Research Topics
| B AlexanderSummaryAffiliation: King's College London Country: UK Publications
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Publications
Differentiation between the effects of unprocessed portal blood and reduced liver function on brain indole amine metabolism in the portacaval shunted ratB Alexander
Department of Surgery, King s College School of Medicine and Dentistry, The Rayne Institute, London
Metab Brain Dis 13:137-46. 1998..p<0.001, Newman-Keuls ANOVAR followed by Student's unpaired t-test for individual comparisons, (data shown are mean +/- SEM)...- Hepato-cardiovascular response and its regulationXiang Nong Li
Department of General Surgery, Affiliated Hospital of Xuzhou Medical College, 99 West Huaihai Road, Xuzhou 221002, Jiangsu Province, China
World J Gastroenterol 11:676-80. 2005..To determine the possible existence of a hepato-cardiovascular response and its regulatory mechanism in normal rats... - Hyperammonaemia reduces intracellular 22Na (sodium) ion and extracellular 86Rb ion concentrations in the blood-brain barrier of the ratBarry Alexander
Department of Physiology, Sherrington School of Physiology, London, United Kingdom
Metab Brain Dis 20:19-33. 2005..These observations may provide a basis for the explanation of NH+ toxicity during hepatic encephalopathy and liver failure-induced cerebral edema... - Hepatic arterial perfusion regulates portal venous flow between hepatic sinusoids and intrahepatic shunts in the normal rat liver in vitroB Alexander
Liver Sciences Unit, Academic Department of Surgery, GKT School of Medicine and Dentistry, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
Pflugers Arch 443:257-64. 2001..The hepatic arterial vasculature, unlike the portal supply, does not possess a collateral shunt circulation and coalesces with the portal vein at an intrasinusoidal location.. - Hypoxia attenuates hepatic arterial vasodilatation and enhances portal venous vasoconstriction to ATP in the perfused rabbit liverB Alexander
Academic Department of Surgery, Liver Sciences Unit, GKT School of Medicine, St Thomas s Hospital, Lambeth Palace Road, London, UK
Eur J Pharmacol 385:181-9. 1999..Both these effects may be characteristic of damage to the microvascular endothelium and may be the result of decreased synthesis of nitric oxide... - Paradoxical cholinergic and purinergic vascular reactivity of rabbit thoracic aorta cold-stored in University of Wisconsin solutionB Alexander
Department of Surgery, King s College School of Medicine and Dentistry, The Rayne Institute, London, UK
J Pharm Pharmacol 51:623-30. 1999.... - Hepatic arterial perfusion decreases intrahepatic shunting and maintains glucose uptake in the rat liverBarry Alexander
Liver Sciences Unit, Academic Department of Surgery, GKT School of Medicine and Dentistry, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
Pflugers Arch 444:291-8. 2002..The microsphere data indicate that confluence between the hepatic arterial and portal venous vasculatures occurs mainly in sinusoidal zone II... - Development of bladder urothelial hyperplasia and carcinoma in portacaval shunted rats is not dependent upon urolithiasisBarry Alexander
Liver Sciences Unit, Academic Department of Surgery, Guys, King s and St Thomas School of Medicine and Dentistry, St Thomas Hospital, London SE1 7EH, UK
Exp Mol Pathol 77:205-9. 2004..0, chi(2) analysis). Urothelial lesions, therefore, can be reproduced in PCS rats. Their occurrence appears independent of bladder stone formation... - Nitric oxide modulates acetylcholine-induced vasodilatation in the hepatic arterial vasculature of the dual-perfused rat liverW Yang
Academic Department of Surgery, Liver Sciences Unit, Guy's, King's and St Thomas' School of Medicine, St Thomas' Hospital, London, UK
Acta Physiol Scand 171:413-8. 2001..In addition, ATP-induced hepatic arterial vasoconstriction is also modulated by the release of nitric oxide (*P < 0.05, Student's paired t-test)... - The transhepatic action of ATP on the hepatic arterial and portal venous vascular beds of the rabbit: the role of nitric oxideD J Browse
Department of Surgery, King s College School of Medicine and Dentistry, Rayne Institute, London
Br J Pharmacol 113:987-93. 1994..This implies that ATP itself, and not a second messenger, diffuses from the portal venous to hepatic arterial vascular bed to elicit the hepatic arterial response... - Adenosine-induced dilatation of the rabbit hepatic arterial bed is mediated by A2-purinoceptorsR T Mathie
Department of Surgery, Royal Postgraduate Medical School, London
Br J Pharmacol 103:1103-7. 1991..6. It is concluded that adenosine-induced dilatation of the hepatic arterial vascular bed is mediated by P1-purinoceptors of the A2 sub-type... - A quantitative evaluation of the permeability of the blood brain barrier of portacaval shunted ratsB Alexander
