Patrick F Bolton

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Chromosome 15q11-13 abnormalities and other medical conditions in individuals with autism spectrum disorders
    Patrick F Bolton
    Department of Child Psychiatry and MRC Centre for Social, Genetic and Developmental Psychiatry, The Institute of Psychiatry, Kings College, London, UK
    Psychiatr Genet 14:131-7. 2004
  2. ncbi request reprint Neuroepileptic correlates of autistic symptomatology in tuberous sclerosis
    Patrick F Bolton
    Department of Child Psychiatry and Centre for Social, Genetic and Developmental Psychiatry, The Institute of Psychiatry, Kings College, Denmark Hill, London SE5 8AF, UK
    Ment Retard Dev Disabil Res Rev 10:126-31. 2004
  3. ncbi request reprint Aetiological relationship between language performance and autistic-like traits in childhood: a twin study
    Katharina Dworzynski
    MRC Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, London, UK
    Int J Lang Commun Disord 42:273-92. 2007
  4. ncbi request reprint Prader-Willi syndrome: intellectual abilities and behavioural features by genetic subtype
    Katja M Milner
    Child and Adolescent Psychiatry Department and MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 46:1089-96. 2005
  5. pmc Medical conditions in autism spectrum disorders
    Patrick F Bolton
    The Social Genetic and Developmental Psychiatry Centre and The Department of Child and Adolescent Psychiatry, The Institute of Psychiatry, King s College London, London, England
    J Neurodev Disord 1:102-13. 2009
  6. doi request reprint Cortical anatomy in autism spectrum disorder: an in vivo MRI study on the effect of age
    Armin Raznahan
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Cereb Cortex 20:1332-40. 2010
  7. doi request reprint Serotonin transporter genotype and neuroanatomy in autism spectrum disorders
    Armin Raznahan
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, KCL, UK
    Psychiatr Genet 19:147-50. 2009
  8. ncbi request reprint Biological markers of intellectual disability in tuberous sclerosis
    Armin Raznahan
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, UK
    Psychol Med 37:1293-304. 2007
  9. ncbi request reprint An association analysis of microsatellite markers across the Prader-Willi/Angelman critical region on chromosome 15 (q11-13) and autism spectrum disorder
    Sarah Curran
    MRC Social, Genetic and Developmental Pyschiatry Centre, Institute of Pyschiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 137:25-8. 2005
  10. ncbi request reprint Monozygotic twins with tuberous sclerosis discordant for the severity of developmental deficits
    Ayla Humphrey
    Developmental Psychiatry Section, University of Cambridge, Addenbrooke s Hospital, Cambridge, Institute of Psychiatry, London, UK
    Neurology 62:795-8. 2004

Detail Information

Publications24

  1. ncbi request reprint Chromosome 15q11-13 abnormalities and other medical conditions in individuals with autism spectrum disorders
    Patrick F Bolton
    Department of Child Psychiatry and MRC Centre for Social, Genetic and Developmental Psychiatry, The Institute of Psychiatry, Kings College, London, UK
    Psychiatr Genet 14:131-7. 2004
    ..The frequency of abnormalities of 15q11-q13 and other possibly causal medical disorders including karyotypic abnormalities was investigated in an unselected series of children who were referred to one of two autism assessment centres...
  2. ncbi request reprint Neuroepileptic correlates of autistic symptomatology in tuberous sclerosis
    Patrick F Bolton
    Department of Child Psychiatry and Centre for Social, Genetic and Developmental Psychiatry, The Institute of Psychiatry, Kings College, Denmark Hill, London SE5 8AF, UK
    Ment Retard Dev Disabil Res Rev 10:126-31. 2004
    ..However, alternative mechanisms to account for the findings cannot yet be ruled out. Future research will have to employ prospective longitudinal designs and treatment trials to clarify the processes involved...
