Joseph N Jarvis

Summary

Country: UK

Publications

  1. pmc The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis
    Joseph N Jarvis
    Research Centre for Infection and Immunity, Division of Clinical Sciences, St George s University of London
    J Infect Dis 207:1817-28. 2013
  2. pmc Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes
    Joseph N Jarvis
    Research Centre for Infection and Immunity, Division of Clinical Sciences, St George s University of London, United Kingdom
    Clin Infect Dis 58:736-45. 2014
  3. pmc Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa
    Joseph N Jarvis
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 8:e69288. 2013
  4. doi request reprint Clinical aspects of visceral leishmaniasis in HIV infection
    Joseph N Jarvis
    The Hospital for Tropical Diseases, University College Hospital, London, UK
    Curr Opin Infect Dis 26:1-9. 2013
  5. pmc Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial
    Joseph N Jarvis
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    AIDS 26:1105-13. 2012
  6. pmc Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    BMC Infect Dis 10:67. 2010
  7. doi request reprint Pulmonary cryptococcosis misdiagnosed as smear-negative pulmonary tuberculosis with fatal consequences
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    Int J Infect Dis 14:e310-2. 2010
  8. pmc Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South Africa
    Joseph N Jarvis
    Department of Medicine, Division of Infectious Diseases, Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 48:856-62. 2009
  9. pmc Symptomatic relapse of HIV-associated cryptococcal meningitis in South Africa: the role of inadequate secondary prophylaxis
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    S Afr Med J 100:378-82. 2010
  10. doi request reprint Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis
    Angela Loyse
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    Clin Infect Dis 54:121-8. 2012

