S D Brain

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc The vasoactive potential of kisspeptin-10 in the peripheral vasculature
    Iain Sawyer
    Vascular Biology Section, Cardiovascular Division, King s College London, British Heart Foundation Centre, London, United Kingdom
    PLoS ONE 6:e14671. 2011
  2. ncbi request reprint An ongoing role of α-calcitonin gene-related peptide as part of a protective network against hypertension, vascular hypertrophy, and oxidative stress
    Sarah Jane Smillie
    Cardiovascular Division, King s College London, Franklin Wilkins Building, London, SE1 9NH, United Kingdom
    Hypertension 63:1056-62. 2014
  3. doi request reprint Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B₄-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1
    Elizabeth S Fernandes
    Programa de Pós Graduação em Biologia Parasitária, Universidade CEUMA, Sao Luis, Brazil
    FASEB J 27:1664-73. 2013
  4. doi request reprint A role for TRPV1 in influencing the onset of cardiovascular disease in obesity
    Nichola J Marshall
    British Heart Foundation Centre of Cardiovascular Excellence and Centre of Integrative Biomedicine, King s College London, London, United Kingdom
    Hypertension 61:246-52. 2013
  5. doi request reprint TRPV1 and TRPA1 channels in inflammatory pain: elucidating mechanisms
    Susan D Brain
    BHF Centre of Cardiovascular Excellence and Section of Integrative Biomedicine, King s College London, London, United Kingdom
    Ann N Y Acad Sci 1245:36-7. 2011
  6. pmc Neuropeptides and their receptors: innovative science providing novel therapeutic targets
    Susan D Brain
    King s College London, Cardiovascular Division, School of Biomedical and Health Sciences, New Hunt s House, Guy s Campus, London SE1 1UL
    Br J Pharmacol 147:S202-11. 2006
  7. pmc Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, King s College, Guy s Campus, London SE1 1UL
    Br J Pharmacol 142:1053-4. 2004
  8. ncbi request reprint Vascular actions of calcitonin gene-related peptide and adrenomedullin
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, King s College London, Guy s Campus, London SE1 1UL, UK
    Physiol Rev 84:903-34. 2004
  9. ncbi request reprint CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine?
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College, Guy s Campus, SE1 1UL, London, UK
    Trends Pharmacol Sci 23:51-3. 2002
  10. ncbi request reprint Sensory neuropeptides: their role in inflammation and wound healing
    S D Brain
    Pharmacology Group, Division of Biomedical Sciences, King s College, London, UK
    Immunopharmacology 37:133-52. 1997

Collaborators

Detail Information

Publications68

  1. pmc The vasoactive potential of kisspeptin-10 in the peripheral vasculature
    Iain Sawyer
    Vascular Biology Section, Cardiovascular Division, King s College London, British Heart Foundation Centre, London, United Kingdom
    PLoS ONE 6:e14671. 2011
    ..Firstly, plasma extravasation indicative of ability to induce oedema formation and secondly decreased peripheral blood flow, indicating microvascular constriction. Thus Kp-10 has vasoactive properties in the peripheral microvasculature...
  2. ncbi request reprint An ongoing role of α-calcitonin gene-related peptide as part of a protective network against hypertension, vascular hypertrophy, and oxidative stress
    Sarah Jane Smillie
    Cardiovascular Division, King s College London, Franklin Wilkins Building, London, SE1 9NH, United Kingdom
    Hypertension 63:1056-62. 2014
    ....
  3. doi request reprint Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B₄-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1
    Elizabeth S Fernandes
    Programa de Pós Graduação em Biologia Parasitária, Universidade CEUMA, Sao Luis, Brazil
    FASEB J 27:1664-73. 2013
    ..TRPV1-KO mice showed impaired myeloperoxidase release, whereas TRPA1-KO mice exhibited diminished production of superoxide. This result provides novel evidence that TRPA1 and TRPV1 contribute to itch via distinct mechanisms...