  3. ncbi request reprint Aetiological relationship between language performance and autistic-like traits in childhood: a twin study
    Katharina Dworzynski
    MRC Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, London, UK
    Int J Lang Commun Disord 42:273-92. 2007
    ..The basis for this association is poorly understood. How early language is related to each of the triad of impairments characteristic of ASDs is also in need of clarification...
  4. ncbi request reprint Prader-Willi syndrome: intellectual abilities and behavioural features by genetic subtype
    Katja M Milner
    Child and Adolescent Psychiatry Department and MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 46:1089-96. 2005
    ..We also tested reports that PWS cases due to the larger type I (TI) form of deletion show differences to cases with the smaller type II (TII) deletion...
  5. pmc Medical conditions in autism spectrum disorders
    Patrick F Bolton
    The Social Genetic and Developmental Psychiatry Centre and The Department of Child and Adolescent Psychiatry, The Institute of Psychiatry, King s College London, London, England
    J Neurodev Disord 1:102-13. 2009
    ..Recent advances in genetics, molecular and systems biology and neuroscience now mean that there are unparalleled opportunities to test causal hypotheses and gain fundamental insights into the nature of autism and its development...
  6. doi request reprint Cortical anatomy in autism spectrum disorder: an in vivo MRI study on the effect of age
    Armin Raznahan
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Cereb Cortex 20:1332-40. 2010
    ..This may reflect primary abnormalities in cortical plasticity and/or be secondary to disturbed interactions between individuals with ASD and their environment...
  7. doi request reprint Serotonin transporter genotype and neuroanatomy in autism spectrum disorders
    Armin Raznahan
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, KCL, UK
    Psychiatr Genet 19:147-50. 2009
    ....
  8. ncbi request reprint Biological markers of intellectual disability in tuberous sclerosis
    Armin Raznahan
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, UK
    Psychol Med 37:1293-304. 2007
    ..We have used univariate and multivariate analyses, including both CT and epilepsy measures as predictors, in an attempt to clarify the pattern of cross-sectional associations between these variables and ID in TS...
  9. ncbi request reprint An association analysis of microsatellite markers across the Prader-Willi/Angelman critical region on chromosome 15 (q11-13) and autism spectrum disorder
    Sarah Curran
    MRC Social, Genetic and Developmental Pyschiatry Centre, Institute of Pyschiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 137:25-8. 2005
    ..Further more systematic work in larger samples is required and confirmation that GABRB3 is imprinted is desirable...
  10. ncbi request reprint Monozygotic twins with tuberous sclerosis discordant for the severity of developmental deficits
    Ayla Humphrey
    Developmental Psychiatry Section, University of Cambridge, Addenbrooke s Hospital, Cambridge, Institute of Psychiatry, London, UK
    Neurology 62:795-8. 2004
    ..The findings also raise questions about the mechanisms giving rise to autism in TS...
  11. ncbi request reprint Neuro-epileptic determinants of autism spectrum disorders in tuberous sclerosis complex
    Patrick F Bolton
    Autism Research Centre, Developmental Psychiatry Section, University of Cambridge, UK
    Brain 125:1247-55. 2002
    ....
  12. ncbi request reprint Case report: Angelman syndrome in an individual with a small SMC(15) and paternal uniparental disomy: a case report with reference to the assessment of cognitive functioning and autistic symptomatology
    Russell John Thompson
    Autism Research Centre, Section of Developmental Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 2AH, United Kingdom
    J Autism Dev Disord 33:171-6. 2003
    ....
  13. doi request reprint The Early Childhood Epilepsy Severity Scale (E-Chess)
    Ayla Humphrey
    Department of Psychiatry, Developmental Psychiatry Section, University of Cambridge, Douglas House, Cambridge, UK
    Epilepsy Res 79:139-45. 2008
    ....
