William Bernal

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
    William Bernal
    Institute of Liver Studies, King s College Hospital, Guy s, King s, and St Thomas s School of Medicine, London, UK
    Lancet 359:558-63. 2002
  2. ncbi request reprint Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
    William Bernal
    Liver Intensive Care Unit, Institute of Liver Studies, Kings College Hospital, Denmark Hill, London, United Kingdom
    Hepatology 46:1844-52. 2007
  3. doi request reprint Lessons from look-back in acute liver failure? A single centre experience of 3300 patients
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, London, United Kingdom
    J Hepatol 59:74-80. 2013
  4. ncbi request reprint Intensive care management of acute liver failure
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Semin Liver Dis 28:188-200. 2008
  5. doi request reprint Outcome after wait-listing for emergency liver transplantation in acute liver failure: a single centre experience
    William Bernal
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Hepatol 50:306-13. 2009
  6. ncbi request reprint Cell-free artificial liver support: design of appropriate clinical studies
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, Denmark Hill, London, UK
    Ther Apher Dial 10:175-9. 2006
  7. doi request reprint Acute liver failure
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, King s College Hospital, London, UK
    Lancet 376:190-201. 2010
  8. ncbi request reprint Liver transplantation in adults with acute liver failure
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, London SE5 9RS, UK
    J Hepatol 40:192-7. 2004
  9. ncbi request reprint Changing patterns of causation and the use of transplantation in the United kingdom
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Semin Liver Dis 23:227-37. 2003
  10. ncbi request reprint Intensive care support therapy
    William Bernal
    Institute of Liver Studies, Kings College Hospital, London, England
    Liver Transpl 9:S15-7. 2003

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
    William Bernal
    Institute of Liver Studies, King s College Hospital, Guy s, King s, and St Thomas s School of Medicine, London, UK
    Lancet 359:558-63. 2002
    ..We investigated the use of arterial blood lactate measurement for the identification of transplantation candidates...
  2. ncbi request reprint Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure
    William Bernal
    Liver Intensive Care Unit, Institute of Liver Studies, Kings College Hospital, Denmark Hill, London, United Kingdom
    Hepatology 46:1844-52. 2007
    ..After admission, ammonia levels remained high in those developing ICH and fell in those who did not. Youth, a requirement for vasopressors, and renal replacement therapy were additional independent risk factors...
  3. doi request reprint Lessons from look-back in acute liver failure? A single centre experience of 3300 patients
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, London, United Kingdom
    J Hepatol 59:74-80. 2013
    ..We reviewed patients treated over a 35-year period at a specialist high-volume ICU, quantifying changes in disease aetiology, severity and evolution of ICU support and ELT use and outcome...
  4. ncbi request reprint Intensive care management of acute liver failure
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Semin Liver Dis 28:188-200. 2008
    ....
  5. doi request reprint Outcome after wait-listing for emergency liver transplantation in acute liver failure: a single centre experience
    William Bernal
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Hepatol 50:306-13. 2009
    ..Though emergency liver transplantation (ELT) is an established treatment for severe acute liver failure (ALF), outcomes are inferior to elective surgery. Despite prioritization, many patients deteriorate, becoming unsuitable for ELT...
  6. ncbi request reprint Cell-free artificial liver support: design of appropriate clinical studies
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, Denmark Hill, London, UK
    Ther Apher Dial 10:175-9. 2006
    ..In the present review, the limitations of current studies are discussed and suggestions made as to the design and conduct of future clinical trials...
  7. doi request reprint Acute liver failure
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, King s College Hospital, London, UK
    Lancet 376:190-201. 2010
    ....
  8. ncbi request reprint Liver transplantation in adults with acute liver failure
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, London SE5 9RS, UK
    J Hepatol 40:192-7. 2004
  9. ncbi request reprint Changing patterns of causation and the use of transplantation in the United kingdom
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, King s College Hospital, London, United Kingdom
    Semin Liver Dis 23:227-37. 2003
    ..The reduction in acetaminophen-related ALF has been paralleled by an increase in the number of transplants performed in ALF of nonacetaminophen etiologies...
  10. ncbi request reprint Intensive care support therapy
    William Bernal
    Institute of Liver Studies, Kings College Hospital, London, England
    Liver Transpl 9:S15-7. 2003
    ..This system is particularly attractive in the treatment of SFSS, however, despite its current clinical application, there are presently limited published data to support its use...
  11. doi request reprint Lung injury and its prognostic significance in acute liver failure
    Vinod K Audimoolam
    1Institute of Liver Studies, Kings College Hospital, London, United Kingdom 2Liver and Antiviral Centre, Imperial College London, St Mary s Hospital Campus, London, United Kingdom 3Department of Radiology, Kings College Hospital, London, United Kingdom
    Crit Care Med 42:592-600. 2014
    ....