Academic Department of Surgery, GKT School of Medicine and Dentistry, St Thomas Hospital, London, UK
Metab Brain Dis 15:93-103. 2000..The reduction in phenylalanine uptake into the brain may help stabilize high cerebral aromatic amino acid levels. *P<0.05, Two-tailed, Student's unpaired t-test... - Functional and compositional studies of arteries stored in University of Wisconsin solution compared with Krebs-Bülbring bufferB Alexander
Department of Surgery, GKT School of Medicine and Dentistry, London, UK
Exp Mol Pathol 71:265-73. 2001..It is concluded that reductions in vasoconstriction in UW-stored tissue are unlikely to be due to increased release of nitric oxide nor reduced availability of myosin light chains for phosphorylation and vasoconstriction... - Location and function of intrahepatic shunts in anaesthetised ratsX Li
Liver Sciences Unit, Academic Department of Surgery, St Thomas's Hospital, Guy's, King's, and St Thomas's School of Medicine, London, UK
Gut 52:1339-46. 2003.... - The dependence of hepatic function upon sufficient oxygen supply during prolonged isolated rat liver perfusionB Alexander
Department of Surgery, King s College School of Medicine and Dentistry, Rayne Institute, London, Great Britain
J Pharmacol Toxicol Methods 39:185-92. 1998..Inclusion of a perfusate oxygen carrier is optimal if livers are to be perfused at physiological pressures. *p < 0.05; **p < 0.01; ***p < 0.001; group 1 versus group 2, Student's unpaired t test... - An investigation of the relationship between the liver and brain using an isolated perfused rat brain preparationB Alexander
Liver Sciences Unit, Academic Department of Surgery, GKT School of Medicine and Dentistry, St Thomas Hospital, Lambeth Palace Road, London, United Kingdom
J Pharmacol Toxicol Methods 42:31-7. 1999.... - Diminished hyperaemic response of the hepatic artery to portal venous occlusion (the buffer response) in Asian hybrid minipigs: a comparison of the response to that observed in dogsB Alexander
Department of Surgery, Royal Postgraduate Medical School, London, UK
J Comp Physiol B 163:5-10. 1993..The adenosine uptake inhibitor dipyridamole did not potentiate responses to adenosine or the buffer response. It is concluded that the minipig is an unsuitable alternative model for the study of the hepatic artery buffer response... - Pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) as a tool for differentiation of P2Y2-receptor-mediated vasorelaxation in guinea pig aortaS J Payne
Liver Sciences Unit, Academic Department of Surgery, GKT School of Medicine, St. Thomas' Hospital, London
Methods Find Exp Clin Pharmacol 24:351-6. 2002..Thus, PPADS is a potentially useful substance that may be used for differentiation between P2Y1 and P2Y2 receptors in the guinea pig aorta... - Reproducible production of thioacetamide-induced macronodular cirrhosis in the rat with no mortalityXiangnong Li
Liver Sciences Unit, Academic Department of Surgery, St. Thomas' Hospital, Guy's, King's and St. Thomas' School of Medicine, London SE1 7EH, UK
J Hepatol 36:488-93. 2002..CONCLUSIONS: Variations in responses to thioacetamide can be easily monitored by weekly weight changes to reduce mortality to zero and simultaneously increase the production and quality of cirrhosis induced in rats... - The action of nitric oxide on hepatic haemodynamics during secondary biliary cirrhosis in the ratWenxuan Yang
Liver Sciences Unit, Academic Department of Surgery, Guys, King's and St. Thomas' School of Medicine and Dentistry, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK
Eur J Pharmacol 461:41-8. 2003..However, portal venous responses in cirrhotic rats were increased to noradrenaline and attenuated to ATP, and were not related to increased NO production... - The role of nitric oxide in systemic and hepatic haemodynamics in the rat in vivoXiangnong Li
St Thomas's Hospital, Guy's, King's and St Thomas' School of Medicine, Lambeth Palace Road, SE1 7EH, London, UK
Naunyn Schmiedebergs Arch Pharmacol 368:142-9. 2003..Inhibition of endogenous NO had no effect on portal haemodynamics. Endogenous NO may not play a major role in regulation of portal haemodynamics in the rat in vivo... - The effect of anticoagulation with subcutaneously delivered polyethylene glycol conjugated hirudin and recombinant tissue plasminogen activator on recurrent stenosis in the rabbit double-balloon injury modelBarry Alexander
Academic Department of Surgery, GKT School of Medicine and Dentistry, 1st Floor North Wing, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK
Thromb Res 113:155-61. 2004..The magnitude of luminal narrowing was significantly reduced by subcutaneous injection of PEG-hirudin. Further studies are required to determine whether this effect can be enhanced by other antithrombins or improved methods of delivery...