  14. ncbi request reprint A prospective longitudinal study of early cognitive development in tuberous sclerosis - a clinic based study
    Ayla Humphrey
    Developmental Psychiatry Section, University of Cambridge Douglas House 18b, Trumpington Road, Cambridge CB2 2AH, England
    Eur Child Adolesc Psychiatry 13:159-65. 2004
    ..In three children, the developmental quotient changed by more than 20 points during the course of the study. The findings are considered in relation to the neurobiological risk factors for cognitive development in Tuberous Sclerosis...
  15. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  16. ncbi request reprint The psychopathologies of children and adolescents with tuberous sclerosis complex (TSC): a postal survey of UK families
    Petrus J de Vries
    Developmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 2AH, UK
    Eur Child Adolesc Psychiatry 16:16-24. 2007
    ..These findings show that TSC can place any child or adolescent at significantly increased risk of a range of neurodevelopmental disabilities. These difficulties, often not recognised, require significant clinical and research attention...
  17. ncbi request reprint Autistic regression associated with seizure onset in an infant with tuberous sclerosis
    Ayla Humphrey
    Developmental Psychiatry Section, University of Cambridge, UK
    Dev Med Child Neurol 48:609-11. 2006
    ..The case suggests the need to consider if possible visual field defects with vigabatrin outweigh the potentially deleterious effects of uncontrolled seizures...
  18. ncbi request reprint Autism spectrum disorders in Prader-Willi and Angelman syndromes: a systematic review
    Marijcke W M Veltman
    Department of Psychiatry, Section of Developmental Psychiatry, University of Cambridge, Cambridge, UK
    Psychiatr Genet 15:243-54. 2005
    ..0176). Thus, the limited available evidence supported the prediction that overexpression of maternally imprinted genes in 15q11-13 confers a risk for ASD. Further research will be required to confirm these findings...
  19. ncbi request reprint Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile X region
    John B Vincent
    Molecular Psychiatry Laboratory, Department of Psychiatry and Behavioural Sciences, Windeyer Institute of Medical Science, University College London, London
    Psychiatr Genet 15:83-90. 2005
    ..1 for a broad phenotype diagnostic model. Thus, this study offers modest support for a susceptibility locus for autism within the Xq27-q28 region. Further genetic investigations of this region are warranted...
  20. ncbi request reprint A paternally inherited duplication in the Prader-Willi/Angelman syndrome critical region: a case and family study
    Marijcke W M Veltman
    Developmental Psychiatry Section, University of Cambridge, Cambridge, UK
    J Autism Dev Disord 35:117-27. 2005
    ..More research is required to determine whether paternally derived duplications that involve 15q11-13 are associated with developmental impairments...
  21. ncbi request reprint Speech-in-noise perception in high-functioning individuals with autism or Asperger's syndrome
    José I Alcántara
    Department of Experimental Psychology, University of Cambridge, UK
    J Child Psychol Psychiatry 45:1107-14. 2004
    ..The objective of this study was threefold: (1) to verify the validity of these reports; (2) to quantify the difficulties experienced; and (3) to propose possible mechanisms to explain the perceptual deficits described...
  22. ncbi request reprint Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands
    John B Vincent
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Am J Med Genet B Neuropsychiatr Genet 129:82-4. 2004
    ..Our own study, screening a larger sample of 196 autism probands, failed to identify any mutations that would affect the coding regions of these genes. Our findings suggest that mutations in these two genes are infrequent in autism...
  23. ncbi request reprint Prader-Willi syndrome--a study comparing deletion and uniparental disomy cases with reference to autism spectrum disorders
    Marijcke W M Veltman
    Developmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 2AH, UK
    Eur Child Adolesc Psychiatry 13:42-50. 2004
    ..They also suggest that there may be cognitive differences between the groups in processing visuo-spatial information...
  24. ncbi request reprint Mutation screening and association analysis of six candidate genes for autism on chromosome 7q
    Elena Bonora
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Eur J Hum Genet 13:198-207. 2005
    ..Association was also detected for several polymorphisms in the promoter and untranslated region of NRCAM, suggesting that alterations in expression of this gene may be linked to autism susceptibility...