Genomes and Genes
E J Bradbury
Affiliation: King's College London
- Chondroitinase ABC promotes functional recovery after spinal cord injuryElizabeth J Bradbury
Sensory Function Group, Centre for Neuroscience Research, Hodgkin Building, Kings College London, Guy s Campus, London Bridge, London SE1 1UL, UK
Nature 416:636-40. 2002..Our results demonstrate that CSPGs are important inhibitory molecules in vivo and suggest that their manipulation will be useful for treatment of human spinal injuries...
- NGF and GDNF ameliorate the increase in ATF3 expression which occurs in dorsal root ganglion cells in response to peripheral nerve injurySharon Averill
Neuroscience Centre, Bart s and The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London E1 4NS, UK
Eur J Neurosci 19:1437-45. 2004....
- Regulation of IL-10 by chondroitinase ABC promotes a distinct immune response following spinal cord injuryAthanasios Didangelos
Wolfson Centre for Age Related Diseases, Guy s Campus, King s College London, London SE1 1UL, United Kingdom
J Neurosci 34:16424-32. 2014..These findings provide novel insights into the effects of ChABC in the injured spinal cord and explain its immunoregulatory activity. ..
- Manipulating the glial scar: chondroitinase ABC as a therapy for spinal cord injuryElizabeth J Bradbury
King s College London, Neurorestoration Group, Wolfson Centre for Age Related Diseases, Guy s Campus, London, United Kingdom
Brain Res Bull 84:306-16. 2011..We discuss putative mechanisms underlying ChABC-mediated repair as well as potential issues and considerations in translating ChABC treatment into a clinical therapy for spinal cord injury...
- Keeping in touch: sensory neurone regeneration in the CNSE J Bradbury
Sensory Function Group, Centre for Neuroscience Research, Hodgkin Building, King s College London, Guy s Campus, London Bridge, SE1 1UL, London, UK
Trends Pharmacol Sci 21:389-94. 2000..The contribution that the study of primary sensory neurones has made to the attainment of this goal will be reviewed...
- Nerve growth factor induces P2X(3) expression in sensory neuronsM S Ramer
Sensory Function Group, Centre for Neuroscience Research, Guy s King s and St Thomas School of Biomedical Science, King s College London, London, UK
J Neurochem 77:864-75. 2001..In both cervical and lumbar DRG, the number of P2X(3)-positive cells increased following GDNF or NGF treatment. De novo expression of P2X(3) in NGF-sensitive nociceptors may contribute to chronic inflammatory pain...
- Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulationI J Lever
Neuroscience Research Center and Department of Pharmacology, Guy's, King's, and St. Thomas' School of Biomedical Sciences, King's College London, London SE1 1UL, United Kingdom
J Neurosci 21:4469-77. 2001..These experiments demonstrate that BDNF release in the dorsal horn is encoded by specific patterns of afferent fiber stimulation and is mediated by NMDA receptor activation...
- NT-3, but not BDNF, prevents atrophy and death of axotomized spinal cord projection neuronsE J Bradbury
Department of Physiology, St Thomas Hospital Medical School, London, UK
Eur J Neurosci 10:3058-68. 1998..These results demonstrate that NT-3 may be of benefit in preventing the secondary cell loss that occurs following spinal injury...
- Intrathecally delivered glial cell line-derived neurotrophic factor produces electrically evoked release of somatostatin in the dorsal horn of the spinal cordP Charbel Issa
Neuroscience Research Centre, Guy's, King's and St Thomas' School of Biomedical Sciences, King's College London, London, UK
J Neurochem 78:221-9. 2001..Conversely capsaicin-induced release of SOM (EC(50) 50 nM) was not modified by GDNF treatment. These results show that GDNF can regulate central synaptic function in SOM-containing sensory neurons...
- Regulation of neuropilin 1 by spinal cord injury in adult ratsMarta Agudo
Neuro Restoration CARD, Wolfson Centre Guy s Campus, King s College London, London Bridge, London SE1 1UL, UK
Mol Cell Neurosci 28:475-84. 2005..Unexpectedly, this increase is bilateral after unilateral rhizotomy...
- Chondroitin sulphate proteoglycans: key modulators of spinal cord and brain plasticityK Bartus
Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London Bridge, SE1 1UL, UK
Exp Neurol 235:5-17. 2012..Here we discuss the potential of CSPG modification to stimulate restorative plasticity after injury, reviewing evidence from studies in the brain, the spinal cord and the periphery...
- Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injuryA W Barritt
Neurorestoration Group, Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
J Neurosci 26:10856-67. 2006..Thus, CSPG digestion promotes robust sprouting of spinal projections in degenerating and denervated areas of the spinal cord; compensatory sprouting of descending systems could be a key mechanism underlying functional recovery...
- A novel control mechanism based on GDNF modulation of somatostatin release from sensory neuronesMarzia Malcangio
Neuroscience Research Centre, Guy s, King s and St Thomas School of Biomedical Sciences, King s College London, London SE1 1UL, UK
FASEB J 16:730-2. 2002..In conclusion we propose GDNF regulation of neuronal SOM release as a novel mechanism that, if explored, may lead to new therapeutic strategies based on local release of somatostatin...