  4. doi request reprint A role for TRPV1 in influencing the onset of cardiovascular disease in obesity
    Nichola J Marshall
    British Heart Foundation Centre of Cardiovascular Excellence and Centre of Integrative Biomedicine, King s College London, London, United Kingdom
    Hypertension 61:246-52. 2013
    ....
  5. doi request reprint TRPV1 and TRPA1 channels in inflammatory pain: elucidating mechanisms
    Susan D Brain
    BHF Centre of Cardiovascular Excellence and Section of Integrative Biomedicine, King s College London, London, United Kingdom
    Ann N Y Acad Sci 1245:36-7. 2011
    ..Transient receptor potential (TRP) receptors are ion channels that mediate pain and inflammation. We provide evidence for the distinct roles of TRPV1 and TRPA1 in arthritis...
  6. pmc Neuropeptides and their receptors: innovative science providing novel therapeutic targets
    Susan D Brain
    King s College London, Cardiovascular Division, School of Biomedical and Health Sciences, New Hunt s House, Guy s Campus, London SE1 1UL
    Br J Pharmacol 147:S202-11. 2006
    ..The study of neuropeptides in animal models has additionally revealed physiological and pathophysiological roles that in turn have led to the ongoing development of new drugs, through utilization predominantly of antagonist activities...
  7. pmc Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, King s College, Guy s Campus, London SE1 1UL
    Br J Pharmacol 142:1053-4. 2004
    ..Goadsby and co-workers present data that now suggest that CGRP antagonists may also block neuronal transmission in migraine...
  8. ncbi request reprint Vascular actions of calcitonin gene-related peptide and adrenomedullin
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, King s College London, Guy s Campus, London SE1 1UL, UK
    Physiol Rev 84:903-34. 2004
    ..The cardiovascular activity of these peptides in a range of species and in human clinical conditions is detailed, and potential therapeutic applications based on use of antagonists and gene targeting of agonists are discussed...
  9. ncbi request reprint CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine?
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College, Guy s Campus, SE1 1UL, London, UK
    Trends Pharmacol Sci 23:51-3. 2002
  10. ncbi request reprint Sensory neuropeptides: their role in inflammation and wound healing
    S D Brain
    Pharmacology Group, Division of Biomedical Sciences, King s College, London, UK
    Immunopharmacology 37:133-52. 1997
    ..In addition, results from clinical trials of recently developed neuropeptide antagonists are discussed...
  11. pmc Interactive contribution of NK(1) and kinin receptors to the acute inflammatory oedema observed in response to noxious heat stimulation: studies in NK(1) receptor knockout mice
    A Rawlingson
    Centre for Cardiovascular Biology and Medicine, King's College London, Guy's Campus, London SE1 1UL, UK
    Br J Pharmacol 134:1805-13. 2001
    ..The results also demonstrate a pivotal link between the kinins and sensory nerves in the microvascular response to burn injury, and for the first time show a rapid involvement of the B(1) receptor in murine skin...
  12. doi request reprint A role for the medial preoptic area in CGRP-induced suppression of pulsatile LH secretion in the female rat
    X F Li
    Division of Reproduction and Endocrinology, London, UK
    Stress 12:259-67. 2009
    ..Additionally, CGRP receptor function may be involved in this brain region in stress-induced suppression of the GnRH pulse generator...
  13. pmc An investigation into the mechanism of capsaicin-induced oedema in rabbit skin
    P Newbold
    Pharmacology Group, King s College, London
    Br J Pharmacol 114:570-7. 1995
    ..However, the oedema is not inhibited by pretreatment with the anti-inflammatory steroid,dexamethasone. Further the mechanisms which lead to the oedema formation observed after intradermal capsaicin remain unknown...
  14. ncbi request reprint The calcitonin gene-related peptide (CGRP) antagonist CGRP(8-37) blocks vasodilatation in inflamed rat skin: involvement of adrenomedullin in addition to CGRP
    D Q Chu
    Centre for Cardiovascular Biology and Medicine, New Hunt's House, King's College, Guy's Campus, London SE1 1UL, UK
    Neurosci Lett 310:169-72. 2001
    ..05). Thus ADM is expressed locally in the inflamed cutaneous microvasculature where it can, in addition to, or as an alternative to CGRP, contribute to IL-1beta-induced vasoactive effects...