  12. doi request reprint Increased model for end-stage liver disease score at the time of liver transplant results in prolonged hospitalization and overall intensive care unit costs
    Matthew R Foxton
    Institute of Liver Studies, Kings College Hospital, London, UK
    Liver Transpl 16:668-77. 2010
    ..Use of MELD as a method of organ allocation results in significant increase in ICU cost after LT. Using TISS as surrogate marker for ICU costs reveals that the cost implications are related to the need for RRT and prolonged ICU stay...
  13. doi request reprint Acute kidney injury in patients admitted to a liver intensive therapy unit with paracetamol-induced hepatotoxicity
    Aisling O'Riordan
    Department of Renal Medicine, King s College Hospital, London, UK
    Nephrol Dial Transplant 26:3501-8. 2011
    ....
  14. doi request reprint Medical and psychiatric outcomes for patients transplanted for acetaminophen-induced acute liver failure: a case-control study
    Constantine J Karvellas
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Int 30:826-33. 2010
    ..Acetaminophen-induced hepatotoxicity is the most common cause of acute liver failure (ALF) in the UK. Patients often consume the drug with suicidal intent or with a background of substance dependence...
  15. doi request reprint Circulating neutrophil dysfunction in acute liver failure
    Nicholas J Taylor
    Liver Intensive Care Unit and Transplantation, King s College London School of Medicine at King s College Hospital, London, UK Institute of Liver Studies and Transplantation, King s College London School of Medicine at King s College Hospital, London, UK
    Hepatology 57:1142-52. 2013
    ..01). Spontaneous neutrophil production of ROS was not significantly increased in any of the cohorts. E. coli-stimulated OB was preserved in ALF/SALF cohorts but was significantly impaired in the SC group (P<0.05)...
  16. ncbi request reprint The impact of organ dysfunction in cirrhosis: survival at a cost?
    Debbie L Shawcross
    King s College London School of Medicine, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Hepatol 56:1054-62. 2012
    ..Historically, critically ill cirrhotics are perceived as having poor prognosis and substantial cost of care...
  17. pmc Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*
    Lucia A Possamai
    1Department of Hepatology, Imperial College London, London, UK 2Institute of Liver Studies at King s College School of Medicine at King s College Hospital, London, UK 3Institute of Human Health and Performance, University College London, London, UK 4Department of Asthma Allergy and Lung Biology, King s College London, London, UK 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada
    Crit Care Med 41:2543-50. 2013
    ..To evaluate the role of hepatocellular and extrahepatic apoptosis during the evolution of acetaminophen-induced acute liver failure...
  18. doi request reprint High density lipoprotein in patients with liver failure; relation to sepsis, adrenal function and outcome of illness
    Frederique Estelle Etogo-Asse
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, London, UK
    Liver Int 32:128-36. 2012
    ..The clinical relevance of HDL level in patients with liver failure remains poorly characterised...
  19. doi request reprint Iron and acetaminophen a fatal combination?
    Vinod K Audimoolam
    Institute of Liver Studies, King s College Hospital, London, UK
    Transpl Int 24:e85-8. 2011
    ..Despite maximum supportive care including liver transplantation in two cases, all patients died. Iron poisoning may have an additive toxic effect in drug-induced acute liver failure and worsen outcome...
  20. ncbi request reprint The significance of autoantibodies and immunoglobulins in acute liver failure: a cohort study
    William Bernal
    Institute of Liver Studies, King s College London School of Medicine, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Hepatol 47:664-70. 2007
    ..We investigated the prevalence of autoimmune features including antibodies to soluble liver antigen (anti-SLA) determined by Radioligand assay (RLA) in ALF patients...
  21. ncbi request reprint Ammonia clearance with haemofiltration in adults with liver disease
    Andrew J Slack
    Institute of Liver Studies, King s College Hospital Foundation Trust, London, UK
    Liver Int 34:42-8. 2014
    ..To evaluate the effect of HF at different treatment intensities on ammonia clearance (AC) and arterial ammonia concentration...
  22. ncbi request reprint Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
    Hepatology 59:1564-76. 2014
    ..Culture of healthy monocytes with AALF liver homogenates, plasma, or rhSLPI induced monocytes with strikingly similar anti-inflammatory characteristics which were reversed by inhibiting the activity of SLPI...
  23. doi request reprint Meta-analysis of performance of Kings's College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure
    Mark J W McPhail
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, London SE5 9RS, UK
    J Hepatol 53:492-9. 2010
    ..Using quantitative techniques, we therefore performed a meta-analysis of outcome data of the KCC for prediction of survival in non-POD ALF...
  24. doi request reprint Haemodynamic response to abdominal decompression in acute Budd-Chiari syndrome
    Deepak Joshi
    Dr D Joshi Institute of Liver Studies, King s College Hospital, London, UK
    Liver Int 31:1171-8. 2011
    ..Intra-abdominal hypertension (IAH) and abdominal compartment syndrome commonly occur in patients with liver disease...
