C Ballard

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial
    Bettina S Husebo
    Department of Public Health and Primary Health Care, University of Bergen, 5020 Bergen, Norway
    BMJ 343:d4065. 2011
  2. pmc Feasibility study of an optimised person-centred intervention to improve mental health and reduce antipsychotics amongst people with dementia in care homes: study protocol for a randomised controlled trial
    Rhiannon Whitaker
    Psychological Services, Oxford Health NHS Foundation Trust, Fulbrook Centre, Oxford OX3 7JU, United Kingdom
    Trials 14:13. 2013
  3. ncbi request reprint Neuropsychiatric symptoms in patients with dementias associated with cortical Lewy bodies: pathophysiology, clinical features, and pharmacological management
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, Wolfson Building, Guy s Campus, London, SE1 1UL, UK
    Drugs Aging 30:603-11. 2013
  4. doi request reprint Is a potential Alzheimer's therapy already in use for other conditions? Can medications for hypertension, diabetes and acne help with the symptoms?
    Anne Corbett
    Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London, SE1 1UL, UK 020 7848 8054 020 7848 6515
    Expert Opin Investig Drugs 22:941-3. 2013
  5. doi request reprint Agitation and aggression in people with Alzheimer's disease
    Clive Ballard
    Wolfson Centre for Age Related Diseases, Guy s Campus, King s College London, London, UK
    Curr Opin Psychiatry 26:252-9. 2013
  6. doi request reprint Improving quality of life for people with dementia in care homes: making psychosocial interventions work
    Vanessa Lawrence
    Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 201:344-51. 2012
  7. pmc Optimised anaesthesia to reduce post operative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, London, United Kingdom
    PLoS ONE 7:e37410. 2012
  8. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
  9. ncbi request reprint Neuroleptic drugs in dementia: benefits and harm
    Clive Ballard
    Medical Research Council Centre for Neurodegeneration Research, King s College London, De Crespigny Park, London SE5 8AF, UK
    Nat Rev Neurosci 7:492-500. 2006
  10. ncbi request reprint Management of agitation and aggression associated with Alzheimer's disease: controversies and possible solutions
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Curr Opin Psychiatry 22:532-40. 2009

Detail Information

Publications61

  1. pmc Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial
    Bettina S Husebo
    Department of Public Health and Primary Health Care, University of Bergen, 5020 Bergen, Norway
    BMJ 343:d4065. 2011
    ..To determine whether a systematic approach to the treatment of pain can reduce agitation in people with moderate to severe dementia living in nursing homes...
  2. pmc Feasibility study of an optimised person-centred intervention to improve mental health and reduce antipsychotics amongst people with dementia in care homes: study protocol for a randomised controlled trial
    Rhiannon Whitaker
    Psychological Services, Oxford Health NHS Foundation Trust, Fulbrook Centre, Oxford OX3 7JU, United Kingdom
    Trials 14:13. 2013
    ....
  3. ncbi request reprint Neuropsychiatric symptoms in patients with dementias associated with cortical Lewy bodies: pathophysiology, clinical features, and pharmacological management
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, Wolfson Building, Guy s Campus, London, SE1 1UL, UK
    Drugs Aging 30:603-11. 2013
    ..Nonpharmacological approaches based on person-centered care and cholinesterase inhibitors should be considered as the first-line treatment for neuropsychiatric symptoms except in extreme cases. ..
  4. doi request reprint Is a potential Alzheimer's therapy already in use for other conditions? Can medications for hypertension, diabetes and acne help with the symptoms?
    Anne Corbett
    Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London, SE1 1UL, UK 020 7848 8054 020 7848 6515
    Expert Opin Investig Drugs 22:941-3. 2013
    ....
  5. doi request reprint Agitation and aggression in people with Alzheimer's disease
    Clive Ballard
    Wolfson Centre for Age Related Diseases, Guy s Campus, King s College London, London, UK
    Curr Opin Psychiatry 26:252-9. 2013
    ..This review outlines the current evidence for pharmacological and nonpharmacological approaches to the treatment of agitation and aggression in these patients...
  6. doi request reprint Improving quality of life for people with dementia in care homes: making psychosocial interventions work
    Vanessa Lawrence
    Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 201:344-51. 2012
    ..Psychosocial interventions can improve behaviour and mood in people with dementia, but it is unclear how to maximise their effectiveness or acceptability in residential settings...
