T Andrew

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, United Kingdom
    J Bone Miner Res 20:67-74. 2005
  2. ncbi Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women
    T Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Twin Res 4:464-77. 2001
  3. ncbi Linkage and association for bone mineral density and heel ultrasound measurements with a simple tandem repeat polymorphism near the osteocalcin gene in female dizygotic twins
    T Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, UK
    Osteoporos Int 13:745-54. 2002
  4. ncbi Genes and osteoporosis
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Curr Osteoporos Rep 2:79-89. 2004
  5. ncbi Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
    Am J Hum Genet 78:480-6. 2006
  6. ncbi Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping
    Toby Andrew
    Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    PLoS Genet 4:e1000220. 2008
  7. ncbi Genetic variation in bone mineral density and calcaneal ultrasound: a study of the influence of menopause using female twins
    D J Hunter
    Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Osteoporos Int 12:406-11. 2001
  8. ncbi Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK
    Osteoporos Int 20:949-53. 2009
  9. ncbi Comparison of three methods of intraocular pressure measurement and their relation to central corneal thickness
    F Carbonaro
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine and St Thomas Hospital Campus, London, UK
    Eye (Lond) 24:1165-70. 2010
  10. ncbi Association of birth weight with osteoporosis and osteoarthritis in adult twins
    L Antoniades
    St Thomas Hospital, Twin Research and Genetic Epidemiology Unit, London, UK
    Rheumatology (Oxford) 42:791-6. 2003

Detail Information

Publications38

  1. ncbi Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, United Kingdom
    J Bone Miner Res 20:67-74. 2005
    ..BMD is highly heritable, but statistical models showed very little overlap of shared genes between the two traits...
  2. ncbi Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women
    T Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Twin Res 4:464-77. 2001
    ..We conclude that the results of twin studies can be generalised to singleton populations for these measures and disease outcomes...
  3. ncbi Linkage and association for bone mineral density and heel ultrasound measurements with a simple tandem repeat polymorphism near the osteocalcin gene in female dizygotic twins
    T Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, UK
    Osteoporos Int 13:745-54. 2002
    ..It is likely that the alleles are in linkage disequilibrium with functional polymorphism(s) in or nearby the osteocalcin gene, which may contribute to the onset of osteoporosis...
  4. ncbi Genes and osteoporosis
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Curr Osteoporos Rep 2:79-89. 2004
    ..Here we argue that future success in finding genes is only possible with improved study design and the use of more rigorous analytic approaches that are now becoming available...
  5. ncbi Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
    Am J Hum Genet 78:480-6. 2006
    ..9) at 14q23.2, and suggestive linkage at 10q26.13 (LOD 2.4) and 3p26.1 (LOD 2.7). This is the first report of loci, mapped in a sample of healthy individuals, that influence mean telomere variation in humans...
  6. ncbi Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping
    Toby Andrew
    Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    PLoS Genet 4:e1000220. 2008
    ..That two mitochondrial regulatory processes in the retina are implicated in the aetiology of myopia is surprising and is likely to provide novel insight into the molecular genetic basis of common myopia...
  7. ncbi Genetic variation in bone mineral density and calcaneal ultrasound: a study of the influence of menopause using female twins
    D J Hunter
    Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Osteoporos Int 12:406-11. 2001
    ..These data stress the importance of accounting for menopause-gene interactions in the genetic analysis of data on osteoporosis...
  8. ncbi Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study
    G Zhai
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK
    Osteoporos Int 20:949-53. 2009
    ....
  9. ncbi Comparison of three methods of intraocular pressure measurement and their relation to central corneal thickness
    F Carbonaro
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine and St Thomas Hospital Campus, London, UK
    Eye (Lond) 24:1165-70. 2010
    ..The purpose of this study was to compare the reliability of the 'gold standard' Goldmann applanation tonometer (GAT), with that of the ocular response analyser (ORA), and the dynamic contour tonometer (DCT)...
  10. ncbi Association of birth weight with osteoporosis and osteoarthritis in adult twins
    L Antoniades
    St Thomas Hospital, Twin Research and Genetic Epidemiology Unit, London, UK
    Rheumatology (Oxford) 42:791-6. 2003
    ..In this study, we explored the association of birth weight with osteoporosis (OP) and osteoarthritis (OA), in a large national cohort of female twins...
