Elvira Bramon

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Mismatch negativity in schizophrenia: a family study
    Elvira Bramon
    Institute of Psychiatry, PO Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 67:1-10. 2004
  2. ncbi request reprint Meta-analysis of the P300 and P50 waveforms in schizophrenia
    Elvira Bramon
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 70:315-29. 2004
  3. ncbi request reprint Dermatoglyphics and Schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count
    Elvira Bramon
    Division of Psychological Medicine, Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 75:399-404. 2005
  4. ncbi request reprint Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study
    Elvira Bramon
    Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 27:960-8. 2005
  5. ncbi request reprint Is there an association between the COMT gene and P300 endophenotypes?
    E Bramon
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Eur Psychiatry 21:70-3. 2006
  6. ncbi request reprint Substantial shared genetic influences on schizophrenia and event-related potentials
    Mei Hua Hall
    Social, Genetic, and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK, and the Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
    Am J Psychiatry 164:804-12. 2007
  7. doi request reprint Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, PO67, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:1162-72. 2009
  8. doi request reprint Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
    Andreina Pauli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 34:2244-58. 2013
  9. doi request reprint Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotype
    Elvira Bramon
    Institute of Psychiatry King s College London, Division of Psychological Medicine and Psychiatry box 63, De Crespigny Park, London SE5 8AF, United Kingdom
    Schizophr Res 103:178-85. 2008
  10. ncbi request reprint P50 auditory evoked potential suppression in bipolar disorder patients with psychotic features and their unaffected relatives
    Katja K Schulze
    Section of General Psychiatry, Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK, and Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
    Biol Psychiatry 62:121-8. 2007

Detail Information

Publications51

  1. ncbi request reprint Mismatch negativity in schizophrenia: a family study
    Elvira Bramon
    Institute of Psychiatry, PO Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 67:1-10. 2004
    ..We investigated whether MMN is a potential marker of genetic vulnerability to schizophrenia by comparing MMN in a group of patients with schizophrenia, their unaffected relatives, and controls...
  2. ncbi request reprint Meta-analysis of the P300 and P50 waveforms in schizophrenia
    Elvira Bramon
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 70:315-29. 2004
    ..To determine whether patients with schizophrenia have abnormalities in the P300 and P50 waves and to quantify the magnitude of any differences from controls...
  3. ncbi request reprint Dermatoglyphics and Schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count
    Elvira Bramon
    Division of Psychological Medicine, Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 75:399-404. 2005
    ..However, the severity or the origin of these ABRC changes has not been established...
  4. ncbi request reprint Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study
    Elvira Bramon
    Institute of Psychiatry, P O Box 63, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 27:960-8. 2005
    ..We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study...
  5. ncbi request reprint Is there an association between the COMT gene and P300 endophenotypes?
    E Bramon
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Eur Psychiatry 21:70-3. 2006
    ..However, the available neurophysiologic evidence suggests that any such association, if present, must be very subtle...
  6. ncbi request reprint Substantial shared genetic influences on schizophrenia and event-related potentials
    Mei Hua Hall
    Social, Genetic, and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK, and the Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
    Am J Psychiatry 164:804-12. 2007
    ..The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia...
  7. doi request reprint Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, PO67, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:1162-72. 2009
    ..The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia...
  8. doi request reprint Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function
    Andreina Pauli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 34:2244-58. 2013
    ..This provides evidence that interactions between the dopamine and the glutamate system, thought to be altered in psychosis, have an impact in executive processing which can be modulated by common genetic variation...
  9. doi request reprint Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotype
    Elvira Bramon
    Institute of Psychiatry King s College London, Division of Psychological Medicine and Psychiatry box 63, De Crespigny Park, London SE5 8AF, United Kingdom
    Schizophr Res 103:178-85. 2008
    ..Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype...
  10. ncbi request reprint P50 auditory evoked potential suppression in bipolar disorder patients with psychotic features and their unaffected relatives
    Katja K Schulze
    Section of General Psychiatry, Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK, and Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA
    Biol Psychiatry 62:121-8. 2007
    ..We therefore assessed whether diminished P50 suppression is associated with familial risk for psychotic bipolar disorder...
