Jonathan N W N Barker
Affiliation: King's College London
Barker J, Palmer C, Zhao Y, Liao H, Hull P, Lee S, et al
. Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. J Invest Dermatol. 2007;127:564-7 pubmed
..This study helps to further define the nature of the AD phenotype associated with FLG null alleles. ..
Petridis C, Navarini A, Dand N, Saklatvala J, Baudry D, Duckworth M, et al
. Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. Nat Commun. 2018;9:5075 pubmed publisher
..These findings indicate that variation affecting the structure and maintenance of the skin, in particular the pilosebaceous unit, is a critical aspect of the genetic predisposition to severe acne. ..
Dand N, Duckworth M, Baudry D, Russell A, Curtis C, Lee S, et al
. HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis. J Allergy Clin Immunol. 2018;: pubmed publisher
..This large observational study suggests that reference to HLA-C*06:02 status could offer substantial clinical benefit when selecting treatments for severe psoriasis. ..
Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, et al
. Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol. 2018;: pubmed publisher
..003). The analysis of an unparalleled resource revealed key clinical and genetic differences between patients with PPP and those with GPP. ..
Mahil S, Capon F, Barker J. Update on psoriasis immunopathogenesis and targeted immunotherapy. Semin Immunopathol. 2016;38:11-27 pubmed publisher
..The translation of mechanistic insights into potential advancements in clinical care will also be described, including several treatments that target the interleukin-23 (IL-23)/T17 immune axis. ..
Mahil S, Capon F, Barker J. Genetics of psoriasis. Dermatol Clin. 2015;33:1-11 pubmed publisher
..The potential for disease stratification and the development of more effective treatments with fewer side effects using genetic data are highlighted. ..
Pink A, Simpson M, Desai N, Trembath R, Barker J. ?-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis. J Invest Dermatol. 2013;133:601-607 pubmed publisher
..In this article, we review the recent genetic data, how they inform disease pathogenesis, and the long-term implications in HS and related diseases...
Hussain S, Berki D, Choon S, Burden A, Allen M, Arostegui J, et al
. IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis. J Allergy Clin Immunol. 2015;135:1067-70.e9 pubmed publisher
Berki D, Liu L, Choon S, David Burden A, Griffiths C, Navarini A, et al
. Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris. J Invest Dermatol. 2015;135:2964-2970 pubmed publisher
..4Ã—10(-5); odds ratio=6.4). These data indicate that the analysis of CARD14 mutations could help stratify pustular psoriasis cohorts but would be mostly uninformative in the context of psoriasis and sporadic PRP. ..