  7. pmc Optimised anaesthesia to reduce post operative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, London, United Kingdom
    PLoS ONE 7:e37410. 2012
    ....
  8. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
    ..The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil...
  9. ncbi request reprint Neuroleptic drugs in dementia: benefits and harm
    Clive Ballard
    Medical Research Council Centre for Neurodegeneration Research, King s College London, De Crespigny Park, London SE5 8AF, UK
    Nat Rev Neurosci 7:492-500. 2006
    ..We recommend that these treatments be limited to the short-term treatment of psychiatric symptoms associated with serious distress or risk...
  10. ncbi request reprint Management of agitation and aggression associated with Alzheimer's disease: controversies and possible solutions
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Curr Opin Psychiatry 22:532-40. 2009
    ..The purpose of this review is to describe the current state of knowledge regarding management of BPSD, with a particular focus on agitation...
  11. ncbi request reprint Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: the VantagE study
    C Ballard
    Wolfson Centre for Age Related Diseases, King s College, London, UK
    Curr Med Res Opin 24:2561-74. 2008
    ..The aim was to evaluate the efficacy, safety and tolerability of rivastigmine capsules in patients diagnosed with probable vascular dementia (VaD)...
  12. doi request reprint Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial)
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, UK
    Am J Geriatr Psychiatry 17:726-33. 2009
    ..Good practice guidelines state that a psychological intervention should usually precede pharmacotherapy, but there are no data evaluating the feasibility of psychological interventions used in this way...
  13. ncbi request reprint Cardiac safety of rivastigmine in Lewy body and Parkinson's disease dementias
    C Ballard
    King s College, London, UK
    Int J Clin Pract 60:639-45. 2006
    ..018) in PDD patients (n = 541). A smaller randomised, placebo-controlled study of rivastigmine in DLB (n = 120) showed similar findings. Rivastigmine appears to have a favourable cardiac safety profile in PDD and DLB patients...
  14. ncbi request reprint Differences in neuropathologic characteristics across the Lewy body dementia spectrum
    C Ballard
    Wolfson Centre for Age Related Diseases, Wolfson Building, Guy s Campus, King s College London, London, SE1 1UL, UK
    Neurology 67:1931-4. 2006
    ....
  15. doi request reprint Management of agitation and aggression associated with Alzheimer disease
    Clive G Ballard
    King s College London, London, UK
    Nat Rev Neurol 5:245-55. 2009
    ....
  16. doi request reprint The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Lancet Neurol 8:151-7. 2009
    ..We aimed to assess whether continued treatment with antipsychotics in people with AD is associated with an increased risk of mortality...
  17. pmc A randomised, blinded, placebo-controlled trial in dementia patients continuing or stopping neuroleptics (the DART-AD trial)
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, London, United Kingdom
    PLoS Med 5:e76. 2008
    ..The aim of this study was to determine the impact of long-term treatment with neuroleptic agents upon global cognitive decline and neuropsychiatric symptoms in patients with Alzheimer disease...
  18. ncbi request reprint Cholinesterases: roles in the brain during health and disease
    Clive G Ballard
    Department of Biomedical Sciences, Wolfson Centre for Age Related Diseases, Hodgkin Building, Guy s Campus, King s College, London, SE1 1UL, UK
    Curr Alzheimer Res 2:307-18. 2005
    ..Focusing on new findings relating to BuChE, we review recent evidence that has extended knowledge into the roles of ChEs in health, disease and aging...
  19. ncbi request reprint Drugs used to relieve behavioral symptoms in people with dementia or an unacceptable chemical cosh? Argument
    Clive Ballard
    Institute of Psychiatry, London, UK
    Int Psychogeriatr 17:4-12; discussion 22-9. 2005
    ....
  20. doi request reprint alpha-Synuclein antibodies recognize a protein present at lower levels in the CSF of patients with dementia with Lewy bodies
    Clive Ballard
    Wolfson Centre for Age Related Disease, King s College London, U K
    Int Psychogeriatr 22:321-7. 2010
    ..Accurate diagnosis is essential to avoid harm and optimize clinical management. There is therefore an urgent need to identify reliable biomarkers...
  21. ncbi request reprint Nonpharmacological treatment of Alzheimer disease
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, England
    Can J Psychiatry 56:589-95. 2011
    ..To review the key nonpharmacological treatment approaches to the cognitive and functional symptoms of Alzheimer disease (AD)...