Detail Information

Publications18

  1. pmc The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis
    Joseph N Jarvis
    Research Centre for Infection and Immunity, Division of Clinical Sciences, St George s University of London
    J Infect Dis 207:1817-28. 2013
    ..A clearer understanding of these immune responses is essential to inform rational development of immunotherapies...
  2. pmc Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes
    Joseph N Jarvis
    Research Centre for Infection and Immunity, Division of Clinical Sciences, St George s University of London, United Kingdom
    Clin Infect Dis 58:736-45. 2014
    ..Cryptococcal meningitis (CM) is a leading cause of death in individuals infected with human immunodeficiency virus (HIV). Identifying factors associated with mortality informs strategies to improve outcomes...
  3. pmc Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa
    Joseph N Jarvis
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 8:e69288. 2013
    ..Prior to programmatic implementation in South Africa we performed a cost-effectiveness analysis of alternative preventive strategies for CM...
  4. doi request reprint Clinical aspects of visceral leishmaniasis in HIV infection
    Joseph N Jarvis
    The Hospital for Tropical Diseases, University College Hospital, London, UK
    Curr Opin Infect Dis 26:1-9. 2013
    ..This review summarizes recent work describing the epidemiology, presentation and outcomes of HIV-associated visceral leishmaniasis and discusses advances in diagnosis and management...
  5. pmc Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial
    Joseph N Jarvis
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    AIDS 26:1105-13. 2012
    ..We performed a randomized controlled trial to determine whether addition of IFNγ to standard therapy increased the rate of clearance of cryptococcal infection in HIV-associated cryptococcal meningitis...
  6. pmc Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    BMC Infect Dis 10:67. 2010
    ..We performed a retrospective study to determine these findings in a setting of high HIV and TB prevalence in Cape Town...
  7. doi request reprint Pulmonary cryptococcosis misdiagnosed as smear-negative pulmonary tuberculosis with fatal consequences
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    Int J Infect Dis 14:e310-2. 2010
    ..Serum cryptococcal antigen testing may facilitate diagnosis in such cases...
  8. pmc Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South Africa
    Joseph N Jarvis
    Department of Medicine, Division of Infectious Diseases, Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Clin Infect Dis 48:856-62. 2009
    ..Screening for cryptococcal antigen in patients who enroll in ART programs may identify those at risk of cryptococcal meningitis and permit targeted use of preemptive therapy...
  9. pmc Symptomatic relapse of HIV-associated cryptococcal meningitis in South Africa: the role of inadequate secondary prophylaxis
    Joseph N Jarvis
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    S Afr Med J 100:378-82. 2010
    ..We carried out a study to examine the contribution of inadequate secondary fluconazole prophylaxis to symptomatic relapses of cryptococcal meningitis...
  10. doi request reprint Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis
    Angela Loyse
    Infectious Diseases Unit, GF Jooste Hospital, Cape Town, South Africa
    Clin Infect Dis 54:121-8. 2012
    ..Alternative, more widely available, and/or more effective antifungal combination treatment regimens are urgently needed...
  11. pmc Histopathology of the arachnoid granulations and brain in HIV-associated cryptococcal meningitis: correlation with cerebrospinal fluid pressure
    Angela Loyse
    Infectious Diseases Unit, GF Jooste Hospital, South Africa
    AIDS 24:405-10. 2010
    ..To investigate the histopathology of the arachnoid granulations in patients with HIV-associated cryptococcal meningitis and correlate the findings with clinical data, in particular cerebrospinal fluid (CSF) opening pressure...
  12. doi request reprint Managing cryptococcosis in the immunocompromised host
    Joseph N Jarvis
    Centre for Infection, Department of Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London, UK
    Curr Opin Infect Dis 21:596-603. 2008
    ..In this context, this review summarizes urgently needed recent work aimed at improving the acute management of cryptococcal infection in immunocompromised hosts...
  13. pmc Very low levels of 25-hydroxyvitamin D are not associated with immunologic changes or clinical outcome in South African patients with HIV-associated cryptococcal meningitis
    Joseph N Jarvis
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom Botswana University of Pennsylvania Partnership, Gaborone, Botswana Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    Clin Infect Dis 59:493-500. 2014
    ..It is not known whether such an association exists with Cryptococcus neoformans...
  14. pmc Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis
    Joseph N Jarvis
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Botswana UPenn Partnership, Gaborone, Botswana Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    PLoS Pathog 11:e1004754. 2015
    ..These results provide a rational basis for future studies of immune modulation in CM, and demonstrate the potential of baseline immune profiling to identify CM patients most at risk of mortality and subsequent IRIS. ..
  15. doi request reprint Cryptococcal immune reconstitution inflammatory syndrome
    Nicky Longley
    Research Centre for Infection and Immunity, Division of Clinical Sciences, St George s University of London, London, UK
    Curr Opin Infect Dis 26:26-34. 2013
    ....
  16. pmc Is HIV-associated tuberculosis a risk factor for the development of cryptococcal disease?
    Joseph N Jarvis
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    AIDS 24:612-4. 2010
    ..6; 95% confidence interval = 1.3-32.7) after adjustment for covariates, including CD4 cell counts. A number of potential mechanisms may underlie this association...
  17. doi request reprint Pulmonary cryptococcosis
    Joseph N Jarvis
    Centre for Infection, Department of Cellular and Molecular Medicine, St George s University of London, London, United Kingdom
    Semin Respir Crit Care Med 29:141-50. 2008
    ..Antifungal treatment with amphotericin B +/- flucytosine is recommended for severe disease, whereas fluconazole is the treatment of choice for mild and localized infections...
  18. pmc Rapid diagnosis of cryptococcal meningitis by use of lateral flow assay on cerebrospinal fluid samples: influence of the high-dose "hook" effect
    Adré Lourens
    Division of Medical Microbiology, Stellenbosch University, National Health Laboratory Services, Tygerberg Hospital, Cape Town, South Africa
    J Clin Microbiol 52:4172-5. 2014
    ..Microscopy is essential for preventing the reporting of false-negative results due to the high-dose "hook" effect. ..