Genomes and Genes
Affiliation: John Radcliffe Hospital
- Adipogenesis and WNT signallingConstantinos Christodoulides
Institute of Metabolic Science, MRC Centre for Obesity and Associated Diseases, Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK
Trends Endocrinol Metab 20:16-24. 2009..Manipulating the WNT pathway to alter adipose cellular makeup, therefore, constitutes an attractive drug-development target to combat obesity-associated metabolic complications...
- PPARs and adipocyte functionConstantinos Christodoulides
Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
Mol Cell Endocrinol 318:61-8. 2010..In this review we discuss the characteristics of PPARs and the role of the different isotypes in adipocyte biology...
- Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling networkClaire Lagathu
Institute of Metabolic Science Metabolic Research Laboratories and Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Diabetes 58:609-19. 2009..Here, we identify the Wnt modulator Dapper1/Frodo1 (Dact1) as a new preadipocyte gene involved in the regulation of murine and human adipogenesis...
- ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesisJustin J Rochford
Department of Clinical Biochemistry, University of Cambridge, Box 232, Level 4, Addenbrooke s Hospital, Hills Rd, Cambridge CB2 2QR, United Kingdom
Mol Cell Biol 24:9863-72. 2004..These findings define, for the first time, a molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta and a novel regulator of early adipogenesis...
- The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesisConstantinos Christodoulides
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QR, UK
J Cell Sci 119:2613-20. 2006..Given the public health importance of disorders of adipose mass, further knowledge of the pathways involved specifically in human adipocyte differentiation might ultimately be of clinical relevance...
- Serum levels of retinol-binding protein 4 and adiponectin in women with polycystic ovary syndrome: associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this conditionThomas M Barber
Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
J Clin Endocrinol Metab 93:2859-65. 2008..Insulin resistance, which associates with levels of retinol-binding protein 4 (RBP4) and adiponectin, is implicated in the development of polycystic ovary syndrome (PCOS)...
- Current treatment protocols can offer a normal or near-normal quality of life in the majority of patients with non-functioning pituitary adenomasCristina Capatina
Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
Clin Endocrinol (Oxf) 78:86-93. 2013..In view of the discordant findings and the advances in the management of these subjects, we aimed to evaluate the QoL in patients with NFA followed up in a tertiary endocrine UK referral centre...
- Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesisMatthias Laudes
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, United Kingdom
J Biol Chem 279:11711-8. 2004....
- Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in manConstantinos Christodoulides
Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom
J Clin Endocrinol Metab 94:3594-601. 2009..FGF21 is also a PPAR gamma target gene in mouse adipose tissue. Little information is available on FGF21 functions in humans...