T Hugh Jones

Summary

Country: UK

Publications

  1. ncbi request reprint Testosterone deficiency: a risk factor for cardiovascular disease?
    T H Jones
    Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK
    Trends Endocrinol Metab 21:496-503. 2010
  2. pmc Testosterone for the aging male; current evidence and recommended practice
    Roger D Stanworth
    Centre of Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, South Yorkshire, United Kingdom
    Clin Interv Aging 3:25-44. 2008
  3. pmc Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study)
    T Hugh Jones
    The Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital, Barnsley, UK
    Diabetes Care 34:828-37. 2011
  4. doi request reprint Effects of testosterone on Type 2 diabetes and components of the metabolic syndrome
    T Hugh Jones
    Academic Unit of Diabetes, Endocrinology and Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    J Diabetes 2:146-56. 2010
  5. doi request reprint 'What should I do with a 60-year old man with a slightly low serum total testosterone concentration and normal levels of serum gonadotrophins'?
    T Hugh Jones
    Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital, Barnsley and Academic Unit of Diabetes, Endocrinology and Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Clin Endocrinol (Oxf) 72:584-8. 2010
  6. doi request reprint Testosterone in obesity, metabolic syndrome and type 2 diabetes
    Roger D Stanworth
    Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, and Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield Medical School, Sheffield, UK
    Front Horm Res 37:74-90. 2009
  7. ncbi request reprint The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process
    T Hugh Jones
    Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, UK
    Atherosclerosis 207:318-27. 2009
  8. ncbi request reprint Physiologic testosterone therapy has no effect on serum levels of tumour necrosis factor-alpha in men with chronic heart failure
    Peter J Pugh
    Teaching Hospitals NHS Trust, and Hormone and Vascular Biology Group, Academic Unit of Endocrinology, Division of Genomic Medicine, The University of Sheffield, Sheffield, United Kingdom
    Endocr Res 31:271-83. 2005
  9. ncbi request reprint Rosiglitazone increases bioactive testosterone and reduces waist circumference in hypogonadal men with type 2 diabetes
    Dheeraj Kapoor
    The Robert Hague Centre for Diabetes and Endocrinology, Barnsley NHS Foundation Trust Hospital, Gawber Road, Barnsley, S75 2EP, UK
    Diab Vasc Dis Res 5:135-7. 2008
  10. ncbi request reprint Physiological testosterone replacement therapy attenuates fatty streak formation and improves high-density lipoprotein cholesterol in the Tfm mouse: an effect that is independent of the classic androgen receptor
    Joanne E Nettleship
    Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, UK
    Circulation 116:2427-34. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Testosterone deficiency: a risk factor for cardiovascular disease?
    T H Jones
    Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK
    Trends Endocrinol Metab 21:496-503. 2010
    ..This manuscript reviews the current evidence supporting a link between low testosterone and cardiovascular disease, highlighting the need for larger, longer-term studies...
  2. pmc Testosterone for the aging male; current evidence and recommended practice
    Roger D Stanworth
    Centre of Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, South Yorkshire, United Kingdom
    Clin Interv Aging 3:25-44. 2008
    ..The options available for treatment have increased in recent years with the availability of a number of testosterone preparations which can reliably produce physiological serum concentrations...
  3. pmc Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study)
    T Hugh Jones
    The Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital, Barnsley, UK
    Diabetes Care 34:828-37. 2011
    ..This study evaluated the effects of testosterone replacement therapy (TRT) on insulin resistance, cardiovascular risk factors, and symptoms in hypogonadal men with type 2 diabetes and/or metabolic syndrome (MetS)...
  4. doi request reprint Effects of testosterone on Type 2 diabetes and components of the metabolic syndrome
    T Hugh Jones
    Academic Unit of Diabetes, Endocrinology and Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    J Diabetes 2:146-56. 2010
    ....
  5. doi request reprint 'What should I do with a 60-year old man with a slightly low serum total testosterone concentration and normal levels of serum gonadotrophins'?
    T Hugh Jones
    Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital, Barnsley and Academic Unit of Diabetes, Endocrinology and Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Clin Endocrinol (Oxf) 72:584-8. 2010
    ..The diagnosis of hypogonadism associated with borderline testosterone levels and the decision to treat should only be made by an experienced clinician...
  6. doi request reprint Testosterone in obesity, metabolic syndrome and type 2 diabetes
    Roger D Stanworth
    Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, and Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield Medical School, Sheffield, UK
    Front Horm Res 37:74-90. 2009
    ..Testosterone replacement therapy should be considered for those men with subsequently confirmed hypogonadism...
  7. ncbi request reprint The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process
    T Hugh Jones
    Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, UK
    Atherosclerosis 207:318-27. 2009
    ....
  8. ncbi request reprint Physiologic testosterone therapy has no effect on serum levels of tumour necrosis factor-alpha in men with chronic heart failure
    Peter J Pugh
    Teaching Hospitals NHS Trust, and Hormone and Vascular Biology Group, Academic Unit of Endocrinology, Division of Genomic Medicine, The University of Sheffield, Sheffield, United Kingdom
    Endocr Res 31:271-83. 2005
    ..The clinically beneficial actions of testosterone in men with CHF are unlikely to be mediated by reducing TNF-alpha...
  9. ncbi request reprint Rosiglitazone increases bioactive testosterone and reduces waist circumference in hypogonadal men with type 2 diabetes
    Dheeraj Kapoor
    The Robert Hague Centre for Diabetes and Endocrinology, Barnsley NHS Foundation Trust Hospital, Gawber Road, Barnsley, S75 2EP, UK
    Diab Vasc Dis Res 5:135-7. 2008
    ..In conclusion, the insulin-sensitiser rosiglitazone increases bioavailable, free and total testosterone and SHBG levels in hypogonadal men with type 2 diabetes...
  10. ncbi request reprint Physiological testosterone replacement therapy attenuates fatty streak formation and improves high-density lipoprotein cholesterol in the Tfm mouse: an effect that is independent of the classic androgen receptor
    Joanne E Nettleship
    Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, UK
    Circulation 116:2427-34. 2007
    ..We used the Tfm mouse to determine whether testosterone modulates atheroma formation via its classic signaling pathway involving the nuclear androgen receptor, conversion to 17beta-estradiol, or an alternative signaling pathway...
  11. ncbi request reprint The effect of testosterone on insulin sensitivity in men with heart failure
    Chris J Malkin
    Department of Cardiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, S10 2JF, United Kingdom
    Eur J Heart Fail 9:44-50. 2007
    ..8+/-0.3%, p=0.02). Testosterone improves fasting insulin sensitivity in men with CHF and may also increase lean body mass, these data suggest a favourable effect of testosterone on an important metabolic component of CHF...
  12. doi request reprint Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes
    Vakkat Muraleedharan
    Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHSFT, Gawber Road, Barnsley S75 2EP, UK
    Eur J Endocrinol 169:725-33. 2013
    ..We report a 6-year follow-up study to examine the effect of baseline testosterone and TRT on all-cause mortality in men with type 2 diabetes and low testosterone...
  13. pmc Statin therapy is associated with lower total but not bioavailable or free testosterone in men with type 2 diabetes
    Roger D Stanworth
    Department of Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK
    Diabetes Care 32:541-6. 2009
    ..We compared testosterone levels and hypogonadal symptoms with statin use in a cross-sectional study of 355 men with type 2 diabetes...
  14. doi request reprint Testosterone and coronary artery disease
    Joanne E Nettleship
    Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, UK
    Front Horm Res 37:91-107. 2009
    ..Consequently, increasing evidence suggests that the process of atherosclerosis is beneficially modulated by testosterone. These studies are the focus of this chapter...
  15. ncbi request reprint Androgen deficiency as a predictor of metabolic syndrome in aging men: an opportunity for intervention?
