C Exley

Summary

Affiliation: Keele University
Country: UK

Publications

  1. ncbi Aluminium and iron, but neither copper nor zinc, are key to the precipitation of beta-sheets of Abeta_{42} in senile plaque cores in Alzheimer's disease
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, UK
    J Alzheimers Dis 10:173-7. 2006
  2. pmc Slow CCL2-dependent translocation of biopersistent particles from muscle to brain
    Zakir Khan
    INSERM, U955, 8 rue du General Sarrail, Creteil, 94010, France
    BMC Med 11:99. 2013
  3. ncbi Brain burdens of aluminum, iron, and copper and their relationships with amyloid-β pathology in 60 human brains
    Christopher Exley
    Lennard Jones Laboratories, The Birchall Centre, Keele University, Staffordshire, UK
    J Alzheimers Dis 31:725-730. 2012
  4. pmc New insight into silica deposition in horsetail (Equisetum arvense)
    Chinnoi Law
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK
    BMC Plant Biol 11:112. 2011
  5. pmc There is (still) too much aluminium in infant formulas
    Shelle Ann M Burrell
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Staffordshire, UK
    BMC Pediatr 10:63. 2010
  6. ncbi Elevated urinary excretion of aluminium and iron in multiple sclerosis
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire, UK
    Mult Scler 12:533-40. 2006
  7. ncbi Organosilicon therapy in Alzheimer's disease?
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Keele, UK
    J Alzheimers Dis 11:301-2; discussion 303-4. 2007
  8. ncbi Aluminium in human breast tissue
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 101:1344-6. 2007
  9. ncbi Non-invasive therapy to reduce the body burden of aluminium in Alzheimer's disease
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, UK
    J Alzheimers Dis 10:17-24; discussion 29-31. 2006
  10. ncbi Elevated urinary aluminium in current and past users of illicit heroin
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Staffordshire, UK
    Addict Biol 12:197-9. 2007

Collaborators

  • Philippa D Darbre
  • Karen Walker
  • Peter Crome
  • François Jérome Authier
  • E H Jeffery
  • Margaret Esiri
  • R A Yokel
  • C Schneider
  • Emily House
  • Ayesha Khan
  • Olga V Korchazhkina
  • James Beardmore
  • Alison E Ashcroft
  • Zakir Khan
  • Chinnoi Law
  • Shelle Ann M Burrell
  • Benjamin Ward
  • Rhayza Maingon
  • Scott Nicholson
  • Fausto Quintal-Tun
  • O Korchazhkina
  • Joanna Collingwood
  • Olga Korchazhkina
  • Christophe Combadiere
  • Xavier Decrouy
  • Josette Cadusseau
  • Meriem Mahrouf-Yorgov
  • Valerie Itier
  • François Lux
  • Romain K Gherardi
  • Olivier Tillement
  • Philippe Moretto
  • Paul G Ince
  • Gill Forster
  • F J Doucet
  • Steven Goodwin
  • Alex Baldwin
  • Matthew Mold
  • Christopher Sampson
  • Richard Ward
  • Amandeep Khela
  • Gordon Rugg
  • Ana Ramos-Díaz
  • Manuel Martínez-Estévez
  • J Armando Muñoz-Sánchez
  • G Wright
  • Armando Escamilla-Bencomo
  • S M Teresa Hernandez-Sotomayor
  • Jon P Dobson
  • Valerie Higenell
  • Guy Berthon
  • Olga Korchazkina
  • Stephen Andrew Spencer
  • James Croom
  • Tamas Kiss
  • M E Rotov