  15. pmc Evidence for ETA and ETB receptors in rat skin and an investigation of their function in the cutaneous microvasculature
    E Lawrence
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 115:840-4. 1995
    ..The findings in this study indicate that there are ETA and ETB receptors in rat skin and agents which activate either receptor act to mediate a decrease in cutaneous blood flow, but have no effect on increased microvascular permeability...
  16. ncbi request reprint Lack of a significant effect of deletion of the tachykinin neurokinin-1 receptor on wound healing in mouse skin
    T Cao
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College London, UK
    Neuroscience 108:695-700. 2001
    ..In conclusion, it is shown that deletion of a functional NK(1) receptor has little effect on wound healing in response to a simple cut in mouse skin...
  17. pmc Calcitonin gene-related peptide increases blood flow and potentiates plasma protein extravasation in the rat knee joint
    H Cambridge
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 106:746-50. 1992
    ..7. These results show that CGRP is a potent vasodilator in the rat knee. CGRP released from sensory nerves may act synergistically with mediators of increased vascular permeability to modify the inflammatory response in this site...
  18. pmc Responses to endothelins in the rat cutaneous microvasculature: a modulatory role of locally-produced nitric oxide
    E Lawrence
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 106:733-8. 1992
    ..Hence, it is suggested that in conditions where endogenous NO release is reduced, vasoconstrictor agents such as the endothelins could induce a dangerous decrease in blood flow possibly leading to ischaemia and tissue necrosis...
  19. pmc A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin
    S R Hughes
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 104:738-42. 1991
    ..6. The results suggest that capsaicin acts to release a rabbit form of CGRP in skin and that CGRP8 37 is a useful antagonist for investigating the potential of CGRP as a neurogenic mediator of inflammation...
  20. doi request reprint The role of corticotrophin-releasing hormone receptors in the calcitonin gene-related peptide-induced suppression of pulsatile luteinising hormone secretion in the female rat
    J E Bowe
    Division of Reproduction and Endocrinology, New Hunt s House, King s College London, Guy s Campus, London, UK
    Stress 11:312-9. 2008
    ....
  21. pmc Effect of a calcitonin gene-related peptide antagonist (CGRP8-37) on skin vasodilatation and oedema induced by stimulation of the rat saphenous nerve
    K J Escott
    Division of Biomedical Sciences, King s College, London
    Br J Pharmacol 110:772-6. 1993
    ....
  22. ncbi request reprint Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2
    C W Tam
    Cardiovascular Division, King s College London, United Kingdom
    Circ Res 98:262-70. 2006
    ..Thus RAMP2 plays a key role in the sensitivity and potency of AM-induced hypotensive responses via the AM1 receptor, providing evidence that this receptor is a selective target for novel therapeutic approaches...
  23. pmc Neonatal lipopolysaccharide exposure exacerbates stress-induced suppression of luteinizing hormone pulse frequency in adulthood
    X F Li
    Division of Reproduction and Endocrinology, 2 36D New Hunt s House, King s College London, Guy s Campus, London, United Kingdom
    Endocrinology 148:5984-90. 2007
    ....
  24. ncbi request reprint Effect of calcitonin gene-related peptide on gonadotrophin-releasing hormone mRNA expression in GT1-7 cells
    J S Kinsey-Jones
    Division of Reproductive Health, Endocrinology and Development, King s College London, UK
    J Neuroendocrinol 17:541-4. 2005
    ..These results suggest that CGRP down regulates expression of GnRH mRNA, via CGRP receptors in the GT1-7 cell, thus implying that a potential direct action of CGRP may mediate a suppressive effect on the GnRH neural network...