- Delayed treatment with chondroitinase ABC reverses chronic atrophy of rubrospinal neurons following spinal cord injuryLucy M Carter
King s College London, Neurorestoration Group, Wolfson Centre for Age Related Diseases, Wolfson Wing, Hodgkin Building, Guy s Campus, London Bridge, London SE1 1UL, UK
Exp Neurol 228:149-56. 2011..Thus, modulation of the extracellular matrix can mediate neuroprotective effects both early and late after spinal cord injury...
- The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injuryLucy M Carter
Neurorestoration Group, Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, UK
J Neurosci 28:14107-20. 2008....
- Chondroitinase ABC-mediated plasticity of spinal sensory functionWilliam B J Cafferty
Neurorestoration Group, The Wolfson Centre for Age Related Diseases, King s College London, London SE11UL, United Kingdom
J Neurosci 28:11998-2009. 2008..Furthermore, comprehensive understanding of these targets may lead to therapeutic interventions that can be spatially tailored to specific circuitry, thereby reducing unwanted maladaptive axon growth of distal pathways...
- Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinaseBritta J Eickholt
Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
PLoS ONE 2:e869. 2007..Our data identify p110delta as an important signaling component for efficient axonal elongation in the developing and regenerating nervous system...
- Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cordPing K Yip
Neurorestoration Group, Wolfson CARD, 2 MRC Centre for Developmental Biology, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
Hum Mol Genet 15:3107-18. 2006....
- Role of spinal microglia in rat models of peripheral nerve injury and inflammationAnna K Clark
Neurorestoration, Wolfson Centre for Age Related Diseases, King s College London, Wolfson Wing, Hodgkin Building, Guys Campus, London SE1 1UL, UK
Eur J Pain 11:223-30. 2007..Furthermore, it would appear that the time course of microglia activation and their contribution to inflammatory pain is dependent on the inflammatory stimulus administered...
- Glial cell line-derived neurotrophic factor increases calcitonin gene-related peptide immunoreactivity in sensory and motoneurons in vivoMatt S Ramer
Sensory Function Group, Centre for Neuroscience Research, King s College London, Guy s Campus, London Bridge, London, UK
Eur J Neurosci 18:2713-21. 2003....
- Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injuryMichelle L Starkey
Neurorestoration Group, Wolfson Centre for Age Related Diseases, Wolfson Wing, King s College London, London Bridge, London
J Comp Neurol 513:51-68. 2009..This study supports the hypothesis that SPRR1A is a regeneration-associated gene and that SPRR1A provides a valuable marker to assess the regenerative potential of injured neurons...
- Assessing behavioural function following a pyramidotomy lesion of the corticospinal tract in adult miceMichelle L Starkey
Neurorestoration Group, CARD Wolfson Wing, Hodgkin Building, King s College London, Guy s Campus, London Bridge, London SE1 IUL, UK
Exp Neurol 195:524-39. 2005....
- Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cordB J Kerr
Neuroscience Research Centre, Guy s, King s, and St Thomas School of Biomedical Sciences, Kings College London, London SE1 7EH, United Kingdom
J Neurosci 19:5138-48. 1999....
- Effects of Etanercept and Minocycline in a rat model of spinal cord injuryFabien Marchand
Neurorestoration Group, King s College London, Wolfson Wing, Wolfson Centre for Age Related Diseases, Hodgkin Building, Guy s Campus, London SE1 1UL, United Kingdom
Eur J Pain 13:673-81. 2009..Pharmacological targeting of TNF-alpha may offer therapeutic opportunities for treating SCI pain...
- Laminar distribution of GABAA- and glycine-receptor mediated tonic inhibition in the dorsal horn of the rat lumbar spinal cord: effects of picrotoxin and strychnine on expression of Fos-like immunoreactivityJohn N Cronin
Department of Physiology, Hodgkin Building, King s College London, London SE1 1UL, UK
Pain 112:156-63. 2004..GABAA antagonists also induce hypersensitivity to noxious inputs. The blockade of tonic inhibition in the superficial dorsal horn shown here may underlie this hyperalgesia...
- Spinal cord repair strategies: why do they work?Elizabeth J Bradbury
Neurorestoration Group, Wolfson Wing, Hodgkin Building, Guy s Campus, King s College London, London Bridge, London SE1 1UL, UK
Nat Rev Neurosci 7:644-53. 2006..We also discuss several more speculative mechanisms that might putatively explain or confound some of the reported outcomes of experimental interventions...
- Therapeutic time window for the application of chondroitinase ABC after spinal cord injuryGuillermo Garcia-Alias
Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 0PY, UK
Exp Neurol 210:331-8. 2008..The area of chondroitinase ABC digestion visualized by stub antibody staining included widespread digestion around the lateral ventricles and partial digestion of cervical spinal cord white matter, but not grey matter...
- Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cordDaniel J Webber
University of Cambridge, Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
Regen Med 2:929-45. 2007..SCNPCs are multipotent, can be expanded in vitro, have the capacity to differentiate into CNS cell lineages and are capable of long-term survival following transplantation...
- A clonal cell line from immortalized olfactory ensheathing glia promotes functional recovery in the injured spinal cordM Teresa Moreno-Flores
Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain
Mol Ther 13:598-608. 2006..These data indicate that certain immortalized cell lines derived from a single cell can maintain the regenerative properties of primary OEG...