroimaging characteristics of Brazilian patients with Parkinson's disease and mutations in PARK2 or PARK8 genesOrlando G P Barsottini
Instituto Israelita de Ensino e Pesquisa, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil
Arq Neuropsiquiatr 67:7-11. 2009..To describe clinical and neuroimaging (SPECT) characteristics of Brazilian patients with Parkinson's disease (PD) and mutations in PARK2 or PARK8 genes...
- Mental health research in Brazil: policies, infrastructure, financing and human resourcesJair de Jesus Mari
Departmento de Psiquiatria, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
Rev Saude Publica 40:161-9. 2006....
- Neuropsychological function in patients with chronic hepatitis CLucas C Quarantini
Liver Int 28:893-4; author reply 894-5. 2008
- Psychosis during peginterferon-alpha 2a and ribavirin therapy: case reportLucas C Quarantini
Neuropsychiatry Department, Federal University of Bahia, Salvador, BA, Brazil
Braz J Infect Dis 10:406-7. 2006..We report a case of psychotic disorder that occurred during therapy with pegylated Interferon-alpha given associated with ribavirin. After good response to psychiatric treatment, it became possible to finish the anti-viral therapy...
- Incidence of psychiatric side effects during pegylated interferon- alpha retreatment in nonresponder hepatitis C virus-infected patientsLucas C Quarantini
University Hospital, Federal University of Bahia School of Medicine, Salvador Bahia, Brazil
Liver Int 27:1098-102. 2007..Evaluate the incidence of mental disorders using pegylated interferon plus ribavirin retreatment in nonresponder hepatitis C virus-infected patients...
- Refractory schizophrenia: a neglected clinical problemJoão Guilherme Fiorani Borgio
Rev Bras Psiquiatr 29:292-3. 2007
- High frequency of unrecognized mental disorders in HCV-infected patientsSusana Carolina Batista-Neves
University Hospital, Faculdade de Medicina, Universidade Federal da Bahia, Bahia, Brazil
Gen Hosp Psychiatry 30:80-2. 2008..This study indexed the frequency of psychiatric disorders among hepatitis C virus (HCV)-infected patients...
- Methylphenidate DAT binding in adolescents with Attention-Deficit/ Hyperactivity Disorder comorbid with Substance Use Disorder--a single photon emission computed tomography with [Tc(99m)]TRODAT-1 studyClaudia M Szobot
ADHD Outpatient Clinic, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre POA, Estado do Rio Grande do Sul RS, Brasil
Neuroimage 40:1195-201. 2008..However, it has been demonstrated that drug addiction is associated with dopaminergic system changes that may affect MPH brain effects, emphasizing the need to better understand MPH actions in subjects with ADHD+SUD...
- Kinetic modelling of [123I]CNS 1261--a potential SPET tracer for the NMDA receptorKjell Erlandsson
Institute of Nuclear Medicine, Royal Free and University College Medical School, Middlesex Hospital, Mortimer Street, London W1T 3AA, UK
Nucl Med Biol 30:441-54. 2003..This distribution concurs with [(11)C]-ketamine and [(18)F]-memantine PET studies. These data provide a methodological basis for further direct in vivo challenge studies...
- Effect of amantadine on depressive symptoms in chronic hepatitis C patients treated with pegylated interferon: a randomized, controlled pilot studyLucas C Quarantini
Department of Neuropsychiatry, Federal University of Bahia School of Medicine, Brazil
Clin Neuropharmacol 29:138-43. 2006..Assess the effect of amantadine on depressive symptoms during interferon alfa therapy for hepatitis C virus infection...
- [Cannabis: what is the extent of its harmful effects?]Flavia S Jungerman
Rev Bras Psiquiatr 27:5-6. 2005
- Can molecular imaging techniques identify biomarkers for neuropsychiatric disorders?Rodrigo A Bressan
Rev Bras Psiquiatr 29:102-4. 2007