  22. ncbi request reprint Atypical antipsychotics for the treatment of behavioral and psychological symptoms in dementia, with a particular focus on longer term outcomes and mortality
    Clive Ballard
    Wolfson Centre for Age Related Diseases, Wolfson Wing, King s College London, Guy s Campus, Hodgkin Building, London, UK
    Expert Opin Drug Saf 10:35-43. 2011
    ..Recent evidence has highlighted safety concerns regarding antipsychotics in these individuals...
  23. ncbi request reprint Management of neuropsychiatric symptoms in people with dementia
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    CNS Drugs 24:729-39. 2010
    ..Adequately powered randomized controlled trials for the treatment of clinically significant agitation are urgently needed to explore alternative pharmacological therapies...
  24. doi request reprint Alzheimer's disease
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Lancet 377:1019-31. 2011
    ..In this Seminar, we provide an overview of recent evidence regarding the epidemiology, pathogenesis, diagnosis, and treatment of Alzheimer's disease, and discuss potential ways to reduce the risk of developing the disease...
  25. ncbi request reprint NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia
    C G Ballard
    Wolfson Centre for Age Related Diseases, Guys Campus, King s College London, London, UK
    Neurology 63:983-8. 2004
    ....
  26. doi request reprint Treatment of dementia with Lewy bodies and Parkinson's disease dementia
    Clive Ballard
    Centre for Age Related Diseases, Wolfson Building, King s College London, Guy s Campus, London SE1 1UL, UK
    Drugs Aging 28:769-77. 2011
    ....
  27. doi request reprint Pain treatment of agitation in patients with dementia: a systematic review
    B S Husebo
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Int J Geriatr Psychiatry 26:1012-8. 2011
    ..If this is correct, individual pain treatment could be of benefit in ameliorating agitation and other behavioral changes in people with dementia...
  28. ncbi request reprint Quality of life for people with dementia living in residential and nursing home care: the impact of performance on activities of daily living, behavioral and psychological symptoms, language skills, and psychotropic drugs
    C Ballard
    Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England, UK
    Int Psychogeriatr 13:93-106. 2001
    ..02; SW 11.4% vs. 2.7%, t = 3.0, p = .004; EA 56.5% vs. 71.9%; t = 3.5, p = .001) were associated with reduced QOL, but symptoms from the NPI were not. More focused prescribing of psychotropics and better staff training are essential...
  29. ncbi request reprint Donepezil for the treatment of agitation in Alzheimer's disease
    Robert J Howard
    Medical Research Council Neurogeneration Research Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    N Engl J Med 357:1382-92. 2007
    ..Agitation is a common and distressing symptom in patients with Alzheimer's disease. Cholinesterase inhibitors improve cognitive outcomes in such patients, but the benefits of these drugs for behavioral disturbances are unclear...
  30. doi request reprint Amyloid beta concentrations in older people with Down syndrome and dementia
    Emma L Jones
    Wolfson Centre for Age Related Disease, Wolfson CARD, Guy s Campus, King s College London, London SE1 1UL, United Kingdom
    Neurosci Lett 451:162-4. 2009
    ..These data suggest that other factors play important roles in determining the onset and progression of dementia in the Down syndrome population...
  31. ncbi request reprint The extended tau haplotype and the age of onset of dementia in Down syndrome
    Emma L Jones
    Wolfson Centre for Age Related Disease, Guy s Campus, King s College London, London, UK
    Dement Geriatr Cogn Disord 26:199-202. 2008
    ..Most people with Down syndrome (DS) develop Alzheimer's disease (AD). The extended tau haplotype has been linked to AD. In this study, we examined the haplotype's effect on the age of onset of AD in DS...
  32. ncbi request reprint Endogenous neurogenesis in the human brain following cerebral infarction
    Stephen L Minger
    Stem Cell Biology Laboratory, Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Regen Med 2:69-74. 2007
    ....
  33. ncbi request reprint Aggressive behavior and neuroleptic medication are associated with increased number of alpha1-adrenoceptors in patients with Alzheimer disease
    Sally I Sharp
    King s College London, Wolfson Centre for Age Related Diseases, UK
    Am J Geriatr Psychiatry 15:435-7. 2007
    ..Aggressive behavior in dementia is a major clinical management problem...