  25. pmc The calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS blocks CGRP and adrenomedullin vasoactive responses in the microvasculature
    A D Grant
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, U K
    Br J Pharmacol 142:1091-8. 2004
    ....
  26. pmc The modulation of inflammatory oedema by calcitonin gene-related peptide
    P Newbold
    Biomedical Sciences Division, King s College, London
    Br J Pharmacol 108:705-10. 1993
    ..Little evidence was obtained for an anti-inflammatory effect of CGRP in either the rat skin or paw...
  27. ncbi request reprint Studies of the microvascular effects of adrenomedullin and related peptides
    D Q Chu
    Centre for Cardiovascular Biology and Medicine, New Hunt's House, King's College, Guy's Campus, SE1 1EL, London, UK
    Peptides 22:1881-6. 2001
    ..A correlation of microvascular activity with effects mediated via CRLR and RAMP is discussed...
  28. ncbi request reprint Neurokinin-1 receptor agonists are involved in mediating neutrophil accumulation in the inflamed, but not normal, cutaneous microvasculature: an in vivo study using neurokinin-1 receptor knockout mice
    T Cao
    Centre for Cardiovascular Biology and Medicine and Messengers and Signaling Group, King s College London, London, United Kingdom
    J Immunol 164:5424-9. 2000
    ..05), but did not cause further reduction of the suppressed response of knockout mice. The results provide evidence that kinin receptors participate in NK1 receptor-dependent neutrophil accumulation in inflamed mouse skin...
  29. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
    ....
  30. ncbi request reprint Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female rat
    X F Li
    Division of Reproductive Health, Endocrinology and Development, King s College London, Guy s Campus, London, UK
    J Neuroendocrinol 18:602-10. 2006
    ..These results suggest that hypoglycaemia and LPS stress-induced LH suppression involves activation of CRF(2) while restraint stress-induced inhibition of LH pulses involves both CRF(1) and CRF(2)...
  31. ncbi request reprint The assessment of vasoactive properties of CGRP and adrenomedullin in the microvasculature: a study using in vivo and in vitro assays in the mouse
    Christina Tam
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, Guy s Campus, King s College, London, SE1 1UK
    J Mol Neurosci 22:117-24. 2004
    ..Furthermore, the results demonstrate the increased potency of CGRP in the microvasculature when compared with the structurally distinct peptide VIP and PGE1...
  32. ncbi request reprint B1 and B2 antagonists and bradykinin-induced blood flow in rat skin inflammation
    T Cao
    Centre for Cardiovascular Biology and Medicine, King s College, London, UK
    Inflamm Res 51:295-9. 2002
    ..The aim of the present study was to examine the contribution of the two kinin receptors B1 and B2 to the increased blood flow observed in response to bradykinin (BK) in a blister model under different injury conditions...
  33. doi request reprint A reactive oxygen species-mediated component in neurogenic vasodilatation
    Anna Starr
    Cardiovascular Division, King s College London, Franklin Wilkins Building, Waterloo Campus, London SE1 9NH, UK
    Cardiovasc Res 78:139-47. 2008
    ..This study was designed to investigate in vivo mechanisms involved in TRPV1-mediated peripheral vasodilatation...
  34. ncbi request reprint Generation of peroxynitrite in localised, moderate temperature burns
    A Rawlingson
    Cardiovascular Biology and Medicie, New Hunt s House, King s College London, UK
    Burns 26:223-7. 2000
    ..This data is the first to show protein nitration in thermally injured, oedematous skin and strongly suggests that ONOO- is generated in thermally damaged cutaneous tissue...
  35. pmc Altered microvascular reactivity to endothelin-1, endothelin-3 and NG-nitro-L-arginine methyl ester in streptozotocin-induced diabetes mellitus
    E Lawrence
    Pharmacology Group, Biomedical Sciences Division, King s College, London
    Br J Pharmacol 106:1035-40. 1992
    ..The effect of the nitric oxide synthase inhibitor L-NAME is also suppressed in the diabetics, suggesting that there may be decreased local production of, or response, to nitric oxide...
  36. ncbi request reprint Comparative effect of Phoneutria nigriventer spider venom and capsaicin on the rat paw oedema
    S K Costa
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, SP, Brazil
    Life Sci 69:1573-85. 2001
    ....
  37. doi request reprint Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo
    Gabor Pozsgai
    King s College London British Heart Foundation Centre, Cardiovascular Division and Centre of Integrative Biomedicine, King s College London, Franklin Wilkins Building, London SE1 9NH, UK
    Cardiovasc Res 87:760-8. 2010
    ....
  38. ncbi request reprint Stress-induced suppression of the gonadotropin-releasing hormone pulse generator in the female rat: a novel neural action for calcitonin gene-related peptide
    Xiao Feng Li
    Centre for Reproduction, Endocrinology and Diabetes, New Hunt s House, King s College London, Guy s Campus, United Kingdom
    Endocrinology 145:1556-63. 2004
    ....
  39. pmc Phoneutria nigriventer spider venom activates 5-HT4 receptors in rat-isolated vagus nerve
    Soraia K P Costa
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College London, London SE1 1UL
    Br J Pharmacol 139:59-64. 2003
    ..nigriventer spider...
  40. ncbi request reprint A role for substance P in arthritis?
    J E Keeble
    Centre for Cardiovascular Biology and Medicine, King s College, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Neurosci Lett 361:176-9. 2004
    ..However, the therapeutic potential of NK(1) receptor antagonists in the treatment of rheumatoid arthritis remains controversial...
  41. pmc Protein nitration in cutaneous inflammation in the rat: essential role of inducible nitric oxide synthase and polymorphonuclear leukocytes
    S A B Greenacre
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    Br J Pharmacol 136:985-94. 2002
    ..The NO-derived iNOS also has a role in stimulating further neutrophil accumulation into skin. This suggests a close mechanistic coupling between neutrophils, NO production and protein nitration...
  42. ncbi request reprint Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature
    Soraia K P Costa
    Centre for Cardiovascular Biology and Medicine, King s College, Guy s Campus London SE1, 1UL, UK
    J Neuroimmunol 171:99-109. 2006
    ..The NK1 receptor agonist influences the accumulation of monocytes in addition to that of PMN by 4 h, thus revealing an important influence of the NK1 receptor on TNFalpha mediated events in mouse skin...
  43. ncbi request reprint An examination of neurogenic mechanisms involved in mustard oil-induced inflammation in the mouse
    Andrew D Grant
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    Eur J Pharmacol 507:273-80. 2005
    ..These data suggest that both a tachykinin NK1 receptor agonist and a CGRP agonist are active as vasodilators, producing redundancy, requiring blockade of both mediators to prevent vasodilatation...
  44. pmc Evidence of a role for NK1 and CGRP receptors in mediating neurogenic vasodilatation in the mouse ear
    Andrew D Grant
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, Guy s Campus, King s College, London, SE1 1UL
    Br J Pharmacol 135:356-62. 2002
    ..The results indicate that neurogenic vasodilatation can be measured in the mouse ear. The capsaicin-induced increased blood flow involves activation of, and possible interactions between, both NK(1) and CGRP(1) receptors...
  45. ncbi request reprint Use of NK(1) knockout mice to analyze substance P-induced edema formation
    T Cao
    Pharmacology Group and Vascular Biology Research Centre, School of Biomedical Sciences, King s College, London SW3 6LX, United Kingdom
    Am J Physiol 277:R476-81. 1999
    ..The evidence is in keeping with an NK(1) receptor on mast cells...
  46. pmc Calcitonin gene-related peptide-induced suppression of luteinizing hormone pulses in the rat: the role of endogenous opioid peptides
    J E Bowe
    Division of Reproducive Health, Endocrinology and Development, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    J Physiol 566:921-8. 2005
    ..They also suggest that the mu and kappa, but not the delta, opioid receptors may be responsible for mediating the effects of CGRP on LH pulses...