  11. ncbi Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
    J B Richards
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Lancet 371:1505-12. 2008
    ..Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density...
  12. ncbi A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25
    Pirro G Hysi
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, London, UK
    Nat Genet 42:902-5. 2010
    ..001). The identification of a susceptibility locus for refractive error on 15q25 will be important in characterizing the molecular mechanism responsible for the most common cause of visual impairment...
  13. ncbi A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins
    Christopher J Hammond
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, and West Kent Eye Center, Princess Royal University Hospital, Orpington, United Kingdom
    Am J Hum Genet 75:294-304. 2004
    ....
  14. ncbi The relation between insulin resistance and hemostasis: pleiotropic genes and common environment
    Marlies de Lange
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
    Twin Res 6:152-61. 2003
    ....
  15. ncbi Identification of QTLs for serum lipid levels in a female sib-pair cohort: a novel application to improve the power of two-locus linkage analysis
    Mario Falchi
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Hum Mol Genet 14:2971-9. 2005
    ....
  16. ncbi An investigation of unique and shared gene effects on speed of sound and bone density using axial transmission quantitative ultrasound and DXA in twins
    Karen M Knapp
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, United Kingdom
    J Bone Miner Res 18:1525-30. 2003
    ..Genetic influences were found for all SOS and BMD measurements. A combination of shared and unique genetic influences was found to control BMD and SOS at the radius...
  17. ncbi Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins
    Alexander J MacGregor
    St Thomas Hospital, London, UK
    Arthritis Rheum 51:160-7. 2004
    ....
  18. ncbi Estimating heritability and shared environmental effects for refractive error in twin and family studies
    Margarida C Lopes
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:126-31. 2009
    ..This large twin study aimed to explore the role of shared environment in refractive error...
  19. ncbi Heritability of intraocular pressure: a classical twin study
    F Carbonaro
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, London, UK
    Br J Ophthalmol 92:1125-8. 2008
    ..To estimate the heritability of intraocular pressure (IOP) by performing a classical twin study and to determine whether the use of different instruments influences calculation of eye IOP heritability...
  20. ncbi Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs
    M Y M Ng
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH
    J Med Genet 42:235-9. 2005
    ..We also tested for linkage with haemorrhoids (H), as a separate venous anomaly at the same locus...
  21. ncbi Obesity, cigarette smoking, and telomere length in women
    A M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, London, UK
    Lancet 366:662-4. 2005
    ..017), and each pack-year smoked was equivalent to an additional 5 bp of telomere length lost (18%) compared with the rate in the overall cohort. Our results emphasise the pro-ageing effects of obesity and cigarette smoking...
  22. ncbi The heritability of corneal hysteresis and ocular pulse amplitude: a twin study
    Francis Carbonaro
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, London, United Kingdom
    Ophthalmology 115:1545-9. 2008
    ..To examine the roles of genetic and environmental factors in corneal hysteresis and ocular pulse amplitude by performing a classic twin study...
  23. ncbi Joint linkage and association of six single-nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus
    Marlies de Lange
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Arterioscler Thromb Vasc Biol 26:1914-9. 2006
    ..The current study investigated 6 single-nucleotide polymorphisms (SNPs) within the FXIII A-subunit gene to locate functional polymorphism(s) responsible for variation in FXIII activation...
  24. ncbi Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study
    Guy Leschziner
    Division of Neurosciences, Imperial College London, London, UK
    Lancet Neurol 5:668-76. 2006
    ..We aimed to determine the effect of the ABCB1 gene on epilepsy drug response, using a unique large cohort of epilepsy patients with prospectively measured seizure and drug response outcomes...
  25. ncbi Bayesian survival analysis in genetic association studies
    Ioanna Tachmazidou
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Bioinformatics 24:2030-6. 2008
    ..Coalescent-based approaches are promising for LD mapping, as the coalescent offers a good approximation to the evolutionary history of mutations...