  34. ncbi request reprint Efficacy of pain treatment on mood syndrome in patients with dementia: a randomized clinical trial
    B S Husebo
    Department of Global Public Health and Primary Care, Center for Elderly and Nursing Home Medicine, University of Bergen, Bergen, Norway Center for Age Related Medicine, Stavanger University Hospital, Stavanger, Norway
    Int J Geriatr Psychiatry 29:828-36. 2014
    ..An association between pain and depressive symptoms has been reported, but the impact of pain management on depression and other mood symptoms has not been investigated...
  35. ncbi request reprint Choline acetyltransferase activity in vascular dementia and stroke
    Sally I Sharp
    Wolfson Centre for Age Related Diseases, Guy s Campus, London, UK
    Dement Geriatr Cogn Disord 28:233-8. 2009
    ..Alterations in cholinergic activity have not been systematically studied in types of cerebrovascular disease. We examined cholinergic function at postmortem, focussing on stroke and vascular dementia (VaD)...
  36. ncbi request reprint Increased binding to 5-HT1A and 5-HT2A receptors is associated with large vessel infarction and relative preservation of cognition
    Mark S J Elliott
    King s College London, Wolfson Centre for Age Related Diseases, London, UK
    Brain 132:1858-65. 2009
    ..The results also highlight the importance of the cortical 5-HT(1A) receptor in mediating cognition...
  37. doi request reprint Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia
    Sally I Sharp
    King s College London, Wolfson Centre for Age Related Diseases, London, UK
    Dement Geriatr Cogn Disord 26:330-8. 2008
    ..Serotonin 1A receptors (5-HT(1A)) have not been studied in dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) patients with depression...
  38. ncbi request reprint Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients
    Andrea Tasker
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurosci Lett 442:297-9. 2008
    ..Linear regression analysis, controlling for gender, diagnosis, age at death and study centre, showed that the number of BCHE-K alleles was associated with increasing BuChE activity (p=0.009)...
  39. ncbi request reprint Towards defining the neuropathological substrates of vascular dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 226:75-80. 2004
    ..Similar to other common dementias consensus criteria for VaD need unambiguous definition to impact on preventative and treatment strategies and are critical for selective recruitment to clinical trials...
  40. ncbi request reprint The relationship between antipsychotic treatment and quality of life for patients with dementia living in residential and nursing home care facilities
    Clive G Ballard
    Institute for Aging and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    J Clin Psychiatry 65:23-8. 2004
    ..g., side effects) and hence enable physicians to make rational treatment choices between different pharmacologic agents...
  41. ncbi request reprint Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies
    Clive G Ballard
    Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Am J Psychiatry 161:843-9. 2004
    ..This investigation was undertaken to clarify the neuropathological substrates of key psychiatric symptoms in dementia with Lewy bodies...
  42. ncbi request reprint Definition and diagnosis of dementia with Lewy bodies
    Clive G Ballard
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 17:15-24. 2004
    ....
  43. ncbi request reprint A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcome
    Clive G Ballard
    Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    J Clin Psychiatry 65:114-9. 2004
    ..Although few placebo-controlled neuroleptic discontinuation studies have been conducted in people with dementia, such studies are essential to inform key clinical decisions...
  44. ncbi request reprint Regulation of attention and response to therapy in dementia by butyrylcholinesterase
    Kirsty K O'Brien
    MRC Building, MRC University of Newcastle Centre Development for Clinical Brain Ageing, Newcastle upon Tyne, NE1 3BZ, UK
    Pharmacogenetics 13:231-9. 2003
    ..Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related enzyme butyrylcholinesterase is less well understood...
  45. ncbi request reprint Dementia with Lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Semin Clin Neuropsychiatry 8:46-57. 2003
    ..Dementia developing late in the course of PD shares many of the same clinical and pathological characteristics...
  46. ncbi request reprint Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa
    Clive G Ballard
    Wolfson Research Centre, Newcastle General Hospital, Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom
    J Clin Psychiatry 63:553-8. 2002
    ..We conducted a placebo-controlled trial to determine the value of aromatherapy with essential oil of Melissa officinalis (lemon balm) for agitation in people with severe dementia...
  47. ncbi request reprint Butyrylcholinesterase: impact on symptoms and progression of cognitive impairment
    Andrea Tasker
    Institute for Ageing and Health, MRC Building, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Expert Rev Neurother 5:101-6. 2005
    ..It is a priority for future clinical trials to determine whether agents which inhibit butyrylcholinesterase and acetylcholinesterase have a greater clinical efficacy...
