Research Topics
Species | I T JohnsonSummaryCountry: UK Publications
| Collaborators
|
Detail Information
Publications
Anticarcinogenic effects of diet-related apoptosis in the colorectal mucosaI T Johnson
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Food Chem Toxicol 40:1171-8. 2002..Further mechanistic and clinical studies are required to establish whether such dietary effects can be exploited to achieve preventive or therapeutic effects in humans...- Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteersE K Lund
Institute of Food Research, Norwich Research Park, Colney, United Kingdom
Am J Clin Nutr 69:250-5. 1999..Most dietary iron remains unabsorbed and hence may be available to participate in Fenton-driven free radical generation in conjunction with the colonic microflora, leading to the production of carcinogens or direct damage to colonocytes... - Polyphenolic compounds: interactions with the gut and implications for human healthJ M Gee
Institute of Food Research, Norwich Laboratory, Norwich Research Park, Colney, NR4 7UA, UK
Curr Med Chem 8:1245-55. 2001..Future research should therefore focus on the biological effects of flavonoids in the human body, using biomarkers to define their effects at each stage in the onset of neoplasia... - Chronic exposure to high levels of dietary iron fortification increases lipid peroxidation in the mucosa of the rat large intestineE K Lund
Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
J Nutr 131:2928-31. 2001..These results may be relevant to epidemiological evidence showing that dietary iron is associated with the risk of proximal colon cancer in humans... - Quercetin glucosides interact with the intestinal glucose transport pathwayJ M Gee
Nutrition Diet and Health Department, Institute of Food Research, Norwich Laboratory, Norfolk, UK
Free Radic Biol Med 25:19-25. 1998..These studies suggest that purified quercetin glucosides are capable of interacting with the sodium dependent glucose transport receptors in the mucosal epithelium and may therefore be absorbed by the small intestine in vivo... 
Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosaN J Belshaw
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Br J Cancer 99:136-42. 2008..Methylation of the genes selected by the models may play a role in the earliest stages of the development of colorectal neoplasia...- New food components and gastrointestinal healthI T Johnson
Institute of Food Research, Norwich, Norfolk, UK
Proc Nutr Soc 60:481-8. 2001.... - Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivoP Latham
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Gut 49:97-105. 2001..The data suggest a mechanism whereby polyunsaturated fatty acids may influence the susceptibility of colorectal crypt cells to induction or progression of neoplasia... 
The procyanidin-mediated induction of apoptosis and cell-cycle arrest in esophageal adenocarcinoma cells is not dependent on p21(Cip1/WAF1)R Pierini
Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK
Cancer Lett 270:234-41. 2008..However, blocking the PA-induced up-regulation of p21 expression with siRNA did not alter PA-mediated changes in apoptosis and cell cycle, demonstrating that p21 is not responsible for the PA-induced effects...- Review article: nutrition, obesity and colorectal cancerI T Johnson
Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
Aliment Pharmacol Ther 26:161-81. 2007..The age-adjusted incidence of colorectal cancer is higher in prosperous industrialized countries than elsewhere. Dietary factors may account for 75% of sporadic colorectal cancer in the west, but the mechanisms remain obscure... - Olive oil supplementation in healthy adults: effects in cell membrane fatty acid composition and platelet functionI M Vicario
Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, UK
Ann Nutr Metab 42:160-9. 1998..None of these changes in fatty acid composition in the different tissues were related to significant changes in serum cholesterol-related variables or in clotting factors or adenosine diphosphate-induced platelet aggregation... - Evidence for consistent patterns between flavonoid structures and cellular activitiesF Depeint
Institute of Food Research, Norwich Research Park, Colney, UK
Proc Nutr Soc 61:97-103. 2002..The present review also presents a summary of mechanistic data on a few elected compounds... - Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitroA P Wilkinson
Nutrition and Consumer Sciences Division, Institute of Food Research, Colney, Norwich NR4 7UA, UK
Xenobiotica 33:255-64. 2003.... - New approaches to the role of diet in the prevention of cancers of the alimentary tractI T Johnson
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Mutat Res 551:9-28. 2004..The future challenge is to fully characterise and evaluate these effects at the cellular and molecular level, so at to exploit their full potential as protective mechanisms for the population as a whole... - Methylation of the ESR1 CpG island in the colorectal mucosa is an 'all or nothing' process in healthy human colon, and is accelerated by dietary folate supplementation in the mouseN J Belshaw
Institute of Food Research, Colney Lane, Norwich NR4 7UA, UK
Biochem Soc Trans 33:709-11. 2005..Preliminary studies with a rodent model suggest the rate of age-dependent methylation of ESR1 is modifiable by dietary folate... - Systematic review: the chemoprevention of oesophageal adenocarcinomaS Mehta
Department of Upper Gastrointestinal Surgery, Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
Aliment Pharmacol Ther 22:759-68. 2005..Dietary agents, however, have a more favourable side-effect profile and may prove to be an attractive alternative, although more work is needed to fully explore this prospect...