  26. ncbi Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies
    Francis Carbonaro
    Department of Twin Research and Genetic Epidemiology, King s College London School of Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5115-9. 2009
    ..This was a cohort study in which 344 pairs of twins, 163 monozygotic (MZ) and 181 dizygotic (DZ), were enrolled...
  27. ncbi Heritability of the second to fourth digit ratio (2d:4d): A twin study
    Simon N Paul
    Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, London, United Kingdom
    Twin Res Hum Genet 9:215-9. 2006
    ..However the current study design does not preclude the possibility of confounding between heritability estimates and unobserved prenatal effects...
  28. ncbi ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research
    G D Leschziner
    Division of Neurosciences, Imperial College, London, UK
    Pharmacogenomics J 7:154-79. 2007
    ..We have produced recommendations for future research that will aid clarification of the association between ABCB1 genotypes and factors related to PGP activity...
  29. ncbi Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach
    Guy D Leschziner
    Imperial College London, London, UK
    Pharmacogenet Genomics 17:217-20. 2007
    ..In addition, no evidence for a role of other common ABCB1 polymorphisms was found using a potentially more powerful gene-wide tagging approach...
  30. ncbi Genome-wide scan for blood pressure suggests linkage to chromosome 11, and replication of loci on 16, 17, and 22
    Marlies de Lange
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Rd, London SE1 7EH, UK
    Hypertension 44:872-7. 2004
    ..Future studies should focus on the fine mapping of these replicated regions, which include potential candidate genes...
  31. ncbi The heritable determinants of cartilage oligomeric matrix protein
    Frances M K Williams
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Arthritis Rheum 54:2147-51. 2006
    ..An association between COMP and OA has been shown, yet the precise factors governing serum levels of COMP remain unclear. The aim of this study was to determine whether genetic factors influence serum levels of COMP...
  32. ncbi Functional constraint and small insertions and deletions in the ENCODE regions of the human genome
    Taane G Clark
    Department of Epidemiology and Public Health, Imperial College, Norfolk Place, London, W2 1PG, UK
    Genome Biol 8:R180. 2007
    ..We relate indels to known genomic annotation features and measures of evolutionary constraint...
  33. ncbi The genetics of coronary heart disease: the contribution of twin studies
    Alun Evans
    Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, Northern Ireland, UK
    Twin Res 6:432-41. 2003
    ..Twin studies have also contributed to our understanding of the life course hypothesis, and GenomEUtwin has the potential to add to this...
  34. ncbi Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort
    Scott G Wilson
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia
    Eur J Hum Genet 14:340-8. 2006
    ..0067) and P2RX4 (P = 0.017). These data provide replication and refinement of the 12q24 obesity locus and suggest that genes involved in phospholipase and purinoreceptor pathways may regulate fat accumulation and distribution...
  35. ncbi Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
    John P A Ioannidis
    Department of Hygiene and Epidemology, University of Ioannina School of Medicine, Ioannina, Greece
    J Bone Miner Res 22:173-83. 2007
    ..Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manner...
  36. ncbi Gamma regression improves Haseman-Elston and variance components linkage analysis for sib-pairs
    Mathew J Barber
    Department of Medical Genetics, University of Cambridge, Cambridge, UK
    Genet Epidemiol 26:97-107. 2004
    ..68: 1198-1211) and is therefore more powerful than ordinary least squares, but has the added advantage of being robust to deviations from multivariate normality and provides (often overlooked) model-fit diagnostics for linkage analysis...
  37. ncbi Genome-wide association studies of quantitative traits with related individuals: little (power) lost but much to be gained
    Peter M Visscher
    Genetic Epidemiology, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Eur J Hum Genet 16:387-90. 2008
    ..Therefore, the advantages of using relatives in GWAS for quantitative traits may well outweigh the small disadvantage in terms of statistical power...
  38. ncbi The association between polymorphisms in RLIP76 and drug response in epilepsy
    Guy D Leschziner
    Imperial College London, Division of Neuroscience, Charing Cross Campus, Room 10E07, St Dunstan s Road, London W6 8RF, UK
    Pharmacogenomics 8:1715-22. 2007
    ..We aimed to look for an association with outcomes reflecting drug response in a larger prospective cohort, with gene-wide coverage...