  47. ncbi request reprint Basal and activity-induced release of substance P from primary afferent fibres in NK1 receptor knockout mice: evidence for negative feedback
    Isobel J Lever
    Centre for Neuroscience, Hodgkin Building, Guy s Campus, King s College, London SE1 1UL, UK
    Neuropharmacology 45:1101-10. 2003
    ..05, n=5 to 6 mice/strain). These results provide evidence for the existence of NK1 autoreceptors on sensory nerves in skin, which may be relevant to the modulation of their peripheral pathophysiological effector functions...
  48. pmc The ability of neuropeptide Y to mediate responses in the murine cutaneous microvasculature: an analysis of the contribution of Y1 and Y2 receptors
    Duc Quyen Chu
    Centre for Cardiovascular Biology and Medicine, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL
    Br J Pharmacol 140:422-30. 2003
    ..Our results do not provide evidence for a potent proinflammatory activity of NPY in the cutaneous microvasculature...
  49. doi request reprint Protection of angiotensin II-induced vascular hypertrophy in vascular smooth muscle-targeted receptor activity-modifying protein 2 transgenic mice
    Lihuan Liang
    Cardiovascular Division, King s College London, Franklin Wilkins Building, Waterloo Campus, London SE1 9NH, UK
    Hypertension 54:1254-61. 2009
    ....
  50. ncbi request reprint How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom
    Soraia K P Costa
    Cardiovascular Division, King s College, Guy s Campus, London SE1 1UL, UK
    Vascul Pharmacol 45:209-14. 2006
    ..Thus, a distinct separation between endogenous microvascular and PNV nociceptive NK(1)-dependent effects is suggested...
  51. ncbi request reprint Neutrophils in development of multiple organ failure in sepsis
    K A Brown
    Division of Medical Education, King s College School of Medicine, London, UK
    Lancet 368:157-69. 2006
    ..We further suggest that targeting neutrophils and their interactions with blood vessel walls could be a worthwhile therapeutic strategy for sepsis...
  52. pmc Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms
    Andrew D Grant
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, Guy s Campus, King s College, London SE1 1UL, UK
    J Physiol 543:1007-14. 2002
    ..These findings are in keeping with a role for NKB in mediating plasma extravasation in diseases such as pre-eclampsia...
  53. pmc Functional significance of inducible nitric oxide synthase induction and protein nitration in the thermally injured cutaneous microvasculature
    Andrew Rawlingson
    Centre for Cardiovascular Biology and Medicine, King s College London, London, United Kingdom
    Am J Pathol 162:1373-80. 2003
    ..Our observations provide evidence for the involvement of reactive species in the inflammatory response after burn. The use of selective iNOS inhibitors may represent a novel approach for the management of human burn injuries...
  54. pmc Effect of high-fat feeding on expression of genes controlling availability of dopamine in mouse hypothalamus
    Alex K Lee
    Nutritional Sciences Division, King s College London, London, United Kingdom
    Nutrition 26:411-22. 2010
    ..Quantifying changes in hypothalamic gene expression in the presence of nutrient excess may identify novel responsive elements...
  55. pmc 4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo
    Rabea Graepel
    Cardiovascular Division, King s College London, Waterloo Campus, London, United Kingdom
    J Pharmacol Exp Ther 337:117-24. 2011
    ..These data indicate the potential of TRPA1 as an oxidant sensor for vasodilator responses in vivo. However, 4-ONE also triggers TRPA1-independent effects that relate to edema formation and pain...
  56. ncbi request reprint Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation
    Julie Keeble
    Cardiovascular Division, New Hunt s House, King s College London, Guy s Campus, London, UK
    Arthritis Rheum 52:3248-56. 2005
    ..To investigate the endogenous involvement of transient receptor potential vanilloid 1 (TRPV1) in a model of knee joint inflammation in the mouse...
  57. ncbi request reprint Endothelial cells play an essential role in the thermal hyperalgesia induced by nerve growth factor
    Paul A Foster
    Centre for Cardiovascular Biology and Medicine, King s College, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    FASEB J 17:1703-5. 2003
    ....
  58. ncbi request reprint Cellular pathology changes in rat skin following intradermal injection of nerve growth factor: neutrophil-dependent and -independent events
    Paul A Foster
    Centre for Cardiovascular Biology and Medicine, King s College, London, UK
    J Pathol 197:245-55. 2002
    ..The results also suggest that NGF can have a profound effect on rat muscle and that this effect may be related to muscle regeneration...
  59. ncbi request reprint The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin
    Natalie Clark
    Cardiovascular Division, King s College London, Waterloo Campus, 150 Stamford St, London SE1 9NH, UK
    FASEB J 21:3747-55. 2007
    ..The findings are relevant to developing strategies that increase the beneficial, and reduce the harmful, components of sepsis to prevent and treat this often fatal condition...
  60. ncbi request reprint Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom
    Soraia K P Costa
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, P O Box 6111, 13081 970, SP, Campinas, Brazil
    Neurosci Lett 318:158-62. 2002
    ..We conclude that bradykinin generation is involved in the PNV-induced pleural leukocyte migration in rats, where it can directly activate sensory nerves contributing to a neurogenic inflammatory mechanism...
  61. ncbi request reprint Interaction between interleukin 1beta and endogenous neurokinin 1 receptor agonists in mediating plasma extravasation and neutrophil accumulation in the cutaneous microvasculature of the rat
    Erika Pinter
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Pecs University, Szigeti u 12, 7643, Pecs, Hungary
    Neurosci Lett 318:13-6. 2002
    ..v.). We conclude that IL-1beta-induced neutrophil accumulation can be influenced in a pro-inflammatory manner by ongoing neurogenic inflammation, of relevance to the sensory nerve input that occurs during ongoing inflammatory disease...
  62. pmc Alarin is a vasoactive peptide
    Radmila Santic
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
    Proc Natl Acad Sci U S A 104:10217-22. 2007
    ..Alarin adds another facet to the surprisingly high-functional redundancy of the galanin family of peptides...
  63. ncbi request reprint Targeted disruption of the galanin gene attenuates inflammatory responses in murine skin
    Sabine M Schmidhuber
    Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
    J Mol Neurosci 34:149-55. 2008
    ..These data indicate that Gal KO mice demonstrate abnormal neurogenic inflammatory responses in murine skin compared to strain-matched wild-type mice...
  64. ncbi request reprint Galanin-like peptides exert potent vasoactive functions in vivo
    Sabine M Schmidhuber
    Department of Pediatrics, Paracelsus Private Medical University Salzburg, Salzburg, Austria
    J Invest Dermatol 127:716-21. 2007
    ..These results indicate functional activity of GALP in the periphery in vivo and suggest a potential role as an inflammatory modulator...
  65. ncbi request reprint Tachykinins regulate the function of platelets
    Gwenda J Graham
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading, Berkshire, RG6 6AJ, UK
    Blood 104:1058-65. 2004
    ..Together our data implicate tachykinins, specifically SP and EKA/B, in the regulation of platelet function...
  66. pmc Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis
    Mirna Marques Bezerra
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil
    Br J Pharmacol 141:172-82. 2004
    ..NOS inhibitors and a PN scavenger were able to reduce the cellular infiltration, while displaying opposite effects on cartilage homeostasis either by enhancing or ameliorating the damage, respectively...
  67. ncbi request reprint Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model
    Agnes Bánvölgyi
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624 Pecs, Szigeti u 12, Hungary
    J Neuroimmunol 169:86-96. 2005
    ..A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides...
  68. ncbi request reprint Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis
    Mirna M Bezerra
    Department of Physiology and Pharmacology, Faculty of Medicine of Sobral, Federal University of Ceara, Rua Geraldo Rangel, S N, Derby, Sobral, Ceara, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 374:265-73. 2007
    ..Scavenging of reactive nitrogen species (e.g. peroxynitrite) inhibits neutrophil migration and joint hyperalgesia in the acute phase of zymosan arthritis in rats...