  48. ncbi request reprint Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias
    Dag Aarsland
    Section of Geriatric Psychiatry, Central Hospital, Rogaland, Stavanger, Norway
    J Clin Psychiatry 66:633-7. 2005
    ..Severe sensitivity to neuroleptic agents is a major clinical problem in dementia with Lewy bodies (DLB), but has not been determined in Parkinson's disease (PD) and PD with dementia (PDD)...
  49. ncbi request reprint Lewy body disease: thalamic cholinergic activity related to dementia and parkinsonism
    Iryna Ziabreva
    Institute for Ageing and Health, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurobiol Aging 27:433-8. 2006
    ..These findings show that significant thalamic presynaptic cholinergic deficits occur only in cases of combined cortical and subcortical neurodegeneration in which dementia developed after prolonged parkinsonism...
  50. ncbi request reprint Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies
    Gordon K Wilcock
    From the Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, UK
    J Clin Psychiatry 69:341-8. 2008
    ..The current retrospective analysis evaluated the efficacy and safety of memantine in a subpopulation of patients with Alzheimer's disease exhibiting behavioral symptoms of agitation/aggression or psychosis at baseline...
  51. ncbi request reprint An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers
    Andrew B Scholey
    Brain Sciences Institute, Swinburne University, Melbourne, Vic, 3122, Australia
    Psychopharmacology (Berl) 198:127-39. 2008
    ..In recent controlled trials, administration of sage extracts with established cholinergic properties improved cognitive function in young adults...
  52. ncbi request reprint Transferrin gene polymorphism in Alzheimer's disease and dementia with Lewy bodies in humans
    Rafiqul I Hussain
    MRC Building, Institute for the Health of the Elderly, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Neurosci Lett 317:13-6. 2002
    ..Given the contrasting findings between reports of altered TF C2 allele frequencies, the TF locus would not appear to be a strong risk factor for AD in this population...
  53. ncbi request reprint Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia
    Margaret A Piggott
    IAH Research Laboratories, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 10:231-44. 2007
    ..D2 receptor binding did not vary with cognitive decline (MMSE) or visual hallucinations, but was significantly higher with increased extrapyramidal symptoms...
  54. ncbi request reprint Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias
    Louise M Allan
    Institute for Aging and Health, University of Newcastle upon Tyne, United Kingdom
    J Am Geriatr Soc 53:1681-7. 2005
    ....
  55. ncbi request reprint Subtle attentional deficits in the absence of dementia are associated with an increased risk of post-operative delirium
    David P Lowery
    University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 23:390-4. 2007
    ..Accurate prediction is imperative for clinical trials and prevention strategies...
  56. doi request reprint Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia
    Ezra Mulugeta
    Wolfson Centre for Age Related Diseases, Institute of Psychiatry, King s College London, London, UK
    Dement Geriatr Cogn Disord 25:278-86. 2008
    ....
  57. ncbi request reprint Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies
    Thanasak Teaktong
    Institute for Ageing and Health, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE46BE, UK
    Behav Brain Res 161:299-305. 2005
    ..Upregulation of M2 and M4 muscarinic receptors in cingulate and adjacent cortex may thus contribute to the development of psychosis in DLB, with potential implications for treatments with drugs acting on these receptors...
  58. ncbi request reprint Disturbances of consciousness in dementia with Lewy bodies associated with alteration in nicotinic receptor binding in the temporal cortex
    Clive G Ballard
    Centre Development in Clinical Brain Aging, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, London, UK
    Conscious Cogn 11:461-74. 2002
    ....
  59. ncbi request reprint Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies
    Andrew B Singleton
    Medical Research Council University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 14:167-75. 2002
    ..This study demonstrates that DLB shares the APO epsilon4 allele with AD as a common risk factor, but that there are differences in the way the epsilon4 allele affects the phenotypic expression of disease...
  60. ncbi request reprint Association between mild vascular cognitive impairment and impaired activities of daily living in older stroke survivors without dementia
    Sally Stephens
    University of Newcastle, UK
    J Am Geriatr Soc 53:103-7. 2005
    ..To determine the relationship between mild vascular cognitive impairment (mVCI) and functional disability in older stroke survivors without dementia...
  61. ncbi request reprint Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline
    Margaret A Piggott
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, United Kingdom
    Synapse 61:903-11. 2007
    ..That the reduction of D2 receptors correlated with cognitive decline suggests that neuroleptics, as dopamine D2 receptor antagonists, may have a deleterious effect on cognition in DLB...