N J Abbott

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Dynamics of CNS barriers: evolution, differentiation, and modulation
    N Joan Abbott
    Blood Brain Barrier Group, Wolfson Centre for Age Related Diseases, King s College University of London, London, UK
    Cell Mol Neurobiol 25:5-23. 2005
  2. ncbi request reprint Astrocyte-endothelial interactions at the blood-brain barrier
    N Joan Abbott
    Wolfson Centre for Age Related Diseases, King s College London, UK
    Nat Rev Neurosci 7:41-53. 2006
  3. pmc Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance
    Adjanie Patabendige
    King s College London, Institute of Pharmaceutical Science, BBB Group, Franklin Wilkins Building, 150 Stamford St, London SE1 9NH, UK
    Brain Res 1521:1-15. 2013
  4. doi request reprint Blood-brain barrier structure and function and the challenges for CNS drug delivery
    N Joan Abbott
    BBB Group, Institute of Pharmaceutical Science, King s College London, London, UK
    J Inherit Metab Dis 36:437-49. 2013
  5. pmc Astrocyte-endothelial interactions and blood-brain barrier permeability
    N Joan Abbott
    Centre for Neuroscience Research, King s College London, UK
    J Anat 200:629-38. 2002
  6. ncbi request reprint The blood-brain barrier in systemic lupus erythematosus
    N J Abbott
    Centre for Neuroscience Research, King s College London, Guy s Campus, London SE1 1UL, UK
    Lupus 12:908-15. 2003
  7. ncbi request reprint Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
    N Joan Abbott
    Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 1UL, UK
    Neurochem Int 45:545-52. 2004
  8. ncbi request reprint Inflammatory mediators and modulation of blood-brain barrier permeability
    N J Abbott
    Division of Physiology, GKT School of Biomedical Sciences, King s College London, UK
    Cell Mol Neurobiol 20:131-47. 2000
  9. ncbi request reprint Assays to predict drug permeation across the blood-brain barrier, and distribution to brain
    N J Abbott
    Blood Brain Barrier Group, Pharmaceutical Science Division, King s College London, UK
    Curr Drug Metab 9:901-10. 2008
  10. doi request reprint Structure and function of the blood-brain barrier
    N Joan Abbott
    King s College London, Blood Brain Barrier Group, Pharmaceutical Science Division, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Neurobiol Dis 37:13-25. 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Dynamics of CNS barriers: evolution, differentiation, and modulation
    N Joan Abbott
    Blood Brain Barrier Group, Wolfson Centre for Age Related Diseases, King s College University of London, London, UK
    Cell Mol Neurobiol 25:5-23. 2005
    ..Less is known about the modulation of the CP. (6) The challenge for the next era of CNS barrier studies will be to apply new knowledge from proteomics and genomics to understanding the in vivo condition in physiology and pathology...
  2. ncbi request reprint Astrocyte-endothelial interactions at the blood-brain barrier
    N Joan Abbott
    Wolfson Centre for Age Related Diseases, King s College London, UK
    Nat Rev Neurosci 7:41-53. 2006
    ..An understanding of how these interactions are disturbed in pathological conditions could lead to the development of new protective and restorative therapies...
  3. pmc Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance
    Adjanie Patabendige
    King s College London, Institute of Pharmaceutical Science, BBB Group, Franklin Wilkins Building, 150 Stamford St, London SE1 9NH, UK
    Brain Res 1521:1-15. 2013
    ..This article is part of a Special Issue entitled Electrical Synapses...
  4. doi request reprint Blood-brain barrier structure and function and the challenges for CNS drug delivery
    N Joan Abbott
    BBB Group, Institute of Pharmaceutical Science, King s College London, London, UK
    J Inherit Metab Dis 36:437-49. 2013
    ..For many of these diseases it is still not clear how best to deliver appropriate drugs to the CNS, and a concerted approach using a variety of models and methods can give critical insights and indicate practical solutions...
  5. pmc Astrocyte-endothelial interactions and blood-brain barrier permeability
    N Joan Abbott
    Centre for Neuroscience Research, King s College London, UK
    J Anat 200:629-38. 2002
    ..The role of barrier induction and modulation in normal physiology and in pathology is discussed...
  6. ncbi request reprint The blood-brain barrier in systemic lupus erythematosus
    N J Abbott
    Centre for Neuroscience Research, King s College London, Guy s Campus, London SE1 1UL, UK
    Lupus 12:908-15. 2003
    ..Both can result in barrier breakdown. Neurological syndromes could then be secondary to damage to the BBB. The implications for treatment of NPSLE are discussed...
  7. ncbi request reprint Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
    N Joan Abbott
    Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 1UL, UK
    Neurochem Int 45:545-52. 2004
    ....
  8. ncbi request reprint Inflammatory mediators and modulation of blood-brain barrier permeability
    N J Abbott
    Division of Physiology, GKT School of Biomedical Sciences, King s College London, UK
    Cell Mol Neurobiol 20:131-47. 2000
    ....
  9. ncbi request reprint Assays to predict drug permeation across the blood-brain barrier, and distribution to brain
    N J Abbott
    Blood Brain Barrier Group, Pharmaceutical Science Division, King s College London, UK
    Curr Drug Metab 9:901-10. 2008
    ....
  10. doi request reprint Structure and function of the blood-brain barrier
    N Joan Abbott
    King s College London, Blood Brain Barrier Group, Pharmaceutical Science Division, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Neurobiol Dis 37:13-25. 2010
    ..The BBB is subject to short and long-term regulation, which may be disturbed in pathology. Any programme for drug discovery or delivery, to target or avoid the CNS, needs to consider the special features of the BBB...
  11. doi request reprint An improved in vitro blood-brain barrier model: rat brain endothelial cells co-cultured with astrocytes
    N Joan Abbott
    Institute of Pharmaceutical Science, Blood Brain Barrier Group, King s College London, London, UK
    Methods Mol Biol 814:415-30. 2012
    ..The whole procedure takes ∼2 weeks, using pre-frozen astrocytes, from isolation of RBECs to generation of high-resistance/low-permeability RBEC monolayers...
  12. ncbi request reprint Transporting therapeutics across the blood-brain barrier
    N J Abbott
    Biomedical Sciences Division, King s College London, UK
    Mol Med Today 2:106-13. 1996
    ..In this article, we review the properties of this barrier that complicate drug delivery to the brain, and some of the most hopeful strategies for overcoming or bypassing the barrier in humans...
  13. ncbi request reprint Glial induction of blood-brain barrier-like L-system amino acid transport in the ECV304 cell line
    M Chishty
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College, London, United Kingdom
    Glia 39:99-104. 2002
    ..Furthermore, it appears that L-system-mediated transport of amino acids can be modulated by several distinct pathways...
  14. ncbi request reprint Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines
    M Chishty
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, U K
    J Drug Target 9:223-8. 2001
    ..The results indicate that differences in the ability of classical and modern antihistamines to interact with Pgp at the BBB may determine their CNS penetration and as a consequence the presence or absence of central side-effects...
  15. ncbi request reprint Pluripotent protective effects of carnosine, a naturally occurring dipeptide
    A R Hipkiss
    Molecular Biology and Biophysics Group, King s College London, Strand, United Kingdom
    Ann N Y Acad Sci 854:37-53. 1998
    ....
  16. ncbi request reprint Cross reactivity of polyclonal GFAP antiserum: implications for the in-vitro characterisation of brain endothelium
    Diana E M Dolman
    BBB Group, Centre for Neuroscience Research, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Brain Res 1012:185-6. 2004
    ..We conclude that staining of endothelial cells with the polyclonal GFAP antiserum is due to cross reactivity with another protein...
