M Avkiran

Summary

Affiliation: King's College London
Country: UK

Publications

  1. Puhl S, Weeks K, Ranieri A, Avkiran M. Assessing structural and functional responses of murine hearts to acute and sustained β-adrenergic stimulation in vivo. J Pharmacol Toxicol Methods. 2016;79:60-71 pubmed publisher
    ..Additionally, our data indicate that acute dobutamine stimulation unmasks early signs of LV dysfunction in the remodelled heart, even at a stage when basal function is enhanced. ..
  2. Ranieri A, Kemp E, Burgoyne J, Avkiran M. β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573. J Mol Cell Cardiol. 2018;115:20-31 pubmed publisher
    ..This is likely to regulate the phosphorylation status of specific B56δ-PP2A substrates, which remain to be identified. ..
  3. Avkiran M, Rowland A, Cuello F, Haworth R. Protein kinase d in the cardiovascular system: emerging roles in health and disease. Circ Res. 2008;102:157-63 pubmed publisher
    ..This review provides a primer on PKD signaling, using information gained from studies in multiple cell types, and discusses recent data that suggest novel functions for PKD-mediated pathways in the heart and the circulation. ..
  4. Weeks K, Ranieri A, Karaś A, Bernardo B, Ashcroft A, Molenaar C, et al. ?-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55?-PP2A-Mediated Dephosphorylation. J Am Heart Assoc. 2017;6: pubmed publisher
    ....

Detail Information

Publications4

  1. Puhl S, Weeks K, Ranieri A, Avkiran M. Assessing structural and functional responses of murine hearts to acute and sustained β-adrenergic stimulation in vivo. J Pharmacol Toxicol Methods. 2016;79:60-71 pubmed publisher
    ..Additionally, our data indicate that acute dobutamine stimulation unmasks early signs of LV dysfunction in the remodelled heart, even at a stage when basal function is enhanced. ..
  2. Ranieri A, Kemp E, Burgoyne J, Avkiran M. β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573. J Mol Cell Cardiol. 2018;115:20-31 pubmed publisher
    ..This is likely to regulate the phosphorylation status of specific B56δ-PP2A substrates, which remain to be identified. ..
  3. Avkiran M, Rowland A, Cuello F, Haworth R. Protein kinase d in the cardiovascular system: emerging roles in health and disease. Circ Res. 2008;102:157-63 pubmed publisher
    ..This review provides a primer on PKD signaling, using information gained from studies in multiple cell types, and discusses recent data that suggest novel functions for PKD-mediated pathways in the heart and the circulation. ..
  4. Weeks K, Ranieri A, Karaś A, Bernardo B, Ashcroft A, Molenaar C, et al. ?-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55?-PP2A-Mediated Dephosphorylation. J Am Heart Assoc. 2017;6: pubmed publisher
    ....