Detail Information

Publications52

  1. ncbi Aluminium and iron, but neither copper nor zinc, are key to the precipitation of beta-sheets of Abeta_{42} in senile plaque cores in Alzheimer's disease
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, UK
    J Alzheimers Dis 10:173-7. 2006
    ..Whether such metal-Abeta_{42} synergisms are an integral part of the aetiology of AD remains to be confirmed...
  2. pmc Slow CCL2-dependent translocation of biopersistent particles from muscle to brain
    Zakir Khan
    INSERM, U955, 8 rue du General Sarrail, Creteil, 94010, France
    BMC Med 11:99. 2013
    ....
  3. ncbi Brain burdens of aluminum, iron, and copper and their relationships with amyloid-β pathology in 60 human brains
    Christopher Exley
    Lennard Jones Laboratories, The Birchall Centre, Keele University, Staffordshire, UK
    J Alzheimers Dis 31:725-730. 2012
    ..Future research should test the hypothesis that, in individuals with moderate to severe amyloid pathology, low brain copper is a predisposition to developing dementia...
  4. pmc New insight into silica deposition in horsetail (Equisetum arvense)
    Chinnoi Law
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK
    BMC Plant Biol 11:112. 2011
    ..Tissue extracts from horsetails grown hydroponically and also collected from the wild were acid-digested in a microwave oven and their silica 'skeletons' visualised using the fluor, PDMPO, and fluorescence microscopy...
  5. pmc There is (still) too much aluminium in infant formulas
    Shelle Ann M Burrell
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Staffordshire, UK
    BMC Pediatr 10:63. 2010
    ..We have measured the aluminium content of a number of widely used infant formulas to determine if their contamination by aluminium and consequent issues of child health persists...
  6. ncbi Elevated urinary excretion of aluminium and iron in multiple sclerosis
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire, UK
    Mult Scler 12:533-40. 2006
    ..If aluminium is involved in MS then an increased dietary intake of its natural antagonist, silicon, might be a therapeutic option...
  7. ncbi Organosilicon therapy in Alzheimer's disease?
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Keele, UK
    J Alzheimers Dis 11:301-2; discussion 303-4. 2007
  8. ncbi Aluminium in human breast tissue
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 101:1344-6. 2007
    ..Whether differences in the regional distribution of aluminium in the breast are related to the known higher incidence of tumours in the outer upper quadrant of the breast remains to be ascertained...
  9. ncbi Non-invasive therapy to reduce the body burden of aluminium in Alzheimer's disease
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, UK
    J Alzheimers Dis 10:17-24; discussion 29-31. 2006
    ..7 +/- 9.5 to 21.7 +/- 13.8 nmol/mmol creatinine). The reduction in urinary aluminium supported the future longer-term use of silicic acid as non-invasive therapy for reducing the body burden of aluminium in Alzheimer's disease...
  10. ncbi Elevated urinary aluminium in current and past users of illicit heroin
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Staffordshire, UK
    Addict Biol 12:197-9. 2007
    ..Further research will be required to determine if adventitious aluminium has a role in heroin use-related neuropathology and neurology...
  11. ncbi Aluminum in tobacco and cannabis and smoking-related disease
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, United Kingdom
    Am J Med 119:276.e9-11. 2006
    ..The study aimed to confirm the very high content of aluminum in tobacco and cannabis and to provide for the first time evidence that such aluminum could be biologically available...
  12. ncbi A vexing Commentary on the important issue of aluminium and Alzheimer' disease
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, UK
    J Alzheimers Dis 10:451-2. 2006
  13. pmc Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK
    C Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire, UK
    J Neurol Neurosurg Psychiatry 77:877-9. 2006
    ....
  14. doi Silicon in life: whither biological silicification?
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire, UK
    Prog Mol Subcell Biol 47:173-84. 2009
    ....
  15. ncbi A biogeochemical cycle for aluminium?
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 97:1-7. 2003
    ..A fully fledged biogeochemical cycle for aluminium should explain the biospheric abundance of this element and whether we should expect its (continued) active involvement in biochemical evolution...
  16. doi A role for the body burden of aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire ST5 5BG, UK
    Med Hypotheses 72:135-9. 2009
    ....
  17. doi Aluminium, iron and copper in human brain tissues donated to the Medical Research Council's Cognitive Function and Ageing Study
    Emily House
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Stoke on Trent, Staffordshire, ST5 5BG, UK
    Metallomics 4:56-65. 2012
    ..When these values are subtracted from tissue digest values the absolute metal contents could be considered as conservative and yet they may still reflect aspects of ageing and neurodegenerative disease in individual brains...
  18. pmc Spherulites of amyloid-beta42 in vitro and in Alzheimer's disease
    Christopher Exley
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Staffordshire, UK
    J Alzheimers Dis 20:1159-65. 2010
    ....
  19. doi Human pro-islet amyloid polypeptide (ProIAPP(1-48)) forms amyloid fibrils and amyloid spherulites in vitro
    Christopher Exley
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Staffordshire, UK
    J Inorg Biochem 104:1125-9. 2010
    ....
  20. doi The immunobiology of aluminium adjuvants: how do they really work?
    Christopher Exley
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK
    Trends Immunol 31:103-9. 2010
    ....
  21. ncbi Darwin, natural selection and the biological essentiality of aluminium and silicon
    Christopher Exley
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK
    Trends Biochem Sci 34:589-93. 2009
    ....
  22. ncbi Metal-mediated formation of fibrillar ABri amyloid
    Ayesha Khan
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 98:2006-10. 2004
    ..Co-incubation of ABri with either Zn(II) or Cu(II) precipitated the peptide but did not result in the formation of amyloid fibrils...
  23. ncbi Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease
    Emily House
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, UK
    J Alzheimers Dis 6:291-301. 2004
    ....
  24. ncbi Plasmin cleaves Abeta42 in vitro and prevents its aggregation into beta-pleated sheet structures
    C Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, School of Chemistry and Physics, Keele University, Staffordshire, ST5 5BG, UK
    Neuroreport 12:2967-70. 2001
    ..Plasmin may fulfil a similar role in vivo...
  25. ncbi No effect of aluminium upon the hydrolysis of ATP in the coronary circulation of the isolated working rat heart
    O Korchazhkina
    Birchall Centre for Inorganic Chemistry and Materials Science, Department of Chemistry, Keele University, Staffordshire, UK
    J Inorg Biochem 76:121-6. 1999
    ..Aluminium did not influence the hydrolysis of ATP by this enzyme...
  26. ncbi Action of Al-ATP on the isolated working rat heart
    O Korchazhkina
    Birchall Centre for Inorganic Chemistry and Materials Science, Department of Chemistry, Keele University, Staffordshire, UK
    J Inorg Biochem 69:153-8. 1998
    ..We have demonstrated for the first time an influence of Al-ATP on heart function. Perhaps more pertinently we present the first evidence that Al-ATP may influence the function of ATP-specific receptors...
  27. ncbi Promotion of formation of amyloid fibrils by aluminium adenosine triphosphate (AlATP)
    C Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, School of Chemistry and Physics, Keele University, Staffordshire, UK
    J Inorg Biochem 84:215-24. 2001
    ..However, it was blocked by suramin, a P2 ATP receptor antagonist, and this has prompted us to speculate that the precursor proteins to beta amyloid and amylin may be substrates or receptors for ATP in vivo...
  28. ncbi Redox cycling of iron by Abeta42
    Ayesha Khan
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
    Free Radic Biol Med 40:557-69. 2006
    ....
  29. ncbi Measurement by reversed-phase high-performance liquid chromatography of malondialdehyde in normal human urine following derivatisation with 2,4-dinitrophenylhydrazine
    Olga Korchazhkina
    Centre for Science and Technology in Medicine, University of Keele, Hartshill, ST4 7QB, Stoke on Trent, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 794:353-62. 2003
    ..181+/-0.063 microM/mmol creatinine. We demonstrate that the commonly used TBA assay in conjunction with HPLC may overestimate the MDA concentration in human urine by almost 10-fold...
  30. ncbi The pro-oxidant activity of aluminum
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, UK
    Free Radic Biol Med 36:380-7. 2004
    ..Biol. Med. 13: 79-81; 1992). This thesis has been examined herein and it is concluded that much, if not all, of the pro-oxidant activity of aluminum might be explained by the formation of an aluminum superoxide semireduced radical ion...
  31. ncbi Aluminium-containing DTP vaccines
    Christopher Exley
    Keele University, Staffordshire, UK
    Lancet Infect Dis 4:324; discussion 325. 2004
  32. ncbi Silicic acid (Si(OH)(4)) is a significant influence upon the atomic absorption signal of aluminium measured by graphite furnace atomic absorption spectrometry (GFAAS)
    C Schneider
    Birchall Centre for Inorganic Chemistry and Materials Science, School of Chemistry and Physics, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 87:45-50. 2001
    ....
  33. ncbi Direct and indirect identification of the formation of hydroxyaluminosilicates in acidic solutions
    F J Doucet
    Birchall Centre for Inorganic Chemistry and Materials Science, School of Chemistry and Physics, Keele University, Keele, Staffordshire ST5 5BG, UK
    J Inorg Biochem 87:71-9. 2001
    ..This information is essential to our understanding of the biological availability and hence toxicity of Al in biota, including man...
  34. pmc Copper abolishes the beta-sheet secondary structure of preformed amyloid fibrils of amyloid-beta(42)
    Emily House
    The Birchall Centre, Lennard Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
    J Alzheimers Dis 18:811-7. 2009
    ..Copper may protect against the presence of beta-sheets of Abeta(42) in vivo, and its binding by fibrillar Abeta(42) could have implications for Alzheimer's disease therapy...
  35. ncbi The degradation of Abeta(25-35) by the serine protease plasmin is inhibited by aluminium
    Olga V Korchazhkina
    Centre for Science and Technology in Medicine, Keele University, Staffordshire, UK
    J Alzheimers Dis 4:357-67. 2002
    ..The activity of plasmin was halved by pre-mixing it with aluminium (Al) prior to its addition to the peptide. An interaction between Al and proteases involved in the catabolism of Abeta might define the putative link between Al and AD...
  36. ncbi A molecular mechanism of aluminium-induced Alzheimer's disease?
    C Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Department of Chemistry, Keele University, Staffordshire, UK
    J Inorg Biochem 76:133-40. 1999
    ..This mechanism involves the potentiation of the activities of neurotransmitters by the action of Al-ATP at adenosine 5'-triphosphate (ATP) receptors in the brain...
  37. ncbi Aluminum toxicokinetics
    C Exley
    Department of Chemistry, Keele University, Staffordshire, United Kingdom
    J Toxicol Environ Health 48:569-84. 1996
    ..Our hope in highlighting these unresolved issues (summarized in Table 1) is that they will be addressed in future research...
  38. ncbi The precipitation of mucin by aluminium
    C Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Department of Chemistry, Keele University, Staffordshire, UK
    J Inorg Biochem 70:195-206. 1998
    ..Considering the ubiquitous nature of mucin and the degree to which it is conserved within biota the interactions of Al with mucin may have wide ranging implications for biological systems...
  39. ncbi Does antiperspirant use increase the risk of aluminium-related disease, including Alzheimer's disease?
    C Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Dept of Chemistry, Keele University, Staffordshire, UK
    Mol Med Today 4:107-9. 1998
    ..But can the frequent use of aluminium-based antiperspirants lead to the accumulation of toxic levels of aluminium? And are there measures that we can take to reduce such accumulation without reducing the effectiveness of antiperspirants?..
  40. ncbi The aluminium-amyloid cascade hypothesis and Alzheimer's disease
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire, UK
    Subcell Biochem 38:225-34. 2005
    ..Whether AD is also part of this ongoing selection process remains to be elucidated..
  41. ncbi Copper(II) inhibits the formation of amylin amyloid in vitro
    Benjamin Ward
    School of Medicine, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 102:371-5. 2008
    ..If amylin amyloid is cytotoxic to beta-cells then Cu(II) should protect against the degeneration of the islets in type-2 diabetes mellitus...
  42. ncbi Aluminium: a natural adjuvant in Leishmania transmission via sand flies?
    Rhayza Maingon
    Centre for Applied Entomology and Parasitology Research Institute for Science and Technology in Medicine, Keele University, Staffordshire, UK
    Trans R Soc Trop Med Hyg 102:1140-2. 2008
    ..Aluminium may be acting as a natural adjuvant in some forms of leishmaniasis...
  43. ncbi A systems biology approach to the blood-aluminium problem: the application and testing of a computational model
    James Beardmore
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 101:1187-91. 2007
    ..To use this approach to begin to solve the blood-aluminium problem we shall need to increase the complexity of the model to better reflect the heterogeneity of a biological system such as the blood...
  44. ncbi Does either the gastrointestinal peptide PYY or the neuropeptide NPY bind aluminium?
    Olga V Korchazhkina
    Centre for Science and Technology in Medicine, Keele University, Staffordshire, UK
    J Inorg Biochem 94:372-80. 2003
    ..We were unable to demonstrate any direct interaction between either peptide and aluminium although we have speculated upon an in vivo mechanism whereby PYY, in particular, might form a stable complex with aluminium...
  45. doi Towards a model of non-equilibrium binding of metal ions in biological systems
    James Beardmore
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire, UK
    J Inorg Biochem 103:205-9. 2009
    ..Generically the model highlighted the significance of kinetic in addition to thermodynamic constraints in defining the fate of metal ions in biological systems...
  46. ncbi Metals accelerate the formation and direct the structure of amyloid fibrils of NAC
    Ayesha Khan
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 99:1920-7. 2005
    ..These spirals of twisted fibrils were especially abundant in the presence of added Al(III) and it is speculated that NAC binding of Al(III) may be important in their formation and subsequent stability...
  47. ncbi Aluminum in antiperspirants: more than just skin deep
    Christopher Exley
    Am J Med 117:969-70. 2004
  48. ncbi Aluminum: a potential pro-oxidant in sunscreens/sunblocks?
    Scott Nicholson
    Free Radic Biol Med 43:1216-7. 2007
  49. ncbi Aluminium, tau and Alzheimer's disease
    Christopher Exley
    J Alzheimers Dis 12:313-5; author reply 317-8. 2007
  50. ncbi Comment on "the biological behaviour and bioavailability of aluminium in man" by N. D. Priest, JEM, 2004, 6, 375
    Christopher Exley
    J Environ Monit 7:640; author reply 641-2. 2005
  51. ncbi Aluminium-adsorbed vaccines
    Christopher Exley
    Lancet Infect Dis 6:189. 2006
  52. ncbi Aluminium-induced phospholipid signal transduction pathway in Coffea arabica suspension cells and its amelioration by silicic acid
    Fausto Quintal-Tun
    Unidad de Bioquímica y Biología Molecular de Plantas, Centro de Investigación Científica de Yucatán, Calle 43, No 130, Chuburná de Hidalgo, C P 97200 Mérida, Yucatan, Mexico
    J Inorg Biochem 101:362-9. 2007
    ..These results suggest that Al is capable to exert its effects upon signal transduction as Al((aq))(3+) acting upon a mechanism linked to the phosphoinositide signal transduction pathway...