Kourosh R Ahmadi

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint Classical twin design in modern pharmacogenomics studies
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, 1st Floor, South Wing, Block 4, Westminster Bridge Road, London, SE1 7EH, UK
    Pharmacogenomics 11:215-26. 2010
  2. doi request reprint Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, King s College London, Lambeth Palace Rd, London, SE1 7EH, UK
    Eur J Drug Metab Pharmacokinet 38:63-7. 2013
  3. doi request reprint Genetic epidemiology of induced CYP3A4 activity
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, London, UK
    Pharmacogenet Genomics 21:642-51. 2011
  4. pmc Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
    Nat Genet 43:1131-8. 2011
  5. doi request reprint The basis of differential responses to folic acid supplementation
    Ioana Cotlarciuc
    Department of Twin Research and Genetic Epidemiology, King s College Hospital, London, UK
    J Nutrigenet Nutrigenomics 4:99-109. 2011
  6. doi request reprint Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    J Proteome Res 10:2807-16. 2011
  7. pmc Epidemiology and genetic epidemiology of the liver function test proteins
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 4:e4435. 2009
  8. pmc Genetic loci influencing kidney function and chronic kidney disease
    John C Chambers
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
    Nat Genet 42:373-5. 2010

Detail Information

Publications8

  1. doi request reprint Classical twin design in modern pharmacogenomics studies
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital Campus, 1st Floor, South Wing, Block 4, Westminster Bridge Road, London, SE1 7EH, UK
    Pharmacogenomics 11:215-26. 2010
    ....
  2. doi request reprint Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, King s College London, Lambeth Palace Rd, London, SE1 7EH, UK
    Eur J Drug Metab Pharmacokinet 38:63-7. 2013
    ..We report the first GWAS of variation in induced CYP3A4 activity and our preliminary results indicate a complex genetic architecture underpinning induced CYP3A4 enzyme activity...
  3. doi request reprint Genetic epidemiology of induced CYP3A4 activity
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, St Thomas Hospital, London, UK
    Pharmacogenet Genomics 21:642-51. 2011
    ....
  4. pmc Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
    Nat Genet 43:1131-8. 2011
    ..Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function...
  5. doi request reprint The basis of differential responses to folic acid supplementation
    Ioana Cotlarciuc
    Department of Twin Research and Genetic Epidemiology, King s College Hospital, London, UK
    J Nutrigenet Nutrigenomics 4:99-109. 2011
    ..We used the classical twin model to partition the variability in changes in plasma tHcy levels through folic acid supplementation into genetic, environmental, and confounding epidemiological factors...
  6. doi request reprint Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    J Proteome Res 10:2807-16. 2011
    ..This regression model demonstrated significant (p < 0.00001) predictive ability when applied to an independent validation set. Our results highlight the promise of metabonomics for predicting CYP3A4-mediated drug response...
  7. pmc Epidemiology and genetic epidemiology of the liver function test proteins
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 4:e4435. 2009
    ..The liver function test (LFT) is among the most commonly used clinical investigations to assess hepatic function, severity of liver diseases and the effect of therapies, as well as to detect drug-induced liver injury (DILI)...
  8. pmc Genetic loci influencing kidney function and chronic kidney disease
    John C Chambers
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
    Nat Genet 42:373-5. 2010
    ..0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease...