Affiliation: King's College London
- Investigating the role of context in learning to read: a direct test of Goodman's modelN Archer
Department of Experimental Psychology, Oxford University, UK
Br J Psychol 92:579-91. 2001..We report a study which tests both predictions and supports the first but not the second...
- Premorbid personality and behavioral and psychological symptoms in probable Alzheimer diseaseNicola Archer
King s College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London, UK
Am J Geriatr Psychiatry 15:202-13. 2007....
- The NEO-FFI is a reliable measure of premorbid personality in patients with probable Alzheimer's diseaseNicola Archer
Section of Old Age Psychiatry, King s College London, Institute of Psychiatry, Section of Old Age Psychiatry, Denmark Hill, London, UK
Int J Geriatr Psychiatry 21:477-84. 2006..To assess the inter-informant reliability, intra-informant reliability and internal consistency of the NEO-FFI as a measure of premorbid personality in patients with Alzheimer's Disease (AD)...
- The role of premorbid personality and cognitive factors in awareness of illness, memory, and behavioural functioning in Alzheimer's diseaseJ Gilleen
Psychological Medicine, Department of Old Age Psychiatry, Institute of Psychiatry, King s College London, London, UK
Cogn Neuropsychiatry 17:227-45. 2012..Moreover, the study aims to contrast the strength of the relationship of premorbid personality and awareness with that of cognitive factors...
- Midlife Neuroticism and the age of onset of Alzheimer's diseaseN Archer
Medical Research Council MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, UK
Psychol Med 39:665-73. 2009..We aimed to examine whether midlife Neuroticism was associated with earlier age of onset of Alzheimer's disease (AD)...
- A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD)P Proitsi
King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Neurobiol Aging 32:434-42. 2011..Although there is evidence for distinct behavioural sub-phenotypes in Alzheimer's disease (AD), their inter-relationships and the effect of clinical variables on their expression have been little investigated...
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer diseaseAndrew Grupe
Celera Diagnostics, Alameda, CA, USA
Am J Hum Genet 78:78-88. 2006..0165). These results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder...
- Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further studyLynnette J Cook
Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, UK
Am J Med Genet B Neuropsychiatr Genet 132:5-8. 2005..Replication analyses of these two loci failed to detect any significant association for disease in our case-control samples...
- Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer diseaseYonghong Li
Celera Diagnostics, Alameda, California 94502, USA
Hum Mutat 25:270-7. 2005..43 [95% CI: 1.61-3.67]; OR(het)=2.15 [95% CI: 1.46-3.17]; P=0.00006) in the combined sample set. Our data raise the possibility that genetic variations in APBB2 may affect LOAD susceptibility...
- Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's diseaseVictoria Busby
Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
Neuromolecular Med 5:133-46. 2004..None of these SNPs was associated with disease. Although an excellent candidate, we conclude that CTNNA3 is unlikely to account for the AD susceptibility locus on chromosome 10...
- Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's diseaseGillian Hamilton
MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, Kings College London, Denmark Hill, London SE5 8AF, UK
Neurosci Lett 401:77-80. 2006..Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD...
- Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's diseaseDenise Harold
Department of Psychological Medicine, University of Wales College of Medicine, CF14 4XN, Cardiff, UK
Hum Genet 113:258-67. 2003..Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium...
- Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's diseasePaul Hollingworth
Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
J Am Geriatr Soc 54:1348-54. 2006..To investigate behavioral components of Alzheimer's disease (AD) and to analyze behavioral components in relation to disease severity, apolipoprotein E genotype (APOE), sex, years of education, age at onset, and cognitive impairment...
- Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's diseaseLynnette J Cook
Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
Neurosci Lett 358:142-6. 2004..70, 95% confidence interval=0.52-0.95, P=0.019). These data suggest that this variant warrants further examination in large case-control series...
- Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's diseaseAbdul Hye
Department of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE 58 AF, UK
Neurosci Lett 373:1-4. 2005....