David L H Bennett

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway
    Margarita Calvo
    Wolfson CARD, Kings College London, Hodgkin Building, Guys Campus, SE1 1UL, London, United Kingdom
    Glia 59:554-68. 2011
  2. doi request reprint Interview: Key questions in pain research: clinical observations informing research and vice versa
    David Bennett
    Neurorestoration Group, CARD Wolfson Wing, Hodgkin Building, Guy s Campus, London Bridge, London, SE1 1UL, UK
    Pain Manag 1:123-5. 2011
  3. ncbi request reprint Neurotrophic factors: important regulators of nociceptive function
    D L Bennett
    Dept Physiology, St Thomas Hospital Medical School, Lambeth Palace Rd, London, SE1 7EH, UK
    Neuroscientist 7:13-7. 2001
  4. pmc The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5 year retrospective study
    D L H Bennett
    Department of Neurorestoration, CARD Wolfson Wing, Hodgkin Building, Guy s Campus, King s College London, London Bridge, London SE11UL, UK
    J Neurol Neurosurg Psychiatry 79:1376-81. 2008
  5. ncbi request reprint Artemin has potent neurotrophic actions on injured C-fibres
    David L H Bennett
    Wolfson Centre for Age Related Disease, King s College London, Guy s Campus, London, UK
    J Peripher Nerv Syst 11:330-45. 2006
  6. pmc Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury
    Margarita Calvo
    Wolfson Center for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 30:5437-50. 2010
  7. pmc A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat
    James R Perkins
    The Wolfson Centre for Age Related Diseases, Wolfson Wing, Hodgkin Building, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    Mol Pain 10:7. 2014
  8. pmc Characterisation and mechanisms of bradykinin-evoked pain in man using iontophoresis
    Kathryn J Paterson
    Wolfson Centre for Age Related Disease, King s College London, London, UK
    Pain 154:782-92. 2013
  9. pmc Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood
    Florence R Fricker
    Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    J Neurosci 31:3225-33. 2011
  10. pmc PainNetworks: a web-based resource for the visualisation of pain-related genes in the context of their network associations
    James R Perkins
    Institute of Structural and Molecular Biology, University College London, London, UK
    Pain 154:2586.e1-12. 2013

