Research Topics
Genomes and GenesSpecies | Elvira BramonSummaryAffiliation: King's College London Country: UK Publications
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Publications
Mismatch negativity in schizophrenia: a family studyElvira Bramon
Institute of Psychiatry, PO Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Schizophr Res 67:1-10. 2004..We investigated whether MMN is a potential marker of genetic vulnerability to schizophrenia by comparing MMN in a group of patients with schizophrenia, their unaffected relatives, and controls...- Is there an association between the COMT gene and P300 endophenotypes?E Bramon
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Eur Psychiatry 21:70-3. 2006..However, the available neurophysiologic evidence suggests that any such association, if present, must be very subtle... - Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family studyElvira Bramon
Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
Neuroimage 27:960-8. 2005..We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study... - Dermatoglyphics and Schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge countElvira Bramon
Division of Psychological Medicine, Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
Schizophr Res 75:399-404. 2005..However, the severity or the origin of these ABRC changes has not been established... - Meta-analysis of the P300 and P50 waveforms in schizophreniaElvira Bramon
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, P O Box 63, De Crespigny Park, London SE5 8AF, UK
Schizophr Res 70:315-29. 2004..To determine whether patients with schizophrenia have abnormalities in the P300 and P50 waves and to quantify the magnitude of any differences from controls... - Substantial shared genetic influences on schizophrenia and event-related potentialsMei Hua Hall
Social, Genetic, and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK, and the Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
Am J Psychiatry 164:804-12. 2007..The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia... 
Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophreniaDiana P Prata
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, PO67, De Crespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 66:1162-72. 2009..The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia...- Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotypeElvira Bramon
Institute of Psychiatry King s College London, Division of Psychological Medicine and Psychiatry box 63, De Crespigny Park, London SE5 8AF, United Kingdom
Schizophr Res 103:178-85. 2008..Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype... - Stroop-test interference in bipolar disorderEugenia Kravariti
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 194:285-6. 2009..Having a first-degree relative with bipolar disorder, even a familial, psychotic form, did not confer risk for enhanced susceptibility to interference in our studies... - Executive functioning in familial bipolar I disorder patients and their unaffected relativesKatja K Schulze
King s Health Partners, Institute of Psychiatry, Department of Psychosis Studies and Department of Psychology, King s College London, NIHR Biomedical Research Centre, London, UK
Bipolar Disord 13:208-16. 2011..To compare the executive function of patients with familial bipolar I disorder (BP-I) with a history of psychotic symptoms to their first-degree relatives and normal controls... - P50 auditory evoked potential suppression in bipolar disorder patients with psychotic features and their unaffected relativesKatja K Schulze
Section of General Psychiatry, Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK, and Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
Biol Psychiatry 62:121-8. 2007..We therefore assessed whether diminished P50 suppression is associated with familial risk for psychotic bipolar disorder... - Memory functioning in familial bipolar I disorder patients and their relativesSeema Quraishi
NIHR Biomedical Research Centre for Mental Health, South London and Maudsley Foundation NHS Trust and Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Bipolar Disord 11:209-14. 2009..The aim of this study was to compare the memory function of patients with familial bipolar I disorder (BD I) who had shown psychotic features, their non-psychotic, non-bipolar first-degree relatives, and normal controls... - Genetic overlap between bipolar illness and event-related potentialsMei Hua Hall
Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
Psychol Med 37:667-78. 2007.... - Increased inferior frontal activation during word generation: a marker of genetic risk for schizophrenia but not bipolar disorder?Sergi G Costafreda
Institute of Psychiatry, King s College London, London, United Kingdom
Hum Brain Mapp 30:3287-98. 2009..Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia... - Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relativesColm McDonald
Division of Psychological Medicine, Institute of Psychiatry, London, UK
Am J Psychiatry 163:478-87. 2006..The authors used region-of-interest morphometry to volumetrically assess brain structures frequently implicated in psychotic illness in families affected with schizophrenia or psychotic bipolar disorder... 
Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophreniaDiana P Prata
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London WC2R 2LS, United Kingdom
Proc Natl Acad Sci U S A 106:13600-5. 2009....- Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controlsEvangelos Vassos
King s College London, Institute of Psychiatry, Department of Psychological Medicine and Psychiatry and NIHR Biomedical Research Centre, London, UK
J Psychiatr Res 44:795-8. 2010..05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals... - White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI-EEG studyPaolo Fusar-Poli
Psychosis Clinical Academic Group, Institute of Psychiatry, King s Health Partners, King s College London, London, UK
J Psychiatry Neurosci 36:239-48. 2011..The relation between these factors in the development of illness is almost unknown. We studied the relation between white matter volumes and P300 in prodromal psychosis... - Auditory P300 in patients with bipolar disorder and their unaffected relativesKatja K Schulze
Division of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
Bipolar Disord 10:377-86. 2008.... - Differential effects of DAAO on regional activation and functional connectivity in schizophrenia, bipolar disorder and controlsSergio Alessandro Papagni
Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, UK
Neuroimage 56:2283-91. 2011..Our results suggest that genetic variation in DAAO has a significant impact on both regional activation and functional connectivity, and provide evidence for a diagnosis-dependent pattern of gene action... - Familial liability to schizophrenia and premorbid adjustmentMuriel Walshe
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 191:260-1. 2007..Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence. This may represent a familial (presumed genetic) effect... - Genetic vulnerability to psychosis and cortical function: epistatic effects between DAAO and G72Andrea Mechelli
Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF UK
Curr Pharm Des 18:510-7. 2012..Future studies could explore the effects of DAAO and G72 in individuals with prodromal symptoms of psychosis, in order to elucidate glutamate dysfunction in this critical phase of the disorder... - Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluencyDiana P Prata
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
Hum Brain Mapp 33:143-53. 2012..Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder... - Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosisNicolas A Crossley
Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
Hum Brain Mapp 30:4129-37. 2009..However, the stage of the disorder at which these functional alterations occur is unclear. We addressed this issue by using functional MRI (fMRI) to study subjects in the prodromal and first episode phases of schizophrenia... - Heritability and reliability of P300, P50 and duration mismatch negativityMei Hua Hall
Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80, De Crespigny Park, London, SE5 8AF, UK
Behav Genet 36:845-57. 2006..Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test-retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs... - White matter microstructural impairments and genetic liability to familial bipolar I disorderChristopher A Chaddock
Department of Psychiatry, PO 63, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Br J Psychiatry 194:527-34. 2009..Subtle abnormalities in frontal white matter have been reported in bipolar disorder... - Association between BDNF val66 met genotype and episodic memoryEmma Dempster
Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 134:73-5. 2005..When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R2 = 0.077 P = 0.01), which is consistent with previous findings... - COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophreniaIrene Rebollo-Mesa
Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
Psychiatr Genet 21:98-105. 2011..In this study, we aimed to assess the moderating effects of the catechol-O-methyl transferase (COMT) (Val(158/108)Met) genotype on antipsychotic medication-induced changes in the cognitive performance of patients with chronic schizophrenia... - Selective attention deficits reflect increased genetic vulnerability to schizophreniaFrancesca M Filbey
Department of Psychiatry, Institute of Psychiatry, King s College, De Crespigny Park, SE5 8AF London, UK
Schizophr Res 101:169-75. 2008..Impairment in attention is prominent in schizophrenia and may be a valuable genetic indicator for vulnerability to this disease... - Neural correlates of executive function and working memory in the 'at-risk mental state'Matthew R Broome
Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
Br J Psychiatry 194:25-33. 2009..People with prodromal symptoms have a very high risk of developing psychosis... - The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relativesKatja Schulze
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
J Psychiatr Res 40:589-98. 2006..28, p=0.01). There were no significant between-group differences in the relationship between measures of eye movement and morphometry... - Association between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gatingRachel H Flomen
Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London, UK
Eur J Hum Genet 21:76-81. 2013..Four out of six previous association studies found association of different psychiatric phenotypes with the same 2-bp deletion allele... - Gray matter alterations related to P300 abnormalities in subjects at high risk for psychosis: longitudinal MRI-EEG studyPaolo Fusar-Poli
Psychosis Clinical Academic Group, Institute of Psychiatry, King s College London, London, UK
Neuroimage 55:320-8. 2011..Psychotic disorders are characterized by gray matter and volumetric and electrophysiological abnormalities. The relationship between these factors in the onset of psychotic illness is unclear... - What causes the onset of psychosis?Matthew R Broome
Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Schizophr Res 79:23-34. 2005..Thus, a plausible model of the onset of psychosis needs to draw not only on neuroscience, but also on the insights of social psychiatry and cognitive psychology... - Long-term maternal recall of obstetric complications in schizophrenia researchMuriel Walshe
King s College London, King s Health Partners, Institute of Psychiatry, Department of Psychosis Studies and NIHR Biomedical Research Centre, London, SE5 8AF, UK
Psychiatry Res 187:335-40. 2011..Assessing the cognition of participants in retrospective studies may allow future studies to increase the reliability of their data... - Insight in individuals with an At Risk Mental StateJulia M Lappin
King s College London Institute of Psychiatry, PO63, Division of Psychological Medicine, London SE5 8AF, UK
Schizophr Res 90:238-44. 2007..We compared the level and quality of insight in the ARMS and in first episode psychosis... - Cognitive performance in presumed obligate carriers for psychosisTimothea Toulopoulou
Division of Psychological Medicine, Institute of Psychiatry, London, UK
Br J Psychiatry 187:284-5. 2005.... - Alterations in white matter evident before the onset of psychosisFrancesco Carletti
To whom correspondence should be addressed Department of Psychosis Studies, Institute of Psychiatry, Box P067, De Crespigny Park, SE5 8AF London, UK tel 44 0 20 7848 0049, fax 44 0 20 7848 0976, E mail
Schizophr Bull 38:1170-9. 2012..The onset of schizophrenia may be associated with a progressive reduction in the integrity of the frontal WM... - Sustained attention in bipolar I disorder patients with familial psychosis and their first-degree relativesMuriel Walshe
Department of Psychosis Studies, PO Box 63, Institute of Psychiatry, King s College London KCL, De Crespigny Park, London SE5 8AF, UK
Psychiatry Res 199:70-3. 2012..Patients were impaired compared to relatives, but the latter did not differ from controls. Having a relative with familial, psychotic BD does not confer risk for SA deficits... - Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypesColm McDonald
Division of Psychological Medicine, Institute of Psychiatry, London
Arch Gen Psychiatry 61:974-84. 2004..For more than a century, it has been uncertain whether or not the major diagnostic categories of psychosis--schizophrenia and bipolar disorder--are distinct disease entities with specific genetic causes and neuroanatomical substrates... - Abnormal P300 in people with high risk of developing psychosisElvira Bramon
Institute of Psychiatry, Division of Psychological Medicine Box 63, De Crespigny Park, London, SE5 8AF, UK
Neuroimage 41:553-60. 2008..We examined whether neurophysiological markers could help to identify those who are particularly vulnerable... - Distribution of symptom dimensions across Kraepelinian divisionsDimitris G Dikeos
Institute of Psychiatry, SGDP Building, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Br J Psychiatry 189:346-53. 2006..Dimensional structures are established for many psychiatric diagnoses, but dimensions have not been compared between diagnostic groups... - Neurophysiological alterations in the prepsychotic phasesNicolas A Crossley
Department of Psychosis Studies Institute of Psychiatry, King s College London, SE58AF, UK
Curr Pharm Des 18:479-85. 2012..We particularly focus in the P300, Mismatch-Negativity (MMN) and P50 paradigms, discussing the main findings, but also the limitations and challenges in electrophysiological studies in this population... - COMT gene polymorphism and corpus callosum morphometry in preterm born adultsAnirban Dutt
NIHR Biomedical Research Centre, Institute of Psychiatry King s College London, London, UK
Neuroimage 54:148-53. 2011..It is not known whether this polymorphism is associated with CC morphometry in individuals born preterm... - Outreach and support in south London (OASIS): implementation of a clinical service for prodromal psychosis and the at risk mental stateMatthew R Broome
OASIS, PO 67, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Eur Psychiatry 20:372-8. 2005..CONCLUSION: It is feasible to provide a clinical service for people with prodromal symptoms in a deprived inner city area with a large ethnic minority population... - Genetic overlap between P300, P50, and duration mismatch negativityMei Hua Hall
Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 141:336-43. 2006..Within paradigm, P300 amplitude and latency shared about half of their genetic effects... - Large recurrent microdeletions associated with schizophreniaHreinn Stefansson
CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
Nature 455:232-6. 2008..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia... - Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit geneEmma L Dempster
Division of Cellular and Molecular Biology, Toronto Western Research Institute, Toronto Western Hospital, McLaughlin Pavillion, 6th Floor Room 415, 399 Bathurst St, Toronto, Ont M5T 2S8, Canada
Am J Psychiatry 163:1832-4. 2006..CHRNA7 is involved in memory formation, a core dysfunction in schizophrenia. The authors set out to determine if this locus is associated with memory dysfunction in schizophrenia... - Further evidence for shared genetic effects between psychotic bipolar disorder and P50 suppression: a combined twin and family studyMei Hua Hall
Psychology Research Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Am J Med Genet B Neuropsychiatr Genet 147:619-27. 2008..The non-specificity of impaired P50 suppression may reflect the impact of shared psychosis susceptibility genes...