  17. ncbi request reprint Metabolic and permeability changes caused by thiamine deficiency in immortalized rat brain microvessel endothelial cells
    I A Romero
    Physiology Group, Biomedical Sciences Division, King s College London, Strand, UK
    Brain Res 756:133-40. 1997
    ..The relative role of the BBB in the pathogenesis of thiamine deficiency is discussed...
  18. ncbi request reprint Flavonoid permeability across an in situ model of the blood-brain barrier
    Kuresh A Youdim
    Antioxidant Research Group, Wolfson Centre for Age Related Diseases, Centre for Neuroscience Research, Guy s King s and St Thomas s School of Biomedical Sciences, King s College, London SE1 1UL, UK
    Free Radic Biol Med 36:592-604. 2004
    ..In conclusion, the results demonstrate that flavonoids are able to traverse the BBB in vivo. However, the permeability of certain flavonoids in vivo is influenced by their lipophilicity and interactions with efflux transporters...
  19. ncbi request reprint An electrophysiological method for measuring the potassium permeability of the nerve perineurium
    N J Abbott
    Biomedical Sciences Division, King s College London, UK
    Brain Res 776:204-13. 1997
    ..The method gives real-time information on the K+ permeability of the nerve perineurium and its modulation by experimental treatments...
  20. ncbi request reprint Drug resistance in epilepsy: the role of the blood-brain barrier
    N Joan Abbott
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, King s College London, UK
    Novartis Found Symp 243:38-47; discussion 47-53, 180-5. 2002
    ..This complicates interpretation of drug resistance in epilepsy, and therapeutic strategies...
  21. ncbi request reprint Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture
    Diana Dolman
    Blood Brain Barrier Research Group, Wolfson Centre for Age Related Diseases, Guy s Kings and St Thomas School of Biomedical Sciences, King s College London, UK
    J Neurochem 93:825-33. 2005
    ..Our results support the concept that expression of AQP1, which is seen in many non-brain endothelia, is suppressed in the specialized endothelium of the blood-brain barrier...
  22. ncbi request reprint Lipids in blood-brain barrier models in vitro II: Influence of glial cells on lipid classes and lipid fatty acids
    Stefanie D Krämer
    Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, London, United Kingdom SE1 1UL
    In Vitro Cell Dev Biol Anim 38:566-71. 2002
    ..It is concluded that glioma C6 cells are able to induce a more in vivo-like FA pattern in BBB cell culture models. However, changes were not significant for the individual PUFAs, and their levels did not reach in vivo values...
  23. ncbi request reprint Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier
    Andreas Reichel
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, UK
    J Drug Target 10:277-83. 2002
    ....
  24. ncbi request reprint S-adenosylmethionine is substrate for carrier mediated transport at the blood-brain barrier in vitro
    Mansoor Chishty
    Blood Brain Barrier Research Unit, Neuroscience Research Centre, GKT School of Biomedical Sciences, King s College London, Hodgkin Building, Guy s Campus, London SE1 1UL, UK
    Brain Res 942:46-50. 2002
    ....
  25. ncbi request reprint Modulation of the effects of extracellular ATP on [Ca2+]i in rat brain microvacular endothelial cells
    M Nobles
    King s College London, Biomedical Sciences Division, Physiology Group, Strand, UK
    Eur J Pharmacol 361:119-27. 1998
    ..It is concluded that cyclic nucleotides, nitric oxide, and prostaglandin synthesis pathways are able to interact with the Ca2+ second messenger pathway in rat brain endothelial cells activated by extracellular ATP...
  26. ncbi request reprint Lipids in blood-brain barrier models in vitro I: Thin-layer chromatography and high-performance liquid chromatography for the analysis of lipid classes and long-chain polyunsaturated fatty acids
    Stefanie D Krämer
    Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, London, United Kingdom SE1 1UL
    In Vitro Cell Dev Biol Anim 38:557-65. 2002
    ..The results provide a useful framework for studies on the effects of lipid modulation and give reference information for the development of further BBB models...