  11. doi request reprint Stroop-test interference in bipolar disorder
    Eugenia Kravariti
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 194:285-6. 2009
    ..Having a first-degree relative with bipolar disorder, even a familial, psychotic form, did not confer risk for enhanced susceptibility to interference in our studies...
  12. doi request reprint Executive functioning in familial bipolar I disorder patients and their unaffected relatives
    Katja K Schulze
    King s Health Partners, Institute of Psychiatry, Department of Psychosis Studies and Department of Psychology, King s College London, NIHR Biomedical Research Centre, London, UK
    Bipolar Disord 13:208-16. 2011
    ..To compare the executive function of patients with familial bipolar I disorder (BP-I) with a history of psychotic symptoms to their first-degree relatives and normal controls...
  13. doi request reprint Memory functioning in familial bipolar I disorder patients and their relatives
    Seema Quraishi
    NIHR Biomedical Research Centre for Mental Health, South London and Maudsley Foundation NHS Trust and Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Bipolar Disord 11:209-14. 2009
    ..The aim of this study was to compare the memory function of patients with familial bipolar I disorder (BD I) who had shown psychotic features, their non-psychotic, non-bipolar first-degree relatives, and normal controls...
  14. ncbi request reprint Heritability and reliability of P300, P50 and duration mismatch negativity
    Mei Hua Hall
    Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80, De Crespigny Park, London, SE5 8AF, UK
    Behav Genet 36:845-57. 2006
    ..Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test-retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs...
  15. ncbi request reprint Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives
    Colm McDonald
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Am J Psychiatry 163:478-87. 2006
    ..The authors used region-of-interest morphometry to volumetrically assess brain structures frequently implicated in psychotic illness in families affected with schizophrenia or psychotic bipolar disorder...
  16. doi request reprint Increased inferior frontal activation during word generation: a marker of genetic risk for schizophrenia but not bipolar disorder?
    Sergi G Costafreda
    Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:3287-98. 2009
    ..Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia...
  17. ncbi request reprint Genetic overlap between bipolar illness and event-related potentials
    Mei Hua Hall
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 37:667-78. 2007
    ....
  18. doi request reprint Sustained attention in bipolar I disorder patients with familial psychosis and their first-degree relatives
    Muriel Walshe
    Department of Psychosis Studies, PO Box 63, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Psychiatry Res 199:70-3. 2012
    ..Patients were impaired compared to relatives, but the latter did not differ from controls. Having a relative with familial, psychotic BD does not confer risk for SA deficits...
  19. pmc Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London WC2R 2LS, United Kingdom
    Proc Natl Acad Sci U S A 106:13600-5. 2009
    ....
  20. pmc White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI-EEG study
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group, Institute of Psychiatry, King s Health Partners, King s College London, London, UK
    J Psychiatry Neurosci 36:239-48. 2011
    ..The relation between these factors in the development of illness is almost unknown. We studied the relation between white matter volumes and P300 in prodromal psychosis...
  21. doi request reprint Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
    Evangelos Vassos
    King s College London, Institute of Psychiatry, Department of Psychological Medicine and Psychiatry and NIHR Biomedical Research Centre, London, UK
    J Psychiatr Res 44:795-8. 2010
    ..05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals...
  22. doi request reprint Differential effects of DAAO on regional activation and functional connectivity in schizophrenia, bipolar disorder and controls
    Sergio Alessandro Papagni
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, UK
    Neuroimage 56:2283-91. 2011
    ..Our results suggest that genetic variation in DAAO has a significant impact on both regional activation and functional connectivity, and provide evidence for a diagnosis-dependent pattern of gene action...
  23. ncbi request reprint Familial liability to schizophrenia and premorbid adjustment
    Muriel Walshe
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 191:260-1. 2007
    ..Unaffected siblings from multiply affected families also had poor academic functioning in adolescence, with a decline between childhood and adolescence. This may represent a familial (presumed genetic) effect...
  24. doi request reprint Auditory P300 in patients with bipolar disorder and their unaffected relatives
    Katja K Schulze
    Division of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
    Bipolar Disord 10:377-86. 2008
    ....
  25. pmc Association between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gating
    Rachel H Flomen
    Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London, UK
    Eur J Hum Genet 21:76-81. 2013
    ..Four out of six previous association studies found association of different psychiatric phenotypes with the same 2-bp deletion allele...
  26. ncbi request reprint Genetic vulnerability to psychosis and cortical function: epistatic effects between DAAO and G72
    Andrea Mechelli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF UK
    Curr Pharm Des 18:510-7. 2012
    ..Future studies could explore the effects of DAAO and G72 in individuals with prodromal symptoms of psychosis, in order to elucidate glutamate dysfunction in this critical phase of the disorder...
  27. doi request reprint Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency
    Diana P Prata
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Hum Brain Mapp 33:143-53. 2012
    ..Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder...
  28. doi request reprint Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis
    Nicolas A Crossley
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:4129-37. 2009
    ..However, the stage of the disorder at which these functional alterations occur is unclear. We addressed this issue by using functional MRI (fMRI) to study subjects in the prodromal and first episode phases of schizophrenia...
  29. doi request reprint White matter microstructural impairments and genetic liability to familial bipolar I disorder
    Christopher A Chaddock
    Department of Psychiatry, PO 63, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 194:527-34. 2009
    ..Subtle abnormalities in frontal white matter have been reported in bipolar disorder...
  30. doi request reprint Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity
    Diana P Prata
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, King s Health Partners, London, United Kingdom
    Hum Brain Mapp 34:2025-31. 2013
    ..This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity...
  31. doi request reprint COMT (Val(158/108)Met) genotype moderates the impact of antipsychotic medication on verbal IQ in twins with schizophrenia
    Irene Rebollo-Mesa
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Psychiatr Genet 21:98-105. 2011
    ..In this study, we aimed to assess the moderating effects of the catechol-O-methyl transferase (COMT) (Val(158/108)Met) genotype on antipsychotic medication-induced changes in the cognitive performance of patients with chronic schizophrenia...
  32. doi request reprint Neural correlates of executive function and working memory in the 'at-risk mental state'
    Matthew R Broome
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 194:25-33. 2009
    ..People with prodromal symptoms have a very high risk of developing psychosis...
  33. ncbi request reprint The relationship between eye movement and brain structural abnormalities in patients with schizophrenia and their unaffected relatives
    Katja Schulze
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    J Psychiatr Res 40:589-98. 2006
    ..28, p=0.01). There were no significant between-group differences in the relationship between measures of eye movement and morphometry...
  34. doi request reprint Selective attention deficits reflect increased genetic vulnerability to schizophrenia
    Francesca M Filbey
    Department of Psychiatry, Institute of Psychiatry, King s College, De Crespigny Park, SE5 8AF London, UK
    Schizophr Res 101:169-75. 2008
    ..Impairment in attention is prominent in schizophrenia and may be a valuable genetic indicator for vulnerability to this disease...
  35. ncbi request reprint Association between BDNF val66 met genotype and episodic memory
    Emma Dempster
    Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 134:73-5. 2005
    ..When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R2 = 0.077 P = 0.01), which is consistent with previous findings...
  36. pmc Alterations in white matter evident before the onset of psychosis
    Francesco Carletti
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Schizophr Bull 38:1170-9. 2012
    ..We addressed these issues by using diffusion tensor imaging (DTI) to study subjects at ultra high risk (UHR) of psychosis before and after the onset of illness...
  37. doi request reprint Gray matter alterations related to P300 abnormalities in subjects at high risk for psychosis: longitudinal MRI-EEG study
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group, Institute of Psychiatry, King s College London, London, UK
    Neuroimage 55:320-8. 2011
    ..Psychotic disorders are characterized by gray matter and volumetric and electrophysiological abnormalities. The relationship between these factors in the onset of psychotic illness is unclear...
  38. doi request reprint Long-term maternal recall of obstetric complications in schizophrenia research
    Muriel Walshe
    King s College London, King s Health Partners, Institute of Psychiatry, Department of Psychosis Studies and NIHR Biomedical Research Centre, London, SE5 8AF, UK
    Psychiatry Res 187:335-40. 2011
    ..Assessing the cognition of participants in retrospective studies may allow future studies to increase the reliability of their data...
  39. ncbi request reprint What causes the onset of psychosis?
    Matthew R Broome
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 79:23-34. 2005
    ..Thus, a plausible model of the onset of psychosis needs to draw not only on neuroscience, but also on the insights of social psychiatry and cognitive psychology...
  40. ncbi request reprint Insight in individuals with an At Risk Mental State
    Julia M Lappin
    King s College London Institute of Psychiatry, PO63, Division of Psychological Medicine, London SE5 8AF, UK
    Schizophr Res 90:238-44. 2007
    ..We compared the level and quality of insight in the ARMS and in first episode psychosis...
  41. ncbi request reprint Genetic overlap between P300, P50, and duration mismatch negativity
    Mei Hua Hall
    Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:336-43. 2006
    ..Within paradigm, P300 amplitude and latency shared about half of their genetic effects...
  42. ncbi request reprint Cognitive performance in presumed obligate carriers for psychosis
    Timothea Toulopoulou
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Br J Psychiatry 187:284-5. 2005
    ....
  43. doi request reprint Abnormal P300 in people with high risk of developing psychosis
    Elvira Bramon
    Institute of Psychiatry, Division of Psychological Medicine Box 63, De Crespigny Park, London, SE5 8AF, UK
    Neuroimage 41:553-60. 2008
    ..We examined whether neurophysiological markers could help to identify those who are particularly vulnerable...
  44. ncbi request reprint Distribution of symptom dimensions across Kraepelinian divisions
    Dimitris G Dikeos
    Institute of Psychiatry, SGDP Building, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 189:346-53. 2006
    ..Dimensional structures are established for many psychiatric diagnoses, but dimensions have not been compared between diagnostic groups...
  45. ncbi request reprint Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes
    Colm McDonald
    Division of Psychological Medicine, Institute of Psychiatry, London
    Arch Gen Psychiatry 61:974-84. 2004
    ..For more than a century, it has been uncertain whether or not the major diagnostic categories of psychosis--schizophrenia and bipolar disorder--are distinct disease entities with specific genetic causes and neuroanatomical substrates...
  46. ncbi request reprint Neurophysiological alterations in the prepsychotic phases
    Nicolas A Crossley
    Department of Psychosis Studies Institute of Psychiatry, King s College London, SE58AF, UK
    Curr Pharm Des 18:479-85. 2012
    ..We particularly focus in the P300, Mismatch-Negativity (MMN) and P50 paradigms, discussing the main findings, but also the limitations and challenges in electrophysiological studies in this population...
  47. doi request reprint COMT gene polymorphism and corpus callosum morphometry in preterm born adults
    Anirban Dutt
    NIHR Biomedical Research Centre, Institute of Psychiatry King s College London, London, UK
    Neuroimage 54:148-53. 2011
    ..It is not known whether this polymorphism is associated with CC morphometry in individuals born preterm...
  48. ncbi request reprint Outreach and support in south London (OASIS): implementation of a clinical service for prodromal psychosis and the at risk mental state
    Matthew R Broome
    OASIS, PO 67, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Eur Psychiatry 20:372-8. 2005
    ..While recent research points to the potential benefits of clinical intervention before the first episode of psychosis, the logistical feasibility of this is unclear...
  49. doi request reprint Further evidence for shared genetic effects between psychotic bipolar disorder and P50 suppression: a combined twin and family study
    Mei Hua Hall
    Psychology Research Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Am J Med Genet B Neuropsychiatr Genet 147:619-27. 2008
    ..The non-specificity of impaired P50 suppression may reflect the impact of shared psychosis susceptibility genes...
  50. pmc Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...
  51. ncbi request reprint Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene
    Emma L Dempster
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, Toronto Western Hospital, McLaughlin Pavillion, 6th Floor Room 415, 399 Bathurst St, Toronto, Ont M5T 2S8, Canada
    Am J Psychiatry 163:1832-4. 2006
    ..CHRNA7 is involved in memory formation, a core dysfunction in schizophrenia. The authors set out to determine if this locus is associated with memory dysfunction in schizophrenia...