  25. pmc Percutaneous tracheostomy in patients with severe liver disease and a high incidence of refractory coagulopathy: a prospective trial
    Georg Auzinger
    Institute of Liver Studies, Liver Intensive Care Unit, King s College Hospital, London SE5 9RS, United Kingdom
    Crit Care 11:R110. 2007
    ..To assess the safety of percutaneous dilational tracheostomy (PDT) performed by experienced operators in critically ill patients with liver disease and coagulopathy...
  26. doi request reprint Voriconazole hepatotoxicity in severe liver dysfunction
    Pablo Solís-Muñoz
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital of London, United Kingdom
    J Infect 66:80-6. 2013
    ..There are no studies regarding to these effects in patients with severe liver dysfunction...
  27. ncbi request reprint High values of intrathoracic blood volume in hepatopulmonary syndrome
    Deepak Joshi
    Liver Intensive Therapy Unit, Institute of Liver Studies, King s College Hospital, London, UK
    Crit Care Resusc 11:129-31. 2009
    ..Evidence is now emerging that certain clinical scenarios can lead to increased ITBVI values. We report two cases of persistently high ITBVI in patients with hepatic cirrhosis complicated by hepatopulmonary syndrome...
  28. ncbi request reprint Reduced monocyte HLA-DR expression: a novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Institute of Liver Studies, King s College Hospital, London, UK
    Hepatology 44:34-43. 2006
    ..In conclusion, the strong relationship of monocyte HLA-DR expression with indices of disease severity, mediators of inflammation and outcome indicates a key role for this molecule as a biomarker of disease severity and prognosis...
  29. ncbi request reprint Actin-free Gc globulin: a rapidly assessed biomarker of organ dysfunction in acute liver failure and cirrhosis
    Charalambos G Antoniades
    Institute of Liver Studies, Kings College Hospital, London, United Kingdom
    Liver Transpl 13:1254-61. 2007
    ....
  30. doi request reprint Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans
    Charalambos Gustav Antoniades
    Institute of Liver Studies and Cellular Biology of Inflammation, King s College London, London, United Kingdom
    Hepatology 56:735-46. 2012
    ..Levels of CCL2, CCL3, interleukin (IL)-6, IL-10, and transforming growth factor-β1 were significantly elevated in AALF liver tissue relative to chronic liver disease controls...
  31. ncbi request reprint Aerobic capacity during cardiopulmonary exercise testing and survival with and without liver transplantation for patients with chronic liver disease
    William Bernal
    Liver Intensive Therapy Unit, Institute of Liver Studies, King s College Hospital, King s College London, London, United Kingdom
    Liver Transpl 20:54-62. 2014
    ..AC should be evaluated as a modifiable factor for improving patient survival whether or not LT is anticipated...
  32. doi request reprint Critical care and cirrhosis: outcome and benefit
    Julia Wendon
    Institute of Liver Studies, Kings College Hospital, Denmark Hill, London, UK
    Curr Opin Crit Care 17:533-7. 2011
    ..This review examines the evidence for treatment options and outcomes...
  33. ncbi request reprint Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation
    Mohamed Habib
    Department of Haematological Medicine, King s Thrombosis Centre, London, UK
    Liver Int 34:672-8. 2014
    ..Our aim was to evaluate the haemostatic profile in patients with acute liver injury/failure (ALI/ALF) compared with healthy controls...
  34. ncbi request reprint Serum total cortisol and free cortisol index give different information regarding the hypothalamus-pituitary-adrenal axis reserve in patients with liver impairment
    Royce P Vincent
    Department of Chemical Pathology, King s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
    Ann Clin Biochem 46:505-7. 2009
    ..The aim of this study was to compare total cortisol and FCI in the interpretation of SST in patients with liver impairment...
  35. ncbi request reprint Comment on Camus et al.: "Molecular adsorbent recirculating system dialysis in patients with acute liver failure who are assessed for liver transplantation"
    Constantine J Karvellas
    Intensive Care Med 33:1102-3; author reply 1104-5. 2007
  36. ncbi request reprint More on serum phosphate and prognosis of acute liver failure
    William Bernal
    Hepatology 38:533-4. 2003
  37. pmc UK legislation on analgesic packs: before and after study of long term effect on poisonings
    Keith Hawton
    Centre for Suicide Research, University of Oxford Department of Psychiatry, Warneford Hospital, Headington, Oxford OX3 7JX
    BMJ 329:1076. 2004
    ..To evaluate the long term effect of legislation limiting the size of packs of analgesics sold over the counter...
  38. doi request reprint Disease-specific autoantibodies in patients with acute liver failure: the King's College London Experience
    William Bernal
    Hepatology 47:1096-7; author reply 1097. 2008
  39. ncbi request reprint Old versus new antiepileptic drugs: the SANAD study
    Debbie Shawcross
    Lancet 370:314-5; author reply 315-6. 2007
  40. doi request reprint Variation in blood ammonia concentration with site of measurement and evidence of brain and muscle uptake in patients with acute liver failure
    William Bernal
    Liver Int 28:415-7. 2008