Kourosh R Ahmadi

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Epidemiology and genetic epidemiology of the liver function test proteins
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 4:e4435. 2009
  2. doi Classical twin design in modern pharmacogenomics studies
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, 1st Floor, South Wing, Block 4, Westminster Bridge Road, London, SE1 7EH, UK
    Pharmacogenomics 11:215-26. 2010
  3. doi Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, King s College London, Lambeth Palace Rd, London, SE1 7EH, UK
    Eur J Drug Metab Pharmacokinet 38:63-7. 2013
  4. doi Genetic epidemiology of induced CYP3A4 activity
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, London, UK
    Pharmacogenet Genomics 21:642-51. 2011
  5. doi Unravelling the basis of variability in cobalamin levels in the general population
    Toby Andrew
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Br J Nutr 110:1672-9. 2013
  6. doi Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    J Proteome Res 10:2807-16. 2011
  7. pmc Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
    Nat Genet 43:1131-8. 2011
  8. doi The basis of differential responses to folic acid supplementation
    Ioana Cotlarciuc
    Department of Twin Research and Genetic Epidemiology, King s College Hospital, London, UK
    J Nutrigenet Nutrigenomics 4:99-109. 2011
  9. pmc Quantitative trait loci for bone lengths on chromosome 5 using dual energy X-Ray absorptiometry imaging in the Twins UK cohort
    Usha Chinappen-Horsley
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital, London, United Kingdom
    PLoS ONE 3:e1752. 2008
  10. doi Rapid quantification of quinine and its major metabolite (3S)-3-hydroxyquinine in diluted urine by UPLC-MS/MS
    James Heaton
    Pharmaceutical Science Division, School of Biomedical and Health Sciences, King s College London, United Kingdom
    J Pharm Biomed Anal 55:494-9. 2011

Detail Information

Publications13

  1. pmc Epidemiology and genetic epidemiology of the liver function test proteins
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 4:e4435. 2009
    ..The liver function test (LFT) is among the most commonly used clinical investigations to assess hepatic function, severity of liver diseases and the effect of therapies, as well as to detect drug-induced liver injury (DILI)...
  2. doi Classical twin design in modern pharmacogenomics studies
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, 1st Floor, South Wing, Block 4, Westminster Bridge Road, London, SE1 7EH, UK
    Pharmacogenomics 11:215-26. 2010
    ....
  3. doi Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, King s College London, Lambeth Palace Rd, London, SE1 7EH, UK
    Eur J Drug Metab Pharmacokinet 38:63-7. 2013
    ..We report the first GWAS of variation in induced CYP3A4 activity and our preliminary results indicate a complex genetic architecture underpinning induced CYP3A4 enzyme activity...
  4. doi Genetic epidemiology of induced CYP3A4 activity
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, London, UK
    Pharmacogenet Genomics 21:642-51. 2011
    ....
  5. doi Unravelling the basis of variability in cobalamin levels in the general population
    Toby Andrew
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Br J Nutr 110:1672-9. 2013
    ..Characterisation of the heritable component of variation in Cbl levels can facilitate the early diagnosis and prognosis of Cbl insufficiency/deficiency in individuals at a higher risk of associated diseases...
  6. doi Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    J Proteome Res 10:2807-16. 2011
    ..This regression model demonstrated significant (p < 0.00001) predictive ability when applied to an independent validation set. Our results highlight the promise of metabonomics for predicting CYP3A4-mediated drug response...
  7. pmc Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
    Nat Genet 43:1131-8. 2011
    ..Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function...
  8. doi The basis of differential responses to folic acid supplementation
    Ioana Cotlarciuc
    Department of Twin Research and Genetic Epidemiology, King s College Hospital, London, UK
    J Nutrigenet Nutrigenomics 4:99-109. 2011
    ..We used the classical twin model to partition the variability in changes in plasma tHcy levels through folic acid supplementation into genetic, environmental, and confounding epidemiological factors...
  9. pmc Quantitative trait loci for bone lengths on chromosome 5 using dual energy X-Ray absorptiometry imaging in the Twins UK cohort
    Usha Chinappen-Horsley
    Twin Research and Genetic Epidemiology Unit, King s College London School of Medicine, St Thomas Hospital, London, United Kingdom
    PLoS ONE 3:e1752. 2008
    ..Replication and further fine mapping of this region is ongoing to determine potential genes influencing bone size and diseases affecting bone...
  10. doi Rapid quantification of quinine and its major metabolite (3S)-3-hydroxyquinine in diluted urine by UPLC-MS/MS
    James Heaton
    Pharmaceutical Science Division, School of Biomedical and Health Sciences, King s College London, United Kingdom
    J Pharm Biomed Anal 55:494-9. 2011
    ..The method was shown to be suitable for quantitatively determining the ratio of quinine to (3S)-3-hydroxyquinine for a cohort of samples from an epidemiological study...
  11. pmc Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
    Kerrin S Small
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Nat Genet 43:561-4. 2011
    ..This trans-eQTL network provides a mechanistic understanding of the effect of the KLF14 locus on metabolic disease risk and offers a potential model for other complex traits...
  12. ncbi Lack of association between leukocyte telomere length and genetic variants in two ageing-related candidate genes
    Feng Zhang
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, King s College London, United Kingdom
    Mech Ageing Dev 128:415-22. 2007
    ....
  13. pmc Genetic loci influencing kidney function and chronic kidney disease
    John C Chambers
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
    Nat Genet 42:373-5. 2010
    ..0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease...