Research Topics
| J DobsonSummaryAffiliation: Keele University Country: UK Publications
Research Grants
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Detail Information
Publications
Gene therapy progress and prospects: magnetic nanoparticle-based gene deliveryJ Dobson
Institute for Science and Technology in Medicine, Keele University, Hartshill, Stoke on Trent, UK
Gene Ther 13:283-7. 2006..The advantages and difficulties associated with magnetic nanoparticle-based transfection will be discussed as will the underlying physical principles, recent studies and potential future applications...- Magnetic micro- and nano-particle-based targeting for drug and gene deliveryJon Dobson
Keele University, Institute for Science and Technology in Medicine, Hartshill, Stoke on Trent, UK
Nanomedicine (Lond) 1:31-7. 2006.... 
Remote control of cellular behaviour with magnetic nanoparticlesJon Dobson
Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Harsthill, Stoke on Trent, UK
Nat Nanotechnol 3:139-43. 2008..In particular, we focus on applications in tissue engineering and regenerative medicine...
Safety implications of high-field MRI: actuation of endogenous magnetic iron oxides in the human bodyJon Dobson
Institute for Science and Technology in Medicine, Keele University, Hartshill, Stoke on Trent, United Kingdom
PLoS ONE 4:e5431. 2009..PRINCIPAL FINDING AND CONCLUSIONS: Results show that, even at 9.4 Tesla, forces on these particles are unlikely to disrupt normal cellular function via nanomagnetic actuation...- Magnetic targeting of mechanosensors in bone cells for tissue engineering applicationsSteven Hughes
Institute of Science and Technology in Medicine, Keele University Medical School, Hartshill Campus, Thornburrow Drive, Hartshill, Stoke on Trent ST4 7QB, UK
J Biomech 40:S96-104. 2007..Magnetic particle technology presents a potentially valuable tool for tissue engineering which permits the delivery of highly localised mechano-inductive forces directly to cells... - On the structural form of iron in ferritin cores associated with progressive supranuclear palsy and Alzheimer's diseaseJ Dobson
Centre for Science and Technology in Medicine, Department of Biomedical Engineering and Medical Physics, Keele University, Hartshill, Stoke on Trent, UK
Cell Mol Biol (Noisy-le-grand) 47:OL49-50. 2001..This is a highly important result as magnetic and electron microscopy analysis has demonstrated the presence of magnetite (Fe3O4) and maghemite (gammaFe2O3) in human brain tissue... - Development of magnetic particle techniques for long-term culture of bone cells with intermittent mechanical activationSarah H Cartmell
Centre for Science and Technology in Medicine, University of Keele, Thornburrow Drive, Hartshill, ST4 70B Stoke on Trent, UK
IEEE Trans Nanobioscience 1:92-7. 2002..Also, mechanical stimulation of human osteoblasts by magnetic particle technology appears to have an influence on osteoblastic activity... - Toxicological aspects and applications of nanoparticles in paediatric respiratory diseaseJon Dobson
Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke on Trent, UK
Paediatr Respir Rev 8:62-6. 2007..Some of these applications, along with recent studies on the toxic effects of nanoparticulate emissions will be reviewed in this article... - Magnetic micro- and nanoparticle mediated activation of mechanosensitive ion channelsSteven Hughes
Institute of Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB, UK
Med Eng Phys 27:754-62. 2005..In this review, we will focus on novel techniques, which use magnetic micro- and nanoparticles coupled to external applied magnetic fields for activating and investigating MS ion channels and cytoskeletal mechanics... - Principles and design of a novel magnetic force mechanical conditioning bioreactor for tissue engineering, stem cell conditioning, and dynamic in vitro screeningJon Dobson
Institute of Science and Technology in Medicine, Keele University, Stoke on Trent ST4 7QB, UK
IEEE Trans Nanobioscience 5:173-7. 2006.... - Investigation of age-related variations in biogenic magnetite levels in the human hippocampusJon Dobson
Centre for Science and Technology in Medicine, Department of Biomedical Engineering and Medical Physics, Keele University, Thornburrow Drive, Hartshill, Stoke on Trent ST4 7QB, UK
Exp Brain Res 144:122-6. 2002..This trend is not seen in females and may have implications for iron metabolism and neurological disorders associated with disruptions in normal iron homeostasis... - Magnetic iron compounds in neurological disordersJon Dobson
Centre for Science and Technology in Medicine, Keele University, Hartshill, Stoke on Trent, United Kingdom
Ann N Y Acad Sci 1012:183-92. 2004..This paper reviews recent work on the identification and analysis of magnetic iron compounds associated with neurological disorders... - Surface activation and targeting strategies of superparamagnetic iron oxide nanoparticles in cancer-oriented diagnosis and therapyMeng Meng Lin
Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke on Trent, UK
Nanomedicine (Lond) 5:109-33. 2010.... - Nanoscale biogenic iron oxides and neurodegenerative diseaseJ Dobson
Centre for Science and Technology in Medicine, Department of Biomedical Engineering and Medical Physics, Keele University, Thornburrow Drive, Hartshill, Stroke on Trent ST4 7QB, UK
FEBS Lett 496:1-5. 2001..In addition, the presence of biogenic magnetite in affected tissue should also provide improved mechanisms for early detection through the modification of MRI pulse sequences... - Magnetic nanoparticles for gene and drug deliveryStuart C McBain
Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Harsthill, Stoke on Trent, UK
Int J Nanomedicine 3:169-80. 2008..Here we review advances in magnetic nanoparticle design, in vitro and animal experiments with magnetic nanoparticle-based drug and gene delivery, and clinical trials of drug targeting... - Preparation and characterization of iron oxide-silica composite particles using mesoporous SBA-15 silica as template and their internalization into mesenchymal stem cell and human bone cell linesHumphrey H P Yiu
Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, ST4 7QB, UK
IEEE Trans Nanobioscience 9:165-70. 2010..Internalization of these particles into human cell lines (mesenchymal stem cells and human bone cells), which indicates their potential in medicine and biotechnology, is also discussed... - Biogenic magnetite in the nematode caenorhabditis elegansCharles G Cranfield
Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent ST4 7QB, UK
Proc Biol Sci 271:S436-9. 2004..elegans. Its presence may have confounding effects on experiments involving electromagnetic fields as well as implications for the use of this nematode as a model system for iron biomineralization in multi-cellular organisms... - Analysis of EEG data from weak-field magnetic stimulation of mesial temporal lobe epilepsy patientsJ Dobson
Centre for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, ST4 7QB, Stoke on Trent, UK
Brain Res 868:386-91. 2000..Similar results also have been observed in the analysis of both human and rat brains by employing weak, alternating magnetic field stimulation. Further study is necessary in order to optimize the magnetic field exposure protocol... - In situ characterization and mapping of iron compounds in Alzheimer's disease tissueJ F Collingwood
Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB United Kingdom
J Alzheimers Dis 7:267-72. 2005..These results demonstrate a practical means of correlating iron compounds and disease pathology in-situ and have clear implications for disease pathogenesis and potential therapies... - Development of superparamagnetic iron oxide nanoparticles (SPIONS) for translation to clinical applicationsMeng Meng Lin
Institute for Science and Technology in Medicine, Keele University, ST4 7QB, UK
IEEE Trans Nanobioscience 7:298-305. 2008..In this review article, synthetic routes, surface modification and functionaliztion of SPIONs, as well as the major biomedical applications are summarized, with emphasis on in vivo applications... - Selective activation of mechanosensitive ion channels using magnetic particlesSteven Hughes
Institute of Science and Technology in Medicine, Keele University School of Medicine, Stoke on Trent, Staffordshire ST4 7QB, UK
J R Soc Interface 5:855-63. 2008.... - Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patientsDimitri Hautot
Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, and Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
Biochim Biophys Acta 1772:21-5. 2007..The mutated ferritin protein appears to be responsible for the presence of iron oxide nano-particules, which in turn could be responsible for extensive damage in the brain... - Mapping and characterization of iron compounds in Alzheimer's tissueJoanna Collingwood
Institute of Science and Technology in Medicine, Keele University, Staffordshire, ST4 7QB, UK
J Alzheimers Dis 10:215-22. 2006.... - Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core materialJoanna F Collingwood
Institute of Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke on Trent, UK
J Alzheimers Dis 14:235-45. 2008..The size distribution of the magnetite cores implies formation from a ferritin precursor, implicating a malfunction of the primary iron storage protein in the brain... - The influence of static magnetic fields on mechanosensitive ion channel activity in artificial liposomesSteven Hughes
Medical Research Unit, Institute of Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke on Trent, Staffordshire, ST4 7QB, UK
Eur Biophys J 34:461-8. 2005.... - Improved method of recombinant AAV2 delivery for systemic targeted gene therapyCathryn Mah
Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
Mol Ther 6:106-12. 2002..These studies demonstrate a novel method to deliver rAAV vectors more effectively that could prove to be a successful alternative mode of virus-mediated human gene therapy... - Magnetic iron compounds in the human brain: a comparison of tumour and hippocampal tissueFranziska Brem
Institute of Geophysics, , 8093 Zurich, Switzerland
J R Soc Interface 3:833-41. 2006..These findings suggest that brain tumour tissue contains an elevated amount of remanent iron oxide phases... - Characterization of iron compounds in tumour tissue from temporal lobe epilepsy patients using low temperature magnetic methodsFranziska Brem
ETH Honggerberg, Institute of Geophysics, CH 8093 Zurich, Switzerland
Biometals 18:191-7. 2005..Our results demonstrate that low temperature magnetic measurements provide a useful and sensitive tool for the characterisation of magnetic iron compounds in human tissue... - A potential iron-based mechanism for enhanced deposition of amyloid plaques due to cognitive stimulation in Alzheimer diseaseJon Dobson
J Neuropathol Exp Neurol 63:674-5. 2004 - Looking for biogenic magnetite in brain ferritin using NMR relaxometryYves Gossuin
Biological Physics Department, University of Mons Hainaut, Mons, Belgium
NMR Biomed 18:469-72. 2005..Consequently, the magnetization of this 'magnetite-like' phase must be very low compared with that of magnetite... - Preliminary evaluation of nanoscale biogenic magnetite-based ferromagnetic transduction mechanisms for mobile phone bioeffectsCharles Cranfield
Centre for Science and Technology in Medicine, University of Keele, Stoke-on-Trent, ST4 7QB UK
IEEE Trans Nanobioscience 2:40-3. 2003..037). Though there appears to be a repeatable trend toward higher cell mortality in magnetite-producing bacteria exposed to mobile phone emissions, it is not yet clear that this would extrapolate to a deleterious health effect in humans... - Iron: the Redox-active center of oxidative stress in Alzheimer diseaseRudy J Castellani
Department of Pathology, University of Maryland, Baltimore, MD, USA
Neurochem Res 32:1640-5. 2007..In this review, we discuss the role of iron in the progression of AD... - Increased levels of magnetic iron compounds in Alzheimer's diseaseQuentin Pankhurst
London Centre for Nanotechnology and Department of Physics and Astronomy, University College London, London, UK
J Alzheimers Dis 13:49-52. 2008..These results provide insights which may guide current efforts to develop iron-based MRI diagnosis of AD... - Experimental evaluation of the magnetic properties of commercially available magnetic microspheresJoan Connolly
Department of Physics, University of Western Australia, Nedlands, WA 6009, Australia
Biomed Mater Eng 15:421-31. 2005..There is a significant paramagnetic component in the superparamagnetic microspheres. This is also present to a lesser extent in a nanoparticle suspension...
Research Grants
- NANOSCALE IRON PHASES IN NEURODEGENERATIVE DISEASESJon Dobson; Fiscal Year: 2005..The Pl's combination of skills and experience related to the research proposed here is unique and unavailable in the US. ..