    Dheeraj Kapoor
    Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK
    Drugs Aging 25:357-69. 2008
    ..This review discusses the role that testosterone may play in the pathogenesis of metabolic syndrome in men and also examines the potential role of testosterone replacement therapy in this condition...
  16. ncbi request reprint Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity
    Dheeraj Kapoor
    The Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK
    Diabetes Care 30:911-7. 2007
    ..The aim of our study was to assess the prevalence of clinical hypogonadism, based on both symptoms and biochemical available measures of testosterone deficiency, in men with type 2 diabetes...
  17. ncbi request reprint Mechanisms of agonist-induced constriction in isolated human mesenteric arteries
    Joanne Hall
    Hormone and Vascular Biology Group, Academic Unit of Endocrinology, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Vascul Pharmacol 44:427-33. 2006
    ....
  18. ncbi request reprint Intrinsic responses of rat coronary arteries in vitro: influence of testosterone, calcium, and effective transmural pressure
    Peter J Pugh
    Department of Cardiology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Endocrine 19:155-61. 2002
    ..Furthermore, addition of testosterone reduces intrinsic coronary artery tone. These findings may have important implications for men with angina and low plasma testosterone levels...
  19. pmc The vasodilatory action of testosterone: a potassium-channel opening or a calcium antagonistic action?
    Richard D Jones
    Endocrine Heart and Pituitary Group, Academic Unit of Endocrinology, Division of Genomic Medicine, The University of Sheffield, Sheffield, S10 2RX, UK
    Br J Pharmacol 138:733-44. 2003
  20. pmc Characterization of the vasodilatory action of testosterone in the human pulmonary circulation
    Alyson M Smith
    Academic Unit of Diabetes, Endocrinology and Metabolism, The University of Sheffield, Sheffield, UK
    Vasc Health Risk Manag 4:1459-66. 2008
    ..In addition, a secondary aim was to determine whether there was any difference in the response to testosterone dependent upon gender...
  21. doi request reprint Low serum testosterone and increased mortality in men with coronary heart disease
    Chris J Malkin
    Department of Cardiology, Royal Hallamshire Hospital, Sheffield, UK
    Heart 96:1821-5. 2010
    ..To examine the effect of serum testosterone levels on survival in a consecutive series of men with confirmed coronary disease and calculate the prevalence of testosterone deficiency...
  22. doi request reprint Testosterone and heart failure
    Chris J Malkin
    Department of Cardiology Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
    Curr Opin Endocrinol Diabetes Obes 17:262-8. 2010
    ..Anabolic deficiency is a major component of the CHF syndrome and testosterone replacement therapy has been subject to recent trials...
  23. ncbi request reprint Acute haemodynamic effects of testosterone in men with chronic heart failure
    Peter J Pugh
    Department of Cardiology, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK
    Eur Heart J 24:909-15. 2003
    ..The aim of this study was to determine the acute haemodynamic effects of testosterone administration in men with heart failure...
  24. doi request reprint Testosterone and insulin resistance in the metabolic syndrome and T2DM in men
    Preethi M Rao
    Academic Unit of Diabetes, Endocrinology and Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, UK
    Nat Rev Endocrinol 9:479-93. 2013
    ..Testosterone is also involved in lipid homeostasis in major insulin-responsive target tissues, such as liver, adipose tissue and skeletal muscle. ..
  25. ncbi request reprint Testosterone and cardiovascular risk in men
    Daniel M Kelly
    Department of Human Metabolism, Medical School, The University of Sheffield, Sheffield, UK
    Front Horm Res 43:1-20. 2014
    ..Clinical monitoring and titration of testosterone dose is therefore of paramount importance...
  26. ncbi request reprint Altered circulating hormone levels, endothelial function and vascular reactivity in the testicular feminised mouse
    Richard D Jones
    Department of Cardiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Glossop Road, Sheffield, S10 2JF, UK
    Eur J Endocrinol 148:111-20. 2003
    ..The aim of the present study was to determine whether androgen insensitivity and hypotestosteronaemia in the Tfm mouse are associated with abnormal vascular reactivity or hormone status...