  27. ncbi request reprint Interaction of nucleoside analogues with nucleoside transporters in rat brain endothelial cells
    Mansoor Chishty
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, UK
    J Drug Target 12:265-72. 2004
    ....
  28. ncbi request reprint Functional characterisation of nucleoside transport in rat brain endothelial cells
    Mansoor Chishty
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, UK
    Neuroreport 14:1087-90. 2003
    ..This study suggests that nucleoside transport at the in situ BBB may be mediated by ei and es equilibrative transporters and by cit and cif concentrative transporters...
  29. ncbi request reprint Interaction between flavonoids and the blood-brain barrier: in vitro studies
    Kuresh A Youdim
    Antioxidant Research Group, Wolfson Center for Age Related Diseases, Centre for Neuroscience Research, Guy s, King s and St Thomas s School of Biomedical Sciences, King s College, London, UK
    J Neurochem 85:180-92. 2003
    ..The results demonstrate that flavonoids and some metabolites are able to traverse the BBB, and that the potential for permeation is consistent with compound lipophilicity...
  30. ncbi request reprint Bradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier
    Alexander S Easton
    Centre for Neuroscience Research, School of Biomedical Sciences, King s College London, London SE1 1UL, UK
    Brain Res 953:157-69. 2002
    ..Thus bradykinin reduced TEER through B(2) receptor-linked release of Ca(2+) from thapsigargin-sensitive stores, leading to activation of PLA(2) and metabolism of arachidonic acid by 5-lipoxygenase...
  31. doi request reprint All vertebrates started out with a glial blood-brain barrier 4-500 million years ago
    Magnus Bundgaard
    Department of Medical Physiology, University of Copenhagen, Panum Institute, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Glia 56:699-708. 2008
    ..There are important implications for the development, physiology, and pathology of the mammalian BBB, and for the roles of endothelium and glia in CNS barrier layers...
  32. ncbi request reprint Strategies to advance translational research into brain barriers
    Edward Neuwelt
    Oregon Health and Science University, Department of Neurology, Veterans Administration Medical Center, Portland, OR, USA
    Lancet Neurol 7:84-96. 2008
    ..At a recent meeting of expert panels, essential and high-priority recommendations to propel brain barrier research forward in six topical areas were developed and these recommendations are presented here...
  33. ncbi request reprint Blood-brain barrier opened by stimulation of the parasympathetic sphenopalatine ganglion: a new method for macromolecule delivery to the brain
    David Yarnitsky
    Department of Neurology, Rambam Medical Center, Technion Faculty of Medicine, Haifa, Israel
    J Neurosurg 101:303-9. 2004
    ..Drug delivery across the blood-brain barrier remains a significant challenge. Based on earlier findings, the authors hypothesized that parasympathetic innervation of the brain vasculature could be used to augment drug delivery to the brain...
  34. ncbi request reprint Brain to blood efflux transport of adenosine: blood-brain barrier studies in the rat
    Aleksandra J Isakovic
    Institute of Biochemistry, School of Medicine, Belgrade, Serbia and Montenegro
    J Neurochem 90:272-86. 2004
    ..88, 65.1 +/- 14.1 and 71.1 +/- 16.9 micro m, respectively. This could be due to either competition of unlabelled molecules with [(14)C] adenosine or competition with its metabolites hypoxanthine and adenine for the same transport sites...
  35. ncbi request reprint Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy
    Matteo Marroni
    Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Curr Drug Targets 4:297-304. 2003
    ..This second line of defense for xenobiotics may have profound implications for the pharmacokinetic properties of antiepileptic drugs and their capacity to reach neuronal targets...
  36. ncbi request reprint An overview of in vitro techniques for blood-brain barrier studies
    Andreas Reichel
    Schering AG, Berlin, Germany
    Methods Mol Med 89:307-24. 2003