David A Harrison

Summary

Affiliation: Intensive Care National Audit and Research Centre
Country: UK

Publications

  1. ncbi request reprint Development and validation of risk models to predict outcomes following in-hospital cardiac arrest attended by a hospital-based resuscitation team
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, Napier House, 24 High Holborn, London WC1V 6AZ, UK Electronic address
    Resuscitation 85:993-1000. 2014
  2. pmc Risk factors for invasive fungal disease in critically ill adult patients: a systematic review
    Hannah Muskett
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London, WC1H 9HR, UK
    Crit Care 15:R287. 2011
  3. pmc Community-acquired pneumonia on the intensive care unit: secondary analysis of 17,869 cases in the ICNARC Case Mix Programme Database
    Mark Woodhead
    Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Crit Care 10:S1. 2006
  4. pmc Case mix, outcome and activity for patients admitted to intensive care units requiring chronic renal dialysis: a secondary analysis of the ICNARC Case Mix Programme Database
    Colin A Hutchison
    University Hospital Birmingham NHS Foundation Trust, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, B15 2TH, UK
    Crit Care 11:R50. 2007
  5. pmc Bench-to-bedside review: the evaluation of complex interventions in critical care
    Anthony Delaney
    Northern Clinical School, Faculty of Medicine, University of Sydney, Intensive Care Unit, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW, 2065, Australia
    Crit Care 12:210. 2008
  6. pmc Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database
    Peter A Hampshire
    Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK
    Crit Care 13:R137. 2009
  7. pmc Case mix, outcome, and activity for admissions to UK critical care units with severe acute pancreatitis: a secondary analysis of the ICNARC Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 11:S1. 2007
  8. ncbi request reprint The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London, United Kingdom
    Crit Care Med 35:1703-8. 2007
  9. pmc The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 10:R42. 2006
  10. doi request reprint Outcome prediction in critical care: the ICNARC model
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Curr Opin Crit Care 14:506-12. 2008

Detail Information

Publications33

  1. ncbi request reprint Development and validation of risk models to predict outcomes following in-hospital cardiac arrest attended by a hospital-based resuscitation team
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, Napier House, 24 High Holborn, London WC1V 6AZ, UK Electronic address
    Resuscitation 85:993-1000. 2014
    ..The aim of this study was to develop and validate risk models to predict outcomes following in-hospital cardiac arrest attended by a hospital-based resuscitation team in UK hospitals...
  2. pmc Risk factors for invasive fungal disease in critically ill adult patients: a systematic review
    Hannah Muskett
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London, WC1H 9HR, UK
    Crit Care 15:R287. 2011
    ....
  3. pmc Community-acquired pneumonia on the intensive care unit: secondary analysis of 17,869 cases in the ICNARC Case Mix Programme Database
    Mark Woodhead
    Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Crit Care 10:S1. 2006
    ..This paper describes the case mix, outcome and activity for admissions to intensive care units (ICUs) with community-acquired pneumonia (CAP)...
  4. pmc Case mix, outcome and activity for patients admitted to intensive care units requiring chronic renal dialysis: a secondary analysis of the ICNARC Case Mix Programme Database
    Colin A Hutchison
    University Hospital Birmingham NHS Foundation Trust, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, B15 2TH, UK
    Crit Care 11:R50. 2007
    ....
  5. pmc Bench-to-bedside review: the evaluation of complex interventions in critical care
    Anthony Delaney
    Northern Clinical School, Faculty of Medicine, University of Sydney, Intensive Care Unit, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW, 2065, Australia
    Crit Care 12:210. 2008
    ..These aspects of study design impact upon the evaluation of complex interventions in critical care. Clinicians should also consider these specific issues when implementing new complex interventions into their practice...
  6. pmc Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database
    Peter A Hampshire
    Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK
    Crit Care 13:R137. 2009
    ....
  7. pmc Case mix, outcome, and activity for admissions to UK critical care units with severe acute pancreatitis: a secondary analysis of the ICNARC Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 11:S1. 2007
    ..We describe the case mix, outcome, and activity of admissions with SAP who were identified from a high-quality clinical database...
  8. ncbi request reprint The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London, United Kingdom
    Crit Care Med 35:1703-8. 2007
    ..Some scores cannot be applied until several days into hospital admission. We thus sought to develop a new and more sensitive outcome prediction score--the Pancreatitis Outcome Prediction (POP) Score--for these high-risk patients...
  9. pmc The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 10:R42. 2006
    ..We interrogated a high quality clinical database to examine trends in the incidence and mortality of severe sepsis over a nine-year period...
  10. doi request reprint Outcome prediction in critical care: the ICNARC model
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Curr Opin Crit Care 14:506-12. 2008
    ..To describe the background to, rationale for, and structure and performance of the Intensive Care National Audit & Research Centre risk prediction model...
  11. ncbi request reprint The effects of critical care outreach services before and after critical care: a matched-cohort analysis
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    J Crit Care 25:196-204. 2010
    ..The purpose of the study was to evaluate the effect of visits from critical care outreach services (CCOS) before admission to and following discharge from critical care...
  12. ncbi request reprint Recalibration of risk prediction models in a large multicenter cohort of admissions to adult, general critical care units in the United Kingdom
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Crit Care Med 34:1378-88. 2006
    ..To assess the performance of published risk prediction models in common use in adult critical care in the United Kingdom and to recalibrate these models in a large representative database of critical care admissions...
  13. pmc The impact of the introduction of critical care outreach services in England: a multicentre interrupted time-series analysis
    Haiyan Gao
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 11:R113. 2007
    ..We undertook a multicentre interrupted time-series analysis of the impact of CCOS, as characterised by the case mix, outcome and activity of admissions to adult, general critical care units in England...
  14. doi request reprint Post hoc insights from PAC-Man--the U.K. pulmonary artery catheter trial
    Sheila E Harvey
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK
    Crit Care Med 36:1714-21. 2008
    ..K. intensive care units and to generate hypotheses to guide future research by examining subsets of patients included in the PAC-Man Study...
  15. pmc Case mix, outcomes and comparison of risk prediction models for admissions to adult, general and specialist critical care units for head injury: a secondary analysis of the ICNARC Case Mix Programme Database
    Jonathan A Hyam
    Department of Neurosurgery, Charing Cross Hospital, London, UK
    Crit Care 10:S2. 2006
    ..This report describes the case mix and outcome (mortality, intensive care unit (ICU) and hospital length of stay) for admissions to ICU for head injury and evaluates the predictive ability of five risk adjustment models...
  16. ncbi request reprint Winter excess mortality in intensive care in the UK: an analysis of outcome adjusted for patient case mix and unit workload
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, WC1H 9HR London, UK
    Intensive Care Med 30:1900-7. 2004
    ..To investigate whether mortality in UK intensive care units is higher in winter than in non-winter and to explore the importance of variations in case mix and increased pressure on ICUs...
  17. pmc Case mix, outcome and length of stay for admissions to adult, general critical care units in England, Wales and Northern Ireland: the Intensive Care National Audit & Research Centre Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Crit Care 8:R99-111. 2004
    ..The paper also describes the case mix, outcome and activity of the admissions in the Case Mix Programme Database (CMPD)...
  18. ncbi request reprint A new risk prediction model for critical care: the Intensive Care National Audit & Research Centre (ICNARC) model
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, London, UK
    Crit Care Med 35:1091-8. 2007
    ..To develop a new model to improve risk prediction for admissions to adult critical care units in the UK...
  19. ncbi request reprint Systematic review and evaluation of physiological track and trigger warning systems for identifying at-risk patients on the ward
    Haiyan Gao
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London, WC1H 9HR, UK
    Intensive Care Med 33:667-79. 2007
    ....
  20. doi request reprint The association between deprivation and hospital mortality for admissions to critical care units in England
    Catherine A Welch
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, WC1H 9HR, London, UK
    J Crit Care 25:382-90. 2010
    ..It is important to be aware if an association exists because risk prediction models do not adjust for deprivation...
  21. pmc Drotrecogin alfa (activated): real-life use and outcomes for the UK
    Kathryn M Rowan
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 12:R58. 2008
    ..1% absolute reduction in 28-day mortality. Drotrecogin alfa (activated; DrotAA) was subsequently approved for use in patients with severe sepsis...
  22. ncbi request reprint The Protocolised Management in Sepsis (ProMISe) trial statistical analysis plan
    G Sarah Power
    Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, United Kingdom
    Crit Care Resusc 15:311-7. 2013
    ..The rationale for the ProMISe trial derives from a single-centre United States RCT that reported a reduction in hospital mortality from 46.5% to 30.5%...
  23. pmc Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice?
    M Zia Sadique
    Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London, WC1H 9SH, UK
    Crit Care 15:R228. 2011
    ..There is little evidence on whether DrotAA is cost-effective in routine clinical practice. We assessed whether DrotAA is cost-effective in routine practice for adult patients with severe sepsis and multiple organ systems failing...
  24. pmc Identification and characterisation of the high-risk surgical population in the United Kingdom
    Rupert M Pearse
    William Harvey Research Institute, Queen Mary s School of Medicine and Dentistry, London, UK
    Crit Care 10:R81. 2006
    ..The aim of the present study was to estimate the size of the high-risk general surgical population and to describe the outcome and intensive care unit (ICU) resource use...
  25. doi request reprint Effect of specialist retrieval teams on outcomes in children admitted to paediatric intensive care units in England and Wales: a retrospective cohort study
    Padmanabhan Ramnarayan
    Children s Acute Transport Service, Great Ormond Street Hospital, London, UK
    Lancet 376:698-704. 2010
    ..We studied the outcome of children transferred from local hospitals to PICUs...
  26. ncbi request reprint Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial
    Sheila Harvey
    Intensive Care National Audit and Research Centre, London, UK
    Lancet 366:472-7. 2005
    ..Our aim was, therefore, to ascertain whether hospital mortality is reduced in critically ill patients when they are managed with a PAC...
  27. ncbi request reprint End-of-life decisions: a cohort study of the withdrawal of all active treatment in intensive care units in the United Kingdom
    Hannah Wunsch
    Department of Anesthesiology, Columbia University, New York Presbyterian Hospital, New York, NY 10025, USA
    Intensive Care Med 31:823-31. 2005
    ..To describe the epidemiology of active treatment withdrawal in a nationally representative cohort of intensive care units (ICUs) focusing on between-unit differences...
  28. doi request reprint Variation in critical care services across North America and Western Europe
    Hannah Wunsch
    Department of Anesthesiology, Columbia University, New York, NY, USA
    Crit Care Med 36:2787-93, e1-9. 2008
    ..Yet, little is known regarding international variation in critical care services. We sought to understand differences in critical care delivery by comparing data on the distribution of services in eight countries...
  29. ncbi request reprint Risk prediction models: recalibration
    David A Harrison
    Crit Care Med 35:326-7. 2007
  30. pmc Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database
    Dheeraj Gupta
    Department of Respiratory Medicine, Birmingham Heartlands Solihull NHS Trust, Birmingham, UK
    Crit Care 8:R112-21. 2004
    ....
  31. ncbi request reprint A new measure of acute physiological derangement for patients with exacerbations of obstructive airways disease: the COPD and Asthma Physiology Score
    Martin J Wildman
    Department of Respiratory Medicine, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    Respir Med 101:1994-2002. 2007
    ..This depends on the severity of the acute deterioration and the patient's functional reserve. There are currently no validated disease-specific scores that measure the severity of the acute exacerbation...
  32. ncbi request reprint Health services research in critical care using administrative data
    Hannah Wunsch
    Department of Anesthesiology, Columbia Presbyterian Medical Center, Columbia University, New York, NY 10032, USA
    J Crit Care 20:264-9. 2005
    ..The article concludes with a step-wise approach to conducting studies of critical care based on administrative data...
  33. pmc Recognising and responding to acute illness in patients in hospital
    Kathryn M Rowan
    BMJ 335:1165-6. 2007