Collaborators

Detail Information

Publications24

  1. pmc Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway
    Margarita Calvo
    Wolfson CARD, Kings College London, Hodgkin Building, Guys Campus, SE1 1UL, London, United Kingdom
    Glia 59:554-68. 2011
    ....
  2. doi request reprint Interview: Key questions in pain research: clinical observations informing research and vice versa
    David Bennett
    Neurorestoration Group, CARD Wolfson Wing, Hodgkin Building, Guy s Campus, London Bridge, London, SE1 1UL, UK
    Pain Manag 1:123-5. 2011
    ..He is a member of the Wellcome Trust-funded London Pain Consortium and Vice-Director of the 'Europain' Investigational Medicines Initiative. He is also an Associate Editor of Pain Management. ..
  3. ncbi request reprint Neurotrophic factors: important regulators of nociceptive function
    D L Bennett
    Dept Physiology, St Thomas Hospital Medical School, Lambeth Palace Rd, London, SE1 7EH, UK
    Neuroscientist 7:13-7. 2001
    ..This review highlights some of the key roles played by these molecules and in particular the role of NGF in the peripheral sensitization of nociceptors and brain-derived neurotrophic factor (BDNF) as a central pain modulator...
  4. pmc The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5 year retrospective study
    D L H Bennett
    Department of Neurorestoration, CARD Wolfson Wing, Hodgkin Building, Guy s Campus, King s College London, London Bridge, London SE11UL, UK
    J Neurol Neurosurg Psychiatry 79:1376-81. 2008
    ..Previous studies have suggested that combined nerve and muscle biopsy (usually of the superficial peroneal nerve and peroneus brevis muscle) produces a higher diagnostic yield than nerve biopsy alone in the investigation of vasculitis...
  5. ncbi request reprint Artemin has potent neurotrophic actions on injured C-fibres
    David L H Bennett
    Wolfson Centre for Age Related Disease, King s College London, Guy s Campus, London, UK
    J Peripher Nerv Syst 11:330-45. 2006
    ..Given the potent neurotrophic actions of ARTN on C-fibres, it may therefore provide potential for the treatment of nerve injury, particularly in the maintenance of small fibre function...
  6. pmc Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury
    Margarita Calvo
    Wolfson Center for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 30:5437-50. 2010
    ..Furthermore, consequent to such changes, the mechanical pain-related hypersensitivity and cold allodynia were reduced. NRG1-erbB signaling therefore represents a novel pathway regulating the injury response of microglia...
  7. pmc A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat
    James R Perkins
    The Wolfson Centre for Age Related Diseases, Wolfson Wing, Hodgkin Building, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    Mol Pain 10:7. 2014
    ..Finally we take advantage of the "agnostic" approach of RNA-seq to discover areas of expression outside of annotated exons that show marked changes in expression following nerve injury...
  8. pmc Characterisation and mechanisms of bradykinin-evoked pain in man using iontophoresis
    Kathryn J Paterson
    Wolfson Centre for Age Related Disease, King s College London, London, UK
    Pain 154:782-92. 2013
    ..In naïve skin, B2R signaling predominates, however, cutaneous inflammation results in enhanced B1R responses...
  9. pmc Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood
    Florence R Fricker
    Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    J Neurosci 31:3225-33. 2011
    ..Juxtacrine Neuregulin-1 signaling is therefore dispensable for maintenance of the myelin sheath in adult animals but has a key role in reparative processes after nerve injury...
  10. pmc PainNetworks: a web-based resource for the visualisation of pain-related genes in the context of their network associations
    James R Perkins
    Institute of Structural and Molecular Biology, University College London, London, UK
    Pain 154:2586.e1-12. 2013
    ..We expect this resource to grow over time and become a valuable asset to the pain community. ..
  11. pmc α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage
    Ryan Patel
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, United Kingdom, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, OX1 2JD, United Kingdom, and University of Cincinnati, College of Medicine, Cincinnati, Ohio 45229
    J Neurosci 33:16412-26. 2013
    ..Thus, α2δ-1 is essential for rapid development of mechanical hypersensitivity in a nerve injury model of neuropathic pain. ..
  12. doi request reprint The mechanisms of microgliosis and pain following peripheral nerve injury
    Margarita Calvo
    Wolfson CARD, Kings College London, UK
    Exp Neurol 234:271-82. 2012
    ..Modulating microglial functions offers a novel therapeutic opportunity following nerve injury which ideally would involve reducing the pro-inflammatory nature of these cells whilst retaining their potential beneficial functions...
  13. pmc Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance
    Florence R Fricker
    Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    J Neurosci 29:7667-78. 2009
    ..Sensory neuronal survival and axonal maintenance, however, are not dependent on axon-derived neuregulin-1 signaling in adulthood...
  14. pmc CXCL5 mediates UVB irradiation-induced pain
    John M Dawes
    Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, UK
    Sci Transl Med 3:90ra60. 2011
    ..Our findings demonstrate that the chemokine CXCL5 is a peripheral mediator of UVB-induced inflammatory pain, likely in humans as well as rats...
  15. ncbi request reprint Botulinum toxin-A treatment reduces human mechanical pain sensitivity and mechanotransduction
    Kathryn Paterson
    Wolfson Centre for Age Related Disease, King s College London, London
    Ann Neurol 75:591-6. 2014
    ..Inhibition of mechanotransduction provides a novel locus of action of BoNT-A, further understanding of which may extend its use as an analgesic agent...
  16. pmc Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis
    Matthew Thakur
    Neuropharmacology of Pain Group, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
    PLoS ONE 7:e33730. 2012
    ..This significant neuropathic component needs to be taken into account when interpreting studies using this model, particularly at doses greater than 1 mg MIA...
  17. pmc Conduction failure following spinal cord injury: functional and anatomical changes from acute to chronic stages
    Nicholas D James
    The Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 31:18543-55. 2011
    ..Thus, using a clinically relevant SCI model, we have identified a population of axons present at chronic injury stages that are intact but fail to conduct and are therefore a prime target for therapeutic strategies to restore function...
  18. ncbi request reprint Relationship between dry eye symptoms and pain sensitivity
    Jelle Vehof
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Waterloo, London, England2Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
    JAMA Ophthalmol 131:1304-8. 2013
    ..Dry eye disease (DED) is common, but little is known about factors contributing to symptoms of dry eye, given the poor correlation between these symptoms and objective signs at the ocular surface...
  19. pmc ReadqPCR and NormqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data
    James R Perkins
    Institute of Structural and Molecular Biology, University College of London, London, UK
    BMC Genomics 13:296. 2012
    ..So far nothing in R exists to unite these methods, together with other functions to read in and normalise the data using the chosen reference gene(s)...
  20. ncbi request reprint The role of the immune system in the generation of neuropathic pain
    Margarita Calvo
    Department of Neurorestoration, Wolfson CARD, King s College London, London, UK
    Lancet Neurol 11:629-42. 2012
    ..An important challenge for the future is to establish to what extent this immune response initiates or maintains neuropathic pain in patients and thus whether it is amenable to therapy...
  21. ncbi request reprint A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome
    Barbara Kremeyer
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Neuron 66:671-80. 2010
    ..TRPA1 antagonists inhibit the mutant channel, promising a useful therapy for this disorder. Our findings provide evidence that variation in the TRPA1 gene can alter pain perception in humans...
  22. ncbi request reprint Systems biology approaches to finding novel pain mediators
    Ana Antunes-Martins
    The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London, UK
    Wiley Interdiscip Rev Syst Biol Med 5:11-35. 2013
    ....
  23. ncbi request reprint Molecular forms of NGF in human and rat neuropathic tissues: decreased NGF precursor-like immunoreactivity in human diabetic skin
    Yiangos Yiangou
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    J Peripher Nerv Syst 7:190-7. 2002
    ..The different molecular forms derived from prepro-NGF are likely to be of importance in sensory mechanisms, and deserve further investigation...
  24. pmc Intermediate Charcot-Marie-Tooth disease due to a novel Trp101Stop myelin protein zero mutation associated with debilitating neuropathic pain
    Juan D Ramirez
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Pain 153:1763-8. 2012
    ..In this kindred, the neuropathy was relatively mild in severity, however, neuropathic pain was an important and disabling outcome...